Dusp3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dusp3
Entrez Gene ID	498003
Full Name	dual specificity phosphatase 3
Synonyms	RGD1560049
General protein information	Preferred Names dual specificity phosphatase 3 Names dual specificity protein phosphatase 3 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)-like vaccinia virus phosphatase VH1-related
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001173376.2	NP_001166847.1	dual specificity protein phosphatase 3
XM_006247402.3	XP_006247464.1	dual specificity protein phosphatase 3 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DUSP3	XP_003315464.1
Canis lupus familiaris (dog)	DUSP3	XP_537624.3
Xenopus tropicalis (tropical clawed frog)	LOC100498529	XP_002937631.1
Homo sapiens (human)	DUSP3	NP_004081.1
	DUSP3	XP_001113754.1
Bos taurus (cattle)	DUSP3	NP_001069842.1
Mus musculus (house mouse)	Dusp3	NP_082483.1
Rattus norvegicus (Norway rat)	Dusp3	NP_001166847.1
Gallus gallus (chicken)	DUSP3	XP_423280.4
Danio rerio (zebrafish)	dusp3a	XP_001340818.2

Gene Ontology
Bibliography

Related articles in PubMed

Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration.
Chen YR, Chou HC, Yang CH, Chen HY, Liu YW, Lin TY, Yeh CL, Chao WT, Tsou HH, Chuang HC, Tan TH
Oncogene36(47)6509-6517(2017 Nov)

The family-wide structure and function of human dual-specificity protein phosphatases.
Jeong DG, Wei CH, Ku B, Jeon TJ, Chien PN, Kim JK, Park SY, Hwang HS, Ryu SY, Park H, Kim DS, Kim SJ, Ryu SE
Acta crystallographica. Section D, Biological crystallography70(Pt 2)421-35(2014 Feb)

Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip.
Quiel A, J?rgen B, Greinacher A, Lassen S, W?rl R, Witt S, Schweder T
Biosensors & bioelectronics36(1)207-11(2012 Jun-Jul)

The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer.
Arnoldussen YJ, Lorenzo PI, Pretorius ME, Waehre H, Risberg B, Maelandsmo GM, Danielsen HE, Saatcioglu F
Cancer research68(22)9255-64(2008 Nov)

Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR.
Henkens R, Delvenne P, Arafa M, Moutschen M, Zeddou M, Tautz L, Boniver J, Mustelin T, Rahmouni S
BMC cancer8147(2008 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dusp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dusp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa34942	NM_001173376.2 Latest version!	Rattus norvegicus dual specificity phosphatase 3 (Dusp3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa33750	XM_006247402.3 Latest version!	Rattus norvegicus dual specificity phosphatase 3 (Dusp3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dusp3 ( NM_001173376.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001166847.1 Rattus norvegicus dual specificity phosphatase 3 (Dusp3), mRNA.

Price & Availability↑

CloneID	ORa34942
Clone ID Related Accession (Same CDS sequence)	NM_001173376.2
Accession Version	NM_001173376.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity protein phosphatase 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC098160.6. On Oct 10, 2014 this sequence version replaced NM_001173376.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC169043.1, CK477238.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCAGGGCC CCGCCGCCGC CATGTCCGGC TCTTTTGAGC TCTCGGTGCA AGATCTCAAC 
GACCTGCTCT CGGACGGCAG CGGCTGCTAT AGCCTCCCGA GCCAGCCCTG CAACGAGGTC 
ATCCCGAGGG TCTACGTGGG CAACGCGTCT GTGGCTCAGG ACATCACCCA GCTGCAGAAA 
TTGGGCATCA CCCACGTCCT GAATGCTGCT GAGGGCAGGT CCTTCATGCA TGTCAACACC 
AGTGCTAGCT TCTACAAGGA TACGGGCATC ACCTACATGG GCATCAAGGC CAATGACACG 
CAGGAGTTCA ACCTCAGTGC TTACTTTGAA AGGGCTGCAG ACTTCATTGA CCAGGCCCTG 
GCCCATAAAA ATGGCCGGGT GCTTGTCCAT TGCCGTGAGG GCTACAGTCG CTCTCCAACG 
CTAGTCATCG CCTACCTCAT GTTGCGACAG AAGATGGATG TCAGGTCTGC TCTGAGCACT 
GTGAGGCAGA ATCGTGAGAT CGGCCCCAAC GATGGTTTCC TGGCCCAACT CTGCCAGCTC 
AATGACAGAC TAGCCGAGGA GGGCAAGGTG AAACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166847.1
CDS	6..584
Translation	MQGPAAAMSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVIPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYKDTGITYMGIKANDTQEFNLSAYFERAADFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMLRQKMDVRSALSTVRQNREIGPNDGFLAQLCQLNDRLAEEGKVKL

Target ORF information:

RefSeq Version	NM_001173376.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus dual specificity phosphatase 3 (Dusp3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173376.2

ORF Insert Sequence:

ATGCAGGGCC CCGCCGCCGC CATGTCCGGC TCTTTTGAGC TCTCGGTGCA AGATCTCAAC 
GACCTGCTCT CGGACGGCAG CGGCTGCTAT AGCCTCCCGA GCCAGCCCTG CAACGAGGTC 
ATCCCGAGGG TCTACGTGGG CAACGCGTCT GTGGCTCAGG ACATCACCCA GCTGCAGAAA 
TTGGGCATCA CCCACGTCCT GAATGCTGCT GAGGGCAGGT CCTTCATGCA TGTCAACACC 
AGTGCTAGCT TCTACAAGGA TACGGGCATC ACCTACATGG GCATCAAGGC CAATGACACG 
CAGGAGTTCA ACCTCAGTGC TTACTTTGAA AGGGCTGCAG ACTTCATTGA CCAGGCCCTG 
GCCCATAAAA ATGGCCGGGT GCTTGTCCAT TGCCGTGAGG GCTACAGTCG CTCTCCAACG 
CTAGTCATCG CCTACCTCAT GTTGCGACAG AAGATGGATG TCAGGTCTGC TCTGAGCACT 
GTGAGGCAGA ATCGTGAGAT CGGCCCCAAC GATGGTTTCC TGGCCCAACT CTGCCAGCTC 
AATGACAGAC TAGCCGAGGA GGGCAAGGTG AAACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dusp3 ( XM_006247402.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006247464.1 Rattus norvegicus dual specificity phosphatase 3 (Dusp3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa33750
Clone ID Related Accession (Same CDS sequence)	XM_006247402.3
Accession Version	XM_006247402.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity protein phosphatase 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006247402.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGATGG GGTGTGGAAC AACCCAGTGT TTATATGCCC TGTGTTACGA TGATCCGATC 
AAGGGCCCCG CCGCCGCCAT GTCCGGCTCT TTTGAGCTCT CGGTGCAAGA TCTCAACGAC 
CTGCTCTCGG ACGGCAGCGG CTGCTATAGC CTCCCGAGCC AGCCCTGCAA CGAGGTCATC 
CCGAGGGTCT ACGTGGGCAA CGCGTCTGTG GCTCAGGACA TCACCCAGCT GCAGAAATTG 
GGCATCACCC ACGTCCTGAA TGCTGCTGAG GGCAGGTCCT TCATGCATGT CAACACCAGT 
GCTAGCTTCT ACAAGGATAC GGGCATCACC TACATGGGCA TCAAGGCCAA TGACACGCAG 
GAGTTCAACC TCAGTGCTTA CTTTGAAAGG GCTGCAGACT TCATTGACCA GGCCCTGGCC 
CATAAAAATG GCCGGGTGCT TGTCCATTGC CGTGAGGGCT ACAGTCGCTC TCCAACGCTA 
GTCATCGCCT ACCTCATGTT GCGACAGAAG ATGGATGTCA GGTCTGCTCT GAGCACTGTG 
AGGCAGAATC GTGAGATCGG CCCCAACGAT GGTTTCCTGG CCCAACTCTG CCAGCTCAAT 
GACAGACTAG CCGAGGAGGG CAAGGATCCC TGGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006247464.1
CDS	68..706
Translation	MAMGCGTTQCLYALCYDDPIKGPAAAMSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVIPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYKDTGITYMGIKANDTQEFNLSAYFERAADFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMLRQKMDVRSALSTVRQNREIGPNDGFLAQLCQLNDRLAEEGKDPWN

Target ORF information:

RefSeq Version	XM_006247402.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus dual specificity phosphatase 3 (Dusp3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006247402.3

ORF Insert Sequence:

ATGGCGATGG GGTGTGGAAC AACCCAGTGT TTATATGCCC TGTGTTACGA TGATCCGATC 
AAGGGCCCCG CCGCCGCCAT GTCCGGCTCT TTTGAGCTCT CGGTGCAAGA TCTCAACGAC 
CTGCTCTCGG ACGGCAGCGG CTGCTATAGC CTCCCGAGCC AGCCCTGCAA CGAGGTCATC 
CCGAGGGTCT ACGTGGGCAA CGCGTCTGTG GCTCAGGACA TCACCCAGCT GCAGAAATTG 
GGCATCACCC ACGTCCTGAA TGCTGCTGAG GGCAGGTCCT TCATGCATGT CAACACCAGT 
GCTAGCTTCT ACAAGGATAC GGGCATCACC TACATGGGCA TCAAGGCCAA TGACACGCAG 
GAGTTCAACC TCAGTGCTTA CTTTGAAAGG GCTGCAGACT TCATTGACCA GGCCCTGGCC 
CATAAAAATG GCCGGGTGCT TGTCCATTGC CGTGAGGGCT ACAGTCGCTC TCCAACGCTA 
GTCATCGCCT ACCTCATGTT GCGACAGAAG ATGGATGTCA GGTCTGCTCT GAGCACTGTG 
AGGCAGAATC GTGAGATCGG CCCCAACGAT GGTTTCCTGG CCCAACTCTG CCAGCTCAAT 
GACAGACTAG CCGAGGAGGG CAAGGATCCC TGGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration.
Oncogene36(47)6509-6517(2017 Nov)
Chen YR,Chou HC,Yang CH,Chen HY,Liu YW,Lin TY,Yeh CL,Chao WT,Tsou HH,Chuang HC,Tan TH

The family-wide structure and function of human dual-specificity protein phosphatases.
Acta crystallographica. Section D, Biological crystallography70(Pt 2)421-35(2014 Feb)
Jeong DG,Wei CH,Ku B,Jeon TJ,Chien PN,Kim JK,Park SY,Hwang HS,Ryu SY,Park H,Kim DS,Kim SJ,Ryu SE

Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip.
Biosensors & bioelectronics36(1)207-11(2012 Jun-Jul)
Quiel A,J?rgen B,Greinacher A,Lassen S,W?rl R,Witt S,Schweder T

The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer.
Cancer research68(22)9255-64(2008 Nov)
Arnoldussen YJ,Lorenzo PI,Pretorius ME,Waehre H,Risberg B,Maelandsmo GM,Danielsen HE,Saatcioglu F

Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR.
BMC cancer8147(2008 May)
Henkens R,Delvenne P,Arafa M,Moutschen M,Zeddou M,Tautz L,Boniver J,Mustelin T,Rahmouni S