Me2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Me2
Entrez Gene ID	307270
Full Name	malic enzyme 2
General protein information	Preferred Names malic enzyme 2 Names NAD-dependent malic enzyme, mitochondrial malic enzyme 2, NAD(+)-dependent, mitochondrial
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18q12.2

mRNA and Protein(s)

mRNA	Protein	Name
XM_006254923.3	XP_006254985.1	NAD-dependent malic enzyme, mitochondrial isoform X1
NM_001107376.2	NP_001100846.2	NAD-dependent malic enzyme, mitochondrial

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ME2	NP_001070282.1
Oryza sativa (rice)	Os01g0723400	NP_001044107.1
Homo sapiens (human)	ME2	NP_002387.1
Pan troglodytes (chimpanzee)	ME2	XP_001154897.1
	ME2	XP_001099883.2
Danio rerio (zebrafish)	LOC100537927	XP_003198629.1
Arabidopsis thaliana (thale cress)	NADP-ME3	NP_197960.1
Arabidopsis thaliana (thale cress)	NADP-ME2	NP_196728.1
Mus musculus (house mouse)	Me2	NP_663469.1
Rattus norvegicus (Norway rat)	Me2	NP_001100846.2
Danio rerio (zebrafish)	me2	NP_001003627.2
Canis lupus familiaris (dog)	ME2	XP_005615454.1
Xenopus tropicalis (tropical clawed frog)	me2	NP_001015690.1

Gene Ontology
Bibliography

Related articles in PubMed

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.
Jiang P, Du W, Mancuso A, Wellen KE, Yang X
Nature493(7434)689-93(2013 Jan)

Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells.
MacDonald MJ, Longacre MJ, Kendrick MA
Archives of biochemistry and biophysics488(2)100-4(2009 Aug)

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell115(5)629-40(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Me2 activity in Islets of Langerhans cells was measured by a spectrophotometric enzyme assay by utilizing the distinct kinetic properties of Me2.
Title: Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells.

The following Me2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Me2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00090	NM_001107376.2 Latest version!	Rattus norvegicus malic enzyme 2 (Me2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa38501	XM_006254923.3 Latest version!	Rattus norvegicus malic enzyme 2 (Me2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Me2 ( NM_001107376.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100846.2 Rattus norvegicus malic enzyme 2 (Me2), mRNA.

Price & Availability↑

CloneID	ORa00090
Clone ID Related Accession (Same CDS sequence)	NM_001107376.2
Accession Version	NM_001107376.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1755bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	NAD-dependent malic enzyme, mitochondrial
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07032519.1, CB556640.1, EV771591.1, CB794492.1, BF522605.1 and CV796911.1. On Jan 24, 2009 this sequence version replaced NM_001107376.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTTCCC GGTTAAGAGC TGTTACCACT CCTTGCACTT TGACCTGCCG CAGAGTGCAC 
CTGAAGGAGA AGGGCAAGCC ACTCATGTTG AATCCAAGAA CAAACAAGGG GATGGCGTTT 
ACATTACAAG AACGACAAAT GCTTGGTCTT CAAGGACTTT TACCTCCTAA AATAGAGACA 
CAGGATATTC AAGCCTTACG ATTCCATAGA AACTTGAAAA AAATGACTAG CCCTTTGGAA 
AAATACATCT ATATAATGGG CATACAAGAA AGAAACGAGA AACTGTTTTA TAGAATACTA 
CAGGATGATA TTGAAAGTCT GATGCCAATT GTGTACACAC CAACAGTTGG TCTTGCCTGT 
TGTCAATACG GACATATCTT TAGGAGACCT AAGGGATTGT TTATTTCAAT CTCAGACAGA 
GGTCATGTTA GATCAATTGT GGATAACTGG CCAGAAAATC ATGTTAAGGC TGTTGTGGTG 
ACTGATGGAG AGAGAATCCT GGGACTTGGA GATTTGGGTG TCTATGGAAT GGGGATTCCA 
GTCGGGAAGC TTTGCTTGTA TACAGCATGC GCAGGAATCC AGCCTGAGAA ATGCCTGCCT 
GTGTGCATCG ATGTAGGGAC TGATAACATG GCTCTACTGA AAGACCCGTT TTATATGGGC 
TTGTATCAGA AGCGAGACCG CTCCCAGCTC TATGACGATC TGATGGATGA GTTTATGAAG 
GCGATCACTG ACAGATATGG CCGGAACACA CTTATTCAGT TTGAAGACTT TGGAAATCAT 
AATGCATTCA GATTCTTAAA AAAATACCAG GAAAAATACT GTACCTTCAA TGACGACATT 
CAAGGGACTG CTGCAGTTGC CTTGTCTGGT CTCCTTGCGG CCCAAAGAGT GATTAATAAA 
CCAATCTCAG AACACAGAAT CTTATTCCTC GGGGCAGGAG AGGCTGCACT TGGAATTGCG 
AAGCTTATAG TCATATCAAT GATGGAAAGT GGTCTCTCAG AAGAGGAGGC ACAGAGAAAG 
ATCTGGATGT TCGACAAGAA CGGCTTGCTA GTTAAGGGCC GGACTGCTAG AATAGATAGT 
AACCAGGAAC CATATGCTCA TGCTGCCTCA GAGAACATAC CTGCAACCTT TGAAGATGCA 
GTAAATAAAC TTAAGCCTTC AGTTATAATT GGAGTGGCAG GTGCTGGCCC GCTTTTTACT 
CCTGGCGTAA TTAAAGCCAT GGCCGCTATC AACGAGAGGC CCATAATATT TGCTTTAAGC 
AATCCTACAG CACAGGCCGA GTGCACTGCC GAAGACGCTT ACACACTTAC AGAGGGCAGG 
TGCTTGTTTG CCAGTGGCAG CCCATTTGAG CCGGTGAGAC TCCAGGATGG GCGTGTCTTC 
ACCCCGGGCC AAGGGAACAA TGCATACATC TTCCCAGGTG TGGCTTTAGC TGTTATTCTC 
TGTGAAGCCC GACACATCAG TGACACCGTT TTCTTAGAAG CTGCAAAGGC ACTGACATCC 
CAATTGACAG ATGAAGAGTT AGCCCAAGGG AGGCTTTACC CATCACTTGC TAATATTCAG 
GAAGTTTCTG CTAACATAGC TATTAAAATT GCAGAGTACC TGTACGCTAA TAAAATGGCT 
TTCCGATACC CAGAGCCCGA GGACAAGGCC AAATATGTGA AGGAAAGGAT ATGGCGGAGT 
AATTATGTTT CCCTGCTGCC AGATGTGTAT GATTGGCCAG AGTCGTCATT GAAGCCTCCG 
CAGATACCAG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100846.2
CDS	100..1854
Translation	MFSRLRAVTTPCTLTCRRVHLKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACCQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIQPEKCLPVCIDVGTDNMALLKDPFYMGLYQKRDRSQLYDDLMDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLKKYQEKYCTFNDDIQGTAAVALSGLLAAQRVINKPISEHRILFLGAGEAALGIAKLIVISMMESGLSEEEAQRKIWMFDKNGLLVKGRTARIDSNQEPYAHAASENIPATFEDAVNKLKPSVIIGVAGAGPLFTPGVIKAMAAINERPIIFALSNPTAQAECTAEDAYTLTEGRCLFASGSPFEPVRLQDGRVFTPGQGNNAYIFPGVALAVILCEARHISDTVFLEAAKALTSQLTDEELAQGRLYPSLANIQEVSANIAIKIAEYLYANKMAFRYPEPEDKAKYVKERIWRSNYVSLLPDVYDWPESSLKPPQIPE

Target ORF information:

RefSeq Version	NM_001107376.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus malic enzyme 2 (Me2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107376.2

ORF Insert Sequence:

ATGTTTTCCC GGTTAAGAGC TGTTACCACT CCTTGCACTT TGACCTGCCG CAGAGTGCAC 
CTGAAGGAGA AGGGCAAGCC ACTCATGTTG AATCCAAGAA CAAACAAGGG GATGGCGTTT 
ACATTACAAG AACGACAAAT GCTTGGTCTT CAAGGACTTT TACCTCCTAA AATAGAGACA 
CAGGATATTC AAGCCTTACG ATTCCATAGA AACTTGAAAA AAATGACTAG CCCTTTGGAA 
AAATACATCT ATATAATGGG CATACAAGAA AGAAACGAGA AACTGTTTTA TAGAATACTA 
CAGGATGATA TTGAAAGTCT GATGCCAATT GTGTACACAC CAACAGTTGG TCTTGCCTGT 
TGTCAATACG GACATATCTT TAGGAGACCT AAGGGATTGT TTATTTCAAT CTCAGACAGA 
GGTCATGTTA GATCAATTGT GGATAACTGG CCAGAAAATC ATGTTAAGGC TGTTGTGGTG 
ACTGATGGAG AGAGAATCCT GGGACTTGGA GATTTGGGTG TCTATGGAAT GGGGATTCCA 
GTCGGGAAGC TTTGCTTGTA TACAGCATGC GCAGGAATCC AGCCTGAGAA ATGCCTGCCT 
GTGTGCATCG ATGTAGGGAC TGATAACATG GCTCTACTGA AAGACCCGTT TTATATGGGC 
TTGTATCAGA AGCGAGACCG CTCCCAGCTC TATGACGATC TGATGGATGA GTTTATGAAG 
GCGATCACTG ACAGATATGG CCGGAACACA CTTATTCAGT TTGAAGACTT TGGAAATCAT 
AATGCATTCA GATTCTTAAA AAAATACCAG GAAAAATACT GTACCTTCAA TGACGACATT 
CAAGGGACTG CTGCAGTTGC CTTGTCTGGT CTCCTTGCGG CCCAAAGAGT GATTAATAAA 
CCAATCTCAG AACACAGAAT CTTATTCCTC GGGGCAGGAG AGGCTGCACT TGGAATTGCG 
AAGCTTATAG TCATATCAAT GATGGAAAGT GGTCTCTCAG AAGAGGAGGC ACAGAGAAAG 
ATCTGGATGT TCGACAAGAA CGGCTTGCTA GTTAAGGGCC GGACTGCTAG AATAGATAGT 
AACCAGGAAC CATATGCTCA TGCTGCCTCA GAGAACATAC CTGCAACCTT TGAAGATGCA 
GTAAATAAAC TTAAGCCTTC AGTTATAATT GGAGTGGCAG GTGCTGGCCC GCTTTTTACT 
CCTGGCGTAA TTAAAGCCAT GGCCGCTATC AACGAGAGGC CCATAATATT TGCTTTAAGC 
AATCCTACAG CACAGGCCGA GTGCACTGCC GAAGACGCTT ACACACTTAC AGAGGGCAGG 
TGCTTGTTTG CCAGTGGCAG CCCATTTGAG CCGGTGAGAC TCCAGGATGG GCGTGTCTTC 
ACCCCGGGCC AAGGGAACAA TGCATACATC TTCCCAGGTG TGGCTTTAGC TGTTATTCTC 
TGTGAAGCCC GACACATCAG TGACACCGTT TTCTTAGAAG CTGCAAAGGC ACTGACATCC 
CAATTGACAG ATGAAGAGTT AGCCCAAGGG AGGCTTTACC CATCACTTGC TAATATTCAG 
GAAGTTTCTG CTAACATAGC TATTAAAATT GCAGAGTACC TGTACGCTAA TAAAATGGCT 
TTCCGATACC CAGAGCCCGA GGACAAGGCC AAATATGTGA AGGAAAGGAT ATGGCGGAGT 
AATTATGTTT CCCTGCTGCC AGATGTGTAT GATTGGCCAG AGTCGTCATT GAAGCCTCCG 
CAGATACCAG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Me2 ( XM_006254923.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254985.1 Rattus norvegicus malic enzyme 2 (Me2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa38501
Clone ID Related Accession (Same CDS sequence)	XM_006254923.3
Accession Version	XM_006254923.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1776bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	NAD-dependent malic enzyme, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254923.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTAAACT GGAGAGAGAA GATGTTTTCC CGGTTAAGAG CTGTTACCAC TCCTTGCACT 
TTGACCTGCC GCAGAGTGCA CCTGAAGGAG AAGGGCAAGC CACTCATGTT GAATCCAAGA 
ACAAACAAGG GGATGGCGTT TACATTACAA GAACGACAAA TGCTTGGTCT TCAAGGACTT 
TTACCTCCTA AAATAGAGAC ACAGGATATT CAAGCCTTAC GATTCCATAG AAACTTGAAA 
AAAATGACTA GCCCTTTGGA AAAATACATC TATATAATGG GCATACAAGA AAGAAACGAG 
AAACTGTTTT ATAGAATACT ACAGGATGAT ATTGAAAGTC TGATGCCAAT TGTGTACACA 
CCAACAGTTG GTCTTGCCTG TTGTCAATAC GGACATATCT TTAGGAGACC TAAGGGATTG 
TTTATTTCAA TCTCAGACAG AGGTCATGTT AGATCAATTG TGGATAACTG GCCAGAAAAT 
CATGTTAAGG CTGTTGTGGT GACTGATGGA GAGAGAATCC TGGGACTTGG AGATTTGGGT 
GTCTATGGAA TGGGGATTCC AGTCGGGAAG CTTTGCTTGT ATACAGCATG CGCAGGAATC 
CAGCCTGAGA AATGCCTGCC TGTGTGCATC GATGTAGGGA CTGATAACAT GGCTCTACTG 
AAAGACCCGT TTTATATGGG CTTGTATCAG AAGCGAGACC GCTCCCAGCT CTATGACGAT 
CTGATGGATG AGTTTATGAA GGCGATCACT GACAGATATG GCCGGAACAC ACTTATTCAG 
TTTGAAGACT TTGGAAATCA TAATGCATTC AGATTCTTAA AAAAATACCA GGAAAAATAC 
TGTACCTTCA ATGACGACAT TCAAGGGACT GCTGCAGTTG CCTTGTCTGG TCTCCTTGCG 
GCCCAAAGAG TGATTAATAA ACCAATCTCA GAACACAGAA TCTTATTCCT CGGGGCAGGA 
GAGGCTGCAC TTGGAATTGC GAAGCTTATA GTCATATCAA TGATGGAAAG TGGTCTCTCA 
GAAGAGGAGG CACAGAGAAA GATCTGGATG TTCGACAAGA ACGGCTTGCT AGTTAAGGGC 
CGGACTGCTA GAATAGATAG TAACCAGGAA CCATATGCTC ATGCTGCCTC AGAGAACATA 
CCTGCAACCT TTGAAGATGC AGTAAATAAA CTTAAGCCTT CAGTTATAAT TGGAGTGGCA 
GGTGCTGGCC CGCTTTTTAC TCCTGGCGTA ATTAAAGCCA TGGCCGCTAT CAACGAGAGG 
CCCATAATAT TTGCTTTAAG CAATCCTACA GCACAGGCCG AGTGCACTGC CGAAGACGCT 
TACACACTTA CAGAGGGCAG GTGCTTGTTT GCCAGTGGCA GCCCATTTGA GCCGGTGAGA 
CTCCAGGATG GGCGTGTCTT CACCCCGGGC CAAGGGAACA ATGCATACAT CTTCCCAGGT 
GTGGCTTTAG CTGTTATTCT CTGTGAAGCC CGACACATCA GTGACACCGT TTTCTTAGAA 
GCTGCAAAGG CACTGACATC CCAATTGACA GATGAAGAGT TAGCCCAAGG GAGGCTTTAC 
CCATCACTTG CTAATATTCA GGAAGTTTCT GCTAACATAG CTATTAAAAT TGCAGAGTAC 
CTGTACGCTA ATAAAATGGC TTTCCGATAC CCAGAGCCCG AGGACAAGGC CAAATATGTG 
AAGGAAAGGA TATGGCGGAG TAATTATGTT TCCCTGCTGC CAGATGTGTA TGATTGGCCA 
GAGTCGTCAT TGAAGCCTCC GCAGATACCA GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254985.1
CDS	1844..3619
Translation	MLNWREKMFSRLRAVTTPCTLTCRRVHLKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACCQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIQPEKCLPVCIDVGTDNMALLKDPFYMGLYQKRDRSQLYDDLMDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLKKYQEKYCTFNDDIQGTAAVALSGLLAAQRVINKPISEHRILFLGAGEAALGIAKLIVISMMESGLSEEEAQRKIWMFDKNGLLVKGRTARIDSNQEPYAHAASENIPATFEDAVNKLKPSVIIGVAGAGPLFTPGVIKAMAAINERPIIFALSNPTAQAECTAEDAYTLTEGRCLFASGSPFEPVRLQDGRVFTPGQGNNAYIFPGVALAVILCEARHISDTVFLEAAKALTSQLTDEELAQGRLYPSLANIQEVSANIAIKIAEYLYANKMAFRYPEPEDKAKYVKERIWRSNYVSLLPDVYDWPESSLKPPQIPE

Target ORF information:

RefSeq Version	XM_006254923.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus malic enzyme 2 (Me2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254923.3

ORF Insert Sequence:

ATGCTAAACT GGAGAGAGAA GATGTTTTCC CGGTTAAGAG CTGTTACCAC TCCTTGCACT 
TTGACCTGCC GCAGAGTGCA CCTGAAGGAG AAGGGCAAGC CACTCATGTT GAATCCAAGA 
ACAAACAAGG GGATGGCGTT TACATTACAA GAACGACAAA TGCTTGGTCT TCAAGGACTT 
TTACCTCCTA AAATAGAGAC ACAGGATATT CAAGCCTTAC GATTCCATAG AAACTTGAAA 
AAAATGACTA GCCCTTTGGA AAAATACATC TATATAATGG GCATACAAGA AAGAAACGAG 
AAACTGTTTT ATAGAATACT ACAGGATGAT ATTGAAAGTC TGATGCCAAT TGTGTACACA 
CCAACAGTTG GTCTTGCCTG TTGTCAATAC GGACATATCT TTAGGAGACC TAAGGGATTG 
TTTATTTCAA TCTCAGACAG AGGTCATGTT AGATCAATTG TGGATAACTG GCCAGAAAAT 
CATGTTAAGG CTGTTGTGGT GACTGATGGA GAGAGAATCC TGGGACTTGG AGATTTGGGT 
GTCTATGGAA TGGGGATTCC AGTCGGGAAG CTTTGCTTGT ATACAGCATG CGCAGGAATC 
CAGCCTGAGA AATGCCTGCC TGTGTGCATC GATGTAGGGA CTGATAACAT GGCTCTACTG 
AAAGACCCGT TTTATATGGG CTTGTATCAG AAGCGAGACC GCTCCCAGCT CTATGACGAT 
CTGATGGATG AGTTTATGAA GGCGATCACT GACAGATATG GCCGGAACAC ACTTATTCAG 
TTTGAAGACT TTGGAAATCA TAATGCATTC AGATTCTTAA AAAAATACCA GGAAAAATAC 
TGTACCTTCA ATGACGACAT TCAAGGGACT GCTGCAGTTG CCTTGTCTGG TCTCCTTGCG 
GCCCAAAGAG TGATTAATAA ACCAATCTCA GAACACAGAA TCTTATTCCT CGGGGCAGGA 
GAGGCTGCAC TTGGAATTGC GAAGCTTATA GTCATATCAA TGATGGAAAG TGGTCTCTCA 
GAAGAGGAGG CACAGAGAAA GATCTGGATG TTCGACAAGA ACGGCTTGCT AGTTAAGGGC 
CGGACTGCTA GAATAGATAG TAACCAGGAA CCATATGCTC ATGCTGCCTC AGAGAACATA 
CCTGCAACCT TTGAAGATGC AGTAAATAAA CTTAAGCCTT CAGTTATAAT TGGAGTGGCA 
GGTGCTGGCC CGCTTTTTAC TCCTGGCGTA ATTAAAGCCA TGGCCGCTAT CAACGAGAGG 
CCCATAATAT TTGCTTTAAG CAATCCTACA GCACAGGCCG AGTGCACTGC CGAAGACGCT 
TACACACTTA CAGAGGGCAG GTGCTTGTTT GCCAGTGGCA GCCCATTTGA GCCGGTGAGA 
CTCCAGGATG GGCGTGTCTT CACCCCGGGC CAAGGGAACA ATGCATACAT CTTCCCAGGT 
GTGGCTTTAG CTGTTATTCT CTGTGAAGCC CGACACATCA GTGACACCGT TTTCTTAGAA 
GCTGCAAAGG CACTGACATC CCAATTGACA GATGAAGAGT TAGCCCAAGG GAGGCTTTAC 
CCATCACTTG CTAATATTCA GGAAGTTTCT GCTAACATAG CTATTAAAAT TGCAGAGTAC 
CTGTACGCTA ATAAAATGGC TTTCCGATAC CCAGAGCCCG AGGACAAGGC CAAATATGTG 
AAGGAAAGGA TATGGCGGAG TAATTATGTT TCCCTGCTGC CAGATGTGTA TGATTGGCCA 
GAGTCGTCAT TGAAGCCTCC GCAGATACCA GAATAG