Scgn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scgn
Entrez Gene ID	306942
Full Name	secretagogin, EF-hand calcium binding protein
General protein information	Preferred Names secretagogin, EF-hand calcium binding protein Names secretagogin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17p11

mRNA and Protein(s)

mRNA	Protein	Name
NM_201561.1	NP_963855.1	secretagogin

Pathways from BioSystems

Homologies

Homo sapiens (human)	SCGN	NP_008929.2
Bos taurus (cattle)	SCGN	NP_001092643.1
Danio rerio (zebrafish)	scgn	NP_001005776.1
Mus musculus (house mouse)	Scgn	NP_663374.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012179	XP_320356.2
Pan troglodytes (chimpanzee)	SCGN	XP_518281.2
Rattus norvegicus (Norway rat)	Scgn	NP_963855.1
	SCGN	XP_001082266.1
Drosophila melanogaster (fruit fly)	Cbp53E	NP_476838.1
Xenopus tropicalis (tropical clawed frog)	scgn	NP_001072782.1
Canis lupus familiaris (dog)	SCGN	XP_853640.1
Gallus gallus (chicken)	SCGN	XP_419087.2

Gene Ontology
Bibliography

Related articles in PubMed

Calcium-binding protein, secretagogin, characterizes novel groups of interneurons in the rat striatum.
Kosaka T, Yasuda S, Kosaka K
Neuroscience research11953-60(2017 Jun)

Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration.
Hanics J, Szodorai E, Tortoriello G, Malenczyk K, Keimpema E, Lubec G, Hevesi Z, Lutz MI, Kozsurek M, Pusk?r Z, T?th ZE, Wagner L, Kov?cs GG, H?kfelt TG, Harkany T, Alp?r A
Proceedings of the National Academy of Sciences of the United States of America114(10)E2006-E2015(2017 Mar)

Secretagogin is expressed in sensory CGRP neurons and in spinal cord of mouse and complements other calcium-binding proteins, with a note on rat and human.
Shi TJ, Xiang Q, Zhang MD, Tortoriello G, Hammarberg H, Mulder J, Fried K, Wagner L, Josephson A, Uhl?n M, Harkany T, H?kfelt T
Molecular pain880(2012 Oct)

Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin.
Maj M, Gartner W, Ilhan A, Neziri D, Attems J, Wagner L
The Journal of endocrinology205(1)25-36(2010 Apr)

New functional aspects of the neuroendocrine marker secretagogin based on the characterization of its rat homolog.
Gartner W, Vila G, Daneva T, Nabokikh A, Koc-Saral F, Ilhan A, Majdic O, Luger A, Wagner L
American journal of physiology. Endocrinology and metabolism293(1)E347-54(2007 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Scgn is a CaBP expressed in a subpopulation of nociceptive DRG neurons and their processes in the dorsal horn.
Title: Secretagogin is expressed in sensory CGRP neurons and in spinal cord of mouse and complements other calcium-binding proteins, with a note on rat and human.

There is an association of TAU and the calcium-binding protein SCGN in insulin-secreting cells implicating beta-cells as an extra cerebral site of tauopathy.
Title: Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin.

The sequence homology and the comparable tissue expression patterns of human and rat secretagogin indicate conserved intracellular functions.
Title: New functional aspects of the neuroendocrine marker secretagogin based on the characterization of its rat homolog.

Characterization of the human secretagogin homolog.
Title: Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein.

The following Scgn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scgn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05444	NM_201561.1 Latest version!	Rattus norvegicus secretagogin, EF-hand calcium binding protein (Scgn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scgn ( NM_201561.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_963855.1 Rattus norvegicus secretagogin, EF-hand calcium binding protein (Scgn), mRNA.

Price & Availability↑

CloneID	ORa05444
Clone ID Related Accession (Same CDS sequence)	NM_201561.1
Accession Version	NM_201561.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-10
Organism	Rattus norvegicus(Norway rat)
Product	secretagogin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY513659.1. On Feb 7, 2004 this sequence version replaced XM_225337.1. ##Evidence-Data-START## Transcript exon combination :: AY513659.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGACAACG CACACAGACA AACTCAAGCT CATTTGGATG CTGCCTGCTT CTGGCAGATC 
TGGCAGCGCT TCGACAAGGA TGAAAAAGGT TACATAAAAG AGACAGAGCT GGATGCCTTT 
TTTGACGATT TGCTGGCAAA ATTTGGAATT GAGGACACTC TTATGGAAGA AAATGTGCAG 
AAAATGAAAG AACAGTTAAT GGTTGGCCAT GACATCTCTA AGGAAGGTCG CATACTGATG 
AAAGAGCTTG CCAGTATGTT CTTATCTGAG GACGAAAATT TCCTCTTGTT CTTTCGCCTG 
GAAACTCCCT TGGATAACAG TGTGGAGTTT ATGCAGATTT GGCGCAAGTA TGATGCGGAC 
AGCAGTGGCT TCATATCAGC TGCTGAGCTT TCTAACTTTC TCCGAGATCT TTTCCTCCAC 
CACAAAAAGG TCATTTCCGA GGCTGAGCTG GAAGAGTATA CTAGCACCAT GGAGAAGATC 
TTTGACAGAA ATAAAGATGG TCGTTTGGAT CTTAATGACT TGGCAAGGAT TCTGGCTCTT 
CAGGAAAACT TCCTTCTTCA GTTTAAAATG GATGCTTCTT CTACTGAGGA AAGGAAGAGG 
GACTTTGAGA AAATCTTTGC CCATTATGAT GTTAGTAAAA CTGGAGCCCT GGAAGGCCCA 
GAAGTGGATG GATTTGTCAA AGACATGATG GAACTGGTCC AGCCTAGCAT CAGCGGTGTG 
GATCTTGATA AGTTCCGGGA GATTCTGCTT CGACATTGCG ATGTGAACAA GGATGGAAAG 
ATCCAGAAGT CTGAGCTGGC GCTGTGTCTT GGGCTAAAAA TAAACCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_963855.1
CDS	1..831
Translation	MDNAHRQTQAHLDAACFWQIWQRFDKDEKGYIKETELDAFFDDLLAKFGIEDTLMEENVQKMKEQLMVGHDISKEGRILMKELASMFLSEDENFLLFFRLETPLDNSVEFMQIWRKYDADSSGFISAAELSNFLRDLFLHHKKVISEAELEEYTSTMEKIFDRNKDGRLDLNDLARILALQENFLLQFKMDASSTEERKRDFEKIFAHYDVSKTGALEGPEVDGFVKDMMELVQPSISGVDLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP

Target ORF information:

RefSeq Version	NM_201561.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus secretagogin, EF-hand calcium binding protein (Scgn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_201561.1

ORF Insert Sequence:

ATGGACAACG CACACAGACA AACTCAAGCT CATTTGGATG CTGCCTGCTT CTGGCAGATC 
TGGCAGCGCT TCGACAAGGA TGAAAAAGGT TACATAAAAG AGACAGAGCT GGATGCCTTT 
TTTGACGATT TGCTGGCAAA ATTTGGAATT GAGGACACTC TTATGGAAGA AAATGTGCAG 
AAAATGAAAG AACAGTTAAT GGTTGGCCAT GACATCTCTA AGGAAGGTCG CATACTGATG 
AAAGAGCTTG CCAGTATGTT CTTATCTGAG GACGAAAATT TCCTCTTGTT CTTTCGCCTG 
GAAACTCCCT TGGATAACAG TGTGGAGTTT ATGCAGATTT GGCGCAAGTA TGATGCGGAC 
AGCAGTGGCT TCATATCAGC TGCTGAGCTT TCTAACTTTC TCCGAGATCT TTTCCTCCAC 
CACAAAAAGG TCATTTCCGA GGCTGAGCTG GAAGAGTATA CTAGCACCAT GGAGAAGATC 
TTTGACAGAA ATAAAGATGG TCGTTTGGAT CTTAATGACT TGGCAAGGAT TCTGGCTCTT 
CAGGAAAACT TCCTTCTTCA GTTTAAAATG GATGCTTCTT CTACTGAGGA AAGGAAGAGG 
GACTTTGAGA AAATCTTTGC CCATTATGAT GTTAGTAAAA CTGGAGCCCT GGAAGGCCCA 
GAAGTGGATG GATTTGTCAA AGACATGATG GAACTGGTCC AGCCTAGCAT CAGCGGTGTG 
GATCTTGATA AGTTCCGGGA GATTCTGCTT CGACATTGCG ATGTGAACAA GGATGGAAAG 
ATCCAGAAGT CTGAGCTGGC GCTGTGTCTT GGGCTAAAAA TAAACCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Calcium-binding protein, secretagogin, characterizes novel groups of interneurons in the rat striatum.
Neuroscience research11953-60(2017 Jun)
Kosaka T,Yasuda S,Kosaka K

Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration.
Proceedings of the National Academy of Sciences of the United States of America114(10)E2006-E2015(2017 Mar)
Hanics J,Szodorai E,Tortoriello G,Malenczyk K,Keimpema E,Lubec G,Hevesi Z,Lutz MI,Kozsurek M,Pusk?r Z,T?th ZE,Wagner L,Kov?cs GG,H?kfelt TG,Harkany T,Alp?r A

Secretagogin is expressed in sensory CGRP neurons and in spinal cord of mouse and complements other calcium-binding proteins, with a note on rat and human.
Molecular pain880(2012 Oct)
Shi TJ,Xiang Q,Zhang MD,Tortoriello G,Hammarberg H,Mulder J,Fried K,Wagner L,Josephson A,Uhl?n M,Harkany T,H?kfelt T

Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin.
The Journal of endocrinology205(1)25-36(2010 Apr)
Maj M,Gartner W,Ilhan A,Neziri D,Attems J,Wagner L

New functional aspects of the neuroendocrine marker secretagogin based on the characterization of its rat homolog.
American journal of physiology. Endocrinology and metabolism293(1)E347-54(2007 Jul)
Gartner W,Vila G,Daneva T,Nabokikh A,Koc-Saral F,Ilhan A,Majdic O,Luger A,Wagner L