Neurog1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Neurog1
Entrez Gene ID	29410
Full Name	neurogenin 1
Synonyms	Neurod3,Ngn1
General protein information	Preferred Names neurogenin 1 Names neurogenin-1 NGN-1 neurogenic basic-helix-loop-helix protein neurogenic differentiation 3 neurogenic differentiation factor 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17p14
Summary	may play a role in neuronal differentiation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019207.1	NP_062080.1	neurogenin-1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	NEUROG1	XP_002689240.1
Mus musculus (house mouse)	Neurog1	NP_035026.1
Gallus gallus (chicken)	NEUROG1	NP_990214.1
	NEUROG1	XP_001110622.1
Canis lupus familiaris (dog)	NEUROG1	XP_538637.2
Homo sapiens (human)	NEUROG1	NP_006152.2
Rattus norvegicus (Norway rat)	Neurog1	NP_062080.1
Danio rerio (zebrafish)	neurog1	NP_571116.1
Xenopus tropicalis (tropical clawed frog)	neurog1	NP_001116895.1
Pan troglodytes (chimpanzee)	NEUROG1	XP_003310877.1

Gene Ontology
Bibliography

Related articles in PubMed

Impact of siRNA targeting of ?-catenin on differentiation of rat neural stem cells and gene expression of Ngn1 and BMP4 following in vitro hypoxic-ischemic brain damage.
Zhang X, Zhu C, Luo Q, Dong J, Liu L, Li M, Zhu H, Ma X, Wang J
Molecular medicine reports14(4)3595-601(2016 Oct)

Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism.
Itoh Y, Moriyama Y, Hasegawa T, Endo TA, Toyoda T, Gotoh Y
Nature neuroscience16(4)416-25(2013 Apr)

Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression.
Velkey JM, O'Shea KS
Developmental dynamics : an official publication of the American Association of Anatomists242(3)230-53(2013 Mar)

A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant].
Schr?der JC, L??ig AK, Galetzka D, Peters A, Castle JC, Diederich S, Zechner U, M?ller-Forell W, Keilmann A, Bartsch O
Behavioral and brain functions : BBF97(2013 Feb)

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Ahmed M, Xu J, Xu PX
Development (Cambridge, England)139(11)1965-77(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

beta-Catenin siRNA reduces Ngnl1 and increases BMP4 mRNA expression levels in rat neural stem cells.
Title: Impact of siRNA targeting of ?-catenin on differentiation of rat neural stem cells and gene expression of Ngn1 and BMP4 following in vitro hypoxic-ischemic brain damage.

Tumor necrosis factor-alpha converting enzyme (TACE) may play a role in modulating repulsive guidance molecule (RGM)-induced repulsive behavior of neurons by regulating neogenin expression on the cell surface.
Title: TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule.

Hyperbaric oxygen therapy could promote neurogenesis by beta-catenin-induced activated Ngn1 gene and repress astrocytogenesis by beta-catenin-induced down-regulated BMP-4 gene.
Title: The role of ?-catenin signaling pathway on proliferation of rats neural stem cells after hyperbaric oxygen therapy in vitro.

Results identify ERK5 phosphorylation of Neurogenin 1 as a novel mechanism regulating neuronal fate commitment of cortical progenitors.
Title: ERK5 MAP kinase regulates neurogenin1 during cortical neurogenesis.

Ngn1 is required for Akt-mediated neuronal differentiation and neurite outgrowth
Title: Neurogenin 1 mediates erythropoietin enhanced differentiation of adult neural progenitor cells.

The following Neurog1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Neurog1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42660	NM_019207.1 Latest version!	Rattus norvegicus neurogenin 1 (Neurog1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Neurog1 ( NM_019207.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062080.1 Rattus norvegicus neurogenin 1 (Neurog1), mRNA.

Price & Availability↑

CloneID	ORa42660
Clone ID Related Accession (Same CDS sequence)	NM_019207.1
Accession Version	NM_019207.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	neurogenin-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U67777.1. On Jan 12, 2005 this sequence version replaced XM_346496.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U67777.1 [ECO:0000332] ##Evidence-Data-END##

ATGCCTGCCC CTTTGGAGAC CTGTCTCTCT GACCTCGACT GCGCCAGCAG CAACAGCGGG 
AGCGACCTGT CCAGTTTCCT CACCGACGAG GAGGACTGTG CCAGGCTCCA GCCCCTAGCT 
TCCACCTCAG GGCTGTCCGT GCCAGCCCGC AGGAGCGCGC CCACCCTCTC CGGGGCATCG 
AACGTTCCCG GTGGCCAGGA CGAAGAGCAG GAGCGGCGGC GACGGCGAGG TCGCGCGCGG 
GTGCGGTCCG AGGCGCTGCT GCACTCGCTG CGGAGGAGCC GTCGCGTCAA GGCCAACGAT 
CGCGAGCGCA ACCGTATGCA TAACCTCAAC GCTGCGCTGG ACGCTCTGCG CAGCGTGCTG 
CCCTCGTTCC CCGACGACAC CAAGCTCACC AAGATTGAGA CGCTGCGCTT CGCCTACAAC 
TACATCTGGG CCCTGGCTGA GACACTGCGC CTGGCAGATC AAGGGCTCCC GGGGGGCGGT 
GCCCGGGAGC GCCTCCTGCC TCCGCAGTGT GTCCCCTGCC TGCCCGGTCC CCCGAGCCCG 
GCCAGCGATA CAGAGTCCTG GGGCTCCGGG GCCGCTGCCT CCCCCTGCGC TACTGTGGCG 
TCACCACTCT CTGACCCCAG TAGTCCCTCG GCTTCAGAAG ACTTCACCTA TGGCCCGGGT 
GGTCCCCTTT TCTCCTTTCC TGGCCTGCCC AAAGACCTCC TCCATACGAC ACCCTGCTTC 
ATCCCGTACC ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062080.1
CDS	250..984
Translation	MPAPLETCLSDLDCASSNSGSDLSSFLTDEEDCARLQPLASTSGLSVPARRSAPTLSGASNVPGGQDEEQERRRRRGRARVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPASDTESWGSGAAASPCATVASPLSDPSSPSASEDFTYGPGGPLFSFPGLPKDLLHTTPCFIPYH

Target ORF information:

RefSeq Version	NM_019207.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neurogenin 1 (Neurog1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019207.1

ORF Insert Sequence:

ATGCCTGCCC CTTTGGAGAC CTGTCTCTCT GACCTCGACT GCGCCAGCAG CAACAGCGGG 
AGCGACCTGT CCAGTTTCCT CACCGACGAG GAGGACTGTG CCAGGCTCCA GCCCCTAGCT 
TCCACCTCAG GGCTGTCCGT GCCAGCCCGC AGGAGCGCGC CCACCCTCTC CGGGGCATCG 
AACGTTCCCG GTGGCCAGGA CGAAGAGCAG GAGCGGCGGC GACGGCGAGG TCGCGCGCGG 
GTGCGGTCCG AGGCGCTGCT GCACTCGCTG CGGAGGAGCC GTCGCGTCAA GGCCAACGAT 
CGCGAGCGCA ACCGTATGCA TAACCTCAAC GCTGCGCTGG ACGCTCTGCG CAGCGTGCTG 
CCCTCGTTCC CCGACGACAC CAAGCTCACC AAGATTGAGA CGCTGCGCTT CGCCTACAAC 
TACATCTGGG CCCTGGCTGA GACACTGCGC CTGGCAGATC AAGGGCTCCC GGGGGGCGGT 
GCCCGGGAGC GCCTCCTGCC TCCGCAGTGT GTCCCCTGCC TGCCCGGTCC CCCGAGCCCG 
GCCAGCGATA CAGAGTCCTG GGGCTCCGGG GCCGCTGCCT CCCCCTGCGC TACTGTGGCG 
TCACCACTCT CTGACCCCAG TAGTCCCTCG GCTTCAGAAG ACTTCACCTA TGGCCCGGGT 
GGTCCCCTTT TCTCCTTTCC TGGCCTGCCC AAAGACCTCC TCCATACGAC ACCCTGCTTC 
ATCCCGTACC ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Impact of siRNA targeting of ?-catenin on differentiation of rat neural stem cells and gene expression of Ngn1 and BMP4 following in vitro hypoxic-ischemic brain damage.
Molecular medicine reports14(4)3595-601(2016 Oct)
Zhang X,Zhu C,Luo Q,Dong J,Liu L,Li M,Zhu H,Ma X,Wang J

Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism.
Nature neuroscience16(4)416-25(2013 Apr)
Itoh Y,Moriyama Y,Hasegawa T,Endo TA,Toyoda T,Gotoh Y

Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression.
Developmental dynamics : an official publication of the American Association of Anatomists242(3)230-53(2013 Mar)
Velkey JM,O'Shea KS

A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant].
Behavioral and brain functions : BBF97(2013 Feb)
Schr?der JC,L??ig AK,Galetzka D,Peters A,Castle JC,Diederich S,Zechner U,M?ller-Forell W,Keilmann A,Bartsch O

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Development (Cambridge, England)139(11)1965-77(2012 Jun)
Ahmed M,Xu J,Xu PX