Avpr1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Avpr1a
Entrez Gene ID	25107
Full Name	arginine vasopressin receptor 1A
Synonyms	AVPR,V1a,V1aR
General protein information	Preferred Names arginine vasopressin receptor 1A Names vasopressin V1a receptor antidiuretic hormone receptor 1a arginine vasopressin receptor V1a vascular/hepatic-type arginine vasopressin receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q22
Summary	This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053019.2	NP_444178.2	vasopressin V1a receptor

Pathways from BioSystems

Homologies

	AVPR1A	XP_001116798.2
Canis lupus familiaris (dog)	AVPR1A	NP_001185587.1
Danio rerio (zebrafish)	LOC571591	XP_700287.2
Homo sapiens (human)	AVPR1A	NP_000697.1
Mus musculus (house mouse)	Avpr1a	NP_058543.2
Gallus gallus (chicken)	AVPR1A	NP_001103908.1
Caenorhabditis elegans (roundworm)	CELE_T07D10.2	NP_493193.1
Pan troglodytes (chimpanzee)	AVPR1A	XP_003952184.1
Rattus norvegicus (Norway rat)	Avpr1a	NP_444178.2
Caenorhabditis elegans (roundworm)	F14F4.1	NP_510477.1
Bos taurus (cattle)	AVPR1A	NP_001098460.1
Danio rerio (zebrafish)	avpr1b	XP_683692.1
Xenopus tropicalis (tropical clawed frog)	avpr1a	XP_002931664.1

Gene Ontology
Bibliography

Related articles in PubMed

Age and sex differences in oxytocin and vasopressin V1a receptor binding densities in the rat brain: focus on the social decision-making network.
Smith CJ, Poehlmann ML, Li S, Ratnaseelan AM, Bredewold R, Veenema AH
Brain structure & function222(2)981-1006(2017 03)

Over-expression of V1A receptors in PVN modulates autonomic cardiovascular control.
Lozi? M, Tasi? T, Martin A, Greenwood M, ?arenac O, Hindmarch C, Paton JF, Murphy D, Japund?i?-?igon N
Pharmacological research114185-195(2016 Dec)

Vasopressin V1A receptors mediate the stabilization of intestinal mucosal oxygenation during hypercapnia in septic rats.
Sch?neborn S, Vollmer C, Barthel F, Herminghaus A, Schulz J, Bauer I, Beck C, Picker O
Microvascular research10624-30(2016 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Vasopression V1a receptor binding density was higher in juveniles than in adults in regions associated with reward and socio-spatial memory and higher in adults than in juveniles in key regions of the social decision-making network and in cortical regions.
Title: Age and sex differences in oxytocin and vasopressin V1a receptor binding densities in the rat brain: focus on the social decision-making network.

Increased expression of V1aR in hypothalamic paraventricular nucleus influences autonomic cardiovascular regulation and demarcates vulnerability to stress.
Title: Over-expression of V1A receptors in PVN modulates autonomic cardiovascular control.

Stimulation of V1a receptor induces the downregulation of GLUT9, reabsorption urate transporter, together with the upregulation of ABCG2 and NPT1, secretion urate transporters, all changes of which clearly lead to increase in renal uric acid clearance.
Title: Stimulation of V1a receptor increases renal uric acid clearance via urate transporters: insight into pathogenesis of hypouricemia in SIADH.

Vasopressin V1A receptors mediate the beneficial effects of hypercapnia on microcirculatory oxygenation during sepsis.
Title: Vasopressin V1A receptors mediate the stabilization of intestinal mucosal oxygenation during hypercapnia in septic rats.

This study demonstrated that Vasopressin V1a receptor within the PVN of lactating rats mediate maternal care and anxiety-related behaviour.
Title: Vasopressin V1a, but not V1b, receptors within the PVN of lactating rats mediate maternal care and anxiety-related behaviour.

The following Avpr1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Avpr1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12693	NM_053019.2 Latest version!	Rattus norvegicus arginine vasopressin receptor 1A (Avpr1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Avpr1a ( NM_053019.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_444178.2 Rattus norvegicus arginine vasopressin receptor 1A (Avpr1a), mRNA.

Price & Availability↑

CloneID	ORa12693
Clone ID Related Accession (Same CDS sequence)	NM_053019.2
Accession Version	NM_053019.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1275bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	vasopressin V1a receptor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U39450.1. On Jul 23, 2003 this sequence version replaced NM_053019.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z11690.1, BC088095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGTTTCC CGCGAGGCTC CCAGGATCGG TCCGTGGGCA ACTCCAGCCC GTGGTGGCCT 
CTAACCACCG AGGGCTCCAA CGGCAGTCAG GAGGCAGCCA GGCTTGGGGA AGGTGACAGC 
CCGCTGGGGG ACGTACGCAA TGAGGAGCTG GCCAAACTGG AAATCGCTGT GCTGGCAGTG 
ATTTTTGTGG TGGCTGTGCT GGGCAATAGC AGTGTGCTGC TGGCGCTGCA TCGCACGCCA 
CGCAAGACAT CCCGCATGCA CCTCTTTATC CGACACCTCA GCCTGGCAGA CCTGGCGGTC 
GCCTTCTTCC AAGTATTACC GCAGCTATGC TGGGACATCA CCTACCGCTT CCGCGGGCCG 
GACTGGCTGT GCCGCGTGGT GAAGCACCTG CAGGTGTTTG CCATGTTCGC GTCTGCCTAT 
ATGCTGGTGG TGATGACAGC CGACCGCTAC ATCGCCGTGT GCCACCCGCT CAAGACCCTG 
CAGCAGCCGG CGCGCCGCTC GCGCCTCATG ATCGCCACCT CTTGGGTGCT GAGTTTCATA 
CTAAGCACGC CACAGTACTT TATATTCTCT GTGATCGAAA TCGAGGTGAA CAATGGCACT 
AAAACCCAAG ACTGCTGGGC TACCTTCATC CAGCCCTGGG GTACCCGCGC CTACGTGACC 
TGGATGACCA GCGGTGTCTT CGTGGCACCT GTGGTCGTCT TGGGTACATG CTATGGCTTC 
ATCTGCTACC ACATCTGGCG CAACATCCGC GGAAAGACAG CGTCCTCGCG ACACAGCAAG 
GGTGACAAGG GCTCTGGGGA GGCCGTGGGT CCCTTTCATA AGGGGCTTTT GGTTACACCT 
TGTGTCAGCA GCGTGAAGAG CATTTCCCGC GCCAAGATCC GCACTGTGAA GATGACCTTT 
GTGATTGTAA GCGCCTACAT CCTTTGCTGG GCGCCTTTCT TCATTGTCCA GATGTGGTCA 
GTCTGGGATG AGAATTTCAT CTGGACCGAT TCAGAAAACC CTTCCATCAC AATCACGGCG 
TTGCTGGCTT CCTTGAACAG CTGCTGCAAC CCGTGGATAT ACATGTTTTT CAGTGGCCAT 
CTCCTGCAAG ACTGCGTCCA AAGTTTCCCA TGCTGCCACA GCATGGCGCA GAAATTCGCC 
AAGGATGACT CCGATAGCAT GAGCCGAAGA CAGACTTCTT ATTCTAACAA CCGGAGCCCA 
ACGAACAGCA CTGGGATGTG GAAGGACTCG CCCAAATCTT CCAAATCCAT CAGATTCATT 
CCTGTCTCCA CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444178.2
CDS	242..1516
Translation	MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST

Target ORF information:

RefSeq Version	NM_053019.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus arginine vasopressin receptor 1A (Avpr1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053019.2

ORF Insert Sequence:

ATGAGTTTCC CGCGAGGCTC CCAGGATCGG TCCGTGGGCA ACTCCAGCCC GTGGTGGCCT 
CTAACCACCG AGGGCTCCAA CGGCAGTCAG GAGGCAGCCA GGCTTGGGGA AGGTGACAGC 
CCGCTGGGGG ACGTACGCAA TGAGGAGCTG GCCAAACTGG AAATCGCTGT GCTGGCAGTG 
ATTTTTGTGG TGGCTGTGCT GGGCAATAGC AGTGTGCTGC TGGCGCTGCA TCGCACGCCA 
CGCAAGACAT CCCGCATGCA CCTCTTTATC CGACACCTCA GCCTGGCAGA CCTGGCGGTC 
GCCTTCTTCC AAGTATTACC GCAGCTATGC TGGGACATCA CCTACCGCTT CCGCGGGCCG 
GACTGGCTGT GCCGCGTGGT GAAGCACCTG CAGGTGTTTG CCATGTTCGC GTCTGCCTAT 
ATGCTGGTGG TGATGACAGC CGACCGCTAC ATCGCCGTGT GCCACCCGCT CAAGACCCTG 
CAGCAGCCGG CGCGCCGCTC GCGCCTCATG ATCGCCACCT CTTGGGTGCT GAGTTTCATA 
CTAAGCACGC CACAGTACTT TATATTCTCT GTGATCGAAA TCGAGGTGAA CAATGGCACT 
AAAACCCAAG ACTGCTGGGC TACCTTCATC CAGCCCTGGG GTACCCGCGC CTACGTGACC 
TGGATGACCA GCGGTGTCTT CGTGGCACCT GTGGTCGTCT TGGGTACATG CTATGGCTTC 
ATCTGCTACC ACATCTGGCG CAACATCCGC GGAAAGACAG CGTCCTCGCG ACACAGCAAG 
GGTGACAAGG GCTCTGGGGA GGCCGTGGGT CCCTTTCATA AGGGGCTTTT GGTTACACCT 
TGTGTCAGCA GCGTGAAGAG CATTTCCCGC GCCAAGATCC GCACTGTGAA GATGACCTTT 
GTGATTGTAA GCGCCTACAT CCTTTGCTGG GCGCCTTTCT TCATTGTCCA GATGTGGTCA 
GTCTGGGATG AGAATTTCAT CTGGACCGAT TCAGAAAACC CTTCCATCAC AATCACGGCG 
TTGCTGGCTT CCTTGAACAG CTGCTGCAAC CCGTGGATAT ACATGTTTTT CAGTGGCCAT 
CTCCTGCAAG ACTGCGTCCA AAGTTTCCCA TGCTGCCACA GCATGGCGCA GAAATTCGCC 
AAGGATGACT CCGATAGCAT GAGCCGAAGA CAGACTTCTT ATTCTAACAA CCGGAGCCCA 
ACGAACAGCA CTGGGATGTG GAAGGACTCG CCCAAATCTT CCAAATCCAT CAGATTCATT 
CCTGTCTCCA CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Age and sex differences in oxytocin and vasopressin V1a receptor binding densities in the rat brain: focus on the social decision-making network.
Brain structure & function222(2)981-1006(2017 03)
Smith CJ,Poehlmann ML,Li S,Ratnaseelan AM,Bredewold R,Veenema AH

Over-expression of V1A receptors in PVN modulates autonomic cardiovascular control.
Pharmacological research114185-195(2016 Dec)
Lozi? M,Tasi? T,Martin A,Greenwood M,?arenac O,Hindmarch C,Paton JF,Murphy D,Japund?i?-?igon N

Vasopressin V1A receptors mediate the stabilization of intestinal mucosal oxygenation during hypercapnia in septic rats.
Microvascular research10624-30(2016 07)
Sch?neborn S,Vollmer C,Barthel F,Herminghaus A,Schulz J,Bauer I,Beck C,Picker O