Tat cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tat
Entrez Gene ID	24813
Full Name	tyrosine aminotransferase
General protein information	Preferred Names tyrosine aminotransferase Names tyrosine aminotransferase L-tyrosine:2-oxoglutarate aminotransferase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19q12
Summary	catalyzes the conversion of L-tyrosine and 2-oxoglutarate to 4-hydroxyphenylpyruvate and L-glutamate; involved in gluconeogenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012668.2	NP_036800.1	tyrosine aminotransferase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TAT	XP_511091.2
	TAT	XP_001106194.1
Canis lupus familiaris (dog)	TAT	XP_536796.2
Gallus gallus (chicken)	TAT	XP_004944414.1
Oryza sativa (rice)	Os11g0552000	NP_001068082.2
Homo sapiens (human)	TAT	NP_000344.1
Arabidopsis thaliana (thale cress)	AT5G36160	NP_198465.3
Mus musculus (house mouse)	Tat	NP_666326.1
Oryza sativa (rice)	Os02g0302400	NP_001046626.1
Oryza sativa (rice)	Os06g0345200	NP_001057579.1
Bos taurus (cattle)	TAT	NP_001029762.1
Rattus norvegicus (Norway rat)	Tat	NP_036800.1
Danio rerio (zebrafish)	tat	NP_001071022.1
Drosophila melanogaster (fruit fly)	CG1461	NP_572953.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000327	XP_310789.4
Caenorhabditis elegans (roundworm)	tatn-1	NP_510454.1
Oryza sativa (rice)	Os02g0302700	NP_001046628.1
Xenopus tropicalis (tropical clawed frog)	tat	NP_001006790.1

Gene Ontology
Bibliography

Related articles in PubMed

Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations.
Mehere P, Han Q, Lemkul JA, Vavricka CJ, Robinson H, Bevan DR, Li J
Protein & cell1(11)1023-32(2010 Nov)

Illuminating the interrelated immune and endocrine adaptations after multiple exposures to short immobilization stress by in vivo blocking of IL-6.
Smith C, Wilson NW, Louw A, Myburgh KH
American journal of physiology. Regulatory, integrative and comparative physiology292(4)R1439-47(2007 Apr)

Mercury influences rat liver tyrosine aminotransferase activity and induction by dexamethasone.
Dundjerski J, Brkljaci? J, Elakovi? I, Manitasevi? S, Mati? G
Journal of applied toxicology : JAT26(2)187-90(2006 Mar-Apr)

Xenobiotics and the glucocorticoid receptor: additive antagonistic effects on tyrosine aminotransferase activity in rat hepatoma cells.
Johansson M, Johansson N, Lund BO
Basic & clinical pharmacology & toxicology96(4)309-15(2005 Apr)

[Glucose-fatty acids cycle in cobalt chloride-induced oxidative stress in rats].
Kaliman PA, Okhrimenko SM
Ukrains'kyi biokhimichnyi zhurnal (1999 )77(2)154-8(2005 Mar-Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tat activity in skeletal muscle and liver was determined 24h after the last psychological stress and immobilization stress.
Title: Illuminating the interrelated immune and endocrine adaptations after multiple exposures to short immobilization stress by in vivo blocking of IL-6.

The functionality of Arg315 and Arg417 in rat TAT was investigated for comparison with the conserved Arg292 and Arg386 in aspartate and bacterial aromatic aminotransferases
Title: Involvement of conserved asparagine and arginine residues from the N-terminal region in the catalytic mechanism of rat liver and Trypanosoma cruzi tyrosine aminotransferases.

The following Tat gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tat cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12089	NM_012668.2 Latest version!	Rattus norvegicus tyrosine aminotransferase (Tat), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tat ( NM_012668.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036800.1 Rattus norvegicus tyrosine aminotransferase (Tat), mRNA.

Price & Availability↑

CloneID	ORa12089
Clone ID Related Accession (Same CDS sequence)	NM_012668.2
Accession Version	NM_012668.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine aminotransferase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC089813.1. On Jun 10, 2007 this sequence version replaced NM_012668.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC089813.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052297, SAMEA2689598 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGACTCCT ACGTGATTCA GACGGATGTC GACGACAGCT TGTCCTCAGT TCTGGATGTG 
CATGTCAATA TTGGTGGGAG AAACTCGGTA CAAGGAAGAA AGAAAGGCAG GAAGGCCAGA 
TGGGACGTGA GACCCTCTGA CATGTCCAAT AAGACCTTCA ATCCCATCCG AGCCATCGTG 
GACAACATGA AGGTGCAGCC CAATCCGAAC AAGACCGTGA TTTCTCTGTC AATTGGGGAC 
CCTACTGTGT TTGGGAACCT GCCTACAGAC CCTGAAGTTA CCCAAGCCAT GAAAGATGCC 
CTGGACTCGG GGAAGTACAA TGGCTATGCC CCGTCCATCG GCTACCTATC CAGTCGGGAG 
GAGGTCGCTT CTTACTACCA CTGTCATGAG GCTCCTCTGG AAGCTAAGGA TGTCATTCTG 
ACAAGCGGCT GCAGTCAGGC CATTGAGCTA TGTCTAGCTG TGTTGGCCAA TCCTGGACAA 
AACATCCTCA TTCCAAGGCC CGGGTTTTCC CTCTATAGGA CTTTGGCTGA GTCTATGGGA 
ATTGAGGTCA AGCTCTACAA TCTCCTGCCC GAGAAGTCTT GGGAAATTGA CCTAAAACAA 
CTGGAATCTC TGATCGATGA AAAAACAGCG TGTCTTGTTG TCAACAACCC ATCCAATCCC 
TGTGGCTCCG TGTTCAGTAA GCGGCACCTT CAGAAGATTT TGGCAGTGGC TGAAAGGCAG 
TGTGTCCCCA TCTTAGCTGA CGAGATCTAT GGTGACATGG TGTTTTCAGA TTGCAAATAC 
GAACCACTGG CCAACCTCAG CACCAATGTT CCCATCCTGT CCTGTGGTGG GCTGGCCAAG 
CGCTGGCTGG TTCCTGGCTG GAGGTTGGGC TGGATCCTCA TTCATGATCG AAGAGACATT 
TTTGGCAATG AGATTCGAGA CGGGCTGGTG AAACTGAGTC AGCGGATCCT GGGACCATGC 
ACCATAGTCC AGGGTGCTCT GAAGAGCATC CTTCAGCGAA CCCCTCAGGA GTTCTATCAC 
GACACGTTAA GCTTCCTCAA GTCCAATGCG GACCTCTGCT ATGGGGCACT GGCTGCCATC 
CCTGGACTCC AGCCGGTCCG CCCTTCTGGA GCCATGTACC TTATGGTGGG AATTGAGATG 
GAGCATTTCC CGGAATTCGA GAACGACGTG GAGTTCACAG AGCGGTTGAT TGCGGAGCAG 
GCTGTCCACT GTCTCCCAGC AACGTGCTTC GAGTACCCAA ATTTCTTCCG AGTGGTCATC 
ACAGTCCCCG AGGTGATGAT GCTGGAGGCT TGTAGCCGGA TCCAGGAGTT CTGTGAACAG 
CACTACCACT GTGCTGAAGG CAGCCAGGAG GAGTGTGACA AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036800.1
CDS	45..1409
Translation	MDSYVIQTDVDDSLSSVLDVHVNIGGRNSVQGRKKGRKARWDVRPSDMSNKTFNPIRAIVDNMKVQPNPNKTVISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGYLSSREEVASYYHCHEAPLEAKDVILTSGCSQAIELCLAVLANPGQNILIPRPGFSLYRTLAESMGIEVKLYNLLPEKSWEIDLKQLESLIDEKTACLVVNNPSNPCGSVFSKRHLQKILAVAERQCVPILADEIYGDMVFSDCKYEPLANLSTNVPILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILQRTPQEFYHDTLSFLKSNADLCYGALAAIPGLQPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLIAEQAVHCLPATCFEYPNFFRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK

Target ORF information:

RefSeq Version	NM_012668.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tyrosine aminotransferase (Tat), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012668.2

ORF Insert Sequence:

ATGGACTCCT ACGTGATTCA GACGGATGTC GACGACAGCT TGTCCTCAGT TCTGGATGTG 
CATGTCAATA TTGGTGGGAG AAACTCGGTA CAAGGAAGAA AGAAAGGCAG GAAGGCCAGA 
TGGGACGTGA GACCCTCTGA CATGTCCAAT AAGACCTTCA ATCCCATCCG AGCCATCGTG 
GACAACATGA AGGTGCAGCC CAATCCGAAC AAGACCGTGA TTTCTCTGTC AATTGGGGAC 
CCTACTGTGT TTGGGAACCT GCCTACAGAC CCTGAAGTTA CCCAAGCCAT GAAAGATGCC 
CTGGACTCGG GGAAGTACAA TGGCTATGCC CCGTCCATCG GCTACCTATC CAGTCGGGAG 
GAGGTCGCTT CTTACTACCA CTGTCATGAG GCTCCTCTGG AAGCTAAGGA TGTCATTCTG 
ACAAGCGGCT GCAGTCAGGC CATTGAGCTA TGTCTAGCTG TGTTGGCCAA TCCTGGACAA 
AACATCCTCA TTCCAAGGCC CGGGTTTTCC CTCTATAGGA CTTTGGCTGA GTCTATGGGA 
ATTGAGGTCA AGCTCTACAA TCTCCTGCCC GAGAAGTCTT GGGAAATTGA CCTAAAACAA 
CTGGAATCTC TGATCGATGA AAAAACAGCG TGTCTTGTTG TCAACAACCC ATCCAATCCC 
TGTGGCTCCG TGTTCAGTAA GCGGCACCTT CAGAAGATTT TGGCAGTGGC TGAAAGGCAG 
TGTGTCCCCA TCTTAGCTGA CGAGATCTAT GGTGACATGG TGTTTTCAGA TTGCAAATAC 
GAACCACTGG CCAACCTCAG CACCAATGTT CCCATCCTGT CCTGTGGTGG GCTGGCCAAG 
CGCTGGCTGG TTCCTGGCTG GAGGTTGGGC TGGATCCTCA TTCATGATCG AAGAGACATT 
TTTGGCAATG AGATTCGAGA CGGGCTGGTG AAACTGAGTC AGCGGATCCT GGGACCATGC 
ACCATAGTCC AGGGTGCTCT GAAGAGCATC CTTCAGCGAA CCCCTCAGGA GTTCTATCAC 
GACACGTTAA GCTTCCTCAA GTCCAATGCG GACCTCTGCT ATGGGGCACT GGCTGCCATC 
CCTGGACTCC AGCCGGTCCG CCCTTCTGGA GCCATGTACC TTATGGTGGG AATTGAGATG 
GAGCATTTCC CGGAATTCGA GAACGACGTG GAGTTCACAG AGCGGTTGAT TGCGGAGCAG 
GCTGTCCACT GTCTCCCAGC AACGTGCTTC GAGTACCCAA ATTTCTTCCG AGTGGTCATC 
ACAGTCCCCG AGGTGATGAT GCTGGAGGCT TGTAGCCGGA TCCAGGAGTT CTGTGAACAG 
CACTACCACT GTGCTGAAGG CAGCCAGGAG GAGTGTGACA AATAA