Mafk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mafk
Entrez Gene ID	246760
Full Name	MAF bZIP transcription factor K
General protein information	Preferred Names MAF bZIP transcription factor K Names transcription factor MafK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K v-maf musculoaponeurotic fibrosarcoma oncogene homolog K
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q11
Summary	regulates NGF-promoted neurite outgrowth and neuronal differentiation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006248915.3	XP_006248977.1	transcription factor MafK isoform X1
NM_145673.2	NP_663706.2	transcription factor MafK

Pathways from BioSystems

Homologies

Homo sapiens (human)	MAFK	NP_002351.1
Gallus gallus (chicken)	MAFK	NP_990087.1
Drosophila melanogaster (fruit fly)	maf-S	NP_611500.1
Xenopus tropicalis (tropical clawed frog)	mafk	NP_001090663.1
Canis lupus familiaris (dog)	MAFK	XP_003639134.1
Rattus norvegicus (Norway rat)	Mafk	NP_663706.2
Bos taurus (cattle)	MAFK	NP_001193229.1
Danio rerio (zebrafish)	mafk	NP_001002044.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010405	XP_311544.3
	LOC721769	XP_001117972.1
Mus musculus (house mouse)	Mafk	NP_034887.1

Gene Ontology
Bibliography

Related articles in PubMed

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism.
Hayes JD, Dinkova-Kostova AT
Trends in biochemical sciences39(4)199-218(2014 Apr)

DNA-binding specificities of human transcription factors.
Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J
Cell152(1-2)327-39(2013 Jan)

Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis.
Ohta K, Ohigashi M, Naganawa A, Ikeda H, Sakai M, Nishikawa J, Imagawa M, Osada S, Nishihara T
The Biochemical journal402(3)559-66(2007 Mar)

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation.
Nioi P, Nguyen T, Sherratt PJ, Pickett CB
Molecular and cellular biology25(24)10895-906(2005 Dec)

The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that regulates neurite outgrowth.
T?r?csik B, Angelastro JM, Greene LA
The Journal of neuroscience : the official journal of the Society for Neuroscience22(20)8971-80(2002 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

during early hepatocarcinogenesis, aberrantly expressed MYST histone acetyltransferase 3 may induce glutathione S-transferase placental form expression through the Nrf2-mediated pathway
Title: Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis.

The following Mafk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mafk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13544	NM_145673.2 Latest version!	Rattus norvegicus MAF bZIP transcription factor K (Mafk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa13544	XM_006248915.3 Latest version!	Rattus norvegicus MAF bZIP transcription factor K (Mafk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mafk ( NM_145673.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_663706.2 Rattus norvegicus MAF bZIP transcription factor K (Mafk), mRNA.

Price & Availability↑

CloneID	ORa13544
Clone ID Related Accession (Same CDS sequence)	XM_006248915.3 , NM_145673.2
Accession Version	NM_145673.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor MafK
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC070906.1. On May 24, 2004 this sequence version replaced NM_145673.1. ##Evidence-Data-START## Transcript exon combination :: BC070906.1, CK355288.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906349, SAMN01906357 [ECO:0000348] ##Evidence-Data-END##

ATGACGACTA ATCCCAAGCC CAACAAGACA TTGAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCTGTTC TTAGCGACGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGGC TCACCAAGGA GGAGGTAACT CGGCTGAAGC AGCGGCGGCG CACACTCAAG 
AACCGAGGCT ACGCCGCCAG CTGTCGCATC AAGCGCGTGA CACAGAAGGA GGAGCTGGAG 
CGGCAGCGGG TGGAGCTGCA GCAGGAGGTA GAGAAGCTGG CTCGTGAGAA CAGCAGCATG 
CGTCTGGAGC TGGATGCCCT GCGCTCCAAG TACGAGGCCC TGCAGACCTT CGCACGCACC 
GTGGCCCGAG GGCCTGTCAC ACCCACCAAG GTGGCCACCA CCAGTGTCAT CACCATCGTC 
AAATCCGCAG AGCTCTCCTC CACCTCTGTG CCCTTCTCAG CGGCCTCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663706.2
CDS	193..663
Translation	MTTNPKPNKTLKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVTPTKVATTSVITIVKSAELSSTSVPFSAAS

Target ORF information:

RefSeq Version	NM_145673.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MAF bZIP transcription factor K (Mafk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145673.2

ORF Insert Sequence:

ATGACGACTA ATCCCAAGCC CAACAAGACA TTGAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCTGTTC TTAGCGACGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGGC TCACCAAGGA GGAGGTAACT CGGCTGAAGC AGCGGCGGCG CACACTCAAG 
AACCGAGGCT ACGCCGCCAG CTGTCGCATC AAGCGCGTGA CACAGAAGGA GGAGCTGGAG 
CGGCAGCGGG TGGAGCTGCA GCAGGAGGTA GAGAAGCTGG CTCGTGAGAA CAGCAGCATG 
CGTCTGGAGC TGGATGCCCT GCGCTCCAAG TACGAGGCCC TGCAGACCTT CGCACGCACC 
GTGGCCCGAG GGCCTGTCAC ACCCACCAAG GTGGCCACCA CCAGTGTCAT CACCATCGTC 
AAATCCGCAG AGCTCTCCTC CACCTCTGTG CCCTTCTCAG CGGCCTCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mafk ( XM_006248915.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006248977.1 Rattus norvegicus MAF bZIP transcription factor K (Mafk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa13544
Clone ID Related Accession (Same CDS sequence)	XM_006248915.3 , NM_145673.2
Accession Version	XM_006248915.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor MafK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006248915.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGACTA ATCCCAAGCC CAACAAGACA TTGAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCTGTTC TTAGCGACGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGGC TCACCAAGGA GGAGGTAACT CGGCTGAAGC AGCGGCGGCG CACACTCAAG 
AACCGAGGCT ACGCCGCCAG CTGTCGCATC AAGCGCGTGA CACAGAAGGA GGAGCTGGAG 
CGGCAGCGGG TGGAGCTGCA GCAGGAGGTA GAGAAGCTGG CTCGTGAGAA CAGCAGCATG 
CGTCTGGAGC TGGATGCCCT GCGCTCCAAG TACGAGGCCC TGCAGACCTT CGCACGCACC 
GTGGCCCGAG GGCCTGTCAC ACCCACCAAG GTGGCCACCA CCAGTGTCAT CACCATCGTC 
AAATCCGCAG AGCTCTCCTC CACCTCTGTG CCCTTCTCAG CGGCCTCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006248977.1
CDS	3442..3912
Translation	MTTNPKPNKTLKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVTPTKVATTSVITIVKSAELSSTSVPFSAAS

Target ORF information:

RefSeq Version	XM_006248915.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MAF bZIP transcription factor K (Mafk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006248915.3

ORF Insert Sequence:

ATGACGACTA ATCCCAAGCC CAACAAGACA TTGAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCTGTTC TTAGCGACGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGGC TCACCAAGGA GGAGGTAACT CGGCTGAAGC AGCGGCGGCG CACACTCAAG 
AACCGAGGCT ACGCCGCCAG CTGTCGCATC AAGCGCGTGA CACAGAAGGA GGAGCTGGAG 
CGGCAGCGGG TGGAGCTGCA GCAGGAGGTA GAGAAGCTGG CTCGTGAGAA CAGCAGCATG 
CGTCTGGAGC TGGATGCCCT GCGCTCCAAG TACGAGGCCC TGCAGACCTT CGCACGCACC 
GTGGCCCGAG GGCCTGTCAC ACCCACCAAG GTGGCCACCA CCAGTGTCAT CACCATCGTC 
AAATCCGCAG AGCTCTCCTC CACCTCTGTG CCCTTCTCAG CGGCCTCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism.
Trends in biochemical sciences39(4)199-218(2014 Apr)
Hayes JD,Dinkova-Kostova AT

DNA-binding specificities of human transcription factors.
Cell152(1-2)327-39(2013 Jan)
Jolma A,Yan J,Whitington T,Toivonen J,Nitta KR,Rastas P,Morgunova E,Enge M,Taipale M,Wei G,Palin K,Vaquerizas JM,Vincentelli R,Luscombe NM,Hughes TR,Lemaire P,Ukkonen E,Kivioja T,Taipale J

Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis.
The Biochemical journal402(3)559-66(2007 Mar)
Ohta K,Ohigashi M,Naganawa A,Ikeda H,Sakai M,Nishikawa J,Imagawa M,Osada S,Nishihara T

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation.
Molecular and cellular biology25(24)10895-906(2005 Dec)
Nioi P,Nguyen T,Sherratt PJ,Pickett CB

The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that regulates neurite outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience22(20)8971-80(2002 Oct)
T?r?csik B,Angelastro JM,Greene LA