Pabpc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pabpc1
Entrez Gene ID	171350
Full Name	poly(A) binding protein, cytoplasmic 1
Synonyms	PABP 1,Pabp,Pabp1
General protein information	Preferred Names poly(A) binding protein, cytoplasmic 1 Names polyadenylate-binding protein 1 PABP-1 poly(A)-binding protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q22
Summary	binds with high affinity to poly(A) tails of mRNAs and may be involved in mRNA stabilization and stimulation of translational initiation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_134353.3	NP_599180.1	polyadenylate-binding protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PABPC1	NP_002559.2
Mus musculus (house mouse)	Pabpc1	NP_032800.2
Gallus gallus (chicken)	PABPC1	NP_001026768.1
Caenorhabditis elegans (roundworm)	pab-2	NP_510260.1
Danio rerio (zebrafish)	pabpc1b	NP_957176.1
Arabidopsis thaliana (thale cress)	PAB8	NP_564554.1
Xenopus tropicalis (tropical clawed frog)	pabpc1	NP_001005051.1
Rattus norvegicus (Norway rat)	Pabpc1	NP_599180.1
Canis lupus familiaris (dog)	PABPC1	XP_856708.1
Caenorhabditis elegans (roundworm)	pab-1	NP_001021709.1
Oryza sativa (rice)	Os04g0504800	NP_001053248.1
Bos taurus (cattle)	PABPC1	NP_776993.1
Arabidopsis thaliana (thale cress)	PAB2	NP_195137.5
Oryza sativa (rice)	Os09g0115400	NP_001062583.1
Oryza sativa (rice)	Os08g0314800	NP_001061515.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication.
Suzuki Y, Chin WX, Han Q, Ichiyama K, Lee CH, Eyo ZW, Ebina H, Takahashi H, Takahashi C, Tan BH, Hishiki T, Ohba K, Matsuyama T, Koyanagi Y, Tan YJ, Sawasaki T, Chu JJ, Vasudevan SG, Sano K, Yamamoto N
PLoS pathogens12(1)e1005357(2016 Jan)

JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.
Berg JM, Lee C, Chen L, Galvan L, Cepeda C, Chen JY, Pe?agarikano O, Stein JL, Li A, Oguro-Ando A, Miller JA, Vashisht AA, Starks ME, Kite EP, Tam E, Gdalyahu A, Al-Sharif NB, Burkett ZD, White SA, Fears SC, Levine MS, Wohlschlegel JA, Geschwind DH
Neuron88(6)1173-91(2015 Dec)

Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.
Fischer-Ke?o R, Breuninger S, Hofmann S, Henn M, R?hrig T, Str?bel P, Stoecklin G, Hofmann I
Molecular and cellular biology34(23)4244-56(2014 Dec)

The scanning mechanism of eukaryotic translation initiation.
Hinnebusch AG
Annual review of biochemistry83779-812(2014)

Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR.
Linker K, Pautz A, Fechir M, Hubrich T, Greeve J, Kleinert H
Nucleic acids research33(15)4813-27(2005)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein
Title: Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD function.

The following Pabpc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pabpc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01165	NM_134353.3 Latest version!	Rattus norvegicus poly(A) binding protein, cytoplasmic 1 (Pabpc1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$377.30 $539.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pabpc1 ( NM_134353.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_599180.1 Rattus norvegicus poly(A) binding protein, cytoplasmic 1 (Pabpc1), mRNA.

Price & Availability↑

CloneID	ORa01165
Clone ID Related Accession (Same CDS sequence)	NM_134353.3
Accession Version	NM_134353.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1911bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	polyadenylate-binding protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ298278.1. On Jun 10, 2007 this sequence version replaced NM_134353.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ298278.1, BC083176.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGAACCCCA GCGCCCCCAG CTACCCCATG GCCTCTCTGT ACGTGGGGGA CCTGCACCCC 
GACGTGACCG AGGCGATGCT CTACGAGAAG TTCAGCCCGG CCGGGCCCAT CCTCTCCATC 
CGGGTCTGCA GGGACATGAT CACCCGCCGC TCCTTGGGCT ACGCGTACGT GAACTTCCAG 
CAGCCGGCGG ACGCGGAACG TGCTTTGGAC ACCATGAATT TTGATGTTAT AAAGGGCAAG 
CCAGTACGCA TCATGTGGTC TCAGCGTGAT CCATCACTTC GTAAAAGTGG AGTAGGCAAC 
ATATTCATTA AAAATTTGGA CAAATCCATT GACAATAAAG CACTGTATGA TACGTTTTCT 
GCGTTTGGTA ACATCCTTTC ATGTAAGGTG GTTTGTGATG AAAATGGCTC CAAGGGCTAT 
GGATTTGTAC ATTTTGAAAC ACAGGAAGCA GCTGAAAGAG CTATTGAAAA AATGAATGGA 
ATGCTTCTAA ATGATCGTAA AGTGTTTGTT GGTCGATTTA AATCTCGGAA GGAACGAGAA 
GCAGAACTTG GAGCAAGGGC AAAGGAGTTC ACCAATGTTT ACATCAAGAA CTTTGGAGAA 
GACATGGATG ATGAGCGTCT TAAGGAACTC TTTGGCAAGT TTGGGCCTGC CTTAAGTGTG 
AAAGTAATGA CAGATGAAAG TGGAAAATCC AAAGGATTTG GATTTGTAAG CTTTGAAAGG 
CATGAAGATG CGCAGAAAGC TGTGGATGAG ATGAATGGGA AGGAGCTCAA TGGAAAACAG 
ATTTATGTTG GTCGAGCTCA GAAAAAAGTG GAACGGCAGA CGGAACTTAA GCGCAAATTT 
GAGCAGATGA AGCAAGACAG GATCACCAGA TATCAGGGTG TTAACCTTTA TGTGAAAAAT 
CTTGATGACG GAATTGATGA TGAGCGTCTC CGGAAAGAGT TTTCTCCATT TGGTACAATC 
ACTAGTGCAA AAGTAATGAT GGAGGGTGGG CGCAGCAAAG GATTTGGTTT TGTATGTTTC 
TCCTCCCCTG AAGAAGCCAC TAAAGCAGTT ACGGAGATGA ATGGTAGAAT TGTGGCCACC 
AAGCCACTCT ATGTAGCTTT AGCTCAGCGC AAAGAAGAGC GCCAGGCTCA CCTCACTAAC 
CAGTATATGC AGAGGATGGC AAGTGTACGA GCTGTGCCCA ATCCTGTGAT CAACCCCTAC 
CAGCCAGCAC CTCCTTCAGG TTACTTCATG GCAGCTATCC CACAGACTCA GAACCGTGCT 
GCATACTATC CTCCTAGCCA AATTGCTCAA CTAAGACCAA GTCCTCGCTG GACTGCTCAG 
GGTGCCAGAC CTCATCCATT CCAGAATATG CCCGGTGCTA TCCGCCCAGC TGCTCCTAGA 
CCACCATTTA GTACGATGAG ACCAGCTTCC TCACAGGTTC CACGAGTCAT GTCAACACAG 
CGTGTTGCTA ACACATCAAC ACAGACAATG GGTCCACGTC CTGCAGCTGC TGCTACTGCA 
GCCACTCCTG CTGTCCGCAC TGTTCCCCAG TATAAATACG CTGCGGGAGT CCGCAATCCC 
CAGCAACATC TTAATGCACA GCCACAAGTT ACCATGCAAC AGCCTGCGGT TCATGTGCAA 
GGTCAAGAAC CTTTAACTGC TTCCATGTTG GCATCTGCAC CCCCGCAAGA GCAAAAGCAA 
ATGTTGGGTG AACGGCTGTT TCCTCTTATT CAAGCCATGC ACCCTTCTCT TGCTGGCAAA 
ATTACTGGCA TGCTGTTGGA GATTGATAAC TCAGAATTGC TTCACATGCT TGAGTCTCCA 
GAGTCTCTCC GCTCAAAGGT CGATGAAGCT GTAGCTGTAC TACAAGCCCA CCAAGCGAAA 
GAGGCTGCCC AGAAAGCAGT GAACAGTGCC ACTGGTGTTC CAACTGTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_599180.1
CDS	200..2110
Translation	MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKELFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAATAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPSLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV

Target ORF information:

RefSeq Version	NM_134353.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus poly(A) binding protein, cytoplasmic 1 (Pabpc1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134353.3

ORF Insert Sequence:

ATGAACCCCA GCGCCCCCAG CTACCCCATG GCCTCTCTGT ACGTGGGGGA CCTGCACCCC 
GACGTGACCG AGGCGATGCT CTACGAGAAG TTCAGCCCGG CCGGGCCCAT CCTCTCCATC 
CGGGTCTGCA GGGACATGAT CACCCGCCGC TCCTTGGGCT ACGCGTACGT GAACTTCCAG 
CAGCCGGCGG ACGCGGAACG TGCTTTGGAC ACCATGAATT TTGATGTTAT AAAGGGCAAG 
CCAGTACGCA TCATGTGGTC TCAGCGTGAT CCATCACTTC GTAAAAGTGG AGTAGGCAAC 
ATATTCATTA AAAATTTGGA CAAATCCATT GACAATAAAG CACTGTATGA TACGTTTTCT 
GCGTTTGGTA ACATCCTTTC ATGTAAGGTG GTTTGTGATG AAAATGGCTC CAAGGGCTAT 
GGATTTGTAC ATTTTGAAAC ACAGGAAGCA GCTGAAAGAG CTATTGAAAA AATGAATGGA 
ATGCTTCTAA ATGATCGTAA AGTGTTTGTT GGTCGATTTA AATCTCGGAA GGAACGAGAA 
GCAGAACTTG GAGCAAGGGC AAAGGAGTTC ACCAATGTTT ACATCAAGAA CTTTGGAGAA 
GACATGGATG ATGAGCGTCT TAAGGAACTC TTTGGCAAGT TTGGGCCTGC CTTAAGTGTG 
AAAGTAATGA CAGATGAAAG TGGAAAATCC AAAGGATTTG GATTTGTAAG CTTTGAAAGG 
CATGAAGATG CGCAGAAAGC TGTGGATGAG ATGAATGGGA AGGAGCTCAA TGGAAAACAG 
ATTTATGTTG GTCGAGCTCA GAAAAAAGTG GAACGGCAGA CGGAACTTAA GCGCAAATTT 
GAGCAGATGA AGCAAGACAG GATCACCAGA TATCAGGGTG TTAACCTTTA TGTGAAAAAT 
CTTGATGACG GAATTGATGA TGAGCGTCTC CGGAAAGAGT TTTCTCCATT TGGTACAATC 
ACTAGTGCAA AAGTAATGAT GGAGGGTGGG CGCAGCAAAG GATTTGGTTT TGTATGTTTC 
TCCTCCCCTG AAGAAGCCAC TAAAGCAGTT ACGGAGATGA ATGGTAGAAT TGTGGCCACC 
AAGCCACTCT ATGTAGCTTT AGCTCAGCGC AAAGAAGAGC GCCAGGCTCA CCTCACTAAC 
CAGTATATGC AGAGGATGGC AAGTGTACGA GCTGTGCCCA ATCCTGTGAT CAACCCCTAC 
CAGCCAGCAC CTCCTTCAGG TTACTTCATG GCAGCTATCC CACAGACTCA GAACCGTGCT 
GCATACTATC CTCCTAGCCA AATTGCTCAA CTAAGACCAA GTCCTCGCTG GACTGCTCAG 
GGTGCCAGAC CTCATCCATT CCAGAATATG CCCGGTGCTA TCCGCCCAGC TGCTCCTAGA 
CCACCATTTA GTACGATGAG ACCAGCTTCC TCACAGGTTC CACGAGTCAT GTCAACACAG 
CGTGTTGCTA ACACATCAAC ACAGACAATG GGTCCACGTC CTGCAGCTGC TGCTACTGCA 
GCCACTCCTG CTGTCCGCAC TGTTCCCCAG TATAAATACG CTGCGGGAGT CCGCAATCCC 
CAGCAACATC TTAATGCACA GCCACAAGTT ACCATGCAAC AGCCTGCGGT TCATGTGCAA 
GGTCAAGAAC CTTTAACTGC TTCCATGTTG GCATCTGCAC CCCCGCAAGA GCAAAAGCAA 
ATGTTGGGTG AACGGCTGTT TCCTCTTATT CAAGCCATGC ACCCTTCTCT TGCTGGCAAA 
ATTACTGGCA TGCTGTTGGA GATTGATAAC TCAGAATTGC TTCACATGCT TGAGTCTCCA 
GAGTCTCTCC GCTCAAAGGT CGATGAAGCT GTAGCTGTAC TACAAGCCCA CCAAGCGAAA 
GAGGCTGCCC AGAAAGCAGT GAACAGTGCC ACTGGTGTTC CAACTGTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication.
PLoS pathogens12(1)e1005357(2016 Jan)
Suzuki Y,Chin WX,Han Q,Ichiyama K,Lee CH,Eyo ZW,Ebina H,Takahashi H,Takahashi C,Tan BH,Hishiki T,Ohba K,Matsuyama T,Koyanagi Y,Tan YJ,Sawasaki T,Chu JJ,Vasudevan SG,Sano K,Yamamoto N

JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.
Neuron88(6)1173-91(2015 Dec)
Berg JM,Lee C,Chen L,Galvan L,Cepeda C,Chen JY,Pe?agarikano O,Stein JL,Li A,Oguro-Ando A,Miller JA,Vashisht AA,Starks ME,Kite EP,Tam E,Gdalyahu A,Al-Sharif NB,Burkett ZD,White SA,Fears SC,Levine MS,Wohlschlegel JA,Geschwind DH

Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.
Molecular and cellular biology34(23)4244-56(2014 Dec)
Fischer-Ke?o R,Breuninger S,Hofmann S,Henn M,R?hrig T,Str?bel P,Stoecklin G,Hofmann I

The scanning mechanism of eukaryotic translation initiation.
Annual review of biochemistry83779-812(2014)
Hinnebusch AG

Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR.
Nucleic acids research33(15)4813-27(2005)
Linker K,Pautz A,Fechir M,Hubrich T,Greeve J,Kleinert H