Lcp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lcp2
Entrez Gene ID	155918
Full Name	lymphocyte cytosolic protein 2
Synonyms	Slp76
General protein information	Preferred Names lymphocyte cytosolic protein 2 Names lymphocyte cytosolic protein 2 lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q12
Summary	hematopoietic cell-specific protein; may mediate signaling events in multiple cell types in the immune system [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_130421.2	NP_569105.1	lymphocyte cytosolic protein 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LCP2	XP_001150122.1
Danio rerio (zebrafish)	lcp2a	NP_999882.1
Danio rerio (zebrafish)	lcp2b	XP_001343678.3
Canis lupus familiaris (dog)	LCP2	XP_866864.1
Bos taurus (cattle)	LCP2	NP_001070312.1
Homo sapiens (human)	LCP2	NP_005556.1
	LCP2	XP_001092472.1
Mus musculus (house mouse)	Lcp2	NP_034826.2
Rattus norvegicus (Norway rat)	Lcp2	NP_569105.1
Xenopus tropicalis (tropical clawed frog)	lcp2	NP_001121489.1
Gallus gallus (chicken)	LCP2	NP_990032.1

Gene Ontology
Bibliography

Related articles in PubMed

Scaffold Protein SLP-76 Primes PLC?1 for Activation by ITK-Mediated Phosphorylation.
Devkota S, Joseph RE, Min L, Bruce Fulton D, Andreotti AH
Journal of molecular biology427(17)2734-47(2015 Aug)

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio E, Imbert J, Nijman IJ, Suchanek M, Saito T, W?lfing C, Malissen B, Malissen M
Nature immunology14(8)858-66(2013 Aug)

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.
Lasserre R, Charrin S, Cuche C, Danckaert A, Thoulouze MI, de Chaumont F, Duong T, Perrault N, Varin-Blank N, Olivo-Marin JC, Etienne-Manneville S, Arpin M, Di Bartolo V, Alcover A
The EMBO journal29(14)2301-14(2010 Jul)

Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function.
Wu JN, Jordan MS, Silverman MA, Peterson EJ, Koretzky GA
Journal of immunology (Baltimore, Md. : 1950)172(11)6768-74(2004 Jun)

T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression.
Roose JP, Diehn M, Tomlinson MG, Lin J, Alizadeh AA, Botstein D, Brown PO, Weiss A
PLoS biology1(2)E53(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PLCgamma1 can be primed for ITK-mediated phosphorylation on Y783 by a specific region of the adaptor protein, SLP-76.
Title: Scaffold Protein SLP-76 Primes PLC?1 for Activation by ITK-Mediated Phosphorylation.

The following Lcp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lcp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00389	NM_130421.2 Latest version!	Rattus norvegicus lymphocyte cytosolic protein 2 (Lcp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lcp2 ( NM_130421.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_569105.1 Rattus norvegicus lymphocyte cytosolic protein 2 (Lcp2), mRNA.

Price & Availability↑

CloneID	ORa00389
Clone ID Related Accession (Same CDS sequence)	NM_130421.2
Accession Version	NM_130421.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1578bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	lymphocyte cytosolic protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC100066.1. On Aug 7, 2005 this sequence version replaced NM_130421.1. ##Evidence-Data-START## Transcript exon combination :: BC100066.1, AB072980.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689594 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTTGA AGAATGTCCC CTTTCGCTCA GAGGTCTTAG CCTGGAACCC AGACAACCTT 
GCTGATTATT TCAGGAAGCT GAACTACAGA GACTGTGAGA AGGCTGTGAA GAAATACCAC 
ATTGATGGCG CTCGGTTTTT GAACCTGACA GAAAACGACA TTCAGAAGTT TCCTAAACTG 
AGGATGCCGA TTCTCAGTAA GTTGAGTCAA GATATCAACA AGAACGAAGA GAGAAGGAGC 
ATTTTCACAC GCAAACCCCC GGTTCCACGA TATCCTGAGG AAATAGAAAT CCATGAAGAA 
GACGATGGTG GCTGGTCATC CTTTGAAGAT GACTATGAAA GTCCCAATGA CGACGATCCA 
GATGGGGAGG ATGATGGTGA CTATGAGTCC CCTAACGAGG AGGAAGAGAC GCTAGTGGAC 
GATGCTGCTG ACTATGAGCC GCCACCCTCC AACGATGAGG AGGCTCTGCA GAACTCCATC 
CTGCCTGCCA AGCCTTTCCC CAACACCAAC TCCATGTACA TTGACCGGCC TCCCACCGGC 
AAGGTCTCCC AGCAGCCTCC GGTGCCCCCG CAGAGACCAA TGGCCGCCCT CCCTCCCCTG 
CCAACAGGCC GGAATCACTC GCCCAACCAT GAAGAACCTA GCAGAAATCG GAACCATAAA 
ACAGCAAAGC TGCCTGCTCC ATCAATAGAC AGAAGCACAA AACCTCCCCT GGACCGCTCA 
TTGGCTCCTC CTCTTGACCG AGAGCCCTTA CTGGGAAAGA AACCCTCTGA TAAGCCCTCC 
GCTCCACTGG GAAGGGAGCA TTTACCCAAG ATACAGAAGC CTCCTTTGCC GCCAGCCATG 
GACAGACACG AAAGAAATGA AAGAATCGGA CCCCTGACAG CAAGGAAGCC ACCAGTTCCA 
AGGCATGGAA GGGGACCAGA CAGAAGAGAC AATGATGAAG ATGATGTGCA CCAGAGGCCT 
TTGCCACACC CATCACTACC TTCTATGAGC TCCAACACAT TTCCTTCGAG ATCTACCAAG 
CCCAGCCCCA AGAACACATT CCCATTGCCT CACATGCCGG GAGCCATCTC AGAAAGTAAC 
ATTGGCTTTC AGCAGAGTGC CTCCCTGCCA TCATACTTCT CTCAAGGTCC CAGCAGCAGG 
CCACCTGTCA GAAATGAAGT CAGAAACTTA CCTTTACCAG TTCCAAACAG GCCTCAGCCT 
CCATCTCCTG GGGAAGAAGA GTCTCCATTA GACGAAGAAT GGTATGTCTC TTATATTACC 
CGGCCAGAGG CAGAAGCTGC TCTGAGGAAG ATAAACCAGG ATGGCACCTT CCTGGTTAGA 
GACAGCTCTA AGAAGACAGT GAACAATCCA TATGTCCTCA TGGTGTTGTA CAAAGACAAA 
GTTTACAACA TCCAGATCCG TTACCAGGAG GAAAGTCAAG TCTATTTGTT GGGTACTGGG 
CTTCGGGGAA AAGAGGACTT CCTGTCTGTA TCAGATATTA TTGACTACTT CAGGAAAATG 
CCACTGTTAC TCATTGATGG AAAAAACCGA GGGTCTAGAT ACCAGTGCAC ACTAACACAT 
GCTGCAGGCT GTCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_569105.1
CDS	161..1738
Translation	MALKNVPFRSEVLAWNPDNLADYFRKLNYRDCEKAVKKYHIDGARFLNLTENDIQKFPKLRMPILSKLSQDINKNEERRSIFTRKPPVPRYPEEIEIHEEDDGGWSSFEDDYESPNDDDPDGEDDGDYESPNEEEETLVDDAADYEPPPSNDEEALQNSILPAKPFPNTNSMYIDRPPTGKVSQQPPVPPQRPMAALPPLPTGRNHSPNHEEPSRNRNHKTAKLPAPSIDRSTKPPLDRSLAPPLDREPLLGKKPSDKPSAPLGREHLPKIQKPPLPPAMDRHERNERIGPLTARKPPVPRHGRGPDRRDNDEDDVHQRPLPHPSLPSMSSNTFPSRSTKPSPKNTFPLPHMPGAISESNIGFQQSASLPSYFSQGPSSRPPVRNEVRNLPLPVPNRPQPPSPGEEESPLDEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTVNNPYVLMVLYKDKVYNIQIRYQEESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGCL

Target ORF information:

RefSeq Version	NM_130421.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lymphocyte cytosolic protein 2 (Lcp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130421.2

ORF Insert Sequence:

ATGGCCTTGA AGAATGTCCC CTTTCGCTCA GAGGTCTTAG CCTGGAACCC AGACAACCTT 
GCTGATTATT TCAGGAAGCT GAACTACAGA GACTGTGAGA AGGCTGTGAA GAAATACCAC 
ATTGATGGCG CTCGGTTTTT GAACCTGACA GAAAACGACA TTCAGAAGTT TCCTAAACTG 
AGGATGCCGA TTCTCAGTAA GTTGAGTCAA GATATCAACA AGAACGAAGA GAGAAGGAGC 
ATTTTCACAC GCAAACCCCC GGTTCCACGA TATCCTGAGG AAATAGAAAT CCATGAAGAA 
GACGATGGTG GCTGGTCATC CTTTGAAGAT GACTATGAAA GTCCCAATGA CGACGATCCA 
GATGGGGAGG ATGATGGTGA CTATGAGTCC CCTAACGAGG AGGAAGAGAC GCTAGTGGAC 
GATGCTGCTG ACTATGAGCC GCCACCCTCC AACGATGAGG AGGCTCTGCA GAACTCCATC 
CTGCCTGCCA AGCCTTTCCC CAACACCAAC TCCATGTACA TTGACCGGCC TCCCACCGGC 
AAGGTCTCCC AGCAGCCTCC GGTGCCCCCG CAGAGACCAA TGGCCGCCCT CCCTCCCCTG 
CCAACAGGCC GGAATCACTC GCCCAACCAT GAAGAACCTA GCAGAAATCG GAACCATAAA 
ACAGCAAAGC TGCCTGCTCC ATCAATAGAC AGAAGCACAA AACCTCCCCT GGACCGCTCA 
TTGGCTCCTC CTCTTGACCG AGAGCCCTTA CTGGGAAAGA AACCCTCTGA TAAGCCCTCC 
GCTCCACTGG GAAGGGAGCA TTTACCCAAG ATACAGAAGC CTCCTTTGCC GCCAGCCATG 
GACAGACACG AAAGAAATGA AAGAATCGGA CCCCTGACAG CAAGGAAGCC ACCAGTTCCA 
AGGCATGGAA GGGGACCAGA CAGAAGAGAC AATGATGAAG ATGATGTGCA CCAGAGGCCT 
TTGCCACACC CATCACTACC TTCTATGAGC TCCAACACAT TTCCTTCGAG ATCTACCAAG 
CCCAGCCCCA AGAACACATT CCCATTGCCT CACATGCCGG GAGCCATCTC AGAAAGTAAC 
ATTGGCTTTC AGCAGAGTGC CTCCCTGCCA TCATACTTCT CTCAAGGTCC CAGCAGCAGG 
CCACCTGTCA GAAATGAAGT CAGAAACTTA CCTTTACCAG TTCCAAACAG GCCTCAGCCT 
CCATCTCCTG GGGAAGAAGA GTCTCCATTA GACGAAGAAT GGTATGTCTC TTATATTACC 
CGGCCAGAGG CAGAAGCTGC TCTGAGGAAG ATAAACCAGG ATGGCACCTT CCTGGTTAGA 
GACAGCTCTA AGAAGACAGT GAACAATCCA TATGTCCTCA TGGTGTTGTA CAAAGACAAA 
GTTTACAACA TCCAGATCCG TTACCAGGAG GAAAGTCAAG TCTATTTGTT GGGTACTGGG 
CTTCGGGGAA AAGAGGACTT CCTGTCTGTA TCAGATATTA TTGACTACTT CAGGAAAATG 
CCACTGTTAC TCATTGATGG AAAAAACCGA GGGTCTAGAT ACCAGTGCAC ACTAACACAT 
GCTGCAGGCT GTCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Scaffold Protein SLP-76 Primes PLC?1 for Activation by ITK-Mediated Phosphorylation.
Journal of molecular biology427(17)2734-47(2015 Aug)
Devkota S,Joseph RE,Min L,Bruce Fulton D,Andreotti AH

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Nature immunology14(8)858-66(2013 Aug)
Liang Y,Cucchetti M,Roncagalli R,Yokosuka T,Malzac A,Bertosio E,Imbert J,Nijman IJ,Suchanek M,Saito T,W?lfing C,Malissen B,Malissen M

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.
The EMBO journal29(14)2301-14(2010 Jul)
Lasserre R,Charrin S,Cuche C,Danckaert A,Thoulouze MI,de Chaumont F,Duong T,Perrault N,Varin-Blank N,Olivo-Marin JC,Etienne-Manneville S,Arpin M,Di Bartolo V,Alcover A

Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function.
Journal of immunology (Baltimore, Md. : 1950)172(11)6768-74(2004 Jun)
Wu JN,Jordan MS,Silverman MA,Peterson EJ,Koretzky GA

T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression.
PLoS biology1(2)E53(2003 Nov)
Roose JP,Diehn M,Tomlinson MG,Lin J,Alizadeh AA,Botstein D,Brown PO,Weiss A