Oga cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Oga
Entrez Gene ID	154968
Full Name	meningioma expressed antigen 5 (hyaluronidase)
Synonyms	Ncoat,O-GLCNACASE,OGA
General protein information	Preferred Names meningioma expressed antigen 5 (hyaluronidase) Names protein O-GlcNAcase N-acetyl-beta-D-glucosaminidase N-acetyl-beta-glucosaminidase beta-N-acetylhexosaminidase beta-hexosaminidase bifunctional protein NCOAT meningioma-expressed antigen 5 nuclear cytoplasmic O-GlcNAcase and acetyltransferase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q54
Summary	plays a role in insulin secretion; may be involved in secretion of other glucose regulated hormones [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017588708.1	XP_017444197.1	protein O-GlcNAcase isoform X1
NM_131904.1	NP_571979.1	protein O-GlcNAcase

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Mgea5	NP_076288.1
Bos taurus (cattle)	MGEA5	NP_001193377.1
Danio rerio (zebrafish)	mgea5	XP_002664185.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002287	XP_307891.5
Caenorhabditis elegans (roundworm)	oga-1	NP_001123184.1
Xenopus tropicalis (tropical clawed frog)	mgea5	NP_001120363.1
Rattus norvegicus (Norway rat)	Mgea5	NP_571979.1
Pan troglodytes (chimpanzee)	MGEA5	XP_507996.3
Canis lupus familiaris (dog)	MGEA5	XP_534996.2
Gallus gallus (chicken)	MGEA5	NP_001034394.1
Homo sapiens (human)	MGEA5	NP_036347.1
Drosophila melanogaster (fruit fly)	Oga	NP_650956.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-539 is up-regulated in failing heart, and suppresses O-GlcNAcase expression.
Muthusamy S, DeMartino AM, Watson LJ, Brittian KR, Zafir A, Dassanayaka S, Hong KU, Jones SP
The Journal of biological chemistry289(43)29665-76(2014 Oct)

Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain.
Liu Y, Li X, Yu Y, Shi J, Liang Z, Run X, Li Y, Dai CL, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX
PloS one7(8)e43724(2012)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Impaired vasodilator activity in deoxycorticosterone acetate-salt hypertension is associated with increased protein O-GlcNAcylation.
Lima VV, Giachini FR, Choi H, Carneiro FS, Carneiro ZN, Fortes ZB, Carvalho MH, Webb RC, Tostes RC
Hypertension (Dallas, Tex. : 1979)53(2)166-74(2009 Feb)

Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury.
Ngoh GA, Facundo HT, Hamid T, Dillmann W, Zachara NE, Jones SP
Circulation research104(1)41-9(2009 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This work identifies the first target of miR-539 in the heart and the first miRNA that regulates OGA.
Title: MicroRNA-539 is up-regulated in failing heart, and suppresses O-GlcNAcase expression.

protein O-GlcNAcylation, OGT, and OGA in the rat brain at various ages from embryonic day 15 to the age of 2 years
Title: Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain.

present results provide definitive evidence that O-GlcNAcase antagonizes posthypoxic cardiac myocyte survival
Title: Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury.

Together, these data demonstrate that alloxan is an inhibitor of O-GlcNAc-selective N-acetyl-beta-d-glucosaminidase, with inhibition corresponding to an altered tryptic digest pattern of N-terminal active site peptides.
Title: Alloxan is an inhibitor of O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase.

NCOAT may be regulated to reduce the state of glycosylation of transcriptional activators while increasing the acetylation of histones to allow for the concerted activation of eukaryotic gene transcription
Title: Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities.

The following Oga gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Oga cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00505	NM_131904.1 Latest version!	Rattus norvegicus O-GlcNAcase (Oga), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$538.30 $769.00
ORa56332	XM_017588708.1 Latest version!	Rattus norvegicus meningioma expressed antigen 5 (hyaluronidase) (Mgea5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$475.30 $679.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Oga ( NM_131904.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_571979.1 Rattus norvegicus O-GlcNAcase (Oga), mRNA.

Price & Availability↑

CloneID	ORa00505
Clone ID Related Accession (Same CDS sequence)	NM_131904.1
Accession Version	NM_131904.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2751bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	protein O-GlcNAcase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY039679.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY039679.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906350 [ECO:0000348] ##Evidence-Data-END##

ATGGTGCAGA AGGAGAGTCA AGCGGCGCTG GAGGAGCGGG AGAGTGAGCG CAACGCCAAT 
CCTGCCTCCG TCTCGGGGGC TTCGTTGGAG CCGTCTGCAG CTCCGGCCCC CGGAGAAGAC 
AACCCCTCGG GAGCTGGGGC GGCGGCCGGG ACCGGGGCGG CCGGCGGGGC CCGCAGGTTC 
CTGTGCGGTG TAGTGGAAGG GTTTTATGGA AGACCTTGGG TTATGGAGCA GAGAAAAGAG 
CTCTTTAGAA GGCTTCAGAA ATGGGAATTA AATACATACT TGTATGCTCC GAAGGATGAC 
TACAAACATA GGATGTTTTG GCGAGAGATG TATTCAGTGG AAGAAGCTGA GCAACTTATG 
ACTCTCATCT CTGCTGCACG AGAATATGAG ATAGAATTCA TCTATGCTAT TTCTCCAGGA 
TTAGATATCA CTTTTTCTAA CCCAAAGGAA GTATCAACAT TGAAACGCAA ATTGGACCAG 
GTCTCCCAGT TTGGGTGCAG GTCATTTGCT TTGCTTTTTG ACGATATTGA TCATAACATG 
TGTGCAGCAG ACAAAGAAGT GTTCAGTTCT TTTGCACATG CACAAGTTTC CATCACAAAT 
GAAATCTATC AGTACCTGGG AGAGCCGGAA ACCTTCCTCT TCTGTCCCAC AGAATACTGC 
GGCACTTTCT GTTATCCAAG TGTATCTCAG TCTCCTTACT TGAGGACTGT GGGTGAAAAG 
CTGCTACCTG GAATTGAGGT GCTTTGGACA GGTCCAAAAG TTGTTTCAAA AGAAATTCCA 
GTAGAATCTA TTGAAGAAGT TTCTAAGATC ATTAAGAGAG CCCCAGTGAT CTGGGATAAC 
ATTCATGCTA ATGACTATGA TCAGAAGAGG CTGTTTCTGG GTCCCTACAA AGGAAGATCC 
ACAGAGCTCA TCCCACGGTT GAAGGGAGTG CTGACTAATC CAAATTGTGA ATTTGAAGCC 
AACTATGTTG CCATCCACAC CCTTGCCACT TGGTACAAGT CAAACATGAA CGGAGTGAGG 
AAGGACGTGG TGATGACTGA CAGTGAAGAC AGTACTGTCT CAATACAGAT AAAGTTAGAA 
AATGAAGGCA GTGATGAAGA CATTGAGACT GATGTGCTCT ACAGTCCACA GATGGCTTTA 
AAGCTGGCCT TAACTGAGTG GCTGCAGGAG TTCGGTGTAC CGCATCAGTA CAGCAGTAGA 
CAGGTTGCAC ACAGTGGAGC TAAGACAAGC GTAGTGGACG GGACTCCCTT GGTTGCAGCA 
CCTTCTTTAA ATGCCACAAC TGTAGTTACA ACAGTTTACC AGGAGCCCAT TATGAGCCAG 
GGAGCAGCTT TGAGTGGTGA GCCCTCAGCT CTGACCAAGG AAGAAGAAAA GAAACAGCCA 
GATGAGGAAC CCATGGATAT GGTGGTAGAG AAGCAAGAAG AGTCAGAGCA CAAGAGTGAC 
AACCAGATAC TAACTGAGAT CGTCGAAGCT AAAATGGCAG AGGAGTTGAA ACCAATGGAC 
ACTGATAAGG AAAGCATAGC CGAGTCAAAA TCCCCAGAGA TGTCTATGCA GGAAGACTGC 
ATTAACGACA TCGCTCCTAT GCAGACAGAC GAGCAAGCAA ACAAAGAGCA GTTTGTGCCA 
GGTCCAAATG AAAAACCTTT GTACGCTGCA GAACCAGTGA CTCTGGAGGA TTTACAGTTA 
CTTGCTGATC TCTTCTACCT TCCTTATGAG CATGGACCCA AAGGAGCACA GATGCTACGG 
GAGTTCCAGT GGCTTCGAGC AAACAGTAGT GTTGTCAGTG TCAATTGCAA AGGGAAAGAC 
TCTGAAAAAA TTGAAGAATG GCGGTCACGA GCAGCCAAGT TTGAAGAAAT GTGCGCACTA 
GTGATGGGGA TGTTCACCCG GCTCTCCAAC TGTGCCAACA GGACAATCCT TTATGACATG 
TACTCCTATG TGTGGGATAT CAAGAGTATA ATGTCTATGG TGAAGTCTTT TGTGCAGTGG 
TTAGGGTGTC GTAGTCATTC TTCAGCACAG TTCTTAATTG GAGACCAAGA ACCCTGGGCC 
TTTAGAGGTG GTCTAGCAGG AGAGTTCCAG CGTTTGCTGC CAATTGATGG AGCAAATGAT 
CTCTTTTTCC AACCACCCCC ACTGACTCCT ACCTCCAAGG TTTATACTAT CAGACCTTAT 
TTCCCTAAAG ATGAGGCTTC CGTGTACAAG ATTTGCAGAG AAATGTATGA TGATGGAGTG 
GGTTTACCTT TTCAAAGTCA GCCTGACCTT ATTGGAGACA AGTTAGTAGG AGGACTGCTT 
TCCCTCAGCC TGGATTACTG TTTTGTCCTC GAAGATGAAG ATGGTATTTG TGGTTATGCC 
TTAGGCACTG TAGATGTGAC CCCCTTCATT AAAAAGTGCA AAATTTCCTG GATTCCCTTC 
ATGCAGGAGA AGTATACTAA GCCAAATGGA GACAAAGAGC TCTCAGAAGC TGAGAAAATA 
ATGTTGAGTT TCCATGAAGA GCAGGAGGTA TTACCAGAAA CTTTCCTTGC CAACTTCCCT 
TCTCTGATAA AAATGGATAT TCATAAAAAG GTCACTGACC CAAGTGTTGC CAAAAGCATG 
ATGGCTTGCC TCCTGTCTTC ACTAAAGGCC AATGGCTCCC GGGGGGCTTT CTGTGAAGTA 
AGACCAGATG ATAAAAGGAT TCTGGAATTT TACAGCAAGT TAGGCTGTTT TGAAATTGCA 
AAAATGGAAG GATTTCCAAA GGATGTGGTT ATACTTGGTC GAAGCCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_571979.1
CDS	1..2751
Translation	MVQKESQAALEERESERNANPASVSGASLEPSAAPAPGEDNPSGAGAAAGTGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPSVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKTSVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPSALTKEEEKKQPDEEPMDMVVEKQEESEHKSDNQILTEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCINDIAPMQTDEQANKEQFVPGPNEKPLYAAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCALVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL

Target ORF information:

RefSeq Version	NM_131904.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus O-GlcNAcase (Oga), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_131904.1

ORF Insert Sequence:

ATGGTGCAGA AGGAGAGTCA AGCGGCGCTG GAGGAGCGGG AGAGTGAGCG CAACGCCAAT 
CCTGCCTCCG TCTCGGGGGC TTCGTTGGAG CCGTCTGCAG CTCCGGCCCC CGGAGAAGAC 
AACCCCTCGG GAGCTGGGGC GGCGGCCGGG ACCGGGGCGG CCGGCGGGGC CCGCAGGTTC 
CTGTGCGGTG TAGTGGAAGG GTTTTATGGA AGACCTTGGG TTATGGAGCA GAGAAAAGAG 
CTCTTTAGAA GGCTTCAGAA ATGGGAATTA AATACATACT TGTATGCTCC GAAGGATGAC 
TACAAACATA GGATGTTTTG GCGAGAGATG TATTCAGTGG AAGAAGCTGA GCAACTTATG 
ACTCTCATCT CTGCTGCACG AGAATATGAG ATAGAATTCA TCTATGCTAT TTCTCCAGGA 
TTAGATATCA CTTTTTCTAA CCCAAAGGAA GTATCAACAT TGAAACGCAA ATTGGACCAG 
GTCTCCCAGT TTGGGTGCAG GTCATTTGCT TTGCTTTTTG ACGATATTGA TCATAACATG 
TGTGCAGCAG ACAAAGAAGT GTTCAGTTCT TTTGCACATG CACAAGTTTC CATCACAAAT 
GAAATCTATC AGTACCTGGG AGAGCCGGAA ACCTTCCTCT TCTGTCCCAC AGAATACTGC 
GGCACTTTCT GTTATCCAAG TGTATCTCAG TCTCCTTACT TGAGGACTGT GGGTGAAAAG 
CTGCTACCTG GAATTGAGGT GCTTTGGACA GGTCCAAAAG TTGTTTCAAA AGAAATTCCA 
GTAGAATCTA TTGAAGAAGT TTCTAAGATC ATTAAGAGAG CCCCAGTGAT CTGGGATAAC 
ATTCATGCTA ATGACTATGA TCAGAAGAGG CTGTTTCTGG GTCCCTACAA AGGAAGATCC 
ACAGAGCTCA TCCCACGGTT GAAGGGAGTG CTGACTAATC CAAATTGTGA ATTTGAAGCC 
AACTATGTTG CCATCCACAC CCTTGCCACT TGGTACAAGT CAAACATGAA CGGAGTGAGG 
AAGGACGTGG TGATGACTGA CAGTGAAGAC AGTACTGTCT CAATACAGAT AAAGTTAGAA 
AATGAAGGCA GTGATGAAGA CATTGAGACT GATGTGCTCT ACAGTCCACA GATGGCTTTA 
AAGCTGGCCT TAACTGAGTG GCTGCAGGAG TTCGGTGTAC CGCATCAGTA CAGCAGTAGA 
CAGGTTGCAC ACAGTGGAGC TAAGACAAGC GTAGTGGACG GGACTCCCTT GGTTGCAGCA 
CCTTCTTTAA ATGCCACAAC TGTAGTTACA ACAGTTTACC AGGAGCCCAT TATGAGCCAG 
GGAGCAGCTT TGAGTGGTGA GCCCTCAGCT CTGACCAAGG AAGAAGAAAA GAAACAGCCA 
GATGAGGAAC CCATGGATAT GGTGGTAGAG AAGCAAGAAG AGTCAGAGCA CAAGAGTGAC 
AACCAGATAC TAACTGAGAT CGTCGAAGCT AAAATGGCAG AGGAGTTGAA ACCAATGGAC 
ACTGATAAGG AAAGCATAGC CGAGTCAAAA TCCCCAGAGA TGTCTATGCA GGAAGACTGC 
ATTAACGACA TCGCTCCTAT GCAGACAGAC GAGCAAGCAA ACAAAGAGCA GTTTGTGCCA 
GGTCCAAATG AAAAACCTTT GTACGCTGCA GAACCAGTGA CTCTGGAGGA TTTACAGTTA 
CTTGCTGATC TCTTCTACCT TCCTTATGAG CATGGACCCA AAGGAGCACA GATGCTACGG 
GAGTTCCAGT GGCTTCGAGC AAACAGTAGT GTTGTCAGTG TCAATTGCAA AGGGAAAGAC 
TCTGAAAAAA TTGAAGAATG GCGGTCACGA GCAGCCAAGT TTGAAGAAAT GTGCGCACTA 
GTGATGGGGA TGTTCACCCG GCTCTCCAAC TGTGCCAACA GGACAATCCT TTATGACATG 
TACTCCTATG TGTGGGATAT CAAGAGTATA ATGTCTATGG TGAAGTCTTT TGTGCAGTGG 
TTAGGGTGTC GTAGTCATTC TTCAGCACAG TTCTTAATTG GAGACCAAGA ACCCTGGGCC 
TTTAGAGGTG GTCTAGCAGG AGAGTTCCAG CGTTTGCTGC CAATTGATGG AGCAAATGAT 
CTCTTTTTCC AACCACCCCC ACTGACTCCT ACCTCCAAGG TTTATACTAT CAGACCTTAT 
TTCCCTAAAG ATGAGGCTTC CGTGTACAAG ATTTGCAGAG AAATGTATGA TGATGGAGTG 
GGTTTACCTT TTCAAAGTCA GCCTGACCTT ATTGGAGACA AGTTAGTAGG AGGACTGCTT 
TCCCTCAGCC TGGATTACTG TTTTGTCCTC GAAGATGAAG ATGGTATTTG TGGTTATGCC 
TTAGGCACTG TAGATGTGAC CCCCTTCATT AAAAAGTGCA AAATTTCCTG GATTCCCTTC 
ATGCAGGAGA AGTATACTAA GCCAAATGGA GACAAAGAGC TCTCAGAAGC TGAGAAAATA 
ATGTTGAGTT TCCATGAAGA GCAGGAGGTA TTACCAGAAA CTTTCCTTGC CAACTTCCCT 
TCTCTGATAA AAATGGATAT TCATAAAAAG GTCACTGACC CAAGTGTTGC CAAAAGCATG 
ATGGCTTGCC TCCTGTCTTC ACTAAAGGCC AATGGCTCCC GGGGGGCTTT CTGTGAAGTA 
AGACCAGATG ATAAAAGGAT TCTGGAATTT TACAGCAAGT TAGGCTGTTT TGAAATTGCA 
AAAATGGAAG GATTTCCAAA GGATGTGGTT ATACTTGGTC GAAGCCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Oga ( XM_017588708.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444197.1 Rattus norvegicus meningioma expressed antigen 5 (hyaluronidase) (Mgea5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa56332
Clone ID Related Accession (Same CDS sequence)	XM_017588708.1
Accession Version	XM_017588708.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2847bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	protein O-GlcNAcase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCCAAA CTGGTACAAC AATCTCCAAA GTAGGGCTCC GGACCTGTGG CCCAACGGAC 
CGAGGCCGAA GGGGAGCGGC AGCCGGCGGC AGGAGAATGG TGCAGAAGGA GAGCCAGGCG 
GCGCTGGAGG AGCGGGAGAG TGAGCGCAAC GCCAATCCTG CCTCCGTCTC GGGGGCTTCG 
TTGGAGCCGT CTGCAGCTCC GGCCCCCGGA GAAGACAACC CCTCGGGAGC TGGGGCGGCG 
GCCGGGACCG GGGCGGCCGG CGGGGCCCGC AGGTTCCTGT GCGGTGTAGT GGAAGGGTTT 
TATGGAAGAC CTTGGGTTAT GGAGCAGAGA AAAGAGCTCT TTAGAAGGCT TCAGAAATGG 
GAATTAAATA CATACTTGTA TGCTCCGAAG GATGACTACA AACATAGGAT GTTTTGGCGA 
GAGATGTATT CAGTGGAAGA AGCTGAGCAA CTTATGACTC TCATCTCTGC TGCACGAGAA 
TATGAGATAG AATTCATCTA TGCTATTTCT CCAGGATTAG ATATCACTTT TTCTAACCCA 
AAGGAAGTAT CAACATTGAA ACGCAAATTG GACCAGGTCT CCCAGTTTGG GTGCAGGTCA 
TTTGCTTTGC TTTTTGATGA TATTGATCAT AACATGTGTG CAGCAGACAA AGAAGTGTTC 
AGTTCTTTTG CACATGCACA AGTTTCCATC ACAAATGAAA TCTATCAGTA CCTGGGAGAG 
CCGGAAACCT TCCTCTTCTG TCCCACAGAA TACTGCGGCA CTTTCTGTTA TCCAAGTGTA 
TCTCAGTCTC CTTACTTGAG GACTGTGGGT GAAAAGCTGC TACCTGGAAT TGAGGTGCTT 
TGGACAGGTC CAAAAGTTGT TTCAAAAGAA ATTCCAGTAG AATCTATTGA AGAAGTTTCT 
AAGATCATTA AGAGAGCCCC AGTGATCTGG GATAACATTC ATGCTAATGA CTATGATCAG 
AAGAGGCTGT TTCTGGGTCC CTACAAAGGA AGATCCACAG AGCTCATCCC ACGGTTGAAG 
GGAGTGCTGA CTAATCCAAA TTGTGAATTT GAAGCCAACT ATGTTGCCAT CCACACCCTT 
GCCACTTGGT ACAAGTCAAA CATGAACGGA GTGAGGAAGG ACGTGGTGAT GACTGACAGT 
GAAGACAGTA CTGTCTCAAT ACAGATAAAG TTAGAAAATG AAGGCAGTGA TGAAGACATT 
GAGACTGATG TGCTCTACAG TCCACAGATG GCTTTAAAGC TGGCCTTAAC TGAGTGGCTG 
CAGGAGTTCG GTGTACCGCA TCAGTACAGC AGTAGACAGG TTGCACACAG TGGAGCTAAG 
ACAAGCGTAG TGGACGGGAC TCCCTTGGTT GCAGCACCTT CTTTAAATGC CACAACTGTA 
GTTACAACAG TTTACCAGGA GCCCATTATG AGCCAGGGAG CAGCTTTGAG TGGTGAGCCC 
TCAGCTCTGA CCAAGGAAGA AGAAAAGAAA CAGCCAGATG AGGAACCCAT GGATATGGTG 
GTAGAGAAGC AAGAAGAGTC AGAGCACAAG AGTGACAACC AGATACTAAC TGAGATCGTC 
GAAGCTAAAA TGGCAGAGGA GTTGAAACCA ATGGACACTG ATAAGGAAAG CATAGCCGAG 
TCAAAATCCC CAGAGATGTC TATGCAGGAA GACTGCATTA ACGACATCGC TCCTATGCAG 
ACAGACGAGC AAGCAAACAA AGAGCAGTTT GTGCCAGGTC CAAATGAAAA ACCTTTGTAC 
GCTGCAGAAC CAGTGACTCT GGAGGATTTA CAGTTACTTG CTGATCTCTT CTACCTTCCT 
TATGAGCATG GACCCAAAGG AGCACAGATG CTACGGGAGT TCCAGTGGCT TCGAGCAAAC 
AGTAGTGTTG TCAGTGTCAA TTGCAAAGGG AAAGACTCTG AAAAAATTGA AGAATGGCGG 
TCACGAGCAG CCAAGTTTGA AGAAATGTGC GCACTAGTGA TGGGGATGTT CACCCGGCTC 
TCCAACTGTG CCAACAGGAC AATCCTTTAT GACATGTACT CCTATGTGTG GGATATCAAG 
AGTATAATGT CTATGGTGAA GTCTTTTGTG CAGTGGTTAG GGTGTCGTAG TCATTCTTCA 
GCACAGTTCT TAATTGGAGA CCAAGAACCC TGGGCCTTTA GAGGTGGTCT AGCAGGAGAG 
TTCCAGCGTT TGCTGCCAAT TGATGGAGCA AATGATCTCT TTTTCCAACC ACCCCCACTG 
ACTCCTACCT CCAAGGTTTA TACTATCAGA CCTTATTTCC CTAAAGATGA GGCTTCCGTG 
TACAAGATTT GCAGAGAAAT GTATGATGAT GGAGTGGGTT TACCTTTTCA AAGTCAGCCT 
GACCTTATTG GAGACAAGTT AGTAGGAGGA CTGCTTTCCC TCAGCCTGGA TTACTGTTTT 
GTCCTCGAAG ATGAAGATGG TATTTGTGGT TATGCCTTAG GCACTGTAGA TGTGACCCCC 
TTCATTAAAA AGTGCAAAAT TTCCTGGATT CCCTTCATGC AGGAGAAGTA TACTAAGCCA 
AATGGAGACA AAGAGCTCTC AGAAGCTGAG AAAATAATGT TGAGTTTCCA TGAAGAGCAG 
GAGGTATTAC CAGAAACTTT CCTTGCCAAC TTCCCTTCTC TGATAAAAAT GGATATTCAT 
AAAAAGGTCA CTGACCCAAG TGTTGCCAAA AGCATGATGG CTTGCCTCCT GTCTTCACTA 
AAGGCCAATG GCTCCCGGGG GGCTTTCTGT GAAGTAAGAC CAGATGATAA AAGGATTCTG 
GAATTTTACA GCAAGTTAGG CTGTTTTGAA ATTGCAAAAA TGGAAGGATT TCCAAAGGAT 
GTGGTTATAC TTGGTCGAAG CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444197.1
CDS	356..3202
Translation	MSQTGTTISKVGLRTCGPTDRGRRGAAAGGRRMVQKESQAALEERESERNANPASVSGASLEPSAAPAPGEDNPSGAGAAAGTGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPSVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKTSVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPSALTKEEEKKQPDEEPMDMVVEKQEESEHKSDNQILTEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCINDIAPMQTDEQANKEQFVPGPNEKPLYAAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCALVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL

Target ORF information:

RefSeq Version	XM_017588708.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus meningioma expressed antigen 5 (hyaluronidase) (Mgea5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017588708.1

ORF Insert Sequence:

ATGAGCCAAA CTGGTACAAC AATCTCCAAA GTAGGGCTCC GGACCTGTGG CCCAACGGAC 
CGAGGCCGAA GGGGAGCGGC AGCCGGCGGC AGGAGAATGG TGCAGAAGGA GAGCCAGGCG 
GCGCTGGAGG AGCGGGAGAG TGAGCGCAAC GCCAATCCTG CCTCCGTCTC GGGGGCTTCG 
TTGGAGCCGT CTGCAGCTCC GGCCCCCGGA GAAGACAACC CCTCGGGAGC TGGGGCGGCG 
GCCGGGACCG GGGCGGCCGG CGGGGCCCGC AGGTTCCTGT GCGGTGTAGT GGAAGGGTTT 
TATGGAAGAC CTTGGGTTAT GGAGCAGAGA AAAGAGCTCT TTAGAAGGCT TCAGAAATGG 
GAATTAAATA CATACTTGTA TGCTCCGAAG GATGACTACA AACATAGGAT GTTTTGGCGA 
GAGATGTATT CAGTGGAAGA AGCTGAGCAA CTTATGACTC TCATCTCTGC TGCACGAGAA 
TATGAGATAG AATTCATCTA TGCTATTTCT CCAGGATTAG ATATCACTTT TTCTAACCCA 
AAGGAAGTAT CAACATTGAA ACGCAAATTG GACCAGGTCT CCCAGTTTGG GTGCAGGTCA 
TTTGCTTTGC TTTTTGATGA TATTGATCAT AACATGTGTG CAGCAGACAA AGAAGTGTTC 
AGTTCTTTTG CACATGCACA AGTTTCCATC ACAAATGAAA TCTATCAGTA CCTGGGAGAG 
CCGGAAACCT TCCTCTTCTG TCCCACAGAA TACTGCGGCA CTTTCTGTTA TCCAAGTGTA 
TCTCAGTCTC CTTACTTGAG GACTGTGGGT GAAAAGCTGC TACCTGGAAT TGAGGTGCTT 
TGGACAGGTC CAAAAGTTGT TTCAAAAGAA ATTCCAGTAG AATCTATTGA AGAAGTTTCT 
AAGATCATTA AGAGAGCCCC AGTGATCTGG GATAACATTC ATGCTAATGA CTATGATCAG 
AAGAGGCTGT TTCTGGGTCC CTACAAAGGA AGATCCACAG AGCTCATCCC ACGGTTGAAG 
GGAGTGCTGA CTAATCCAAA TTGTGAATTT GAAGCCAACT ATGTTGCCAT CCACACCCTT 
GCCACTTGGT ACAAGTCAAA CATGAACGGA GTGAGGAAGG ACGTGGTGAT GACTGACAGT 
GAAGACAGTA CTGTCTCAAT ACAGATAAAG TTAGAAAATG AAGGCAGTGA TGAAGACATT 
GAGACTGATG TGCTCTACAG TCCACAGATG GCTTTAAAGC TGGCCTTAAC TGAGTGGCTG 
CAGGAGTTCG GTGTACCGCA TCAGTACAGC AGTAGACAGG TTGCACACAG TGGAGCTAAG 
ACAAGCGTAG TGGACGGGAC TCCCTTGGTT GCAGCACCTT CTTTAAATGC CACAACTGTA 
GTTACAACAG TTTACCAGGA GCCCATTATG AGCCAGGGAG CAGCTTTGAG TGGTGAGCCC 
TCAGCTCTGA CCAAGGAAGA AGAAAAGAAA CAGCCAGATG AGGAACCCAT GGATATGGTG 
GTAGAGAAGC AAGAAGAGTC AGAGCACAAG AGTGACAACC AGATACTAAC TGAGATCGTC 
GAAGCTAAAA TGGCAGAGGA GTTGAAACCA ATGGACACTG ATAAGGAAAG CATAGCCGAG 
TCAAAATCCC CAGAGATGTC TATGCAGGAA GACTGCATTA ACGACATCGC TCCTATGCAG 
ACAGACGAGC AAGCAAACAA AGAGCAGTTT GTGCCAGGTC CAAATGAAAA ACCTTTGTAC 
GCTGCAGAAC CAGTGACTCT GGAGGATTTA CAGTTACTTG CTGATCTCTT CTACCTTCCT 
TATGAGCATG GACCCAAAGG AGCACAGATG CTACGGGAGT TCCAGTGGCT TCGAGCAAAC 
AGTAGTGTTG TCAGTGTCAA TTGCAAAGGG AAAGACTCTG AAAAAATTGA AGAATGGCGG 
TCACGAGCAG CCAAGTTTGA AGAAATGTGC GCACTAGTGA TGGGGATGTT CACCCGGCTC 
TCCAACTGTG CCAACAGGAC AATCCTTTAT GACATGTACT CCTATGTGTG GGATATCAAG 
AGTATAATGT CTATGGTGAA GTCTTTTGTG CAGTGGTTAG GGTGTCGTAG TCATTCTTCA 
GCACAGTTCT TAATTGGAGA CCAAGAACCC TGGGCCTTTA GAGGTGGTCT AGCAGGAGAG 
TTCCAGCGTT TGCTGCCAAT TGATGGAGCA AATGATCTCT TTTTCCAACC ACCCCCACTG 
ACTCCTACCT CCAAGGTTTA TACTATCAGA CCTTATTTCC CTAAAGATGA GGCTTCCGTG 
TACAAGATTT GCAGAGAAAT GTATGATGAT GGAGTGGGTT TACCTTTTCA AAGTCAGCCT 
GACCTTATTG GAGACAAGTT AGTAGGAGGA CTGCTTTCCC TCAGCCTGGA TTACTGTTTT 
GTCCTCGAAG ATGAAGATGG TATTTGTGGT TATGCCTTAG GCACTGTAGA TGTGACCCCC 
TTCATTAAAA AGTGCAAAAT TTCCTGGATT CCCTTCATGC AGGAGAAGTA TACTAAGCCA 
AATGGAGACA AAGAGCTCTC AGAAGCTGAG AAAATAATGT TGAGTTTCCA TGAAGAGCAG 
GAGGTATTAC CAGAAACTTT CCTTGCCAAC TTCCCTTCTC TGATAAAAAT GGATATTCAT 
AAAAAGGTCA CTGACCCAAG TGTTGCCAAA AGCATGATGG CTTGCCTCCT GTCTTCACTA 
AAGGCCAATG GCTCCCGGGG GGCTTTCTGT GAAGTAAGAC CAGATGATAA AAGGATTCTG 
GAATTTTACA GCAAGTTAGG CTGTTTTGAA ATTGCAAAAA TGGAAGGATT TCCAAAGGAT 
GTGGTTATAC TTGGTCGAAG CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-539 is up-regulated in failing heart, and suppresses O-GlcNAcase expression.
The Journal of biological chemistry289(43)29665-76(2014 Oct)
Muthusamy S,DeMartino AM,Watson LJ,Brittian KR,Zafir A,Dassanayaka S,Hong KU,Jones SP

Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain.
PloS one7(8)e43724(2012)
Liu Y,Li X,Yu Y,Shi J,Liang Z,Run X,Li Y,Dai CL,Grundke-Iqbal I,Iqbal K,Liu F,Gong CX

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Impaired vasodilator activity in deoxycorticosterone acetate-salt hypertension is associated with increased protein O-GlcNAcylation.
Hypertension (Dallas, Tex. : 1979)53(2)166-74(2009 Feb)
Lima VV,Giachini FR,Choi H,Carneiro FS,Carneiro ZN,Fortes ZB,Carvalho MH,Webb RC,Tostes RC

Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury.
Circulation research104(1)41-9(2009 Jan)
Ngoh GA,Facundo HT,Hamid T,Dillmann W,Zachara NE,Jones SP

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Oga cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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