IL18 cDNA ORF clone, Oryctolagus cuniculus(rabbit)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL18
Entrez Gene ID	100144338
Full Name	interleukin 18
Gene Type	protein-coding
Organism	Oryctolagus cuniculus(rabbit)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001122940.1	NP_001116412.1	interleukin-18
XM_008258602.2	XP_008256824.1	interleukin-18 isoform X1
XM_008258609.2	XP_008256831.1	interleukin-18 isoform X2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Genetic characterization of interleukins (IL-1?, IL-1?, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs.
Neves F, Abrantes J, Almeida T, de Matos AL, Costa PP, Esteves PJ
Innate immunity21(8)787-801(2015 Nov)

Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-?-induced cardiomyocyte death.
Yoshida T, Friehs I, Mummidi S, del Nido PJ, Addulnour-Nakhoul S, Delafontaine P, Valente AJ, Chandrasekar B
Journal of molecular and cellular cardiology75141-51(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pressure overload, while enhancing IL-18 and IL-18R expression in hypertrophied and failing hearts, markedly attenuated the level of expression of the endogenous IL-18 antagonist IL-18BP.
Title: Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-?-induced cardiomyocyte death.

The following IL18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OOb01125	NM_001122940.1 Latest version!	Oryctolagus cuniculus interleukin 18 (IL18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OOb01125	XM_008258602.2 Latest version!	Oryctolagus cuniculus interleukin 18 (IL18), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OOb01126	XM_008258609.2 Latest version!	Oryctolagus cuniculus interleukin 18 (IL18), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL18 ( NM_001122940.1 ) cDNA ORF clone, Oryctolagus cuniculus(rabbit) -> NP_001116412.1 Oryctolagus cuniculus interleukin 18 (IL18), mRNA.

Price & Availability↑

CloneID	OOb01125
Clone ID Related Accession (Same CDS sequence)	NM_001122940.1 , XM_008258602.2
Accession Version	NM_001122940.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-24
Organism	Oryctolagus cuniculus(rabbit)
Product	interleukin-18
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU419127.1. ##Evidence-Data-START## Transcript exon combination :: EU419127.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3321799, SAMEA3321800 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCTG AACCAGAAGA GGCTTGCATC AACTTTGTGG GAATGAAATT TATTGACAAC 
ACACTTTACT TTATAACTGA AAACGATGAG AACCTGGAAT CAGATTACTT TGGCAAGCTT 
GAACCGAAAA TCTCCATCAT ACGAAACCTG AATGACCAAG TTCTCTTCAT GGACCAAGGA 
CAGCAACCTG TGTTTGAGGA TATGCCCGAT TCTGACTGTA TAGAAAATGC ACCCCAGACC 
ATTTTTATAA TATATATGTA TAAAGACAGC AATACTAGAG GCATGGCTGT AAGCCTCTCT 
GTGAAGTGTA AGAAAATTTT TACACTCTCC TGTGAGAACA AAATTATTTC CTTTAAGGAA 
CTCACTCCTC CTAATGACAT CAACGATACA AAAAGTGACA TCATATTCTT TCAGAAACAT 
CTCGCAGGAC AGAAAGATAA GATGCAGTTT GAGTCTTCAT TGTATGACGG ATACTTTCTA 
GCTTGTGGAA AGGAGAAAGA TCTTTTCAAA CTTGTTTTGA AACGTAAAGA TGACAAAAAC 
GATAAATCTG TAATTTTCAG TGTCCAAAAC AAGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116412.1
CDS	1..579
Translation	MAAEPEEACINFVGMKFIDNTLYFITENDENLESDYFGKLEPKISIIRNLNDQVLFMDQGQQPVFEDMPDSDCIENAPQTIFIIYMYKDSNTRGMAVSLSVKCKKIFTLSCENKIISFKELTPPNDINDTKSDIIFFQKHLAGQKDKMQFESSLYDGYFLACGKEKDLFKLVLKRKDDKNDKSVIFSVQNKN

Target ORF information:

RefSeq Version	NM_001122940.1
Organism	Oryctolagus cuniculus(rabbit)
Definition	Oryctolagus cuniculus interleukin 18 (IL18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001122940.1

ORF Insert Sequence:

ATGGCTGCTG AACCAGAAGA GGCTTGCATC AACTTTGTGG GAATGAAATT TATTGACAAC 
ACACTTTACT TTATAACTGA AAACGATGAG AACCTGGAAT CAGATTACTT TGGCAAGCTT 
GAACCGAAAA TCTCCATCAT ACGAAACCTG AATGACCAAG TTCTCTTCAT GGACCAAGGA 
CAGCAACCTG TGTTTGAGGA TATGCCCGAT TCTGACTGTA TAGAAAATGC ACCCCAGACC 
ATTTTTATAA TATATATGTA TAAAGACAGC AATACTAGAG GCATGGCTGT AAGCCTCTCT 
GTGAAGTGTA AGAAAATTTT TACACTCTCC TGTGAGAACA AAATTATTTC CTTTAAGGAA 
CTCACTCCTC CTAATGACAT CAACGATACA AAAAGTGACA TCATATTCTT TCAGAAACAT 
CTCGCAGGAC AGAAAGATAA GATGCAGTTT GAGTCTTCAT TGTATGACGG ATACTTTCTA 
GCTTGTGGAA AGGAGAAAGA TCTTTTCAAA CTTGTTTTGA AACGTAAAGA TGACAAAAAC 
GATAAATCTG TAATTTTCAG TGTCCAAAAC AAGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL18 ( XM_008258602.2 ) cDNA ORF clone, Oryctolagus cuniculus(rabbit) -> XP_008256824.1 Oryctolagus cuniculus interleukin 18 (IL18), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OOb01125
Clone ID Related Accession (Same CDS sequence)	NM_001122940.1 , XM_008258602.2
Accession Version	XM_008258602.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-22
Organism	Oryctolagus cuniculus(rabbit)
Product	interleukin-18 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_013669.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 23, 2016 this sequence version replaced XM_008258602.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Oryctolagus cuniculus Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCTG AACCAGAAGA GGCTTGCATC AACTTTGTGG GAATGAAATT TATTGACAAC 
ACACTTTACT TTATAACTGA AAACGATGAG AACCTGGAAT CAGATTACTT TGGCAAGCTT 
GAACCGAAAA TCTCCATCAT ACGAAACCTG AATGACCAAG TTCTCTTCAT GGACCAAGGA 
CAGCAACCTG TGTTTGAGGA TATGCCCGAT TCTGACTGTA TAGAAAATGC ACCCCAGACC 
ATTTTTATAA TATATATGTA TAAAGACAGC AATACTAGAG GCATGGCTGT AAGCCTCTCT 
GTGAAGTGTA AGAAAATTTT TACACTCTCC TGTGAGAACA AAATTATTTC CTTTAAGGAA 
CTCACTCCTC CTAATGACAT CAACGATACA AAAAGTGACA TCATATTCTT TCAGAAACAT 
CTCGCAGGAC AGAAAGATAA GATGCAGTTT GAGTCTTCAT TGTATGACGG ATACTTTCTA 
GCTTGTGGAA AGGAGAAAGA TCTTTTCAAA CTTGTTTTGA AACGTAAAGA TGACAAAAAC 
GATAAATCTG TAATTTTCAG TGTCCAAAAC AAGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008256824.1
CDS	308..886
Translation	MAAEPEEACINFVGMKFIDNTLYFITENDENLESDYFGKLEPKISIIRNLNDQVLFMDQGQQPVFEDMPDSDCIENAPQTIFIIYMYKDSNTRGMAVSLSVKCKKIFTLSCENKIISFKELTPPNDINDTKSDIIFFQKHLAGQKDKMQFESSLYDGYFLACGKEKDLFKLVLKRKDDKNDKSVIFSVQNKN

Target ORF information:

RefSeq Version	XM_008258602.2
Organism	Oryctolagus cuniculus(rabbit)
Definition	Oryctolagus cuniculus interleukin 18 (IL18), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008258602.2

ORF Insert Sequence:

ATGGCTGCTG AACCAGAAGA GGCTTGCATC AACTTTGTGG GAATGAAATT TATTGACAAC 
ACACTTTACT TTATAACTGA AAACGATGAG AACCTGGAAT CAGATTACTT TGGCAAGCTT 
GAACCGAAAA TCTCCATCAT ACGAAACCTG AATGACCAAG TTCTCTTCAT GGACCAAGGA 
CAGCAACCTG TGTTTGAGGA TATGCCCGAT TCTGACTGTA TAGAAAATGC ACCCCAGACC 
ATTTTTATAA TATATATGTA TAAAGACAGC AATACTAGAG GCATGGCTGT AAGCCTCTCT 
GTGAAGTGTA AGAAAATTTT TACACTCTCC TGTGAGAACA AAATTATTTC CTTTAAGGAA 
CTCACTCCTC CTAATGACAT CAACGATACA AAAAGTGACA TCATATTCTT TCAGAAACAT 
CTCGCAGGAC AGAAAGATAA GATGCAGTTT GAGTCTTCAT TGTATGACGG ATACTTTCTA 
GCTTGTGGAA AGGAGAAAGA TCTTTTCAAA CTTGTTTTGA AACGTAAAGA TGACAAAAAC 
GATAAATCTG TAATTTTCAG TGTCCAAAAC AAGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL18 ( XM_008258609.2 ) cDNA ORF clone, Oryctolagus cuniculus(rabbit) -> XP_008256831.1 Oryctolagus cuniculus interleukin 18 (IL18), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OOb01126
Clone ID Related Accession (Same CDS sequence)	XM_008258609.2
Accession Version	XM_008258609.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-22
Organism	Oryctolagus cuniculus(rabbit)
Product	interleukin-18 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_013669.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 23, 2016 this sequence version replaced XM_008258609.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Oryctolagus cuniculus Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTAAAGT ATAAAAGTAT TTCTCTTTCT TTACAAAAGA ACCTGGAATC AGATTACTTT 
GGCAAGCTTG AACCGAAAAT CTCCATCATA CGAAACCTGA ATGACCAAGT TCTCTTCATG 
GACCAAGGAC AGCAACCTGT GTTTGAGGAT ATGCCCGATT CTGACTGTAT AGAAAATGCA 
CCCCAGACCA TTTTTATAAT ATATATGTAT AAAGACAGCA ATACTAGAGG CATGGCTGTA 
AGCCTCTCTG TGAAGTGTAA GAAAATTTTT ACACTCTCCT GTGAGAACAA AATTATTTCC 
TTTAAGGAAC TCACTCCTCC TAATGACATC AACGATACAA AAAGTGACAT CATATTCTTT 
CAGAAACATC TCGCAGGACA GAAAGATAAG ATGCAGTTTG AGTCTTCATT GTATGACGGA 
TACTTTCTAG CTTGTGGAAA GGAGAAAGAT CTTTTCAAAC TTGTTTTGAA ACGTAAAGAT 
GACAAAAACG ATAAATCTGT AATTTTCAGT GTCCAAAACA AGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008256831.1
CDS	44..571
Translation	MVKYKSISLSLQKNLESDYFGKLEPKISIIRNLNDQVLFMDQGQQPVFEDMPDSDCIENAPQTIFIIYMYKDSNTRGMAVSLSVKCKKIFTLSCENKIISFKELTPPNDINDTKSDIIFFQKHLAGQKDKMQFESSLYDGYFLACGKEKDLFKLVLKRKDDKNDKSVIFSVQNKN

Target ORF information:

RefSeq Version	XM_008258609.2
Organism	Oryctolagus cuniculus(rabbit)
Definition	Oryctolagus cuniculus interleukin 18 (IL18), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008258609.2

ORF Insert Sequence:

ATGGTAAAGT ATAAAAGTAT TTCTCTTTCT TTACAAAAGA ACCTGGAATC AGATTACTTT 
GGCAAGCTTG AACCGAAAAT CTCCATCATA CGAAACCTGA ATGACCAAGT TCTCTTCATG 
GACCAAGGAC AGCAACCTGT GTTTGAGGAT ATGCCCGATT CTGACTGTAT AGAAAATGCA 
CCCCAGACCA TTTTTATAAT ATATATGTAT AAAGACAGCA ATACTAGAGG CATGGCTGTA 
AGCCTCTCTG TGAAGTGTAA GAAAATTTTT ACACTCTCCT GTGAGAACAA AATTATTTCC 
TTTAAGGAAC TCACTCCTCC TAATGACATC AACGATACAA AAAGTGACAT CATATTCTTT 
CAGAAACATC TCGCAGGACA GAAAGATAAG ATGCAGTTTG AGTCTTCATT GTATGACGGA 
TACTTTCTAG CTTGTGGAAA GGAGAAAGAT CTTTTCAAAC TTGTTTTGAA ACGTAAAGAT 
GACAAAAACG ATAAATCTGT AATTTTCAGT GTCCAAAACA AGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic characterization of interleukins (IL-1?, IL-1?, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs.
Innate immunity21(8)787-801(2015 Nov)
Neves F,Abrantes J,Almeida T,de Matos AL,Costa PP,Esteves PJ

Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-?-induced cardiomyocyte death.
Journal of molecular and cellular cardiology75141-51(2014 Oct)
Yoshida T,Friehs I,Mummidi S,del Nido PJ,Addulnour-Nakhoul S,Delafontaine P,Valente AJ,Chandrasekar B