Sycn cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sycn
Entrez Gene ID	68416
Full Name	syncollin
Synonyms	0910001K16Rik,1810038B08Rik,SYL
General protein information	Preferred Names syncollin Names syncollin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_026716.3	NP_080992.3	syncollin precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SYCN	XP_002695028.1
Rattus norvegicus (Norway rat)	Sycn	NP_620786.1
Xenopus tropicalis (tropical clawed frog)	LOC100486753	XP_002940405.1
Pan troglodytes (chimpanzee)	SYCN	XP_001135373.1
Mus musculus (house mouse)	Sycn	NP_080992.3
Homo sapiens (human)	SYCN	NP_001073937.1
	LOC695873	XP_001086742.2
Canis lupus familiaris (dog)	SYCN	XP_855368.1
Gallus gallus (chicken)	SYCN	XP_004950408.1

Gene Ontology
Bibliography

Related articles in PubMed

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-? and VEGF-A upregulation.
Soggia A, Ramond C, Akiyama H, Scharfmann R, Duvillie B
Diabetologia57(11)2348-56(2014 Nov)

Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.
Li Z, Parlakian A, Coletti D, Alonso-Martin S, Hourd? C, Joanne P, Gao-Li J, Blanc J, Ferry A, Paulin D, Xue Z, Agbulut O
Journal of cell science127(Pt 21)4589-601(2014 Nov)

Syncollin is required for efficient zymogen granule exocytosis.
W?sle B, Turvey M, Larina O, Thorn P, Skepper J, Morton AJ, Edwardson JM
The Biochemical journal385(Pt 3)721-7(2005 Feb)

Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion.
Antonin W, Wagner M, Riedel D, Brose N, Jahn R
Molecular and cellular biology22(5)1545-54(2002 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

syncollin is required for efficient exocytosis in the pancreatic acinar cell, and it plays a particularly important role in compound exocytosis
Title: Syncollin is required for efficient zymogen granule exocytosis.

The following Sycn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sycn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02880	NM_026716.3 Latest version!	Mus musculus syncollin (Sycn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sycn ( NM_026716.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080992.3 Mus musculus syncollin (Sycn), mRNA.

Price & Availability↑

CloneID	OMu02880
Clone ID Related Accession (Same CDS sequence)	NM_026716.3
Accession Version	NM_026716.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Mus musculus(house mouse)
Product	syncollin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC136456.3. On Apr 30, 2009 this sequence version replaced NM_026716.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BG963694.1, BG270683.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCTGC TGTGCCCACT GCTGCTGGCT TTAGCCCTGG TGGCTGTCCC TGGTGCCCAT 
GGCAATTGCC CGGTGCCCGC AGACCTGAAG AAGTCAGATG GGACGCGTAC GTGCGCCAGA 
CTCTATGAGA AGAGTGATCC ATACTATGAC AACTGCTGCC AGGGGCCCGT GTTGTCTGTG 
GAGCCAGGTA CTGACCTGCC CTATCTGCCC TCGGGCTGGT CTAACACTGC ATCGTCTCTG 
GTAGTGGGCC AGCGCTGTGA GATCACTGTG TGGTCTCTCC CCGGTAAGCA TGGCAAGACC 
CGCAAGTTCA CCGCGGGTTC TTACCCTCGC CTGGAAGAGT ACCGCAAAGG CATCTTTGGA 
GACTGGTCCG ACTCCATCTC TGCCCTCTAC TGCAAGTGCT ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080992.3
CDS	26..430
Translation	MSLLCPLLLALALVAVPGAHGNCPVPADLKKSDGTRTCARLYEKSDPYYDNCCQGPVLSVEPGTDLPYLPSGWSNTASSLVVGQRCEITVWSLPGKHGKTRKFTAGSYPRLEEYRKGIFGDWSDSISALYCKCY

Target ORF information:

RefSeq Version	NM_026716.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus syncollin (Sycn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026716.3

ORF Insert Sequence:

ATGTCCCTGC TGTGCCCACT GCTGCTGGCT TTAGCCCTGG TGGCTGTCCC TGGTGCCCAT 
GGCAATTGCC CGGTGCCCGC AGACCTGAAG AAGTCAGATG GGACGCGTAC GTGCGCCAGA 
CTCTATGAGA AGAGTGATCC ATACTATGAC AACTGCTGCC AGGGGCCCGT GTTGTCTGTG 
GAGCCAGGTA CTGACCTGCC CTATCTGCCC TCGGGCTGGT CTAACACTGC ATCGTCTCTG 
GTAGTGGGCC AGCGCTGTGA GATCACTGTG TGGTCTCTCC CCGGTAAGCA TGGCAAGACC 
CGCAAGTTCA CCGCGGGTTC TTACCCTCGC CTGGAAGAGT ACCGCAAAGG CATCTTTGGA 
GACTGGTCCG ACTCCATCTC TGCCCTCTAC TGCAAGTGCT ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-? and VEGF-A upregulation.
Diabetologia57(11)2348-56(2014 Nov)
Soggia A,Ramond C,Akiyama H,Scharfmann R,Duvillie B

Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.
Journal of cell science127(Pt 21)4589-601(2014 Nov)
Li Z,Parlakian A,Coletti D,Alonso-Martin S,Hourd? C,Joanne P,Gao-Li J,Blanc J,Ferry A,Paulin D,Xue Z,Agbulut O

Syncollin is required for efficient zymogen granule exocytosis.
The Biochemical journal385(Pt 3)721-7(2005 Feb)
W?sle B,Turvey M,Larina O,Thorn P,Skepper J,Morton AJ,Edwardson JM

Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion.
Molecular and cellular biology22(5)1545-54(2002 Mar)
Antonin W,Wagner M,Riedel D,Brose N,Jahn R