Arpc5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Arpc5
Entrez Gene ID	67771
Full Name	actin related protein 2/3 complex, subunit 5
Synonyms	5830443F10Rik,p16-Arc
General protein information	Preferred Names actin related protein 2/3 complex, subunit 5 Names actin-related protein 2/3 complex subunit 5 arp2/3 complex 16 kDa subunit
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 G3

mRNA and Protein(s)

mRNA	Protein	Name
NM_026369.2	NP_080645.2	actin-related protein 2/3 complex subunit 5

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ARPC5	XP_537159.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008895	XP_319641.4
Xenopus tropicalis (tropical clawed frog)	arpc5	NP_001017242.1
Bos taurus (cattle)	ARPC5	NP_001030524.1
Gallus gallus (chicken)	ARPC5	NP_001026732.1
Drosophila melanogaster (fruit fly)	Arpc5	NP_608693.1
Homo sapiens (human)	ARPC5	NP_005708.1
Mus musculus (house mouse)	Arpc5	NP_080645.2
Caenorhabditis elegans (roundworm)	arx-7	NP_491099.1
Pan troglodytes (chimpanzee)	ARPC5	NP_001233430.1
Rattus norvegicus (Norway rat)	Arpc5	NP_001020888.1
Danio rerio (zebrafish)	arpc5b	NP_958917.1
Danio rerio (zebrafish)	arpc5a	NP_919359.2
Caenorhabditis elegans (roundworm)	C46H11.3	NP_491506.1

Gene Ontology
Bibliography

Related articles in PubMed

Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation.
Chang YF, Lee-Chang JS, Imam JS, Buddavarapu KC, Subaran SS, Sinha-Hikim AP, Gorospe M, Rao MK
Proceedings of the National Academy of Sciences of the United States of America109(15)5750-5(2012 Apr)

GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A.
Ichikawa D, Mizuno M, Yamamura T, Miyake S
The Journal of biological chemistry286(50)43465-74(2011 Dec)

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ
PLoS genetics5(6)e1000511(2009 Jun)

Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end.
Mejillano MR, Kojima S, Applewhite DA, Gertler FB, Svitkina TM, Borisy GG
Cell118(3)363-73(2004 Aug)

Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion.
DeMali KA, Barlow CA, Burridge K
The Journal of cell biology159(5)881-91(2002 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Loss of microRNA-dependent regulation of Arpc5, which controls the distribution of germ cell mRNAs between translationally active and inactive pools, results in abnormal round spermatid differentiation and impaired fertility.
Title: Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation.

GRAIL functions via the ubiquitination and degradation of actin cytoskeleton-associated proteins, in particular Arp2/3-5 and coronin 1A
Title: GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A.

The following Arpc5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Arpc5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02113	NM_026369.2 Latest version!	Mus musculus actin related protein 2/3 complex, subunit 5 (Arpc5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Arpc5 ( NM_026369.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080645.2 Mus musculus actin related protein 2/3 complex, subunit 5 (Arpc5), mRNA.

Price & Availability↑

CloneID	OMu02113
Clone ID Related Accession (Same CDS sequence)	NM_026369.2
Accession Version	NM_026369.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Mus musculus(house mouse)
Product	actin-related protein 2/3 complex subunit 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF170085.1 and BC060143.1. On Mar 11, 2009 this sequence version replaced NM_026369.1. ##Evidence-Data-START## Transcript exon combination :: BC060143.1, SRR1660817.116277.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGAAGA ACACGGTGTC GTCGGCCCGC TTCCGGAAGG TGGACGTGGA CGAATATGAC 
GAGAACAAGT TCGTGGACGA GGAGGACGGC GGCGATGGCC AGGCCGGGCC CGACGAGGGC 
GAGGTGGACT CGTGCCTACG GCAAGGAAAC ATGACAGCTG CTCTCCAGGC TGCTCTGAAA 
AACCCCCCTA TTAACACAAA GAGCCAGGCA GTGAAGGACC GTGCAGGCAG CATCGTCTTG 
AAGGTGCTTA TCTCTTTTAA AGCTAATGAT ATTGAAAAGG CAGTGCAGTC TCTGGACAAG 
AACGGTGTGG ACCTCCTAAT GAAGTATATT TATAAAGGCT TTGAGAGCCC ATCTGACAAC 
AGCAGTGCTG TGTTGCTCCA GTGGCATGAA AAGGCCCTTG CTGCTGGAGG AGTGGGGTCC 
ATTGTTCGAG TTTTGACTGC AAGGAAAACC GTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080645.2
CDS	184..639
Translation	MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAVLLQWHEKALAAGGVGSIVRVLTARKTV

Target ORF information:

RefSeq Version	NM_026369.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus actin related protein 2/3 complex, subunit 5 (Arpc5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026369.2

ORF Insert Sequence:

ATGTCGAAGA ACACGGTGTC GTCGGCCCGC TTCCGGAAGG TGGACGTGGA CGAATATGAC 
GAGAACAAGT TCGTGGACGA GGAGGACGGC GGCGATGGCC AGGCCGGGCC CGACGAGGGC 
GAGGTGGACT CGTGCCTACG GCAAGGAAAC ATGACAGCTG CTCTCCAGGC TGCTCTGAAA 
AACCCCCCTA TTAACACAAA GAGCCAGGCA GTGAAGGACC GTGCAGGCAG CATCGTCTTG 
AAGGTGCTTA TCTCTTTTAA AGCTAATGAT ATTGAAAAGG CAGTGCAGTC TCTGGACAAG 
AACGGTGTGG ACCTCCTAAT GAAGTATATT TATAAAGGCT TTGAGAGCCC ATCTGACAAC 
AGCAGTGCTG TGTTGCTCCA GTGGCATGAA AAGGCCCTTG CTGCTGGAGG AGTGGGGTCC 
ATTGTTCGAG TTTTGACTGC AAGGAAAACC GTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America109(15)5750-5(2012 Apr)
Chang YF,Lee-Chang JS,Imam JS,Buddavarapu KC,Subaran SS,Sinha-Hikim AP,Gorospe M,Rao MK

GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A.
The Journal of biological chemistry286(50)43465-74(2011 Dec)
Ichikawa D,Mizuno M,Yamamura T,Miyake S

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
PLoS genetics5(6)e1000511(2009 Jun)
Sansom SN,Griffiths DS,Faedo A,Kleinjan DJ,Ruan Y,Smith J,van Heyningen V,Rubenstein JL,Livesey FJ

Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end.
Cell118(3)363-73(2004 Aug)
Mejillano MR,Kojima S,Applewhite DA,Gertler FB,Svitkina TM,Borisy GG

Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion.
The Journal of cell biology159(5)881-91(2002 Dec)
DeMali KA,Barlow CA,Burridge K