Angptl4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Angptl4
Entrez Gene ID	57875
Full Name	angiopoietin-like 4
Synonyms	Arp4,Bk89,Fiaf,Hfarp,Ng27,Pgar,Pgarg,Pp1158
General protein information	Preferred Names angiopoietin-like 4 Names angiopoietin-related protein 4 425O18-1 angiopoietin-like protein 4 fasting-induced adipose factor fibrinogen/angiopoietin-related protein hepatic fibrinogen/angiopoietin-related protein major histocompatibility complex region NG27 secreted protein Bk89
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_020581.2	NP_065606.2	angiopoietin-related protein 4 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	ANGPTL4	NP_647475.1
Pan troglodytes (chimpanzee)	ANGPTL4	XP_001147708.3
Canis lupus familiaris (dog)	ANGPTL4	XP_005633282.1
Danio rerio (zebrafish)	angptl4	NP_001243132.1
Bos taurus (cattle)	ANGPTL4	NP_001039508.1
Gallus gallus (chicken)	ANGPTL4	XP_001232284.2
Xenopus tropicalis (tropical clawed frog)	angptl4	XP_002938598.1
Rattus norvegicus (Norway rat)	Angptl4	NP_954546.1
Mus musculus (house mouse)	Angptl4	NP_065606.2

Gene Ontology
Bibliography

Related articles in PubMed

Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase.
Yoshida K, Shimizugawa T, Ono M, Furukawa H
Journal of lipid research43(11)1770-2(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

1) ANGPTL4 is not involved in the triglyceride-lowering effect ofbile acids ; 2) ANGPTL4 promotes bile acids absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota.
Title: ANGPTL4 promotes bile acid absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota.

This study shows that TNF-alpha, by a Foxo1 dependent pathway, increases the transcription of ANGPTL4 which is secreted by the cells and causes inactivation of LPL.
Title: TNF-? decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4.

Angptl4-deficient mice show impaired insulin secretion and dysmorphic pancreatic islets.
Title: Angiopoietin-like peptide 4 regulates insulin secretion and islet morphology.

Angptl4 induces obesity-associated metabolic disorders. The present study suggested that Angptl4 promotes liver steatosis and lipolysis, in addition to impairing liver function; while Angptl4 improves glucose tolerance and insulin resistance, in addition to causing the downregulation of various insulin signaling pathway-associated genes.
Title: Angiopoietin-like protein?4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice.

physiological changes in adipose tissue ANGPTL4 expression during fasting and cold resulted in inverse changes in the amount of mature-glycosylated LPL in wild-type mice, but not Angptl4(-/-) mice. We conclude that ANGPTL4 promotes loss of intracellular LPL by stimulating LPL degradation after LPL processing in the endoplasmic reticulum (ER).
Title: Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes.

The following Angptl4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Angptl4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16724	NM_020581.2 Latest version!	Mus musculus angiopoietin-like 4 (Angptl4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Angptl4 ( NM_020581.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_065606.2 Mus musculus angiopoietin-like 4 (Angptl4), mRNA.

Price & Availability↑

CloneID	OMu16724
Clone ID Related Accession (Same CDS sequence)	NM_020581.2
Accession Version	NM_020581.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	angiopoietin-related protein 4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY783212.1, AK014564.1 and AW495750.1. On Aug 5, 2009 this sequence version replaced NM_020581.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021343.1, AK014564.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCTGCG CTCCGACAGC AGGCGCTGCC CTGGTGCTAT GCGCGGCTAC TGCGGGGCTT 
TTGAGCGCGC AAGGGCGCCC TGCACAGCCA GAGCCACCGC GCTTTGCATC CTGGGACGAG 
ATGAACTTGC TGGCTCACGG GCTGCTACAG CTCGGCCATG GGCTGCGCGA ACACGTGGAG 
CGCACCCGTG GGCAGCTGGG CGCGCTGGAG CGCCGCATGG CTGCCTGTGG TAACGCTTGT 
CAGGGGCCCA AGGGAAAAGA TGCACCCTTC AAAGACTCCG AGGATAGAGT CCCTGAAGGC 
CAGACTCCTG AGACTCTGCA GAGTTTGCAG ACTCAGCTCA AGGCTCAAAA CAGCAAGATC 
CAGCAATTGT TCCAGAAGGT GGCCCAGCAG CAGAGATACC TATCAAAGCA GAATCTGAGA 
ATACAGAATC TTCAGAGCCA GATAGACCTC TTGGCCCCCA CGCACCTAGA CAATGGAGTA 
GACAAGACTT CGAGGGGAAA GAGGCTTCCC AAGATGACCC AGCTCATTGG CTTGACTCCC 
AACGCCACCC ACTTACACAG GCCGCCCCGG GACTGCCAGG AACTCTTCCA AGAAGGGGAG 
CGGCACAGTG GACTTTTCCA GATCCAGCCT CTGGGGTCTC CACCATTTTT GGTCAACTGT 
GAGATGACTT CAGATGGAGG CTGGACAGTG ATTCAGAGAC GCCTGAACGG CTCTGTGGAC 
TTCAACCAGT CCTGGGAAGC CTACAAGGAT GGCTTCGGAG ATCCCCAAGG CGAGTTCTGG 
CTGGGCCTGG AAAAGATGCA CAGCATCACA GGGAACCGAG GAAGCCAATT GGCTGTGCAG 
CTCCAGGACT GGGATGGCAA TGCCAAATTG CTCCAATTTC CCATCCATTT GGGGGGTGAG 
GACACAGCCT ACAGCCTGCA GCTCACTGAG CCCACGGCCA ATGAGCTGGG TGCCACCAAT 
GTTTCCCCCA ATGGCCTTTC CCTGCCCTTC TCTACTTGGG ACCAAGACCA TGACCTCCGT 
GGGGACCTTA ACTGTGCCAA GAGCCTCTCT GGTGGCTGGT GGTTTGGTAC CTGTAGCCAT 
TCCAATCTCA ATGGACAATA CTTCCACTCT ATCCCACGGC AACGGCAGGA GCGTAAAAAG 
GGTATCTTCT GGAAAACATG GAAGGGCCGC TACTATCCTC TGCAGGCTAC CACCCTGCTG 
ATCCAGCCCA TGGAGGCTAC AGCAGCCTCT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065606.2
CDS	184..1416
Translation	MRCAPTAGAALVLCAATAGLLSAQGRPAQPEPPRFASWDEMNLLAHGLLQLGHGLREHVERTRGQLGALERRMAACGNACQGPKGKDAPFKDSEDRVPEGQTPETLQSLQTQLKAQNSKIQQLFQKVAQQQRYLSKQNLRIQNLQSQIDLLAPTHLDNGVDKTSRGKRLPKMTQLIGLTPNATHLHRPPRDCQELFQEGERHSGLFQIQPLGSPPFLVNCEMTSDGGWTVIQRRLNGSVDFNQSWEAYKDGFGDPQGEFWLGLEKMHSITGNRGSQLAVQLQDWDGNAKLLQFPIHLGGEDTAYSLQLTEPTANELGATNVSPNGLSLPFSTWDQDHDLRGDLNCAKSLSGGWWFGTCSHSNLNGQYFHSIPRQRQERKKGIFWKTWKGRYYPLQATTLLIQPMEATAAS

Target ORF information:

RefSeq Version	NM_020581.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus angiopoietin-like 4 (Angptl4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020581.2

ORF Insert Sequence:

ATGCGCTGCG CTCCGACAGC AGGCGCTGCC CTGGTGCTAT GCGCGGCTAC TGCGGGGCTT 
TTGAGCGCGC AAGGGCGCCC TGCACAGCCA GAGCCACCGC GCTTTGCATC CTGGGACGAG 
ATGAACTTGC TGGCTCACGG GCTGCTACAG CTCGGCCATG GGCTGCGCGA ACACGTGGAG 
CGCACCCGTG GGCAGCTGGG CGCGCTGGAG CGCCGCATGG CTGCCTGTGG TAACGCTTGT 
CAGGGGCCCA AGGGAAAAGA TGCACCCTTC AAAGACTCCG AGGATAGAGT CCCTGAAGGC 
CAGACTCCTG AGACTCTGCA GAGTTTGCAG ACTCAGCTCA AGGCTCAAAA CAGCAAGATC 
CAGCAATTGT TCCAGAAGGT GGCCCAGCAG CAGAGATACC TATCAAAGCA GAATCTGAGA 
ATACAGAATC TTCAGAGCCA GATAGACCTC TTGGCCCCCA CGCACCTAGA CAATGGAGTA 
GACAAGACTT CGAGGGGAAA GAGGCTTCCC AAGATGACCC AGCTCATTGG CTTGACTCCC 
AACGCCACCC ACTTACACAG GCCGCCCCGG GACTGCCAGG AACTCTTCCA AGAAGGGGAG 
CGGCACAGTG GACTTTTCCA GATCCAGCCT CTGGGGTCTC CACCATTTTT GGTCAACTGT 
GAGATGACTT CAGATGGAGG CTGGACAGTG ATTCAGAGAC GCCTGAACGG CTCTGTGGAC 
TTCAACCAGT CCTGGGAAGC CTACAAGGAT GGCTTCGGAG ATCCCCAAGG CGAGTTCTGG 
CTGGGCCTGG AAAAGATGCA CAGCATCACA GGGAACCGAG GAAGCCAATT GGCTGTGCAG 
CTCCAGGACT GGGATGGCAA TGCCAAATTG CTCCAATTTC CCATCCATTT GGGGGGTGAG 
GACACAGCCT ACAGCCTGCA GCTCACTGAG CCCACGGCCA ATGAGCTGGG TGCCACCAAT 
GTTTCCCCCA ATGGCCTTTC CCTGCCCTTC TCTACTTGGG ACCAAGACCA TGACCTCCGT 
GGGGACCTTA ACTGTGCCAA GAGCCTCTCT GGTGGCTGGT GGTTTGGTAC CTGTAGCCAT 
TCCAATCTCA ATGGACAATA CTTCCACTCT ATCCCACGGC AACGGCAGGA GCGTAAAAAG 
GGTATCTTCT GGAAAACATG GAAGGGCCGC TACTATCCTC TGCAGGCTAC CACCCTGCTG 
ATCCAGCCCA TGGAGGCTAC AGCAGCCTCT TAG