Prex1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prex1
Entrez Gene ID	277360
Full Name	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Synonyms	G630042G04,P-REX1,Setd6
General protein information	Preferred Names phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 Names phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein SET domain containing 6 ptdIns(3,4,5)-dependent Rac exchanger 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 H3

mRNA and Protein(s)

mRNA	Protein	Name
NM_177782.3	NP_808450.2	phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	PREX1	NP_065871.2
Bos taurus (cattle)	PREX1	XP_002692397.3
Canis lupus familiaris (dog)	PREX1	XP_543041.3
Gallus gallus (chicken)	PREX1	XP_004947127.1
Danio rerio (zebrafish)	prex1	XP_699627.3
Pan troglodytes (chimpanzee)	PREX1	XP_003953812.1
	PREX1	XP_002798174.1
Rattus norvegicus (Norway rat)	Prex1	NP_001129190.1
Mus musculus (house mouse)	Prex1	NP_808450.2
Xenopus tropicalis (tropical clawed frog)	prex1	XP_002933203.1

Gene Ontology
Bibliography

Related articles in PubMed

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)

Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis.
Liang Q, Cheng N, Zhang G, Liang Y, Qian F, Wu D, Ye RD
Scientific reports625785(2016 May)

Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.
Pan D, Barber MA, Hornigold K, Baker MJ, Toth JM, Oxley D, Welch HC
The Journal of biological chemistry291(12)6359-75(2016 Mar)

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.
Marei H, Carpy A, Woroniuk A, Vennin C, White G, Timpson P, Macek B, Malliri A
Nature communications710664(2016 Feb)

Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior.
Li J, Chai A, Wang L, Ma Y, Wu Z, Yu H, Mei L, Lu L, Zhang C, Yue W, Xu L, Rao Y, Zhang D
Proceedings of the National Academy of Sciences of the United States of America112(50)E6964-72(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A novel mechanism of P-Rex1 regulation through the GPCR-adaptor protein Norbin.
Title: Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.

Tiam1 and P-Rex1 promote Rac1 anti- and pro-migratory signalling cascades.
Title: Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.

findings suggest a vital role of P-Rex1 signaling in CA1 LTD that is critical for social behavior and cognitive function and offer new insight into the etiology of ASDs
Title: Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior.

Platelet P-Rex and Vav family Rac-GEFs play important proinflammatory roles in leukocyte recruitment.
Title: P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.

We have elucidated a proliferative role of P-Rex1 when Rac1 is deleted in melanoblasts.
Title: A Rac1-independent role for P-Rex1 in melanoblasts.

The following Prex1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prex1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15201	NM_177782.3 Latest version!	Mus musculus phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (Prex1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$972.30 $1389.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prex1 ( NM_177782.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_808450.2 Mus musculus phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (Prex1), mRNA.

Price & Availability↑

CloneID	OMu15201
Clone ID Related Accession (Same CDS sequence)	NM_177782.3
Accession Version	NM_177782.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4953bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK173168.1. On or before Feb 8, 2007 this sequence version replaced XM_485102.4, XM_902969.2, XM_902963.2, XM_902967.2, XM_902966.2, XM_902965.2, XM_914522.2, XM_923308.2, XM_923283.2, XM_923276.2, XM_923299.2, XM_923292.2, XM_923288.2, XM_983285.1, NM_001081380.1, NM_177782.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK173168.1, BC151074.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGAGGCAC CCGGCAGCGG TGGTGGTGAC GGCGGCGGGG ACCCAGGCGG GGACGGTGCG 
CATCCCGATG CTCGCGGCCC CGTCTCCGGG CCGTGCGCGG CCGCCCGCGA CTCGGAGCGC 
CAGCTGCGCC TCCGTCTGTG CGTACTCAAC GAGATCCTGG GCACCGAGCG CGACTACGTG 
GGCACCTTGC GTTTCCTGCA GTCGGCCTTC CTACAGCGGA TCCGGCAGAA TGTGGCCGAC 
TCTGTGGAGA AGGGCCTCAC AGAAGAGAAT GTCAAGGTCC TCTTCTCCAA CATTGAGGAC 
ATCCTGGAAG TCCATAAGGA TTTTCTGGCT GCCCTGGAGT ACTGCTTACA CCCCGAGCCT 
CAGTCTCAGC ACGAACTTGG GAATGTTTTC TTGAAATTTA AGGACAAGTT CTGTGTGTAT 
GAGGAGTACT GCAGCAACCA CGAGAAGGCC CTGCGCCTGT TGGTGGAGCT CAACAAGGTC 
CCTGCTGTGC GTGCCTTCCT CCTGAGCTGC ATGCTTCTGG GGGGCCGGAA GACCACTGAC 
ATTCCTCTGG AAGGCTACCT GCTGTCCCCG ATCCAGAGAA TCTGCAAGTA CCCGCTCCTG 
CTCAAGGAGT TGGCCAAGAG GACCCCCGGC AAGCACCCTG ACCACACCGC GGTACAGAGT 
GCCCTGCAGG CCATGAAGAC TGTCTGCTCC AACATCAATG AGACTAAGAG GCAGATGGAG 
AAGCTGGAGG CCCTGGAGCA GCTGCAGTCT CACATTGAAG GCTGGGAGGG CTCCAACCTC 
ACAGACATCT GCACCGAGCT CCTCCTTCAG GGCAACCTGC TGAAGATCTC TGCGGGCAAC 
ATCCAAGAGA GAGCCTTCTT CCTCTTTGAC AACCTGCTTG TCTACTGCAA GCGGAAGTCT 
AGGGTCACTG GGAGCAAGAA ATCTACCAAA AGGACCAAGT CCATCAACGG CTCCCTGTAC 
ATCTTTAGGG GTCGGATCAA CACTGAGGTC ATGGAAGTGG AGAATGTGGA GGATGGGACA 
GCCGATTACC ACAGCAATGG CTACACTGTC ACCAATGGCT GGAAGATCCA CAACACCGCC 
AAAAACAAGT GGTTCGTGTG TATGGCCAAG ACGGCGGAGG AGAAACAGAA GTGGCTGGAT 
GCCCTGATCC GAGAGCGGGA GCAGCGAGAG AGCCTGAAGC TGGGCATGGA GCGTGACGCG 
TACGTCATGA TTGCGGAGAA GGGGGAGAAG CTGTATCACA TGATGATGAG CAAGAAGGTG 
AACTTGATCA AGGACCGCCG GCGGAAGCTG AGCACCGTCC CCAAGTGCTT CCTTGGCAAT 
GAGTTTGTTG CCTGGCTCCT GGAAATTGGT GAGATCAGCA AGACGGAAGA AGGCGTCAAC 
TTGGGCCAAG CCCTGCTGGA GAATGGTATC ATCCACCATG TCTCTGACAA GCACCAGTTC 
AAGAACGAGC AGGTGATGTA CCGCTTCCGC TACGACGACG GCACTTACAA AGCGCGCAGC 
GAGCTGGAGG ATATCATGTC CAAGGGCGTG AGACTCTACT GCCGGCTGCA CAGCCTGTAC 
GCCCCTGTGA TCAAGGACCG TGATTACCAC CTGAAGACCT ACAAGTCCGT GGTCCCCGGG 
AGCAAGCTGG TAGACTGGCT ACTGGCACAG GGGGACTGCC AGACACGGGA GGAGGCCGTG 
GCGCTTGGTG TGGGCCTGTG CAACAACGGT TTTATGCACC ATGTTCTGGA GAAGAGCGAA 
TTCAAGGATG AGTCCCAGTA CTTCCGCTTC CATGCTGATG AGGAGATGGA GGGGACCAGC 
AGCAAGAACA AACAGCTTCG CAATGACTTC AAGCTGGTGG AGAACATCCT GGCAAAGCGA 
CTGCTGATCC CGCCACAGGA GGACGACTAT GGCTTCGACC TTGAGGAGAA GAACAAGGCT 
GTGGTAGTGA AGTCTGTGCA GAGGGGCTCG CTGGCTGAGA TGGCTGGCCT GCAGGCTGGG 
AGGAAGATTT ACTCCATCAA CGAGGACCTG GTGTTCCTGC GTCCCTTCTC TGAGGTGGAG 
ACCATCCTCA ACCAGTTCTT CTGCTCCCGC CGCCCGCTCC GCCTCCTGGT GGCCACCAAG 
GCCAAAGAGA CCATCAAAGT CCCTGACCAC CCAGAGGCCC TGTCCTTCCA GATTCGAGGA 
ACAGCCCCGC CGTGTGTCTT TGCTGTGGGC AGAGGCTCTG AGGCTGTGGC TGCCGGGCTC 
TGCGCGGGCC AATGCATCCT GAAAGTCAAC GGCACCAGCG TGGCGAATGA TGGCGCCCTG 
GAGGTTCTCG AGCACTTCCA GGCTTTCCGC AACCACAGGG AGGAGGCCCT GGGTCTTTAC 
CAGTGGGTCT ACCACAGCCA CGAGGATGCC CAGCTGGCAC GAGCCAGCCA GGGTGCCCCT 
GATGAGGACC CCCAGGAAGA TGACCAGCCT GACTCAGCCC TGCCCCTGCT GTCCCTGGGT 
CCCCAGCTGA GTCTGCATGA GGACAGCGCT GTGGTCAGCC TGACGCTGGA CAATGTTCAC 
TTGGAGCACG GTGTGGTTTA CGAATACATG AGCACTGCAG GAGCCAAGTG TCACGTGCTG 
GAGAAGATCG TGGAGCCCCG AGGCTGTTTC CGCCTTGCTG CCAAGATCCT TGAGGCCTTT 
GCTGTGGACG ACAGCATCTT CGTGCAGAAC TGTGGGCGGC TCATGGCCAT GAGCAGTGCC 
ATTGTCACCA TGTCCCACTA CGAGTTCCAT AACATCTGTG ACACCAAGCT GGAGAGCATC 
GGCCAGAGGA TCGCCTGCTA CCAGGAGTTT GCAGCCCAGC TGAAGAGTAG GGTCAGCCCC 
CCCTTCAAGC AGGCATCCCT GGAGCCCCAC CCGCTGTGTG GCCTTGACTT CTGCCCCACC 
AACTGTCACG TCAACCTCAT GGAAGTGTCC TACCCCAAGA CCACACCTTC GGTGGGCAGG 
TCCTTCAGCA TCCGCTTCGG ACGCAAACCC TCCCTCATCG GCCTTGACCC AGAACAAGGC 
CTGAACCCCA TGGCCTATAC CCAGCACTGT ATCACCACCA TGGCTGCCCC GTCCTGGAAG 
TGCTCACCTG CTGTAGACGA GGACTCCCAA GGCCAGGGTC TCAATGACAG CAGCTATGGG 
TCAGCCAGTG GTGCCCCGAG CCAGCAAGAC CGCGGCCTGA GCTTTCTGCT CAAACAGGAA 
GACCGTGAGA TCCAGGACGC ATACCTGCAG CTCTTCACTA AGCTGGACGT GGCCCTCAAG 
GAGATGAAGC AGTATGTCAC CCAGATTAAC AGGCTGCTGT CAACCATCAC AGAGCCCACA 
TCAGCTGCCC CTGCGCCCTG TGACCCATCC TTGGTGGAGG AGACCTCATC TTCCCCACCG 
GTCAGTGAGG AGAGTGAAGT GGACCGGACT GACCACAGCG GCATCAAGAA AGTGTGCTTC 
AAGGTGTCGG AGGACGAGCA GGAAGACTCG GGCCACGACA CCATGAGCTA CCGCGACTCC 
TACAGTGAGT GTAACAGCAA TCGGGACTCT GTCCTGTCCT ACACCAGCGT GAGAAGCAAC 
AGTTCGTACC TGGGTAGTGA CGAGATGGGC TCAGGGGATG AGCTGCCCTG TGACATGCGC 
ATCCCGTCCG ACAAGCAGGA CAAACTTCAC GGCTGCCTGG AACATCTCTT TAACCAGGTC 
GATTCCATCC ATGCCCTGCT CAAGGGGCCT GTGATGAGCA GGGCATTTGA GGAGACCAGG 
CATTTCCCCA TGAAGCACAG CTGGCAAGAG TTCAAACAGA AAGAGGAATG CACGGTCCGA 
GGGCGGAACT TGATTCAGAT CAGTATCCAG GAGGACCCTT GGAACCTGCC CAGCTCCATC 
AGGACCCTGG TGGACAACAT CCAGCAATAC GTGGAAGATG GAAAGAACCA GCTGCTTCTG 
GCTCTGCTCA AGTGCACAGA CACGGAGCTG CAGCTGCGCA GGGATGCTGT CTTCTGTCAG 
GCTCTGGTGG CCGCCGTGTG CACTTTCTCG GAGCAGCTGC TGGCCGCCCT TGACTACCGC 
TACAACAACA ACGGCGAGTA TGAAGAGAGC AGCAGAGATG CCAGCCGCAA GTGGCTGGAG 
CAGGTGGCGG CTACAGGTGT CCTGCTGCAC TGGCAGTCTC TGCTGGCACC AGCCTCCGTG 
AAGGAGGAAC GGACCATGCT GGAGGACATC TGGGTGACGC TGTCGGAGCT GGACAATGTC 
ACCTTCTCCT TTAAGCAGCT GGATGAGAAT TCTGTGGCCA ACACCAATGT CTTCTACCAC 
ATCGAGGGCA GTAGGCAGGC ACTGAAGGTA GTCTTCTACC TCGATGGCTT CCACTTCTCC 
AGGCTGCCCT CTCGCCTAGA GGGTGGGGCC AGCCTCAGGC TGCACACGGT GCTCTTCACA 
AAAGCACTGG AGAGCGTGGA AGGGCCCCCG CCCCCTGGAA ACCAGGCAGC AGAAGAGCTG 
CAGCAGGAGA TCAACGCACA GTCCCTGGAG AAGGTGCAGC AGTACTATAG AAAGCTCAGG 
GCGTTCTACC TGGAGCGGTC CAACCTGCCC ACGGATGCTG GCGCCACAGC TGTGAAGATT 
GACCAGCTGA TTCGTCCCAT CAATGCCCTG GATGAGCTCT ACCGCCTCAT GAAGACCTTC 
GTGCACCCCA AAGCGGGTGC TGCTGGGAGC CTGGGTGCTG GTCTCATCCC CGTCTCCTCC 
GAGCTCTGCT ATCGCCTGGG GGCGTGTCAG ATCACCATGT GTGGCACCGG CATGCAGCGG 
AGCACCCTGA GCGTGTCCTT GGAACAAGCA GCCATCTTGG CACGGAGTCA CGGCCTGTTG 
CCCAAGTGTG TCATGCAGGC CACAGACATC ATGCGCAAGC AGGGCCCCCG AGTGGAGATT 
CTGGCCAAAA ACCTCCGCAT CAAGGACCCC ATGCCCCAAG GTGCACCACG CCTCTACCAG 
CTCTGCCAGC CTCCGGTGGA TGGAGACCTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808450.2
CDS	115..5067
Translation	MEAPGSGGGDGGGDPGGDGAHPDARGPVSGPCAAARDSERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLQRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKVPAVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHTAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTELLLQGNLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDALIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMSKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYAPVIKDRDYHLKTYKSVVPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFKDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLIPPQEDDYGFDLEEKNKAVVVKSVQRGSLAEMAGLQAGRKIYSINEDLVFLRPFSEVETILNQFFCSRRPLRLLVATKAKETIKVPDHPEALSFQIRGTAPPCVFAVGRGSEAVAAGLCAGQCILKVNGTSVANDGALEVLEHFQAFRNHREEALGLYQWVYHSHEDAQLARASQGAPDEDPQEDDQPDSALPLLSLGPQLSLHEDSAVVSLTLDNVHLEHGVVYEYMSTAGAKCHVLEKIVEPRGCFRLAAKILEAFAVDDSIFVQNCGRLMAMSSAIVTMSHYEFHNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQASLEPHPLCGLDFCPTNCHVNLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGLNPMAYTQHCITTMAAPSWKCSPAVDEDSQGQGLNDSSYGSASGAPSQQDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSAAPAPCDPSLVEETSSSPPVSEESEVDRTDHSGIKKVCFKVSEDEQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSIHALLKGPVMSRAFEETRHFPMKHSWQEFKQKEECTVRGRNLIQISIQEDPWNLPSSIRTLVDNIQQYVEDGKNQLLLALLKCTDTELQLRRDAVFCQALVAAVCTFSEQLLAALDYRYNNNGEYEESSRDASRKWLEQVAATGVLLHWQSLLAPASVKEERTMLEDIWVTLSELDNVTFSFKQLDENSVANTNVFYHIEGSRQALKVVFYLDGFHFSRLPSRLEGGASLRLHTVLFTKALESVEGPPPPGNQAAEELQQEINAQSLEKVQQYYRKLRAFYLERSNLPTDAGATAVKIDQLIRPINALDELYRLMKTFVHPKAGAAGSLGAGLIPVSSELCYRLGACQITMCGTGMQRSTLSVSLEQAAILARSHGLLPKCVMQATDIMRKQGPRVEILAKNLRIKDPMPQGAPRLYQLCQPPVDGDL

Target ORF information:

RefSeq Version	NM_177782.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (Prex1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177782.3

ORF Insert Sequence:

ATGGAGGCAC CCGGCAGCGG TGGTGGTGAC GGCGGCGGGG ACCCAGGCGG GGACGGTGCG 
CATCCCGATG CTCGCGGCCC CGTCTCCGGG CCGTGCGCGG CCGCCCGCGA CTCGGAGCGC 
CAGCTGCGCC TCCGTCTGTG CGTACTCAAC GAGATCCTGG GCACCGAGCG CGACTACGTG 
GGCACCTTGC GTTTCCTGCA GTCGGCCTTC CTACAGCGGA TCCGGCAGAA TGTGGCCGAC 
TCTGTGGAGA AGGGCCTCAC AGAAGAGAAT GTCAAGGTCC TCTTCTCCAA CATTGAGGAC 
ATCCTGGAAG TCCATAAGGA TTTTCTGGCT GCCCTGGAGT ACTGCTTACA CCCCGAGCCT 
CAGTCTCAGC ACGAACTTGG GAATGTTTTC TTGAAATTTA AGGACAAGTT CTGTGTGTAT 
GAGGAGTACT GCAGCAACCA CGAGAAGGCC CTGCGCCTGT TGGTGGAGCT CAACAAGGTC 
CCTGCTGTGC GTGCCTTCCT CCTGAGCTGC ATGCTTCTGG GGGGCCGGAA GACCACTGAC 
ATTCCTCTGG AAGGCTACCT GCTGTCCCCG ATCCAGAGAA TCTGCAAGTA CCCGCTCCTG 
CTCAAGGAGT TGGCCAAGAG GACCCCCGGC AAGCACCCTG ACCACACCGC GGTACAGAGT 
GCCCTGCAGG CCATGAAGAC TGTCTGCTCC AACATCAATG AGACTAAGAG GCAGATGGAG 
AAGCTGGAGG CCCTGGAGCA GCTGCAGTCT CACATTGAAG GCTGGGAGGG CTCCAACCTC 
ACAGACATCT GCACCGAGCT CCTCCTTCAG GGCAACCTGC TGAAGATCTC TGCGGGCAAC 
ATCCAAGAGA GAGCCTTCTT CCTCTTTGAC AACCTGCTTG TCTACTGCAA GCGGAAGTCT 
AGGGTCACTG GGAGCAAGAA ATCTACCAAA AGGACCAAGT CCATCAACGG CTCCCTGTAC 
ATCTTTAGGG GTCGGATCAA CACTGAGGTC ATGGAAGTGG AGAATGTGGA GGATGGGACA 
GCCGATTACC ACAGCAATGG CTACACTGTC ACCAATGGCT GGAAGATCCA CAACACCGCC 
AAAAACAAGT GGTTCGTGTG TATGGCCAAG ACGGCGGAGG AGAAACAGAA GTGGCTGGAT 
GCCCTGATCC GAGAGCGGGA GCAGCGAGAG AGCCTGAAGC TGGGCATGGA GCGTGACGCG 
TACGTCATGA TTGCGGAGAA GGGGGAGAAG CTGTATCACA TGATGATGAG CAAGAAGGTG 
AACTTGATCA AGGACCGCCG GCGGAAGCTG AGCACCGTCC CCAAGTGCTT CCTTGGCAAT 
GAGTTTGTTG CCTGGCTCCT GGAAATTGGT GAGATCAGCA AGACGGAAGA AGGCGTCAAC 
TTGGGCCAAG CCCTGCTGGA GAATGGTATC ATCCACCATG TCTCTGACAA GCACCAGTTC 
AAGAACGAGC AGGTGATGTA CCGCTTCCGC TACGACGACG GCACTTACAA AGCGCGCAGC 
GAGCTGGAGG ATATCATGTC CAAGGGCGTG AGACTCTACT GCCGGCTGCA CAGCCTGTAC 
GCCCCTGTGA TCAAGGACCG TGATTACCAC CTGAAGACCT ACAAGTCCGT GGTCCCCGGG 
AGCAAGCTGG TAGACTGGCT ACTGGCACAG GGGGACTGCC AGACACGGGA GGAGGCCGTG 
GCGCTTGGTG TGGGCCTGTG CAACAACGGT TTTATGCACC ATGTTCTGGA GAAGAGCGAA 
TTCAAGGATG AGTCCCAGTA CTTCCGCTTC CATGCTGATG AGGAGATGGA GGGGACCAGC 
AGCAAGAACA AACAGCTTCG CAATGACTTC AAGCTGGTGG AGAACATCCT GGCAAAGCGA 
CTGCTGATCC CGCCACAGGA GGACGACTAT GGCTTCGACC TTGAGGAGAA GAACAAGGCT 
GTGGTAGTGA AGTCTGTGCA GAGGGGCTCG CTGGCTGAGA TGGCTGGCCT GCAGGCTGGG 
AGGAAGATTT ACTCCATCAA CGAGGACCTG GTGTTCCTGC GTCCCTTCTC TGAGGTGGAG 
ACCATCCTCA ACCAGTTCTT CTGCTCCCGC CGCCCGCTCC GCCTCCTGGT GGCCACCAAG 
GCCAAAGAGA CCATCAAAGT CCCTGACCAC CCAGAGGCCC TGTCCTTCCA GATTCGAGGA 
ACAGCCCCGC CGTGTGTCTT TGCTGTGGGC AGAGGCTCTG AGGCTGTGGC TGCCGGGCTC 
TGCGCGGGCC AATGCATCCT GAAAGTCAAC GGCACCAGCG TGGCGAATGA TGGCGCCCTG 
GAGGTTCTCG AGCACTTCCA GGCTTTCCGC AACCACAGGG AGGAGGCCCT GGGTCTTTAC 
CAGTGGGTCT ACCACAGCCA CGAGGATGCC CAGCTGGCAC GAGCCAGCCA GGGTGCCCCT 
GATGAGGACC CCCAGGAAGA TGACCAGCCT GACTCAGCCC TGCCCCTGCT GTCCCTGGGT 
CCCCAGCTGA GTCTGCATGA GGACAGCGCT GTGGTCAGCC TGACGCTGGA CAATGTTCAC 
TTGGAGCACG GTGTGGTTTA CGAATACATG AGCACTGCAG GAGCCAAGTG TCACGTGCTG 
GAGAAGATCG TGGAGCCCCG AGGCTGTTTC CGCCTTGCTG CCAAGATCCT TGAGGCCTTT 
GCTGTGGACG ACAGCATCTT CGTGCAGAAC TGTGGGCGGC TCATGGCCAT GAGCAGTGCC 
ATTGTCACCA TGTCCCACTA CGAGTTCCAT AACATCTGTG ACACCAAGCT GGAGAGCATC 
GGCCAGAGGA TCGCCTGCTA CCAGGAGTTT GCAGCCCAGC TGAAGAGTAG GGTCAGCCCC 
CCCTTCAAGC AGGCATCCCT GGAGCCCCAC CCGCTGTGTG GCCTTGACTT CTGCCCCACC 
AACTGTCACG TCAACCTCAT GGAAGTGTCC TACCCCAAGA CCACACCTTC GGTGGGCAGG 
TCCTTCAGCA TCCGCTTCGG ACGCAAACCC TCCCTCATCG GCCTTGACCC AGAACAAGGC 
CTGAACCCCA TGGCCTATAC CCAGCACTGT ATCACCACCA TGGCTGCCCC GTCCTGGAAG 
TGCTCACCTG CTGTAGACGA GGACTCCCAA GGCCAGGGTC TCAATGACAG CAGCTATGGG 
TCAGCCAGTG GTGCCCCGAG CCAGCAAGAC CGCGGCCTGA GCTTTCTGCT CAAACAGGAA 
GACCGTGAGA TCCAGGACGC ATACCTGCAG CTCTTCACTA AGCTGGACGT GGCCCTCAAG 
GAGATGAAGC AGTATGTCAC CCAGATTAAC AGGCTGCTGT CAACCATCAC AGAGCCCACA 
TCAGCTGCCC CTGCGCCCTG TGACCCATCC TTGGTGGAGG AGACCTCATC TTCCCCACCG 
GTCAGTGAGG AGAGTGAAGT GGACCGGACT GACCACAGCG GCATCAAGAA AGTGTGCTTC 
AAGGTGTCGG AGGACGAGCA GGAAGACTCG GGCCACGACA CCATGAGCTA CCGCGACTCC 
TACAGTGAGT GTAACAGCAA TCGGGACTCT GTCCTGTCCT ACACCAGCGT GAGAAGCAAC 
AGTTCGTACC TGGGTAGTGA CGAGATGGGC TCAGGGGATG AGCTGCCCTG TGACATGCGC 
ATCCCGTCCG ACAAGCAGGA CAAACTTCAC GGCTGCCTGG AACATCTCTT TAACCAGGTC 
GATTCCATCC ATGCCCTGCT CAAGGGGCCT GTGATGAGCA GGGCATTTGA GGAGACCAGG 
CATTTCCCCA TGAAGCACAG CTGGCAAGAG TTCAAACAGA AAGAGGAATG CACGGTCCGA 
GGGCGGAACT TGATTCAGAT CAGTATCCAG GAGGACCCTT GGAACCTGCC CAGCTCCATC 
AGGACCCTGG TGGACAACAT CCAGCAATAC GTGGAAGATG GAAAGAACCA GCTGCTTCTG 
GCTCTGCTCA AGTGCACAGA CACGGAGCTG CAGCTGCGCA GGGATGCTGT CTTCTGTCAG 
GCTCTGGTGG CCGCCGTGTG CACTTTCTCG GAGCAGCTGC TGGCCGCCCT TGACTACCGC 
TACAACAACA ACGGCGAGTA TGAAGAGAGC AGCAGAGATG CCAGCCGCAA GTGGCTGGAG 
CAGGTGGCGG CTACAGGTGT CCTGCTGCAC TGGCAGTCTC TGCTGGCACC AGCCTCCGTG 
AAGGAGGAAC GGACCATGCT GGAGGACATC TGGGTGACGC TGTCGGAGCT GGACAATGTC 
ACCTTCTCCT TTAAGCAGCT GGATGAGAAT TCTGTGGCCA ACACCAATGT CTTCTACCAC 
ATCGAGGGCA GTAGGCAGGC ACTGAAGGTA GTCTTCTACC TCGATGGCTT CCACTTCTCC 
AGGCTGCCCT CTCGCCTAGA GGGTGGGGCC AGCCTCAGGC TGCACACGGT GCTCTTCACA 
AAAGCACTGG AGAGCGTGGA AGGGCCCCCG CCCCCTGGAA ACCAGGCAGC AGAAGAGCTG 
CAGCAGGAGA TCAACGCACA GTCCCTGGAG AAGGTGCAGC AGTACTATAG AAAGCTCAGG 
GCGTTCTACC TGGAGCGGTC CAACCTGCCC ACGGATGCTG GCGCCACAGC TGTGAAGATT 
GACCAGCTGA TTCGTCCCAT CAATGCCCTG GATGAGCTCT ACCGCCTCAT GAAGACCTTC 
GTGCACCCCA AAGCGGGTGC TGCTGGGAGC CTGGGTGCTG GTCTCATCCC CGTCTCCTCC 
GAGCTCTGCT ATCGCCTGGG GGCGTGTCAG ATCACCATGT GTGGCACCGG CATGCAGCGG 
AGCACCCTGA GCGTGTCCTT GGAACAAGCA GCCATCTTGG CACGGAGTCA CGGCCTGTTG 
CCCAAGTGTG TCATGCAGGC CACAGACATC ATGCGCAAGC AGGGCCCCCG AGTGGAGATT 
CTGGCCAAAA ACCTCCGCAT CAAGGACCCC ATGCCCCAAG GTGCACCACG CCTCTACCAG 
CTCTGCCAGC CTCCGGTGGA TGGAGACCTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
PLoS genetics12(9)e1006355(2016 Sep)
Wu Y,Wei FY,Kawarada L,Suzuki T,Araki K,Komohara Y,Fujimura A,Kaitsuka T,Takeya M,Oike Y,Suzuki T,Tomizawa K

Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis.
Scientific reports625785(2016 May)
Liang Q,Cheng N,Zhang G,Liang Y,Qian F,Wu D,Ye RD

Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.
The Journal of biological chemistry291(12)6359-75(2016 Mar)
Pan D,Barber MA,Hornigold K,Baker MJ,Toth JM,Oxley D,Welch HC

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.
Nature communications710664(2016 Feb)
Marei H,Carpy A,Woroniuk A,Vennin C,White G,Timpson P,Macek B,Malliri A

Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior.
Proceedings of the National Academy of Sciences of the United States of America112(50)E6964-72(2015 Dec)
Li J,Chai A,Wang L,Ma Y,Wu Z,Yu H,Mei L,Lu L,Zhang C,Yue W,Xu L,Rao Y,Zhang D

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Prex1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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