Sult1e1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sult1e1
Entrez Gene ID	20860
Full Name	sulfotransferase family 1E, member 1
Synonyms	EST,ST1E1,Ste
General protein information	Preferred Names sulfotransferase family 1E, member 1 Names estrogen sulfotransferase, testis isoform sulfotransferase 1E1 sulfotransferase, estrogen preferring
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 E1\|5 43.56 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_023135.2	NP_075624.2	sulfotransferase 1E1

Pathways from BioSystems

Homologies

	SULT1E1	XP_001106765.1
Rattus norvegicus (Norway rat)	ste2	NP_001007719.1
Arabidopsis thaliana (thale cress)	ST4B	NP_172799.1
Arabidopsis thaliana (thale cress)	ST4A	NP_179098.1
Arabidopsis thaliana (thale cress)	SOT18	NP_177549.1
Arabidopsis thaliana (thale cress)	AT3G45080	NP_190094.1
Arabidopsis thaliana (thale cress)	AT2G03750	NP_565305.1
Oryza sativa (rice)	Os01g0311600	NP_001042863.1
Oryza sativa (rice)	Os11g0503900	NP_001067947.1
Oryza sativa (rice)	Os08g0239900	NP_001061330.1
Oryza sativa (rice)	Os12g0270900	NP_001066550.1
Oryza sativa (rice)	Os09g0256100	NP_001062696.1
Arabidopsis thaliana (thale cress)	AT3G45070	NP_190093.1
Arabidopsis thaliana (thale cress)	SOT17	NP_173294.1
Arabidopsis thaliana (thale cress)	AT5G43690	NP_199182.1
Oryza sativa (rice)	Os09g0555150	NP_001175974.1
Oryza sativa (rice)	Os06g0626600	NP_001058118.1
Bos taurus (cattle)	SULT1E1	NP_803454.1
Arabidopsis thaliana (thale cress)	AT2G03770	NP_178472.1
Arabidopsis thaliana (thale cress)	AT4G26280	NP_194358.1
Arabidopsis thaliana (thale cress)	AT2G27570	NP_180325.1
Oryza sativa (rice)	Os04g0526300	NP_001053362.1
Oryza sativa (rice)	Os11g0505200	NP_001176556.1
Oryza sativa (rice)	Os10g0190100	NP_001064274.1
Oryza sativa (rice)	Os07g0605800	NP_001060227.1
Oryza sativa (rice)	Os04g0359300	NP_001173892.1
Homo sapiens (human)	SULT1E1	NP_005411.1
Pan troglodytes (chimpanzee)	SULT1E1	XP_001161190.1
Canis lupus familiaris (dog)	SULT1E1	XP_005628324.1
Arabidopsis thaliana (thale cress)	ST4C	NP_172800.2
Arabidopsis thaliana (thale cress)	SOT16	NP_177550.1
Arabidopsis thaliana (thale cress)	SOT7	NP_174139.1
Arabidopsis thaliana (thale cress)	ST2B	NP_196317.2
Arabidopsis thaliana (thale cress)	ST2A	NP_568177.1
Oryza sativa (rice)	Os12g0137900	NP_001176782.1
Oryza sativa (rice)	Os08g0240000	NP_001061331.1
Mus musculus (house mouse)	Sult1e1	NP_075624.2
Drosophila melanogaster (fruit fly)	St2	NP_649870.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004498	XP_313795.3
Arabidopsis thaliana (thale cress)	SOT12	NP_178471.1
Oryza sativa (rice)	Os02g0684100	NP_001047758.2
Oryza sativa (rice)	Os12g0137600	NP_001066110.1
Oryza sativa (rice)	Os07g0148600	NP_001058893.1
Oryza sativa (rice)	Os11g0450300	NP_001176522.1
Oryza sativa (rice)	Os08g0515000	NP_001062232.2
Oryza sativa (rice)	Os08g0515100	NP_001062233.2
Oryza sativa (rice)	Os08g0297800	NP_001061480.1
Oryza sativa (rice)	Os12g0137700	NP_001176781.1

Gene Ontology
Bibliography

Related articles in PubMed

Sex- and Tissue-Specific Role of Estrogen Sulfotransferase in Energy Homeostasis and Insulin Sensitivity.
Garbacz WG, Jiang M, Xu M, Yamauchi J, Dong HH, Xie W
Endocrinology158(11)4093-4104(2017 Nov)

Gender difference in NASH susceptibility: Roles of hepatocyte Ikk? and Sult1e1.
Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H
PloS one12(8)e0181052(2017)

Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome.
Isbel L, Srivastava R, Oey H, Spurling A, Daxinger L, Puthalakath H, Whitelaw E
PLoS genetics11(12)e1005693(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A crucial adipose- and male-specific role of Est in maintaining the whole-body energy homeostasis.
Title: Sex- and Tissue-Specific Role of Estrogen Sulfotransferase in Energy Homeostasis and Insulin Sensitivity.

Gene profiling identifies sulfotransferase family 1E (Sult1e1), which encodes a sulfotransferase E1 responsible for inactivation of estrogen, as a gene upregulated in non-alcoholic steatohepatitis in both genders and most conspicuously in male IkbkbDeltahep mice having worst non-alcoholic steatohepatitis and lowest plasma estradiol levels.
Title: Gender difference in NASH susceptibility: Roles of hepatocyte Ikk? and Sult1e1.

The role of estrogen sulfotransferase, a conjugating enzyme that sulfonates and deactivates estrogens, in sepsis response is reported.
Title: Oestrogen sulfotransferase ablation sensitizes mice to sepsis.

Liver ischemia and reperfusion (I/R) induced the expression of EST and comprised estrogen activity in an Nrf2-dependent manner. EST ablation gender-specifically affected I/R sensitivity.
Title: Estrogen Sulfotransferase Is an Oxidative Stress-responsive Gene That Gender-specifically Affects Liver Ischemia/Reperfusion Injury.

EST functions as a negative regulator of adipogenesis.
Title: Estrogen sulfotransferase inhibits adipocyte differentiation.

The following Sult1e1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sult1e1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00203	NM_023135.2 Latest version!	Mus musculus sulfotransferase family 1E, member 1 (Sult1e1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sult1e1 ( NM_023135.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075624.2 Mus musculus sulfotransferase family 1E, member 1 (Sult1e1), mRNA.

Price & Availability↑

CloneID	OMu00203
Clone ID Related Accession (Same CDS sequence)	NM_023135.2
Accession Version	NM_023135.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-14
Organism	Mus musculus(house mouse)
Product	sulfotransferase 1E1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB590464.1, AK015750.1 and AC158917.6. On Sep 1, 2009 this sequence version replaced NM_023135.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK015750.1, BC034891.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849381, SAMN00849384 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGACTT CTATGCCTGA GTATTATGAA GTTTTTGGAG AGTTCCGTGG AGTTCTAATG 
GACAAACGGT TCACCAAATA TTGGGAAGAT GTTGAAATGT TCTTGGCAAG GCCAGATGAC 
CTTGTCATTG CTACATATCC TAAATCTGGT ACCACCTGGA TTAGTGAAGT TGTGTATATG 
ATCTATAAAG AAGGTGATGT GGAAAAATGC AAGGAGGATG CAATTTTTAA CAGAATACCT 
TATTTGGAGT GCAGAAACGA AGACCTAATA AATGGAATAA AACAATTAAA AGAGAAGGAA 
TCTCCCAGAA TAGTAAAAAC TCACCTGCCA CCCAAGCTCC TTCCAGCATC ATTTTGGGAA 
AAGAATTGCA AGATGATCTA TCTTTGCCGG AACGCCAAAG ATGTCGCCGT TTCTTATTAC 
TACTTTTTGC TAATGATAAC TAGTTATCCA AATCCTAAAT CTTTTTCTGA ATTTGTGGAG 
AAATTTATGC AAGGGCAAGT TCCGTATGGT TCCTGGTATG ATCATGTGAA AGCTTGGTGG 
GAAAAGAGTA AGAATTCACG TGTTTTATTT ATGTTCTATG AAGACATGAA AGAGGATATC 
AGAAGAGAAG TTGTAAAGCT AATAGAGTTC CTGGAGAGAA AGCCCTCGGC AGAGCTTGTG 
GACAGAATCG TTCAACACAC TTCCTTCCAG GAGATGAAGA ACAATCCATC CACCAATTAT 
ACAATGATGC CAGAGGAAAT GATGAATCAA AAAGTATCAC CATTCATGCG AAAGGGAATT 
ATAGGAGACT GGAAGAACCA CTTCCCAGAA GCCCTGAGGG AGAGATTTGA TGAGCACTAC 
AAGCAGCAGA TGAAGGATTG CACTGTGAAG TTTAGAATGG AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075624.2
CDS	132..1019
Translation	METSMPEYYEVFGEFRGVLMDKRFTKYWEDVEMFLARPDDLVIATYPKSGTTWISEVVYMIYKEGDVEKCKEDAIFNRIPYLECRNEDLINGIKQLKEKESPRIVKTHLPPKLLPASFWEKNCKMIYLCRNAKDVAVSYYYFLLMITSYPNPKSFSEFVEKFMQGQVPYGSWYDHVKAWWEKSKNSRVLFMFYEDMKEDIRREVVKLIEFLERKPSAELVDRIVQHTSFQEMKNNPSTNYTMMPEEMMNQKVSPFMRKGIIGDWKNHFPEALRERFDEHYKQQMKDCTVKFRMEL

Target ORF information:

RefSeq Version	NM_023135.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus sulfotransferase family 1E, member 1 (Sult1e1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023135.2

ORF Insert Sequence:

ATGGAGACTT CTATGCCTGA GTATTATGAA GTTTTTGGAG AGTTCCGTGG AGTTCTAATG 
GACAAACGGT TCACCAAATA TTGGGAAGAT GTTGAAATGT TCTTGGCAAG GCCAGATGAC 
CTTGTCATTG CTACATATCC TAAATCTGGT ACCACCTGGA TTAGTGAAGT TGTGTATATG 
ATCTATAAAG AAGGTGATGT GGAAAAATGC AAGGAGGATG CAATTTTTAA CAGAATACCT 
TATTTGGAGT GCAGAAACGA AGACCTAATA AATGGAATAA AACAATTAAA AGAGAAGGAA 
TCTCCCAGAA TAGTAAAAAC TCACCTGCCA CCCAAGCTCC TTCCAGCATC ATTTTGGGAA 
AAGAATTGCA AGATGATCTA TCTTTGCCGG AACGCCAAAG ATGTCGCCGT TTCTTATTAC 
TACTTTTTGC TAATGATAAC TAGTTATCCA AATCCTAAAT CTTTTTCTGA ATTTGTGGAG 
AAATTTATGC AAGGGCAAGT TCCGTATGGT TCCTGGTATG ATCATGTGAA AGCTTGGTGG 
GAAAAGAGTA AGAATTCACG TGTTTTATTT ATGTTCTATG AAGACATGAA AGAGGATATC 
AGAAGAGAAG TTGTAAAGCT AATAGAGTTC CTGGAGAGAA AGCCCTCGGC AGAGCTTGTG 
GACAGAATCG TTCAACACAC TTCCTTCCAG GAGATGAAGA ACAATCCATC CACCAATTAT 
ACAATGATGC CAGAGGAAAT GATGAATCAA AAAGTATCAC CATTCATGCG AAAGGGAATT 
ATAGGAGACT GGAAGAACCA CTTCCCAGAA GCCCTGAGGG AGAGATTTGA TGAGCACTAC 
AAGCAGCAGA TGAAGGATTG CACTGTGAAG TTTAGAATGG AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sex- and Tissue-Specific Role of Estrogen Sulfotransferase in Energy Homeostasis and Insulin Sensitivity.
Endocrinology158(11)4093-4104(2017 Nov)
Garbacz WG,Jiang M,Xu M,Yamauchi J,Dong HH,Xie W

Gender difference in NASH susceptibility: Roles of hepatocyte Ikk? and Sult1e1.
PloS one12(8)e0181052(2017)
Matsushita N,Hassanein MT,Martinez-Clemente M,Lazaro R,French SW,Xie W,Lai K,Karin M,Tsukamoto H

Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome.
PLoS genetics11(12)e1005693(2015 Dec)
Isbel L,Srivastava R,Oey H,Spurling A,Daxinger L,Puthalakath H,Whitelaw E