Ccl6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccl6
Entrez Gene ID	20305
Full Name	chemokine (C-C motif) ligand 6
Synonyms	MRP-1,Scya6,c10
General protein information	Preferred Names chemokine (C-C motif) ligand 6 Names C-C motif chemokine 6 CC chemokine C10 small-inducible cytokine A6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 C\|11 50.85 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009139.3	NP_033165.1	C-C motif chemokine 6 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ccl6	NP_033165.1
Rattus norvegicus (Norway rat)	Ccl6	NP_001004202.1

Gene Ontology
Bibliography

Related articles in PubMed

Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis.
Zhang C, Yi W, Li F, Du X, Wang H, Wu P, Peng C, Luo M, Hua W, Wong CC, Lee JJ, Li W, Chen Z, Ying S, Ju Z, Shen H
Cell research(2018 Jan)

Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.
N??ez V, Alameda D, Rico D, Mota R, Gonzalo P, Cedenilla M, Fischer T, Bosc? L, Glass CK, Arroyo AG, Ricote M
Proceedings of the National Academy of Sciences of the United States of America107(23)10626-31(2010 Jun)

A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
Kotarsky K, Sitnik KM, Stenstad H, Kotarsky H, Schmidtchen A, Koslowski M, Wehkamp J, Agace WW
Mucosal immunology3(1)40-8(2010 Jan)

The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.
Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J, Peters PJ, Clevers H
Gastroenterology137(4)1333-45.e1-3(2009 Oct)

ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines.
Nardi V, Naveiras O, Azam M, Daley GQ
Blood113(16)3813-20(2009 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mice lacking RXRalpha in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis.
Title: Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.

enhanced expression in intestinal epithelium following immunostimulation with LPS or pro-inflammatory cytokines
Title: A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.

the chemokines CCL6 and CCL9 as genes prominently induced by the type I IFNs and ICSBP
Title: ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines.

CCL6 gene activation and production induced by SCF in the presence or absence of rather specific inhibitors for certain pathways demonstrated that the MEK/MAPK pathway but not the PI-3K pathway was crucial for the SCF-induced CCL6 gene activation.
Title: Stem cell factor-mediated activation pathways promote murine eosinophil CCL6 production and survival.

c10 promotes fibrosis by recruiting macrophages in the inflammatory response to bleomycin in the lung
Title: Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis.

The following Ccl6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccl6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03589	NM_009139.3 Latest version!	Mus musculus chemokine (C-C motif) ligand 6 (Ccl6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccl6 ( NM_009139.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033165.1 Mus musculus chemokine (C-C motif) ligand 6 (Ccl6), mRNA.

Price & Availability↑

CloneID	OMu03589
Clone ID Related Accession (Same CDS sequence)	NM_009139.3
Accession Version	NM_009139.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	C-C motif chemokine 6 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY172106.1, AK002697.1, M58004.1 and AV014853.1. On Mar 2, 2007 this sequence version replaced NM_009139.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M58004.1, AK154553.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849387 [ECO:0000348] ##Evidence-Data-END##

ATGAGAAACT CCAAGACTGC CATTTCATTC TTTATCCTTG TGGCTGTCCT TGGGTCCCAG 
GCTGGCCTCA TACAAGAAAT GGAAAAAGAA GATCGTCGCT ATAACCCTCC AATAATTCAT 
CAAGGCTTTC AAGACACTTC TTCAGACTGC TGCTTCTCTT ATGCCACACA GATCCCATGT 
AAAAGATTTA TATATTATTT CCCCACCAGT GGTGGGTGCA TCAAGCCGGG CATCATCTTT 
ATCAGCAGGA GGGGAACCCA GGTCTGTGCC GACCCCAGCG ATCGGAGAGT TCAGAGGTGC 
CTAAGCACCC TGAAGCAAGG CCCAAGATCT GGGAACAAGG TCATTGCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033165.1
CDS	147..497
Translation	MRNSKTAISFFILVAVLGSQAGLIQEMEKEDRRYNPPIIHQGFQDTSSDCCFSYATQIPCKRFIYYFPTSGGCIKPGIIFISRRGTQVCADPSDRRVQRCLSTLKQGPRSGNKVIA

Target ORF information:

RefSeq Version	NM_009139.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C-C motif) ligand 6 (Ccl6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009139.3

ORF Insert Sequence:

ATGAGAAACT CCAAGACTGC CATTTCATTC TTTATCCTTG TGGCTGTCCT TGGGTCCCAG 
GCTGGCCTCA TACAAGAAAT GGAAAAAGAA GATCGTCGCT ATAACCCTCC AATAATTCAT 
CAAGGCTTTC AAGACACTTC TTCAGACTGC TGCTTCTCTT ATGCCACACA GATCCCATGT 
AAAAGATTTA TATATTATTT CCCCACCAGT GGTGGGTGCA TCAAGCCGGG CATCATCTTT 
ATCAGCAGGA GGGGAACCCA GGTCTGTGCC GACCCCAGCG ATCGGAGAGT TCAGAGGTGC 
CTAAGCACCC TGAAGCAAGG CCCAAGATCT GGGAACAAGG TCATTGCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis.
Cell research(2018 Jan)
Zhang C,Yi W,Li F,Du X,Wang H,Wu P,Peng C,Luo M,Hua W,Wong CC,Lee JJ,Li W,Chen Z,Ying S,Ju Z,Shen H

Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.
Proceedings of the National Academy of Sciences of the United States of America107(23)10626-31(2010 Jun)
N??ez V,Alameda D,Rico D,Mota R,Gonzalo P,Cedenilla M,Fischer T,Bosc? L,Glass CK,Arroyo AG,Ricote M

A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
Mucosal immunology3(1)40-8(2010 Jan)
Kotarsky K,Sitnik KM,Stenstad H,Kotarsky H,Schmidtchen A,Koslowski M,Wehkamp J,Agace WW

The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.
Gastroenterology137(4)1333-45.e1-3(2009 Oct)
Gregorieff A,Stange DE,Kujala P,Begthel H,van den Born M,Korving J,Peters PJ,Clevers H

ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines.
Blood113(16)3813-20(2009 Apr)
Nardi V,Naveiras O,Azam M,Daley GQ