Ccl22 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccl22
Entrez Gene ID	20299
Full Name	chemokine (C-C motif) ligand 22
Synonyms	ABCD-1,DCBCK,MDC,Scya22
General protein information	Preferred Names chemokine (C-C motif) ligand 22 Names C-C motif chemokine 22 CC chemokine ABCD-1 SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED) activated B and dendritic cell-derived dendritic cell and B cell derived chemokine small inducible cytokine subfamily A, member 22 small inducible cytokine subfamily A22 small-inducible cytokine A22
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 C5

mRNA and Protein(s)

mRNA	Protein	Name
NM_009137.2	NP_033163.1	C-C motif chemokine 22 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ccl22	NP_033163.1
Homo sapiens (human)	CCL22	NP_002981.2
Pan troglodytes (chimpanzee)	CCL22	XP_001136513.1
Canis lupus familiaris (dog)	CCL22	XP_003433826.1
Bos taurus (cattle)	CCL22	NP_001092632.1
Rattus norvegicus (Norway rat)	Ccl22	NP_476551.1

Gene Ontology
Bibliography

Related articles in PubMed

Macrophage Subset Expressing CD169 in Peritoneal Cavity-Regulated Mucosal Inflammation Together with Lower Levels of CCL22.
Wang D, Li Q, Yang Y, Hao S, Han X, Song J, Yin Y, Li X, Tanaka M, Qiu CH
Inflammation40(4)1191-1203(2017 Aug)

Immunomodulatory Effect of Imiquimod Through CCL22 Produced by Tumor-associated Macrophages in B16F10 Melanomas.
Furudate S, Fujimura T, Kambayashi Y, Kakizaki A, Hidaka T, Aiba S
Anticancer research37(7)3461-3471(2017 07)

Sterile Inflammation Enhances ECM Degradation in Integrin ?1 KO Embryonic Skin.
Kurbet AS, Hegde S, Bhattacharjee O, Marepally S, Vemula PK, Raghavan S
Cell reports16(12)3334-3347(2016 09)

STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1? Activation.
Yan D, Wang HW, Bowman RL, Joyce JA
Cell reports16(11)2914-2927(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Intratumoral administration of anti-CCL22 antibody inhibited B16F10 melanoma growth.
Title: Immunomodulatory Effect of Imiquimod Through CCL22 Produced by Tumor-associated Macrophages in B16F10 Melanomas.

this study shows that intravenous injection of apoptotic cells induces a subsequent increase in CCL22 expression and CCR4+ Treg cells, which contribute to the maintenance of immune homeostasis at least partially by splenic CD8alpha+ CD103+ dendritic cells
Title: Critical role of CCL22/CCR4 axis in the maintenance of immune homeostasis during apoptotic cell clearance by splenic CD8?(+) CD103(+) dendritic cells.

CCL22-specific antibodies reveal that engagement of two distinct binding domains on CCL22 is required for CCR4-mediated function.
Title: CCL22-specific Antibodies Reveal That Engagement of Two Distinct Binding Domains on CCL22 Is Required for CCR4-mediated Function.

CCL22 has a role in Treg skin homing to suppress depigmentation
Title: CCL22 to Activate Treg Migration and Suppress Depigmentation in Vitiligo.

The immunomodulatory properties of CCL22 could be harnessed for prevention of graft rejection and type 1 diabetes as well as other autoimmune disorders.
Title: Cellular mechanisms of CCL22-mediated attenuation of autoimmune diabetes.

The following Ccl22 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccl22 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18201	NM_009137.2 Latest version!	Mus musculus chemokine (C-C motif) ligand 22 (Ccl22), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccl22 ( NM_009137.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033163.1 Mus musculus chemokine (C-C motif) ligand 22 (Ccl22), mRNA.

Price & Availability↑

CloneID	OMu18201
Clone ID Related Accession (Same CDS sequence)	NM_009137.2
Accession Version	NM_009137.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	C-C motif chemokine 22 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY198556.1, AK155764.1 and BF661256.1. On Jul 31, 2007 this sequence version replaced NM_009137.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF076596.1, AK155083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTACCC TGCGTGTCCC ACTCCTGGTG GCTCTCGTCC TTCTTGCTGT GGCAATTCAG 
ACCTCTGATG CAGGTCCCTA TGGTGCCAAT GTGGAAGACA GTATCTGCTG CCAGGACTAC 
ATCCGTCACC CTCTGCCATC ACGTTTAGTG AAGGAGTTCT TCTGGACCTC AAAATCCTGC 
CGCAAGCCTG GCGTTGTTTT GATAACCGTC AAGAACCGAG ATATCTGTGC CGATCCCAGG 
CAGGTCTGGG TGAAGAAGCT ACTCCATAAA CTGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033163.1
CDS	31..309
Translation	MATLRVPLLVALVLLAVAIQTSDAGPYGANVEDSICCQDYIRHPLPSRLVKEFFWTSKSCRKPGVVLITVKNRDICADPRQVWVKKLLHKLS

Target ORF information:

RefSeq Version	NM_009137.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C-C motif) ligand 22 (Ccl22), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009137.2

ORF Insert Sequence:

ATGGCTACCC TGCGTGTCCC ACTCCTGGTG GCTCTCGTCC TTCTTGCTGT GGCAATTCAG 
ACCTCTGATG CAGGTCCCTA TGGTGCCAAT GTGGAAGACA GTATCTGCTG CCAGGACTAC 
ATCCGTCACC CTCTGCCATC ACGTTTAGTG AAGGAGTTCT TCTGGACCTC AAAATCCTGC 
CGCAAGCCTG GCGTTGTTTT GATAACCGTC AAGAACCGAG ATATCTGTGC CGATCCCAGG 
CAGGTCTGGG TGAAGAAGCT ACTCCATAAA CTGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Macrophage Subset Expressing CD169 in Peritoneal Cavity-Regulated Mucosal Inflammation Together with Lower Levels of CCL22.
Inflammation40(4)1191-1203(2017 Aug)
Wang D,Li Q,Yang Y,Hao S,Han X,Song J,Yin Y,Li X,Tanaka M,Qiu CH

Immunomodulatory Effect of Imiquimod Through CCL22 Produced by Tumor-associated Macrophages in B16F10 Melanomas.
Anticancer research37(7)3461-3471(2017 07)
Furudate S,Fujimura T,Kambayashi Y,Kakizaki A,Hidaka T,Aiba S

Sterile Inflammation Enhances ECM Degradation in Integrin ?1 KO Embryonic Skin.
Cell reports16(12)3334-3347(2016 09)
Kurbet AS,Hegde S,Bhattacharjee O,Marepally S,Vemula PK,Raghavan S

STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1? Activation.
Cell reports16(11)2914-2927(2016 09)
Yan D,Wang HW,Bowman RL,Joyce JA