Nfkbie cDNA ORF clone, Mus musculus(house mouse)

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-?B Signaling.
Malty RH, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, Minic Z, Goebels F, Musso G, Wu Z, Abou-Tok H, Meyer M, Deineko V, Kassir S, Sidhu V, Jessulat M, Scott NE, Xiong X, Vlasblom J, Prasad B, Foster LJ, Alberio T, Garavaglia B, Yu H, Bader GD, Nakamura K, Parkinson J, Babu M
Cell systems5(6)564-577.e12(2017 Dec)

The Nuclear Protein I?B? Forms a Transcriptionally Active Complex with Nuclear Factor-?B (NF-?B) p50 and the Lcn2 Promoter via the N- and C-terminal Ankyrin Repeat Motifs.
Kohda A, Yamazaki S, Sumimoto H
The Journal of biological chemistry291(39)20739-52(2016 09)

The REG?-proteasome forms a regulatory circuit with I?B? and NF?B in experimental colitis.
Xu J, Zhou L, Ji L, Chen F, Fortmann K, Zhang K, Liu Q, Li K, Wang W, Wang H, Xie W, Wang Q, Liu J, Zheng B, Zhang P, Huang S, Shi T, Zhang B, Dang Y, Chen J, O'Malley BW, Moses RE, Wang P, Li L, Xiao J, Hoffmann A, Li X
Nature communications710761(2016 Feb)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

The basic residues Lys-717 and Lys-719 in the C-terminal region of ANK7 contribute to IkappaBzeta binding to the Lcn2 promoter, probably via interaction with the cytosine-rich element required for Lcn2 activation; glutamate substitution for both lysines results in a loss of transcriptionally active complex formation without affecting direct contact of IkappaBzeta with p50.
Title: The Nuclear Protein I?B? Forms a Transcriptionally Active Complex with Nuclear Factor-?B (NF-?B) p50 and the Lcn2 Promoter via the N- and C-terminal Ankyrin Repeat Motifs.

The data imply that regulation of these c-Rel-dependent lymphoid responses is a non-redundant function of IkappaBepsilon.
Title: Inhibitor of kappa B epsilon (I?B?) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells.

In vivo degradation rate constants were measured for NF-kappaB-bound & -unbound IkappaB. Models suggest differential degradation rates of free & bound IkappaB may be a new cross-regulation mechanism imparting functional robustness to the signaling module.
Title: A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity.

An important role is proposed for I kappa B epsilon in the differential regulation of nuclear NF-kappa B activity in stimulated B cells.
Title: Reductions in I kappa B epsilon and changes in NF-kappa B activity during B lymphocyte differentiation.

Neither IkappaBalpha nor IkappaBepsilon deficiency had major effects on natural killer cell generation while their combined absence led to NF-kappaB hyperactivation.
Title: Combined deficiency in IkappaBalpha and IkappaBepsilon reveals a critical window of NF-kappaB activity in natural killer cell differentiation.