Mos cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mos
Entrez Gene ID	17451
Full Name	Moloney sarcoma oncogene
Synonyms	c-mos
General protein information	Preferred Names Moloney sarcoma oncogene Names proto-oncogene serine/threonine-protein kinase mos c-mos proto-oncogene oocyte maturation factor mos proto-oncogene c-Mos
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 A1\|4 2.16 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_020021.2	NP_064405.2	proto-oncogene serine/threonine-protein kinase mos
NM_020021.3	NP_064405.2	proto-oncogene serine/threonine-protein kinase mos

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MOS	XP_002692700.1
Mus musculus (house mouse)	Mos	NP_064405.2
Rattus norvegicus (Norway rat)	Mos	NP_064487.3
Xenopus tropicalis (tropical clawed frog)	LOC100489962	XP_004915249.1
Homo sapiens (human)	MOS	NP_005363.1
	MOS	XP_001087400.2
Canis lupus familiaris (dog)	MOS	XP_544088.4
Gallus gallus (chicken)	MOS	NP_001026687.1
Pan troglodytes (chimpanzee)	MOS	XP_528144.2
Danio rerio (zebrafish)	mos	NP_991143.1

Gene Ontology
Bibliography

Related articles in PubMed

A narrow window of cortical tension guides asymmetric spindle positioning in the mouse oocyte.
Chaigne A, Campillo C, Gov NS, Voituriez R, Sykes C, Verlhac MH, Terret ME
Nature communications66027(2015 Jan)

Possible role of p38 MAPK-MNK1-EMI2 cascade in metaphase-II arrest of mouse oocytes.
Miyagaki Y, Kanemori Y, Tanaka F, Baba T
Biology of reproduction91(2)45(2014 Aug)

CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.
Yu C, Zhang YL, Pan WW, Li XM, Wang ZW, Ge ZJ, Zhou JJ, Cang Y, Tong C, Sun QY, Fan HY
Science (New York, N.Y.)342(6165)1518-21(2013 Dec)

A soft cortex is essential for asymmetric spindle positioning in mouse oocytes.
Chaigne A, Campillo C, Gov NS, Voituriez R, Azoury J, Uma?a-Diaz C, Almonacid M, Queguiner I, Nassoy P, Sykes C, Verlhac MH, Terret ME
Nature cell biology15(8)958-66(2013 Aug)

Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.
Chen J, Melton C, Suh N, Oh JS, Horner K, Xie F, Sette C, Blelloch R, Conti M
Genes & development25(7)755-66(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition
Title: Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.

This suggests that c-mos might play important roles in spermatogenesis
Title: Spatial and temporal expression of c-mos in mouse testis during postnatal development.

Mos protein is unstable in early mouse embryos
Title: Mos and the mitogen-activated protein kinase do not show cytostatic factor activity in early mouse embryos.

In Xenopus oocytes, the N-terminal Pro of murine & Xenopus c-MOS is dispensable for degradation if Ser-2 of c-MOS is replaced by a small non-phosphorylatable residue. The N-terminal Pro residue is not a recognition determinant for a ubiquitin ligase.
Title: Dissection of c-MOS degron.

The following Mos gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mos cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu21624	NM_020021.3 Latest version!	Mus musculus Moloney sarcoma oncogene (Mos), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu21624	NM_020021.2	Mus musculus Moloney sarcoma oncogene (Mos), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mos ( NM_020021.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_064405.2 Mus musculus Moloney sarcoma oncogene (Mos), mRNA.

Price & Availability↑

CloneID	OMu21624
Clone ID Related Accession (Same CDS sequence)	NM_020021.2 , NM_020021.3
Accession Version	NM_020021.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-26
Organism	Mus musculus(house mouse)
Product	proto-oncogene serine/threonine-protein kinase mos
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK133089.1. On Aug 11, 2006 this sequence version replaced NM_020021.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK133089.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 8891345 ##RefSeq-Attributes-END##

ATGCCTTCGC CTCTAAGCCT GTGTCGCTAC CTCCCTCGTG AGCTGTCGCC ATCGGTGGAC 
TCGCGGTCCT GCAGCATTCC TTTGGTGGCC CCGAGGAAGG CAGGGAAGCT CTTCCTGGGG 
ACCACTCCTC CTCGGGCTCC CGGACTGCCA CGCCGGCTGG CCTGGTTCTC CATAGACTGG 
GAACAGGTAT GTCTGATGCA TAGGCTGGGC TCTGGAGGGT TTGGCTCGGT GTATAAAGCC 
ACTTACCACG GTGTTCCTGT GGCCATCAAG CAAGTAAACA AGTGCACCAA GGACCTACGT 
GCATCCCAGC GGAGTTTCTG GGCTGAACTG AACATTGCAA GACTACGCCA CGACAACATA 
GTTCGGGTTG TGGCTGCCAG CACGCGCACG CCCGAAGACT CCAACAGCCT AGGTACCATA 
ATCATGGAGT TTGGGGGCAA CGTGACTCTA CACCAAGTCA TCTACGGTGC CACCCGCTCA 
CCGGAGCCTC TCAGCTGCAG AGAACAACTG AGTTTGGGGA AGTGCCTCAA GTATTCCCTA 
GATGTTGTTA ACGGCCTGCT TTTTCTCCAC TCACAAAGCA TTTTGCACTT GGACCTGAAG 
CCAGCGAACA TTTTGATCAG TGAGCAAGAC GTTTGTAAGA TCAGTGACTT CGGCTGCTCC 
CAGAAGCTGC AGGATCTGCG GTGCCGGCAG GCGTCCCCTC ACCACATAGG GGGCACGTAC 
ACGCACCAAG CTCCGGAGAT CCTGAAAGGA GAGATTGCCA CGCCCAAAGC TGACATCTAC 
TCTTTTGGAA TCACCCTGTG GCAGATGACC ACCAGGGAGG TGCCTTACTC CGGCGAACCT 
CAGTACGTGC AGTATGCAGT GGTTGCCTAC AATCTGCGCC CCTCACTGGC AGGGGCGGTG 
TTCACCGCCT CCCTGACTGG AAAGACACTG CAGAACATCA TCCAGAGCTG CTGGGAGGCC 
CGCGCCCTGC AGAGGCCGGG TGCAGAACTG CTCCAAAGGG ACCTCAAGGC TTTCCGAGGG 
GCACTAGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064405.2
CDS	293..1324
Translation	MPSPLSLCRYLPRELSPSVDSRSCSIPLVAPRKAGKLFLGTTPPRAPGLPRRLAWFSIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDLRASQRSFWAELNIARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPYSGEPQYVQYAVVAYNLRPSLAGAVFTASLTGKTLQNIIQSCWEARALQRPGAELLQRDLKAFRGALG

Target ORF information:

RefSeq Version	NM_020021.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Moloney sarcoma oncogene (Mos), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020021.2

ORF Insert Sequence:

ATGCCTTCGC CTCTAAGCCT GTGTCGCTAC CTCCCTCGTG AGCTGTCGCC ATCGGTGGAC 
TCGCGGTCCT GCAGCATTCC TTTGGTGGCC CCGAGGAAGG CAGGGAAGCT CTTCCTGGGG 
ACCACTCCTC CTCGGGCTCC CGGACTGCCA CGCCGGCTGG CCTGGTTCTC CATAGACTGG 
GAACAGGTAT GTCTGATGCA TAGGCTGGGC TCTGGAGGGT TTGGCTCGGT GTATAAAGCC 
ACTTACCACG GTGTTCCTGT GGCCATCAAG CAAGTAAACA AGTGCACCAA GGACCTACGT 
GCATCCCAGC GGAGTTTCTG GGCTGAACTG AACATTGCAA GACTACGCCA CGACAACATA 
GTTCGGGTTG TGGCTGCCAG CACGCGCACG CCCGAAGACT CCAACAGCCT AGGTACCATA 
ATCATGGAGT TTGGGGGCAA CGTGACTCTA CACCAAGTCA TCTACGGTGC CACCCGCTCA 
CCGGAGCCTC TCAGCTGCAG AGAACAACTG AGTTTGGGGA AGTGCCTCAA GTATTCCCTA 
GATGTTGTTA ACGGCCTGCT TTTTCTCCAC TCACAAAGCA TTTTGCACTT GGACCTGAAG 
CCAGCGAACA TTTTGATCAG TGAGCAAGAC GTTTGTAAGA TCAGTGACTT CGGCTGCTCC 
CAGAAGCTGC AGGATCTGCG GTGCCGGCAG GCGTCCCCTC ACCACATAGG GGGCACGTAC 
ACGCACCAAG CTCCGGAGAT CCTGAAAGGA GAGATTGCCA CGCCCAAAGC TGACATCTAC 
TCTTTTGGAA TCACCCTGTG GCAGATGACC ACCAGGGAGG TGCCTTACTC CGGCGAACCT 
CAGTACGTGC AGTATGCAGT GGTTGCCTAC AATCTGCGCC CCTCACTGGC AGGGGCGGTG 
TTCACCGCCT CCCTGACTGG AAAGACACTG CAGAACATCA TCCAGAGCTG CTGGGAGGCC 
CGCGCCCTGC AGAGGCCGGG TGCAGAACTG CTCCAAAGGG ACCTCAAGGC TTTCCGAGGG 
GCACTAGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mos ( NM_020021.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_064405.2 Mus musculus Moloney sarcoma oncogene (Mos), mRNA.

Price & Availability↑

CloneID	OMu21624
Clone ID Related Accession (Same CDS sequence)	NM_020021.2 , NM_020021.3
Accession Version	NM_020021.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Mus musculus(house mouse)
Product	proto-oncogene serine/threonine-protein kinase mos
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL807387.10. On Aug 17, 2018 this sequence version replaced NM_020021.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK133089.1, BC137690.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 8891345 ##RefSeq-Attributes-END##

ATGCCTTCGC CTCTAAGCCT GTGTCGCTAC CTCCCTCGTG AGCTGTCGCC ATCGGTGGAC 
TCGCGGTCCT GCAGCATTCC TTTGGTGGCC CCGAGGAAGG CAGGGAAGCT CTTCCTGGGG 
ACCACTCCTC CTCGGGCTCC CGGACTGCCA CGCCGGCTGG CCTGGTTCTC CATAGACTGG 
GAACAGGTAT GTCTGATGCA TAGGCTGGGC TCTGGAGGGT TTGGCTCGGT GTATAAAGCC 
ACTTACCACG GTGTTCCTGT GGCCATCAAG CAAGTAAACA AGTGCACCAA GGACCTACGT 
GCATCCCAGC GGAGTTTCTG GGCTGAACTG AACATTGCAA GACTACGCCA CGACAACATA 
GTTCGGGTTG TGGCTGCCAG CACGCGCACG CCCGAAGACT CCAACAGCCT AGGTACCATA 
ATCATGGAGT TTGGGGGCAA CGTGACTCTA CACCAAGTCA TCTACGGTGC CACCCGCTCA 
CCGGAGCCTC TCAGCTGCAG AGAACAACTG AGTTTGGGGA AGTGCCTCAA GTATTCCCTA 
GATGTTGTTA ACGGCCTGCT TTTTCTCCAC TCACAAAGCA TTTTGCACTT GGACCTGAAG 
CCAGCGAACA TTTTGATCAG TGAGCAAGAC GTTTGTAAGA TCAGTGACTT CGGCTGCTCC 
CAGAAGCTGC AGGATCTGCG GTGCCGGCAG GCGTCCCCTC ACCACATAGG GGGCACGTAC 
ACGCACCAAG CTCCGGAGAT CCTGAAAGGA GAGATTGCCA CGCCCAAAGC TGACATCTAC 
TCTTTTGGAA TCACCCTGTG GCAGATGACC ACCAGGGAGG TGCCTTACTC CGGCGAACCT 
CAGTACGTGC AGTATGCAGT GGTTGCCTAC AATCTGCGCC CCTCACTGGC AGGGGCGGTG 
TTCACCGCCT CCCTGACTGG AAAGACACTG CAGAACATCA TCCAGAGCTG CTGGGAGGCC 
CGCGCCCTGC AGAGGCCGGG TGCAGAACTG CTCCAAAGGG ACCTCAAGGC TTTCCGAGGG 
GCACTAGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064405.2
CDS	292..1323
Translation	MPSPLSLCRYLPRELSPSVDSRSCSIPLVAPRKAGKLFLGTTPPRAPGLPRRLAWFSIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDLRASQRSFWAELNIARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPYSGEPQYVQYAVVAYNLRPSLAGAVFTASLTGKTLQNIIQSCWEARALQRPGAELLQRDLKAFRGALG

Target ORF information:

RefSeq Version	NM_020021.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus Moloney sarcoma oncogene (Mos), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020021.3

ORF Insert Sequence:

ATGCCTTCGC CTCTAAGCCT GTGTCGCTAC CTCCCTCGTG AGCTGTCGCC ATCGGTGGAC 
TCGCGGTCCT GCAGCATTCC TTTGGTGGCC CCGAGGAAGG CAGGGAAGCT CTTCCTGGGG 
ACCACTCCTC CTCGGGCTCC CGGACTGCCA CGCCGGCTGG CCTGGTTCTC CATAGACTGG 
GAACAGGTAT GTCTGATGCA TAGGCTGGGC TCTGGAGGGT TTGGCTCGGT GTATAAAGCC 
ACTTACCACG GTGTTCCTGT GGCCATCAAG CAAGTAAACA AGTGCACCAA GGACCTACGT 
GCATCCCAGC GGAGTTTCTG GGCTGAACTG AACATTGCAA GACTACGCCA CGACAACATA 
GTTCGGGTTG TGGCTGCCAG CACGCGCACG CCCGAAGACT CCAACAGCCT AGGTACCATA 
ATCATGGAGT TTGGGGGCAA CGTGACTCTA CACCAAGTCA TCTACGGTGC CACCCGCTCA 
CCGGAGCCTC TCAGCTGCAG AGAACAACTG AGTTTGGGGA AGTGCCTCAA GTATTCCCTA 
GATGTTGTTA ACGGCCTGCT TTTTCTCCAC TCACAAAGCA TTTTGCACTT GGACCTGAAG 
CCAGCGAACA TTTTGATCAG TGAGCAAGAC GTTTGTAAGA TCAGTGACTT CGGCTGCTCC 
CAGAAGCTGC AGGATCTGCG GTGCCGGCAG GCGTCCCCTC ACCACATAGG GGGCACGTAC 
ACGCACCAAG CTCCGGAGAT CCTGAAAGGA GAGATTGCCA CGCCCAAAGC TGACATCTAC 
TCTTTTGGAA TCACCCTGTG GCAGATGACC ACCAGGGAGG TGCCTTACTC CGGCGAACCT 
CAGTACGTGC AGTATGCAGT GGTTGCCTAC AATCTGCGCC CCTCACTGGC AGGGGCGGTG 
TTCACCGCCT CCCTGACTGG AAAGACACTG CAGAACATCA TCCAGAGCTG CTGGGAGGCC 
CGCGCCCTGC AGAGGCCGGG TGCAGAACTG CTCCAAAGGG ACCTCAAGGC TTTCCGAGGG 
GCACTAGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A narrow window of cortical tension guides asymmetric spindle positioning in the mouse oocyte.
Nature communications66027(2015 Jan)
Chaigne A,Campillo C,Gov NS,Voituriez R,Sykes C,Verlhac MH,Terret ME

Possible role of p38 MAPK-MNK1-EMI2 cascade in metaphase-II arrest of mouse oocytes.
Biology of reproduction91(2)45(2014 Aug)
Miyagaki Y,Kanemori Y,Tanaka F,Baba T

CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.
Science (New York, N.Y.)342(6165)1518-21(2013 Dec)
Yu C,Zhang YL,Pan WW,Li XM,Wang ZW,Ge ZJ,Zhou JJ,Cang Y,Tong C,Sun QY,Fan HY

A soft cortex is essential for asymmetric spindle positioning in mouse oocytes.
Nature cell biology15(8)958-66(2013 Aug)
Chaigne A,Campillo C,Gov NS,Voituriez R,Azoury J,Uma?a-Diaz C,Almonacid M,Queguiner I,Nassoy P,Sykes C,Verlhac MH,Terret ME

Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.
Genes & development25(7)755-66(2011 Apr)
Chen J,Melton C,Suh N,Oh JS,Horner K,Xie F,Sette C,Blelloch R,Conti M