M6pr cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	M6pr
Entrez Gene ID	17113
Full Name	mannose-6-phosphate receptor, cation dependent
Synonyms	CD-MPR,Mpr46
General protein information	Preferred Names mannose-6-phosphate receptor, cation dependent Names cation-dependent mannose-6-phosphate receptor 46 kDa mannose 6-phosphate receptor CD Man-6-P receptor MPR 46
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 F1\|6 57.52 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010749.7	NP_034879.2	cation-dependent mannose-6-phosphate receptor precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	M6pr	NP_034879.2
Rattus norvegicus (Norway rat)	LOC100909548	XP_003752148.1
Danio rerio (zebrafish)	m6pr	NP_998370.1
Bos taurus (cattle)	M6PR	NP_786973.1
Gallus gallus (chicken)	M6PR	XP_416477.3
Xenopus tropicalis (tropical clawed frog)	m6pr	NP_001008115.1
Pan troglodytes (chimpanzee)	M6PR	XP_001138077.1
	M6PR	XP_001114044.2
Rattus norvegicus (Norway rat)	M6pr	NP_001007701.1
Canis lupus familiaris (dog)	M6PR	XP_005637236.1
Homo sapiens (human)	M6PR	NP_002346.1

Gene Ontology
Bibliography

Related articles in PubMed

Elwell CA, Czudnochowski N, von Dollen J, Johnson JR, Nakagawa R, Mirrashidi K, Krogan NJ, Engel JN, Rosenberg OS
eLife6(2017 Mar)

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.
Zhou X, Sun L, Bastos de Oliveira F, Qi X, Brown WJ, Smolka MB, Sun Y, Hu F
The Journal of cell biology210(6)991-1002(2015 Sep)

Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier.
Dohgu S, Ryerse JS, Robinson SM, Banks WA
PloS one7(6)e39565(2012)

Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice.
Chavele KM, Martinez-Pomares L, Domin J, Pemberton S, Haslam SM, Dell A, Cook HT, Pusey CD, Gordon S, Salama AD
The Journal of clinical investigation120(5)1469-78(2010 May)

Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity.
Boonen M, Vogel P, Platt KA, Dahms N, Kornfeld S
Molecular biology of the cell20(20)4381-9(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Finally, Chlamydia trachomatis infection interferes with the SNX5:cation-independent mannose-6-phosphate receptor interaction, suggesting that Chlamydia IncE and cation-independent mannose-6-phosphate receptor are dependent on the same binding surface on SNX5.

We conclude that M6PR is an important receptor used by HIV-1 to cross the blood-brain barrier.
Title: Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier.

Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice
Title: Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice.

epinephrine restores the M6P receptor-mediated functional transport of (131)I-P-beta-glucuronidase across the blood brain barrier in adults to levels seen in the neonate
Title: Epinephrine enhances lysosomal enzyme delivery across the blood brain barrier by up-regulation of the mannose 6-phosphate receptor.

the alpha-galactosidase enzyme is incorporated via cation-independent mannose 6-phosphate receptors in Schwann cells
Title: Establishment of immortalized Schwann cells from Fabry mice and their low uptake of recombinant alpha-galactosidase.

The following M6pr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the M6pr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06784	NM_010749.7 Latest version!	Mus musculus mannose-6-phosphate receptor, cation dependent (M6pr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

M6pr ( NM_010749.7 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034879.2 Mus musculus mannose-6-phosphate receptor, cation dependent (M6pr), mRNA.

Price & Availability↑

CloneID	OMu06784
Clone ID Related Accession (Same CDS sequence)	NM_010749.7
Accession Version	NM_010749.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 837bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Mus musculus(house mouse)
Product	cation-dependent mannose-6-phosphate receptor precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF730051.1, BC046956.1 and AK153302.1. On Jan 19, 2017 this sequence version replaced NM_010749.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK153302.1, AK151607.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGTTCCCCT TCTCTGGCTG CTGGAGGACT GAACTGTTAT TGTTGCTACT CCTGGCTGTG 
GCTGTGAGAG AATCCTGGCA GATAGAAGAA AAATCGTGTG ACCTGGTAGG AGAGAAGGAT 
AAGGAGTCAA AGAACGAGGT GGCTCTCCTG GAGAGGTTAC GGCCACTGTT TAACAAAAGT 
TTTGAGAGTA CTGTGGGCCA GGGCTCAGAC ACATACAGCT ACATATTCAG AGTATGCCGG 
GAAGCTAGCA ACCACTCCTC TGGAGCAGGC CTGGTCCAGA TCAACAAAAG CAATGACAAG 
GAGACAGTGG TTGGGAGAAT CAACGAGACT CACATCTTCA ATGGAAGTAA TTGGATCATG 
CTGATATATA AAGGGGGTGA TGAATATGAC AACCACTGTG GCAAAGAGCA GCGCCGTGCA 
GTGGTGATGA TCTCCTGCAA TCGGCACACA CTAGCGGCTA ATTTTAACCC AGTGTCTGAG 
GAACGAGGCA AAGTCCAGGA TTGCTTCTAC CTCTTTGAGA TGGATAGCAG CCTGGCCTGT 
TCACCAGAGG TCTCACACCT CAGTGTGGGC TCGATCTTAC TTGTCATATT TGCATCATTG 
GTTGCTGTCT ATATCATTGG GGGTTTCTTA TACCAGCGAC TGGTAGTGGG GGCCAAGGGA 
ATGGAGCAGT TTCCTCATCT GGCCTTCTGG CAGGATCTTG GCAACCTAGT AGCTGATGGT 
TGTGACTTTG TGTGCCGATC CAAACCCCGC AATGTGCCTG CAGCATATCG TGGAGTGGGA 
GATGACCAGC TGGGTGAAGA GTCGGAAGAA AGGGATGATC ATCTGCTACC AATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034879.2
CDS	449..1285
Translation	MFPFSGCWRTELLLLLLLAVAVRESWQIEEKSCDLVGEKDKESKNEVALLERLRPLFNKSFESTVGQGSDTYSYIFRVCREASNHSSGAGLVQINKSNDKETVVGRINETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLAANFNPVSEERGKVQDCFYLFEMDSSLACSPEVSHLSVGSILLVIFASLVAVYIIGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM

Target ORF information:

RefSeq Version	NM_010749.7
Organism	Mus musculus(house mouse)
Definition	Mus musculus mannose-6-phosphate receptor, cation dependent (M6pr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010749.7

ORF Insert Sequence:

ATGTTCCCCT TCTCTGGCTG CTGGAGGACT GAACTGTTAT TGTTGCTACT CCTGGCTGTG 
GCTGTGAGAG AATCCTGGCA GATAGAAGAA AAATCGTGTG ACCTGGTAGG AGAGAAGGAT 
AAGGAGTCAA AGAACGAGGT GGCTCTCCTG GAGAGGTTAC GGCCACTGTT TAACAAAAGT 
TTTGAGAGTA CTGTGGGCCA GGGCTCAGAC ACATACAGCT ACATATTCAG AGTATGCCGG 
GAAGCTAGCA ACCACTCCTC TGGAGCAGGC CTGGTCCAGA TCAACAAAAG CAATGACAAG 
GAGACAGTGG TTGGGAGAAT CAACGAGACT CACATCTTCA ATGGAAGTAA TTGGATCATG 
CTGATATATA AAGGGGGTGA TGAATATGAC AACCACTGTG GCAAAGAGCA GCGCCGTGCA 
GTGGTGATGA TCTCCTGCAA TCGGCACACA CTAGCGGCTA ATTTTAACCC AGTGTCTGAG 
GAACGAGGCA AAGTCCAGGA TTGCTTCTAC CTCTTTGAGA TGGATAGCAG CCTGGCCTGT 
TCACCAGAGG TCTCACACCT CAGTGTGGGC TCGATCTTAC TTGTCATATT TGCATCATTG 
GTTGCTGTCT ATATCATTGG GGGTTTCTTA TACCAGCGAC TGGTAGTGGG GGCCAAGGGA 
ATGGAGCAGT TTCCTCATCT GGCCTTCTGG CAGGATCTTG GCAACCTAGT AGCTGATGGT 
TGTGACTTTG TGTGCCGATC CAAACCCCGC AATGTGCCTG CAGCATATCG TGGAGTGGGA 
GATGACCAGC TGGGTGAAGA GTCGGAAGAA AGGGATGATC ATCTGCTACC AATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

eLife6(2017 Mar)
Elwell CA,Czudnochowski N,von Dollen J,Johnson JR,Nakagawa R,Mirrashidi K,Krogan NJ,Engel JN,Rosenberg OS

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.
The Journal of cell biology210(6)991-1002(2015 Sep)
Zhou X,Sun L,Bastos de Oliveira F,Qi X,Brown WJ,Smolka MB,Sun Y,Hu F

Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier.
PloS one7(6)e39565(2012)
Dohgu S,Ryerse JS,Robinson SM,Banks WA

Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice.
The Journal of clinical investigation120(5)1469-78(2010 May)
Chavele KM,Martinez-Pomares L,Domin J,Pemberton S,Haslam SM,Dell A,Cook HT,Pusey CD,Gordon S,Salama AD

Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity.
Molecular biology of the cell20(20)4381-9(2009 Oct)
Boonen M,Vogel P,Platt KA,Dahms N,Kornfeld S