Kap cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kap
Entrez Gene ID	16483
Full Name	kidney androgen regulated protein
Synonyms	AW146435,FKSG22
General protein information	Preferred Names kidney androgen regulated protein Names kidney androgen-regulated protein ARP
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 G1\|6 64.03 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010594.2	NP_034724.1	kidney androgen-regulated protein precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Kap	NP_034724.1
Rattus norvegicus (Norway rat)	Kap	NP_434689.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased oxidative stress, the renin-angiotensin system, and sympathetic overactivation induce hypertension in kidney androgen-regulated protein transgenic mice.
Grande MT, Pascual G, Riolobos AS, Clemente-Lorenzo M, Bardaji B, Barreiro L, Tornavaca O, Meseguer A, L?pez-Novoa JM
Free radical biology & medicine51(10)1831-41(2011 Nov)

Different roles for KIF17 and kinesin II in photoreceptor development and maintenance.
Insinna C, Humby M, Sedmak T, Wolfrum U, Besharse JC
Developmental dynamics : an official publication of the American Association of Anatomists238(9)2211-22(2009 Sep)

Kidney androgen-regulated protein transgenic mice show hypertension and renal alterations mediated by oxidative stress.
Tornavaca O, Pascual G, Barreiro ML, Grande MT, Carretero A, Riera M, Garcia-Arumi E, Bardaji B, Gonz?lez-N??ez M, Montero MA, L?pez-Novoa JM, Meseguer A
Circulation119(14)1908-17(2009 Apr)

Identification and characterization of the minimal androgen-regulated kidney-specific kidney androgen-regulated protein gene promoter.
Fan L, Hardy DO, Catteral JF, Zhao J, Li S
Acta biochimica et biophysica Sinica40(12)979-88(2008 Dec)

CCAAT/enhancer binding protein-mediated role of thyroid hormone in the developmental expression of the kidney androgen-regulated protein gene in proximal convoluted tubules.
Teixid? N, Soler M, Rivera N, Bernu?s J, Meseguer A
Molecular endocrinology (Baltimore, Md.)20(2)389-404(2006 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

transgenic mice overexpressing protein specifically in kidney show hypertension associated with oxidative stress
Title: Increased oxidative stress, the renin-angiotensin system, and sympathetic overactivation induce hypertension in kidney androgen-regulated protein transgenic mice.

Overexpression of this gene induces hypertension and chronic renal disease.
Title: Kidney androgen-regulated protein transgenic mice show hypertension and renal alterations mediated by oxidative stress.

defined the minimal Kap147 promoter that may be a good model for the study of kidney PTC-specific expression and molecular mechanisms that lead to an androgen-specific responsiveness in vivo
Title: Identification and characterization of the minimal androgen-regulated kidney-specific kidney androgen-regulated protein gene promoter.

Thyroid hormone modulates CCAAT/enhancer binding protein alpha and beta levels that, in turn, control KAP expression in proximal convoluted tubules cells in developmentally dependent manner.
Title: CCAAT/enhancer binding protein-mediated role of thyroid hormone in the developmental expression of the kidney androgen-regulated protein gene in proximal convoluted tubules.

regulation of KAP promoter in kidney tubules
Title: Hormone-specific regulation of the kidney androgen-regulated gene promoter in cultured mouse renal proximal-tubule cells.

The following Kap gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kap cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06419	NM_010594.2 Latest version!	Mus musculus kidney androgen regulated protein (Kap), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kap ( NM_010594.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034724.1 Mus musculus kidney androgen regulated protein (Kap), mRNA.

Price & Availability↑

CloneID	OMu06419
Clone ID Related Accession (Same CDS sequence)	NM_010594.2
Accession Version	NM_010594.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	kidney androgen-regulated protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK142506.1 and AV000934.1. On Nov 10, 2006 this sequence version replaced NM_010594.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI956209.1, AI317440.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END##

ATGATGCTTT TCAAGGTCCT GGTGATCACT GTCTTCTGTG GTCTGACTGT GGCTTTCCCC 
CTGTCAGAAT TAGTTTCAAT CAATAAAGAA CTACAGAATT CAATCATTGA CCTACTAAAC 
TCAGTCTTTG ACCAACTGGG ATCATACAGA GGGACAAAAG CTCCTCTAGA GGATTATACA 
GATGATGATT TAAGCACTGA CTCTGAGCAG ATCATGGACT TCACGCCAGC CGCAAACAAA 
CAGAATTCTG AGTTCTCTAC TGATGTTGAG ACAGTCTCCT CCGGCTTTCT GGAAGAATTC 
ACTGAGAACA CAGACATCAC AGTGAAAATT CCATTAGCTG GGAATCCAGT CTCCCCTACT 
TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034724.1
CDS	45..410
Translation	MMLFKVLVITVFCGLTVAFPLSELVSINKELQNSIIDLLNSVFDQLGSYRGTKAPLEDYTDDDLSTDSEQIMDFTPAANKQNSEFSTDVETVSSGFLEEFTENTDITVKIPLAGNPVSPTS

Target ORF information:

RefSeq Version	NM_010594.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus kidney androgen regulated protein (Kap), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010594.2

ORF Insert Sequence:

ATGATGCTTT TCAAGGTCCT GGTGATCACT GTCTTCTGTG GTCTGACTGT GGCTTTCCCC 
CTGTCAGAAT TAGTTTCAAT CAATAAAGAA CTACAGAATT CAATCATTGA CCTACTAAAC 
TCAGTCTTTG ACCAACTGGG ATCATACAGA GGGACAAAAG CTCCTCTAGA GGATTATACA 
GATGATGATT TAAGCACTGA CTCTGAGCAG ATCATGGACT TCACGCCAGC CGCAAACAAA 
CAGAATTCTG AGTTCTCTAC TGATGTTGAG ACAGTCTCCT CCGGCTTTCT GGAAGAATTC 
ACTGAGAACA CAGACATCAC AGTGAAAATT CCATTAGCTG GGAATCCAGT CTCCCCTACT 
TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased oxidative stress, the renin-angiotensin system, and sympathetic overactivation induce hypertension in kidney androgen-regulated protein transgenic mice.
Free radical biology & medicine51(10)1831-41(2011 Nov)
Grande MT,Pascual G,Riolobos AS,Clemente-Lorenzo M,Bardaji B,Barreiro L,Tornavaca O,Meseguer A,L?pez-Novoa JM

Different roles for KIF17 and kinesin II in photoreceptor development and maintenance.
Developmental dynamics : an official publication of the American Association of Anatomists238(9)2211-22(2009 Sep)
Insinna C,Humby M,Sedmak T,Wolfrum U,Besharse JC

Kidney androgen-regulated protein transgenic mice show hypertension and renal alterations mediated by oxidative stress.
Circulation119(14)1908-17(2009 Apr)
Tornavaca O,Pascual G,Barreiro ML,Grande MT,Carretero A,Riera M,Garcia-Arumi E,Bardaji B,Gonz?lez-N??ez M,Montero MA,L?pez-Novoa JM,Meseguer A

Identification and characterization of the minimal androgen-regulated kidney-specific kidney androgen-regulated protein gene promoter.
Acta biochimica et biophysica Sinica40(12)979-88(2008 Dec)
Fan L,Hardy DO,Catteral JF,Zhao J,Li S

CCAAT/enhancer binding protein-mediated role of thyroid hormone in the developmental expression of the kidney androgen-regulated protein gene in proximal convoluted tubules.
Molecular endocrinology (Baltimore, Md.)20(2)389-404(2006 Feb)
Teixid? N,Soler M,Rivera N,Bernu?s J,Meseguer A