Dsg3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dsg3
Entrez Gene ID	13512
Full Name	desmoglein 3
Synonyms	bal
General protein information	Preferred Names desmoglein 3 Names desmoglein-3 130 kDa pemphigus vulgaris antigen homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18 A2\|18 11.39 cM
Summary	This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein exhibit loss of keratinocyte cell adhesion resulting in a phenotype that resembles that of patients with pemphigus vulgaris. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_030596.4	NP_085099.2	desmoglein-3 preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dsg3	NP_085099.2
Rattus norvegicus (Norway rat)	Dsg3	NP_001178008.1
	DSG3	XP_001098409.2
Bos taurus (cattle)	DSG3	NP_001179614.1
Homo sapiens (human)	DSG3	NP_001935.2
Pan troglodytes (chimpanzee)	DSG3	XP_523900.3
Canis lupus familiaris (dog)	DSG3	NP_001002983.1

Gene Ontology
Bibliography

Related articles in PubMed

Bone Marrow-Derived Stem Cells Migrate into Intra-epidermal Skin Defects of a Desmoglein-3 knockout Mouse Model but Preserve their Mesodermal Differentiation.
H?nefeld C, Mezger M, M?ller-Hermelink E, Schaller M, M?ller I, Amagai M, Handgretinger R, R?cken M
The Journal of investigative dermatology(2017 Dec)

Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice.
Inoue SI, Takahara S, Yoshikawa T, Niihori T, Yanai K, Matsubara Y, Aoki Y
Human molecular genetics26(23)4715-4727(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Desmoglein 3 deficiency in mice leads to a phenotype characterized by cyclic alopecia in addition to the dramatic skin and mucocutaneous acantholysis observed in pemphigus patients.
Title: A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype.

Dsg3, via p38 MAPK, regulates the spatial distribution of the keratin filament network and stabilizes cell adhesion.
Title: Desmoglein 2 compensates for desmoglein 3 but does not control cell adhesion via regulation of p38 mitogen-activated protein kinase in keratinocytes.

Squamous metaplasia after pulmonary epithelial injury may play a crucial role in redirecting the skin-specific autoimmune reaction to the lungs in paraneoplastic pemphigus (PNP).
Title: Ectopic expression of epidermal antigens renders the lung a target organ in paraneoplastic pemphigus.

Dsg3 deficiency results in perturbation of the desmosomal network at the transcriptional, translational, and interaction level, kinase activation, proteinase-mediated degradation, and hyper-adhesion. (Review)
Title: Desmosomal adhesion and pemphigus vulgaris: the first half of the story.

Thus, Dsg3 does not display a clear function as a tumor suppressor in these mouse skin cancer models
Title: Unimpaired skin carcinogenesis in Desmoglein 3 knockout mice.

The following Dsg3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dsg3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08303	NM_030596.4 Latest version!	Mus musculus desmoglein 3 (Dsg3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$580.30 $829.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dsg3 ( NM_030596.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_085099.2 Mus musculus desmoglein 3 (Dsg3), mRNA.

Price & Availability↑

CloneID	OMu08303
Clone ID Related Accession (Same CDS sequence)	NM_030596.4
Accession Version	NM_030596.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2982bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	desmoglein-3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK037142.1 and AK148657.1. On Feb 3, 2016 this sequence version replaced NM_030596.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK148657.1, AK037142.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGACCTGCC TCTTCCCTAG AGCCTTGGGG TCTCTGGCCC TCCTGATGGT GGTGCTGCTG 
GTACAGGGGG AACTGCATGT GAAGCCGGGA GGACAGCACA GAGAAGATGG GACAGCATTG 
CAGCTGGCCA AAAGAAGGTA CAAACGTGAA TGGGTGAAAT TTGCAAAACC CTGCAGAGAA 
AGAGAAGACA ACTCAAGACG AAACCCAATT GCCAAGATCA CTTCAGATTT CCAAAAAAAC 
CAGAAAATTA CCTACCGCAT TTCTGGAGTG GGAATTGATC AGCCTCCCTT TGGGATCTTT 
GTTGTTGACC CAAACAATGG TGATATCAAC ATAACAGCCA TAGTTGATCG TGAGGAAACC 
CCAAGCTTCC TGATCACATG CCGTGCACTA AATGCCCTGG GACAGGATGT AGAGAGACCA 
CTTATATTAA CAGTGAAAAT TTTAGACGTC AATGATAACC CTCCAATATT TTCACAAACC 
ATATTCAAGG GTGAAATTGA AGAAAATAGT GCTTCAAATT CCCTGGTAAT GATCCTAAAT 
GCCACGGATG CAGATGAACC AAACCATATG AACTCTAAAA TTGCCTTCAA AATTGTCTCC 
CAGGAGCCCG CAGGCATGTC CATGTTCCTC ATCAGCAGAA ACACCGGAGA AGTCCGCACT 
TTGACCAGTT CTCTTGATCG AGAGCAAATT AGTAGCTACC ATCTGGTTGT GAGCGGTGCA 
GACAACGATG GAACAGGACT GTCAACTCAG TGTGAATGTA GTATTAAAAT TAAAGATGTC 
AATGACAACT TCCCAGTGCT CAGAGAGTCT CAGTATTCAG CACGTATTGA AGAAAATACT 
TTGAATGCAG AGCTACTCCG ATTTCAAGTG ACAGACTGGG ATGAAGAATA CACAGATAAT 
TGGTTGGCTG TGTATTTCTT CACCTCTGGG AATGAGGGGA ATTGGTTTGA AATTGAAACA 
GATCCTAGAA CCAATGAAGG CATCCTGAAG GTGGTTAAGG CTCTGGATTA TGAACAAGTG 
CAGAGTATGC AGTTTAGTAT TGCTGTCAGA AACAAAGCTG AGTTCCACCA GTCAGTGATC 
TCTCAGTACC GAGTGCAGTC AACGCCAGTC ACAATTCAAG TCATTGATGT CCGAGAGGGA 
ATCTCATTCC GTCCTCCTTC CAAGACATTT ACTGTGCAAA GGGGTGTAAG CACTAACAAA 
TTAGTTGGTT ACATCCTGGG GACATACCAA GCTACTGATG AGGACACGGG TAAAGCTGCC 
TCCTCTGTCA GATATGTCCT GGGTCGTAAT GATGGTGGTT TGCTTGTTAT TGATTCAAAG 
ACTGCTCAGA TCAAATTTGT CAAAAACATC GACCGAGATT CTACTTTCAT AGTTAACAAG 
ACAATTTCTG CTGAGGTTCT GGCCATAGAC GAAAACACTG GTAAGACCTC CACAGGCACA 
ATATATGTGG AAGTGCCCAG TTTTAATGAA AACTGCCCGT CAGTTGTCCT CGAGAAGAAA 
GACATCTGTA CTTCCTCACC TTCTGTGACC CTCTCAGTGA GAACCCTGGA CAGGGGTAAA 
TACACTGGCC CCTACACAGT GTCCCTGGAG GAGCAGCCAC TGAAGCTGCC AGTCATGTGG 
ACCATCACGA CGCTGAATGC TACATCAGCT CTTCTACAAG CCCAGCAGCA AGTGTCTCCA 
GGAGTGTACA ATGTCCCAGT CATCGTGAAG GACAATCAGG ATGGGCTGTG TGACACACCA 
GAGAGCTTGA CCCTGACAGT GTGTCAATGT GATGACCGGA GCATGTGCAG AGCCCCTATC 
CCGAGCAGAG AGCCTAACAC ATATGGGGAG TCATCCTGGA GGCTGGGGCC TGCTGCCATT 
GGCTTGATCC TGCTAGGACT CCTGATGTTG CTATTGGCCC CACTTCTGCT TCTGACCTGT 
GACTGTGGGT CAGGTCCCAT TGGAGGAGCA GCGACAGGTG GCTTTATCCC AGTGCCCGAT 
GGTTCGGAAG GTACAATTCA TCAGTGGGGA ATCGAAGGAG CTCAGCCCGA AGACAAGGAA 
ATCACAAATA TTTGTGTTCC TCCAGTTACA ACCAATGGAG CCGATTTTAT GGAAAGCTCT 
GAAGTTTGCA CAAATACATA TGCTGGTGGG ACCATGGTAG AAGGTGCTTC AGGAATGGAA 
ATGATTACCA AGCTGGGAGG AGCTACTGGA GCTACAGCGG CACTTGGTCC CTGTTCCTTG 
GGTTATTCAG GAACAATGAG AACAAGGCAT TCCACTGGAG GGACCTTGAA GGACTATGCT 
GCGCCAGTCA ACATGACTTT CCTAGGCTCC TATTTCTCTC AGAAATCACT CGCCTATGCC 
GAGGAAGAGG ATGAGCGCGA AGTGAACGAC TGTTTGCTGA TCTACGATGA TGAAGGCGAG 
GATGCTGCCC CCCACTCCCC CACCCTCAGC TCCTGCAGCA TTTTTGCCGA TGACCTAGAC 
GACAACTTCT TGGATTCCCT TGGCCCCAAA TTTAAAAAGC TTGCAGAGAT CTGTCTCGGT 
ATTGATGACG AAGCCAAGCA AGCAAAGCCA GGCCCTAAAG ACAGTGGTTC TGGGGCTGAT 
ACCTGCGCTC GCTCTATGGA AGTCCCTCAG TCAGGTTCTA ACAGGTACCA GACTTTGCCT 
GGCAGTCTGG AAGTCACCCA AACGGGTTCT AAAATATGCC ACACGCTGTC AGGCAACCAA 
GAAACTTCTG TTATGTCCAC TTCTGGGTCT GTCCACCCTG CTGTTGCCAT CCCTGACCCT 
CTACAGCTTG GGAACTACTT GCTCACAGAA ACTTACTCAA CTTCAGGTTC CTTTGCACAA 
CCCACCACTG TTACCTTTGA CCCCCATGTC ACACAAAATG TCACTGTAAC AGAAAGGGTC 
ATTTGTCCCC TTCCTAGTGC CTCCAGCAGT ATAGTGGCTC CCACAGAACT GCGAGGCTCA 
TACAATATGC TCTATACAAA AGAAACCTGT TCCCATCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_085099.2
CDS	102..3083
Translation	MTCLFPRALGSLALLMVVLLVQGELHVKPGGQHREDGTALQLAKRRYKREWVKFAKPCREREDNSRRNPIAKITSDFQKNQKITYRISGVGIDQPPFGIFVVDPNNGDINITAIVDREETPSFLITCRALNALGQDVERPLILTVKILDVNDNPPIFSQTIFKGEIEENSASNSLVMILNATDADEPNHMNSKIAFKIVSQEPAGMSMFLISRNTGEVRTLTSSLDREQISSYHLVVSGADNDGTGLSTQCECSIKIKDVNDNFPVLRESQYSARIEENTLNAELLRFQVTDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILKVVKALDYEQVQSMQFSIAVRNKAEFHQSVISQYRVQSTPVTIQVIDVREGISFRPPSKTFTVQRGVSTNKLVGYILGTYQATDEDTGKAASSVRYVLGRNDGGLLVIDSKTAQIKFVKNIDRDSTFIVNKTISAEVLAIDENTGKTSTGTIYVEVPSFNENCPSVVLEKKDICTSSPSVTLSVRTLDRGKYTGPYTVSLEEQPLKLPVMWTITTLNATSALLQAQQQVSPGVYNVPVIVKDNQDGLCDTPESLTLTVCQCDDRSMCRAPIPSREPNTYGESSWRLGPAAIGLILLGLLMLLLAPLLLLTCDCGSGPIGGAATGGFIPVPDGSEGTIHQWGIEGAQPEDKEITNICVPPVTTNGADFMESSEVCTNTYAGGTMVEGASGMEMITKLGGATGATAALGPCSLGYSGTMRTRHSTGGTLKDYAAPVNMTFLGSYFSQKSLAYAEEEDEREVNDCLLIYDDEGEDAAPHSPTLSSCSIFADDLDDNFLDSLGPKFKKLAEICLGIDDEAKQAKPGPKDSGSGADTCARSMEVPQSGSNRYQTLPGSLEVTQTGSKICHTLSGNQETSVMSTSGSVHPAVAIPDPLQLGNYLLTETYSTSGSFAQPTTVTFDPHVTQNVTVTERVICPLPSASSSIVAPTELRGSYNMLYTKETCSHL

Target ORF information:

RefSeq Version	NM_030596.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus desmoglein 3 (Dsg3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030596.4

ORF Insert Sequence:

ATGACCTGCC TCTTCCCTAG AGCCTTGGGG TCTCTGGCCC TCCTGATGGT GGTGCTGCTG 
GTACAGGGGG AACTGCATGT GAAGCCGGGA GGACAGCACA GAGAAGATGG GACAGCATTG 
CAGCTGGCCA AAAGAAGGTA CAAACGTGAA TGGGTGAAAT TTGCAAAACC CTGCAGAGAA 
AGAGAAGACA ACTCAAGACG AAACCCAATT GCCAAGATCA CTTCAGATTT CCAAAAAAAC 
CAGAAAATTA CCTACCGCAT TTCTGGAGTG GGAATTGATC AGCCTCCCTT TGGGATCTTT 
GTTGTTGACC CAAACAATGG TGATATCAAC ATAACAGCCA TAGTTGATCG TGAGGAAACC 
CCAAGCTTCC TGATCACATG CCGTGCACTA AATGCCCTGG GACAGGATGT AGAGAGACCA 
CTTATATTAA CAGTGAAAAT TTTAGACGTC AATGATAACC CTCCAATATT TTCACAAACC 
ATATTCAAGG GTGAAATTGA AGAAAATAGT GCTTCAAATT CCCTGGTAAT GATCCTAAAT 
GCCACGGATG CAGATGAACC AAACCATATG AACTCTAAAA TTGCCTTCAA AATTGTCTCC 
CAGGAGCCCG CAGGCATGTC CATGTTCCTC ATCAGCAGAA ACACCGGAGA AGTCCGCACT 
TTGACCAGTT CTCTTGATCG AGAGCAAATT AGTAGCTACC ATCTGGTTGT GAGCGGTGCA 
GACAACGATG GAACAGGACT GTCAACTCAG TGTGAATGTA GTATTAAAAT TAAAGATGTC 
AATGACAACT TCCCAGTGCT CAGAGAGTCT CAGTATTCAG CACGTATTGA AGAAAATACT 
TTGAATGCAG AGCTACTCCG ATTTCAAGTG ACAGACTGGG ATGAAGAATA CACAGATAAT 
TGGTTGGCTG TGTATTTCTT CACCTCTGGG AATGAGGGGA ATTGGTTTGA AATTGAAACA 
GATCCTAGAA CCAATGAAGG CATCCTGAAG GTGGTTAAGG CTCTGGATTA TGAACAAGTG 
CAGAGTATGC AGTTTAGTAT TGCTGTCAGA AACAAAGCTG AGTTCCACCA GTCAGTGATC 
TCTCAGTACC GAGTGCAGTC AACGCCAGTC ACAATTCAAG TCATTGATGT CCGAGAGGGA 
ATCTCATTCC GTCCTCCTTC CAAGACATTT ACTGTGCAAA GGGGTGTAAG CACTAACAAA 
TTAGTTGGTT ACATCCTGGG GACATACCAA GCTACTGATG AGGACACGGG TAAAGCTGCC 
TCCTCTGTCA GATATGTCCT GGGTCGTAAT GATGGTGGTT TGCTTGTTAT TGATTCAAAG 
ACTGCTCAGA TCAAATTTGT CAAAAACATC GACCGAGATT CTACTTTCAT AGTTAACAAG 
ACAATTTCTG CTGAGGTTCT GGCCATAGAC GAAAACACTG GTAAGACCTC CACAGGCACA 
ATATATGTGG AAGTGCCCAG TTTTAATGAA AACTGCCCGT CAGTTGTCCT CGAGAAGAAA 
GACATCTGTA CTTCCTCACC TTCTGTGACC CTCTCAGTGA GAACCCTGGA CAGGGGTAAA 
TACACTGGCC CCTACACAGT GTCCCTGGAG GAGCAGCCAC TGAAGCTGCC AGTCATGTGG 
ACCATCACGA CGCTGAATGC TACATCAGCT CTTCTACAAG CCCAGCAGCA AGTGTCTCCA 
GGAGTGTACA ATGTCCCAGT CATCGTGAAG GACAATCAGG ATGGGCTGTG TGACACACCA 
GAGAGCTTGA CCCTGACAGT GTGTCAATGT GATGACCGGA GCATGTGCAG AGCCCCTATC 
CCGAGCAGAG AGCCTAACAC ATATGGGGAG TCATCCTGGA GGCTGGGGCC TGCTGCCATT 
GGCTTGATCC TGCTAGGACT CCTGATGTTG CTATTGGCCC CACTTCTGCT TCTGACCTGT 
GACTGTGGGT CAGGTCCCAT TGGAGGAGCA GCGACAGGTG GCTTTATCCC AGTGCCCGAT 
GGTTCGGAAG GTACAATTCA TCAGTGGGGA ATCGAAGGAG CTCAGCCCGA AGACAAGGAA 
ATCACAAATA TTTGTGTTCC TCCAGTTACA ACCAATGGAG CCGATTTTAT GGAAAGCTCT 
GAAGTTTGCA CAAATACATA TGCTGGTGGG ACCATGGTAG AAGGTGCTTC AGGAATGGAA 
ATGATTACCA AGCTGGGAGG AGCTACTGGA GCTACAGCGG CACTTGGTCC CTGTTCCTTG 
GGTTATTCAG GAACAATGAG AACAAGGCAT TCCACTGGAG GGACCTTGAA GGACTATGCT 
GCGCCAGTCA ACATGACTTT CCTAGGCTCC TATTTCTCTC AGAAATCACT CGCCTATGCC 
GAGGAAGAGG ATGAGCGCGA AGTGAACGAC TGTTTGCTGA TCTACGATGA TGAAGGCGAG 
GATGCTGCCC CCCACTCCCC CACCCTCAGC TCCTGCAGCA TTTTTGCCGA TGACCTAGAC 
GACAACTTCT TGGATTCCCT TGGCCCCAAA TTTAAAAAGC TTGCAGAGAT CTGTCTCGGT 
ATTGATGACG AAGCCAAGCA AGCAAAGCCA GGCCCTAAAG ACAGTGGTTC TGGGGCTGAT 
ACCTGCGCTC GCTCTATGGA AGTCCCTCAG TCAGGTTCTA ACAGGTACCA GACTTTGCCT 
GGCAGTCTGG AAGTCACCCA AACGGGTTCT AAAATATGCC ACACGCTGTC AGGCAACCAA 
GAAACTTCTG TTATGTCCAC TTCTGGGTCT GTCCACCCTG CTGTTGCCAT CCCTGACCCT 
CTACAGCTTG GGAACTACTT GCTCACAGAA ACTTACTCAA CTTCAGGTTC CTTTGCACAA 
CCCACCACTG TTACCTTTGA CCCCCATGTC ACACAAAATG TCACTGTAAC AGAAAGGGTC 
ATTTGTCCCC TTCCTAGTGC CTCCAGCAGT ATAGTGGCTC CCACAGAACT GCGAGGCTCA 
TACAATATGC TCTATACAAA AGAAACCTGT TCCCATCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bone Marrow-Derived Stem Cells Migrate into Intra-epidermal Skin Defects of a Desmoglein-3 knockout Mouse Model but Preserve their Mesodermal Differentiation.
The Journal of investigative dermatology(2017 Dec)
H?nefeld C,Mezger M,M?ller-Hermelink E,Schaller M,M?ller I,Amagai M,Handgretinger R,R?cken M

Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice.
Human molecular genetics26(23)4715-4727(2017 Dec)
Inoue SI,Takahara S,Yoshikawa T,Niihori T,Yanai K,Matsubara Y,Aoki Y

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Dsg3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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