Alox5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Alox5
Entrez Gene ID	11689
Full Name	arachidonate 5-lipoxygenase
Synonyms	5-LO,5-LOX,5LO,5LX,AI850497,F730011J02
General protein information	Preferred Names arachidonate 5-lipoxygenase Names arachidonate 5-lipoxygenase 5-lipoxygenase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 E3\|6 53.79 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009662.2	NP_033792.1	arachidonate 5-lipoxygenase

Pathways from BioSystems

Homologies

Homo sapiens (human)	ALOX5	NP_000689.1
Oryza sativa (rice)	Os03g0738600	NP_001051212.1
Canis lupus familiaris (dog)	ALOX5	NP_001192042.1
Bos taurus (cattle)	ALOX5	NP_001179721.1
Arabidopsis thaliana (thale cress)	LOX5	NP_188879.2
Pan troglodytes (chimpanzee)	ALOX5	XP_507763.3
	ALOX5	XP_001102354.1
Mus musculus (house mouse)	Alox5	NP_033792.1
Rattus norvegicus (Norway rat)	Alox5	NP_036954.1
Gallus gallus (chicken)	ALOX5	XP_003641560.1
Xenopus tropicalis (tropical clawed frog)	alox5	XP_004915982.1
Oryza sativa (rice)	Os03g0700400	NP_001050993.1
Danio rerio (zebrafish)	alox5a	NP_001243676.1
Arabidopsis thaliana (thale cress)	LOX1	NP_175900.1
Oryza sativa (rice)	Os03g0699700	NP_001050990.1
Oryza sativa (rice)	Os03g0700700	NP_001050995.2

Gene Ontology
Bibliography

Related articles in PubMed

Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.
Rauch F, Geng Y, Lamplugh L, Hekmatnejad B, Gaumond MH, Penney J, Yamanaka Y, Moffatt P
Bone107131-142(2018 Feb)

Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation.
Ibarra-Soria X, Jawaid W, Pijuan-Sala B, Ladopoulos V, Scialdone A, J?rg DJ, Tyser RCV, Calero-Nieto FJ, Mulas C, Nichols J, Vallier L, Srinivas S, Simons BD, G?ttgens B, Marioni JC
Nature cell biology(2018 Jan)

Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation.
Yotsumoto S, Muroi Y, Chiba T, Ohmura R, Yoneyama M, Magarisawa M, Dodo K, Terayama N, Sodeoka M, Aoyagi R, Arita M, Arakawa S, Shimizu S, Tanaka M
Scientific reports7(1)16026(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that 5-lipoxygenase (5-LO)/leukotriene B4 (LTB4) axis orchestrates graft-versus-host disease (GVHD) development and suggest it could be a target for the development of therapeutic strategies for GVHD treatment.
Title: Inhibition of 5-lipoxygenase alleviates graft-versus-host disease.

Findings demonstrate that the up-regulation of the ALOX5 gene pathway is responsible for the development of the biochemical and behavioral sequelae of high Hcy brain levels in the context of a neurodegenerative phenotype.
Title: Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology.

Our data showed that besides the high parasite burden and lack of microbicidal molecules, an imbalance with high COX-2 and 5-LOX eicosanoid expression and a lack of regulatory PPAR-gamma cytoplasm-to-nucleus translocation in macrophages were observed in mice that develop cerebral malaria.
Title: Differences in the modulation of reactive species, lipid bodies, cyclooxygenase-2, 5-lipoxygenase and PPAR-? in cerebral malaria-susceptible and resistant mice.

Homocysteine directly influences 5LO expression levels and establish a previously unknown cross talk between these two pathways.
Title: Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.

This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL
Title: Macrophage LTB

The following Alox5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Alox5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22214	NM_009662.2 Latest version!	Mus musculus arachidonate 5-lipoxygenase (Alox5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Alox5 ( NM_009662.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033792.1 Mus musculus arachidonate 5-lipoxygenase (Alox5), mRNA.

Price & Availability↑

CloneID	OMu22214
Clone ID Related Accession (Same CDS sequence)	NM_009662.2
Accession Version	NM_009662.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	arachidonate 5-lipoxygenase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY205433.1, AK171413.1 and BY555055.1. On Oct 26, 2006 this sequence version replaced NM_009662.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK136868.1, AK170879.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGCCCTCCT ACACGGTCAC CGTGGCCACC GGCAGCCAGT GGTTCGCGGG CACCGACGAC 
TACATCTACC TCAGCCTCAT TGGCTCTGCG GGCTGTAGCG AGAAGCATCT GCTGGACAAG 
GCATTCTACA ATGACTTCGA ACGGGGCGCG GTGGACTCCT ACGATGTCAC CGTGGATGAG 
GAGCTGGGCG AGATCTACCT AGTCAAAATT GAGAAGCGCA AATACTGGCT CCATGATGAC 
TGGTACCTGA AGTACATCAC ACTGAAGACA CCCCACGGGG ACTACATCGA GTTCCCATGT 
TACCGCTGGA TCACAGGCGA GGGCGAGATT GTCCTGAGGG ATGGACGTGC AAAATTGGCC 
CGAGATGACC AAATTCACAT CCTCAAGCAG CACAGACGTA AAGAACTGGA GGCACGGCAA 
AAACAGTATC GATGGATGGA GTGGAACCCC GGCTTCCCTT TGAGTATTGA TGCCAAATGC 
CACAAGGATC TGCCCCGAGA TATCCAGTTT GATAGTGAAA AAGGAGTGGA CTTTGTTCTG 
AACTACTCAA AAGCGATGGA GAACCTGTTC ATCAACCGCT TCATGCACAT GTTCCAGTCT 
TCCTGGCACG ACTTTGCTGA CTTTGAGAAA ATCTTCGTCA AAATCAGCAA CACTATATCT 
GAGCGAGTCA AGAACCACTG GCAGGAAGAC CTCATGTTTG GCTACCAGTT CCTGAATGGC 
TGCAACCCAG TACTCATCAA GCGCTGCACA GCGTTGCCCC CGAAGCTCCC AGTGACCACA 
GAGATGGTGG AGTGCAGCCT AGAGCGGCAG CTCAGTTTAG AACAGGAAGT ACAGGAAGGG 
AACATTTTCA TCGTTGATTA CGAGCTACTG GATGGCATCG ATGCTAACAA AACTGACCCC 
TGTACACACC AGTTCCTGGC TGCCCCCATC TGCCTGCTAT ATAAGAACCT AGCCAACAAG 
ATTGTTCCCA TTGCCATCCA GCTCAACCAA ACCCCTGGAG AGAGTAACCC AATCTTCCTC 
CCTACGGATT CAAAGTACGA CTGGCTTTTG GCCAAAATCT GGGTGCGTTC CAGTGACTTC 
CACGTCCATC AAACGATCAC CCACCTTCTG CGCACGCATC TGGTGTCTGA GGTGTTTGGT 
ATCGCCATGT ACCGCCAGCT GCCTGCTGTG CATCCCCTTT TCAAGCTGCT GGTAGCCCAT 
GTGAGGTTCA CCATTGCTAT CAACACTAAG GCCCGGGAAC AGCTTATCTG CGAGTATGGC 
CTTTTTGACA AGGCCAATGC CACCGGGGGT GGAGGGCACG TGCAGATGGT GCAGAGGGCT 
GTCCAGGATC TGACCTATTC CTCCCTGTGT TTCCCGGAGG CCATCAAGGC CCGGGGCATG 
GACAGCACGG AAGACATCCC CTTCTACTTC TATCGTGATG ATGGACTGCT CGTGTGGGAG 
GCTATCCAGT CGTTCACAAT GGAGGTGGTG AGCATCTACT ATGAGAACGA CCAGGTGGTG 
GAGGAGGACC AGGAACTGCA GGACTTCGTG AAGGATGTTT ACGTGTACGG CATGCGGGGC 
AAAAAGGCCT CAGGTTTCCC CAAGTCCATC AAGAGCAGGG AGAAGCTGTC CGAGTACCTG 
ACGGTGGTGA TCTTCACGGC CTCTGCCCAG CATGCAGCTG TAAACTTCGG CCAGTATGAC 
TGGTGCTCCT GGATCCCCAA CGCTCCTCCA ACTATGCGGG CCCCACCACC CACGGCCAAG 
GGTGTGGTCA CCATCGAGCA GATCGTGGAT ACTCTACCAG ACCGTGGCCG ATCATGTTGG 
CATCTAGGTG CAGTGTGGGC CTTGAGCCAG TTTCAAGAAA ATGAGCTGTT TCTAGGCATG 
TACCCAGAGG AGCATTTCAT TGAGAAGCCA GTGAAGGAAG CCATGATCCG ATTCCGCAAG 
AACCTGGAGG CCATCGTCAG CGTGATCGCC GAGCGCAATA AGAACAAAAA GCTCCCCTAC 
TACTACCTGT CACCAGACAG GATTCCCAAC AGCGTAGCCA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033792.1
CDS	155..2179
Translation	MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGAVDSYDVTVDEELGEIYLVKIEKRKYWLHDDWYLKYITLKTPHGDYIEFPCYRWITGEGEIVLRDGRAKLARDDQIHILKQHRRKELEARQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTALPPKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGESNPIFLPTDSKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLICEYGLFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDSTEDIPFYFYRDDGLLVWEAIQSFTMEVVSIYYENDQVVEEDQELQDFVKDVYVYGMRGKKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI

Target ORF information:

RefSeq Version	NM_009662.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus arachidonate 5-lipoxygenase (Alox5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009662.2

ORF Insert Sequence:

ATGCCCTCCT ACACGGTCAC CGTGGCCACC GGCAGCCAGT GGTTCGCGGG CACCGACGAC 
TACATCTACC TCAGCCTCAT TGGCTCTGCG GGCTGTAGCG AGAAGCATCT GCTGGACAAG 
GCATTCTACA ATGACTTCGA ACGGGGCGCG GTGGACTCCT ACGATGTCAC CGTGGATGAG 
GAGCTGGGCG AGATCTACCT AGTCAAAATT GAGAAGCGCA AATACTGGCT CCATGATGAC 
TGGTACCTGA AGTACATCAC ACTGAAGACA CCCCACGGGG ACTACATCGA GTTCCCATGT 
TACCGCTGGA TCACAGGCGA GGGCGAGATT GTCCTGAGGG ATGGACGTGC AAAATTGGCC 
CGAGATGACC AAATTCACAT CCTCAAGCAG CACAGACGTA AAGAACTGGA GGCACGGCAA 
AAACAGTATC GATGGATGGA GTGGAACCCC GGCTTCCCTT TGAGTATTGA TGCCAAATGC 
CACAAGGATC TGCCCCGAGA TATCCAGTTT GATAGTGAAA AAGGAGTGGA CTTTGTTCTG 
AACTACTCAA AAGCGATGGA GAACCTGTTC ATCAACCGCT TCATGCACAT GTTCCAGTCT 
TCCTGGCACG ACTTTGCTGA CTTTGAGAAA ATCTTCGTCA AAATCAGCAA CACTATATCT 
GAGCGAGTCA AGAACCACTG GCAGGAAGAC CTCATGTTTG GCTACCAGTT CCTGAATGGC 
TGCAACCCAG TACTCATCAA GCGCTGCACA GCGTTGCCCC CGAAGCTCCC AGTGACCACA 
GAGATGGTGG AGTGCAGCCT AGAGCGGCAG CTCAGTTTAG AACAGGAAGT ACAGGAAGGG 
AACATTTTCA TCGTTGATTA CGAGCTACTG GATGGCATCG ATGCTAACAA AACTGACCCC 
TGTACACACC AGTTCCTGGC TGCCCCCATC TGCCTGCTAT ATAAGAACCT AGCCAACAAG 
ATTGTTCCCA TTGCCATCCA GCTCAACCAA ACCCCTGGAG AGAGTAACCC AATCTTCCTC 
CCTACGGATT CAAAGTACGA CTGGCTTTTG GCCAAAATCT GGGTGCGTTC CAGTGACTTC 
CACGTCCATC AAACGATCAC CCACCTTCTG CGCACGCATC TGGTGTCTGA GGTGTTTGGT 
ATCGCCATGT ACCGCCAGCT GCCTGCTGTG CATCCCCTTT TCAAGCTGCT GGTAGCCCAT 
GTGAGGTTCA CCATTGCTAT CAACACTAAG GCCCGGGAAC AGCTTATCTG CGAGTATGGC 
CTTTTTGACA AGGCCAATGC CACCGGGGGT GGAGGGCACG TGCAGATGGT GCAGAGGGCT 
GTCCAGGATC TGACCTATTC CTCCCTGTGT TTCCCGGAGG CCATCAAGGC CCGGGGCATG 
GACAGCACGG AAGACATCCC CTTCTACTTC TATCGTGATG ATGGACTGCT CGTGTGGGAG 
GCTATCCAGT CGTTCACAAT GGAGGTGGTG AGCATCTACT ATGAGAACGA CCAGGTGGTG 
GAGGAGGACC AGGAACTGCA GGACTTCGTG AAGGATGTTT ACGTGTACGG CATGCGGGGC 
AAAAAGGCCT CAGGTTTCCC CAAGTCCATC AAGAGCAGGG AGAAGCTGTC CGAGTACCTG 
ACGGTGGTGA TCTTCACGGC CTCTGCCCAG CATGCAGCTG TAAACTTCGG CCAGTATGAC 
TGGTGCTCCT GGATCCCCAA CGCTCCTCCA ACTATGCGGG CCCCACCACC CACGGCCAAG 
GGTGTGGTCA CCATCGAGCA GATCGTGGAT ACTCTACCAG ACCGTGGCCG ATCATGTTGG 
CATCTAGGTG CAGTGTGGGC CTTGAGCCAG TTTCAAGAAA ATGAGCTGTT TCTAGGCATG 
TACCCAGAGG AGCATTTCAT TGAGAAGCCA GTGAAGGAAG CCATGATCCG ATTCCGCAAG 
AACCTGGAGG CCATCGTCAG CGTGATCGCC GAGCGCAATA AGAACAAAAA GCTCCCCTAC 
TACTACCTGT CACCAGACAG GATTCCCAAC AGCGTAGCCA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.
Bone107131-142(2018 Feb)
Rauch F,Geng Y,Lamplugh L,Hekmatnejad B,Gaumond MH,Penney J,Yamanaka Y,Moffatt P

Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation.
Nature cell biology(2018 Jan)
Ibarra-Soria X,Jawaid W,Pijuan-Sala B,Ladopoulos V,Scialdone A,J?rg DJ,Tyser RCV,Calero-Nieto FJ,Mulas C,Nichols J,Vallier L,Srinivas S,Simons BD,G?ttgens B,Marioni JC

Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation.
Scientific reports7(1)16026(2017 Nov)
Yotsumoto S,Muroi Y,Chiba T,Ohmura R,Yoneyama M,Magarisawa M,Dodo K,Terayama N,Sodeoka M,Aoyagi R,Arita M,Arakawa S,Shimizu S,Tanaka M

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Alox5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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