Grm2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Grm2
Entrez Gene ID	108068
Full Name	glutamate receptor, metabotropic 2
Synonyms	4930441L02Rik,Gprc1b,mGluR2,mGluR7
General protein information	Preferred Names glutamate receptor, metabotropic 2 Names metabotropic glutamate receptor 2 G protein-coupled receptor, family C, group 1, member B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 F1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001160353.1	NP_001153825.1	metabotropic glutamate receptor 2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GRM2	XP_541867.2
Xenopus tropicalis (tropical clawed frog)	grm2	XP_004914127.1
Rattus norvegicus (Norway rat)	Grm2	NP_001099181.1
Mus musculus (house mouse)	Grm2	NP_001153825.1
Gallus gallus (chicken)	GRM2	XP_004944551.1
Homo sapiens (human)	GRM2	NP_000830.2
	GRM2	XP_001095565.1
Bos taurus (cattle)	GRM2	NP_001192795.1
Danio rerio (zebrafish)	grm2a	XP_002662553.3
Danio rerio (zebrafish)	grm7	XP_005172969.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress.
Nasca C, Bigio B, Zelli D, de Angelis P, Lau T, Okamoto M, Soya H, Ni J, Brichta L, Greengard P, Neve RL, Lee FS, McEwen BS
Neuron96(2)402-413.e5(2017 Oct)

NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.
Olszewski RT, Janczura KJ, Bzdega T, Der EK, Venzor F, O'Rourke B, Hark TJ, Craddock KE, Balasubramanian S, Moussa C, Neale JH
Neurochemical research42(9)2646-2657(2017 Sep)

Cross-compartmental Modulation of Dendritic Signals for Retinal Direction Selectivity.
Koren D, Grove JCR, Wei W
Neuron95(4)914-927.e4(2017 Aug)

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.
Mastroiacovo F, Moyanova S, Cannella M, Gaglione A, Verhaeghe R, Bozza G, Madonna M, Motolese M, Traficante A, Riozzi B, Bruno V, Battaglia G, Lodge D, Nicoletti F
Molecular brain10(1)39(2017 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mGlu2 activation exerts effects on striatal physiology that extend beyond modulation of corticostriatal synapses, and has the potential to influence cognition and striatum-related disorders via inhibition of thalamus-derived glutamate and dopamine release.
Title: Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum.

These studies provide a foundation for future research seeking to parse out the roles of mGlu2 from mGlu3, paving the way for better understanding of how these receptors regulate activity in the brain.
Title: Developmental expression of mGlu2 and mGlu3 in the mouse brain.

Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.
Title: Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.

Activation of GABA(B) or mGlu2/3 receptors inhibited both evoked presynaptic Ca(2+) transients and striatal field potentials.
Title: Inhibition of presynaptic calcium transients in cortical inputs to the dorsolateral striatum by metabotropic GABA(B) and mGlu2/3 receptors.

provided evidence that JARID1B via modulation of stemness-related signaling is a putative novel therapeutic target for treating malignant NB
Title: Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.

The following Grm2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Grm2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19627	NM_001160353.1 Latest version!	Mus musculus glutamate receptor, metabotropic 2 (Grm2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$517.30 $739.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Grm2 ( NM_001160353.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001153825.1 Mus musculus glutamate receptor, metabotropic 2 (Grm2), mRNA.

Price & Availability↑

CloneID	OMu19627
Clone ID Related Accession (Same CDS sequence)	NM_001160353.1
Accession Version	NM_001160353.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2619bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Mus musculus(house mouse)
Product	metabotropic glutamate receptor 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY290719.1, CK619406.1, BC115866.1, AC152452.3 and BQ174642.1. On or before May 22, 2009 this sequence version replaced XM_909627.3, XM_001475814.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164136 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAATCCC TGCTTAGGTT CCTGGCACTG CTGCTGCTGC GGGGTGCTGT GGCCGAGGGC 
CCGGCCAAGA AGGTGCTGAC CCTGGAGGGG GACCTGGTGC TGGGTGGGCT GTTCCCAGTG 
CACCAGAAGG GTGGCCCAGC AGAGGAGTGT GGACCTGTTA ATGAGCACCG TGGCATACAG 
CGCCTAGAGG CCATGCTTTT TGCACTGGAC CGCATCAACC GCGACCCCCA TCTGCTGCCT 
GGGGTGCGTT TGGGCGCGCA CATCCTCGAC AGCTGCTCCA AGGATACACA CGCCCTGGAG 
CAGGCCCTGG ACTTTGTGCG TGCCTCACTC AGCCGTGGGG CTGATGGCTC ACGCCACATC 
TGTCCTGACG GCTCCTATGC TACTCTCAGT GATGCTCCCA CAGCTATCAC CGGTGTCATT 
GGCGGCTCCT ACAGTGATGT CTCCATCCAG GTGGCCAATC TCCTGCGGCT GTTCCAGATC 
CCACAGATCA GCTATGCCTC CACCAGCGCC AAGCTGAGCG ACAAGTCCCG TTATGATTAC 
TTTGCTCGCA CCGTGCCCCC AGACTTCTTC CAAGCCAAGG CCATGGCTGA GATTCTCCGC 
TTTTTCAACT GGACGTATGT GTCTACGGTG GCATCTGAGG GTGACTATGG AGAGACAGGC 
ATTGAGGCCT TCGAGCTCGA GGCTCGGGCA CGCAACATCT GCGTGGCCAC TTCGGAGAAG 
GTGGGCCGTG CCATGAGCCG CGCAGCCTTC GAGGGTGTGG TGCGAGCCCT GTTGCAGAAG 
CCCAGCGCCC GTGTGGCTGT GCTCTTCACC CGGTCAGAGG ATGCCCGTGA GCTGCTTGCA 
GCCACCCAGC GTCTCAACGC CAGCTTCACC TGGGTAGCCA GCGACGGCTG GGGGGCCCTA 
GAGAGCGTGG TGGCAGGCAG TGAAAGGGCT GCCGAGGGCG CCATCACCAT TGAGCTGGCC 
TCCTACCCCA TCAGTGACTT TGCCTCCTAC TTCCAGAACT TGGATCCCTG GAACAACAGC 
AGGAACCCTT GGTTCCGTGA GTTCTGGGAG GAGAGGTTCC GTTGCAGCTT CCGGCAGCGA 
GACTGCGCCG CCCACTCTCT GCGGGCCGTA CCCTTTGAAC AGGAGTCAAA GATCATGTTT 
GTGGTCAATG CCGTGTATGC CATGGCCCAC GCTCTGCACA ACATGCACCG TGCCCTCTGT 
CCCAACACCA CCCGCCTCTG CGATGCCATG AGACCTGTCA ATGGGCGCCG CCTCTACAAG 
GACTTCGTGC TCAATGTCAA GTTTGATGCC CCCTTCCGCC CAGCAGATAC CGACGACGAG 
GTCCGCTTTG ACCGCTTTGG AGATGGTATT GGCCGCTACA ACATCTTCAC CTATCTGCGG 
GCAGGCAATG GGCGCTATCG CTACCAGAAG GTAGGCTACT GGGCAGAAGG TCTGACTCTG 
GATACTAGCA TCATCCCATG GGCCTCCCCA TCAGCTGGCA CCCTCCCTGC CTCTCGCTGT 
AGCGAGCCCT GCCTTCAGAA TGAGGTGAAG AGCGTGCAGC CCGGCGAGGT CTGCTGCTGG 
CTCTGCATCC CCTGTCAGCC CTATGAGTAC AGGCTGGATG AGTTCACCTG TGCTGACTGT 
GGCCTGGGCT ACTGGCCTAA TGCCAGTCTG ACTGGATGCT TTGAGCTGCC CCAGGAGTAC 
ATCCGCTGGG GCGACGCCTG GGCGGTGGGA CCTGTCACCA TCGCCTGCCT AGGTGCCCTG 
GCCACCCTCT TTGTGTTGGG TGTCTTCGTG CGGCATAACG CCACACCCGT GGTCAAGGCC 
TCGGGGCGGG AGCTTTGCTA CATTCTGCTG GGAGGCGTCT TCCTCTGCTA CTGCATGACC 
TTCATCTTCA TCGCCAAGCC CTCCACGGCC GTCTGCACCT TAAGGCGCCT CGGGTTGGGG 
ACCGCCTTCT CTGTCTGCTA CTCAGCCCTC CTCACCAAGA CCAATCGCAT CGCTCGCATC 
TTTGGCGGGG CCCGGGAGGG TGCCCAGCGG CCGCGCTTCA TCAGTCCCGC CTCACAGGTG 
GCCATCTGCC TGGCACTTAT CTCGGGCCAG CTGCTCATTG TTGCTGCCTG GCTGGTGGTG 
GAGGCACCTG GCATAGGCAA GGAGACAGCC CCTGAGCGGC GGGAAGTGGT GACCTTGCGC 
TGTAACCACC GTGACGCAAG CATGCTTGGC TCGCTGGCCT ACAACGTGCT CCTCATCGCT 
CTCTGCACGC TCTATGCCTT CAAGACCCGC AAGTGCCCGG AGAACTTCAA CGAGGCCAAG 
TTCATCGGCT TTACCATGTA CACCACCTGT ATCATCTGGC TGGCTTTCCT TCCCATCTTC 
TACGTCACCT CCAGTGATTA TCGGGTGCAG ACCACTACGA TGTGCGTGTC CGTCAGCCTC 
AGTGGCTCTG TGGTGCTCGG CTGCCTCTTT GCACCCAAGC TGCACATTAT CCTCTTCCAG 
CCACAGAAGA ACGTGGTGAG CCACCGGGCA CCTACCAGCC GCTTTGGCAG TGCTGCCCCC 
AGGGCCAGCG CCAACCTTGG TCAAGGGTCT GGATCCCAGC TTGTTCCTAC TGTTTGCAAT 
GGCCGTGAGG TGGTAGACTC AACAACATCG TCGCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001153825.1
CDS	221..2839
Translation	MESLLRFLALLLLRGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATLSDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQNLDPWNNSRNPWFREFWEERFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGNGRYRYQKVGYWAEGLTLDTSIIPWASPSAGTLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGIGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQLVPTVCNGREVVDSTTSSL

Target ORF information:

RefSeq Version	NM_001160353.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutamate receptor, metabotropic 2 (Grm2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001160353.1

ORF Insert Sequence:

ATGGAATCCC TGCTTAGGTT CCTGGCACTG CTGCTGCTGC GGGGTGCTGT GGCCGAGGGC 
CCGGCCAAGA AGGTGCTGAC CCTGGAGGGG GACCTGGTGC TGGGTGGGCT GTTCCCAGTG 
CACCAGAAGG GTGGCCCAGC AGAGGAGTGT GGACCTGTTA ATGAGCACCG TGGCATACAG 
CGCCTAGAGG CCATGCTTTT TGCACTGGAC CGCATCAACC GCGACCCCCA TCTGCTGCCT 
GGGGTGCGTT TGGGCGCGCA CATCCTCGAC AGCTGCTCCA AGGATACACA CGCCCTGGAG 
CAGGCCCTGG ACTTTGTGCG TGCCTCACTC AGCCGTGGGG CTGATGGCTC ACGCCACATC 
TGTCCTGACG GCTCCTATGC TACTCTCAGT GATGCTCCCA CAGCTATCAC CGGTGTCATT 
GGCGGCTCCT ACAGTGATGT CTCCATCCAG GTGGCCAATC TCCTGCGGCT GTTCCAGATC 
CCACAGATCA GCTATGCCTC CACCAGCGCC AAGCTGAGCG ACAAGTCCCG TTATGATTAC 
TTTGCTCGCA CCGTGCCCCC AGACTTCTTC CAAGCCAAGG CCATGGCTGA GATTCTCCGC 
TTTTTCAACT GGACGTATGT GTCTACGGTG GCATCTGAGG GTGACTATGG AGAGACAGGC 
ATTGAGGCCT TCGAGCTCGA GGCTCGGGCA CGCAACATCT GCGTGGCCAC TTCGGAGAAG 
GTGGGCCGTG CCATGAGCCG CGCAGCCTTC GAGGGTGTGG TGCGAGCCCT GTTGCAGAAG 
CCCAGCGCCC GTGTGGCTGT GCTCTTCACC CGGTCAGAGG ATGCCCGTGA GCTGCTTGCA 
GCCACCCAGC GTCTCAACGC CAGCTTCACC TGGGTAGCCA GCGACGGCTG GGGGGCCCTA 
GAGAGCGTGG TGGCAGGCAG TGAAAGGGCT GCCGAGGGCG CCATCACCAT TGAGCTGGCC 
TCCTACCCCA TCAGTGACTT TGCCTCCTAC TTCCAGAACT TGGATCCCTG GAACAACAGC 
AGGAACCCTT GGTTCCGTGA GTTCTGGGAG GAGAGGTTCC GTTGCAGCTT CCGGCAGCGA 
GACTGCGCCG CCCACTCTCT GCGGGCCGTA CCCTTTGAAC AGGAGTCAAA GATCATGTTT 
GTGGTCAATG CCGTGTATGC CATGGCCCAC GCTCTGCACA ACATGCACCG TGCCCTCTGT 
CCCAACACCA CCCGCCTCTG CGATGCCATG AGACCTGTCA ATGGGCGCCG CCTCTACAAG 
GACTTCGTGC TCAATGTCAA GTTTGATGCC CCCTTCCGCC CAGCAGATAC CGACGACGAG 
GTCCGCTTTG ACCGCTTTGG AGATGGTATT GGCCGCTACA ACATCTTCAC CTATCTGCGG 
GCAGGCAATG GGCGCTATCG CTACCAGAAG GTAGGCTACT GGGCAGAAGG TCTGACTCTG 
GATACTAGCA TCATCCCATG GGCCTCCCCA TCAGCTGGCA CCCTCCCTGC CTCTCGCTGT 
AGCGAGCCCT GCCTTCAGAA TGAGGTGAAG AGCGTGCAGC CCGGCGAGGT CTGCTGCTGG 
CTCTGCATCC CCTGTCAGCC CTATGAGTAC AGGCTGGATG AGTTCACCTG TGCTGACTGT 
GGCCTGGGCT ACTGGCCTAA TGCCAGTCTG ACTGGATGCT TTGAGCTGCC CCAGGAGTAC 
ATCCGCTGGG GCGACGCCTG GGCGGTGGGA CCTGTCACCA TCGCCTGCCT AGGTGCCCTG 
GCCACCCTCT TTGTGTTGGG TGTCTTCGTG CGGCATAACG CCACACCCGT GGTCAAGGCC 
TCGGGGCGGG AGCTTTGCTA CATTCTGCTG GGAGGCGTCT TCCTCTGCTA CTGCATGACC 
TTCATCTTCA TCGCCAAGCC CTCCACGGCC GTCTGCACCT TAAGGCGCCT CGGGTTGGGG 
ACCGCCTTCT CTGTCTGCTA CTCAGCCCTC CTCACCAAGA CCAATCGCAT CGCTCGCATC 
TTTGGCGGGG CCCGGGAGGG TGCCCAGCGG CCGCGCTTCA TCAGTCCCGC CTCACAGGTG 
GCCATCTGCC TGGCACTTAT CTCGGGCCAG CTGCTCATTG TTGCTGCCTG GCTGGTGGTG 
GAGGCACCTG GCATAGGCAA GGAGACAGCC CCTGAGCGGC GGGAAGTGGT GACCTTGCGC 
TGTAACCACC GTGACGCAAG CATGCTTGGC TCGCTGGCCT ACAACGTGCT CCTCATCGCT 
CTCTGCACGC TCTATGCCTT CAAGACCCGC AAGTGCCCGG AGAACTTCAA CGAGGCCAAG 
TTCATCGGCT TTACCATGTA CACCACCTGT ATCATCTGGC TGGCTTTCCT TCCCATCTTC 
TACGTCACCT CCAGTGATTA TCGGGTGCAG ACCACTACGA TGTGCGTGTC CGTCAGCCTC 
AGTGGCTCTG TGGTGCTCGG CTGCCTCTTT GCACCCAAGC TGCACATTAT CCTCTTCCAG 
CCACAGAAGA ACGTGGTGAG CCACCGGGCA CCTACCAGCC GCTTTGGCAG TGCTGCCCCC 
AGGGCCAGCG CCAACCTTGG TCAAGGGTCT GGATCCCAGC TTGTTCCTAC TGTTTGCAAT 
GGCCGTGAGG TGGTAGACTC AACAACATCG TCGCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress.
Neuron96(2)402-413.e5(2017 Oct)
Nasca C,Bigio B,Zelli D,de Angelis P,Lau T,Okamoto M,Soya H,Ni J,Brichta L,Greengard P,Neve RL,Lee FS,McEwen BS

NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.
Neurochemical research42(9)2646-2657(2017 Sep)
Olszewski RT,Janczura KJ,Bzdega T,Der EK,Venzor F,O'Rourke B,Hark TJ,Craddock KE,Balasubramanian S,Moussa C,Neale JH

Cross-compartmental Modulation of Dendritic Signals for Retinal Direction Selectivity.
Neuron95(4)914-927.e4(2017 Aug)
Koren D,Grove JCR,Wei W

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.
Molecular brain10(1)39(2017 08)
Mastroiacovo F,Moyanova S,Cannella M,Gaglione A,Verhaeghe R,Bozza G,Madonna M,Motolese M,Traficante A,Riozzi B,Bruno V,Battaglia G,Lodge D,Nicoletti F