KLHL6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KLHL6
Entrez Gene ID	89857
Full Name	kelch like family member 6
General protein information	Preferred Names kelch like family member 6 Names kelch-like protein 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q27.1
Summary	This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
Disorder MIM:	614214

mRNA and Protein(s)

mRNA	Protein	Name
NM_130446.3	NP_569713.2	kelch-like protein 6
XM_011513273.2	XP_011511575.1	kelch-like protein 6 isoform X1
NM_130446.4	NP_569713.2	kelch-like protein 6
XM_011513273.3	XP_011511575.1	kelch-like protein 6 isoform X1
XM_011513274.2	XP_011511576.1	kelch-like protein 6 isoform X2
XM_011513274.3	XP_011511576.1	kelch-like protein 6 isoform X2

Pathways from BioSystems

Homologies

Homo sapiens (human)	KLHL6	NP_569713.2
Pan troglodytes (chimpanzee)	KLHL6	XP_001134897.1
Mus musculus (house mouse)	Klhl6	NP_899246.2
Danio rerio (zebrafish)	klhl6	NP_001005316.2
Xenopus tropicalis (tropical clawed frog)	klhl6	XP_002933397.2
	KLHL6	XP_001106193.1
Canis lupus familiaris (dog)	KLHL6	XP_545220.2
Bos taurus (cattle)	KLHL6	XP_002684931.1
Gallus gallus (chicken)	KLHL6	NP_001026474.2
Rattus norvegicus (Norway rat)	Klhl6	NP_001099337.1

Gene Ontology
Bibliography

Related articles in PubMed

Prognostic value of the cancer oncogene Kelch-like 6 in gastric cancer.
Deng J, Guo J, Ma G, Zhang H, Sun D, Hou Y, Xie X, Guo X, Nie Y, Liang H
The British journal of surgery104(13)1847-1856(2017 Dec)

KLHL6 Is Preferentially Expressed in Germinal Center-Derived B-Cell Lymphomas.
Kunder CA, Roncador G, Advani RH, Gualco G, Bacchi CE, Sabile JM, Lossos IS, Nie K, Tibshirani RJ, Green MR, Alizadeh AA, Natkunam Y
American journal of clinical pathology148(6)465-476(2017 Nov)

Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation.
Bertocci B, Lecoeuche D, Sterlin D, K?hn J, Gaillard B, De Smet A, Lembo F, Bole-Feysot C, Cagnard N, Fadeev T, Dahan A, Weill JC, Reynaud CA
Journal of immunology (Baltimore, Md. : 1950)199(7)2408-2420(2017 Oct)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Abnormal expression of the KLHL6 oncogene promoted gastric cancer progression in vitro and in vivo, and its expression level in tumor tissue was found to be of prognostic value.
Title: Prognostic value of the cancer oncogene Kelch-like 6 in gastric cancer.

KLHL6 was positive mainly in B-cell neoplasms of germinal center derivation, including 95% of follicular lymphomas (106/112)
Title: KLHL6 Is Preferentially Expressed in Germinal Center-Derived B-Cell Lymphomas.

report that KLHL6, which is recurrently mutated in B cell lymphomas, is an off-target of the normal somatic hypermutation process taking place in germinal center (GC) B cells leaving open whether, despite the lack of impact of Klhl6 deficiency on GC B cell expansion, mutants could contribute to the oncogenic process
Title: Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation.

characterization of two genes expressed in centroblasts of human tonsils: deltex (Drosophila) homolog 1 (DTX1), which is related to the Notch pathway and a new Kelch-like protein, KLHL6
Title: Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells.

The following KLHL6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLHL6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05873	NM_130446.4 Latest version!	Homo sapiens kelch like family member 6 (KLHL6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu74104	XM_011513273.3 Latest version!	Homo sapiens kelch like family member 6 (KLHL6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu74105	XM_011513274.3 Latest version!	Homo sapiens kelch like family member 6 (KLHL6), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu05873	NM_130446.3	Homo sapiens kelch like family member 6 (KLHL6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu74104	XM_011513273.2	Homo sapiens kelch like family member 6 (KLHL6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu74105	XM_011513274.2	Homo sapiens kelch like family member 6 (KLHL6), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KLHL6 ( NM_130446.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_569713.2 Homo sapiens kelch like family member 6 (KLHL6), mRNA.

Price & Availability↑

CloneID	OHu05873
Clone ID Related Accession (Same CDS sequence)	NM_130446.3 , NM_130446.4
Accession Version	NM_130446.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1866bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	kelch-like protein 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC069211.15, BP284594.1, BC032348.1, AK097125.1 and AC092960.3. This sequence is a reference standard in the RefSeqGene project. On Feb 28, 2017 this sequence version replaced NM_130446.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGTTGATGG CAGGACAAAG GGGCGCCTGG ACCATGGGTG ATGTGGTCGA GAAGAGTTTG 
GAAGGGCCCC TGGCACCTTC TACAGATGAG CCCTCCCAGA AAACAGGAGA CTTGGTCGAG 
ATCTTAAATG GGGAAAAGGT CAAATTTGAC GACGCGGGAC TCTCCTTAAT TCTTCAGAAT 
GGCCTGGAAA CCCTGCGAAT GGAAAACGCT CTGACAGATG TCATCTTGTG TGTGGACATT 
CAGGAATTCT CCTGCCACCG CGTGGTGCTT GCCGCAGCCA GCAACTATTT CAGGGCCATG 
TTCTGCAACG ATTTAAAGGA AAAGTATGAG AAAAGGATCA TTATTAAAGG GGTTGATGCT 
GAGACCATGC ACACTCTGTT GGACTACACG TACACCAGCA AGGCGCTGAT CACCAAGCAG 
AATGTCCAGC GGGTCCTGGA GGCTGCTAAC CTCTTCCAGT TCCTGCGGAT GGTGGATGCC 
TGTGCCAGCT TCCTCACTGA AGCCTTGAAC CCAGAAAACT GCGTTGGAAT ACTGAGGCTG 
GCTGACACAC ACTCGCTGGA CAGTCTAAAG AAGCAGGTTC AGAGTTACAT CATTCAAAAC 
TTTGTGCAGA TTCTGAACTC TGAGGAGTTT CTTGACCTGC CCGTGGACAC TCTGCACCAC 
ATCTTGAAGA GTGATGACCT TTACGTGACC GAGGAGGCTC AGGTGTTTGA GACCGTGATG 
AGCTGGGTCC GGCACAAGCC ATCAGAACGA CTCTGCTTAC TCCCCTATGT CCTCGAGAAC 
GTGCGCTTAC CGCTTCTGGA CCCGTGGTAC TTTGTGGAGA CGGTGGAAGC AGATCCTCTC 
ATCAGGCAGT GCCCAGAGGT CTTCCCGCTG CTCCAGGAAG CCAGGATGTA CCACCTTTCT 
GGCAATGAGA TCATTTCGGA ACGCACCAAG CCCAGGATGC ATGAGTTCCA GTCTGAGGTG 
TTCATGATCA TTGGCGGCTG CACGAAGGAT GAACGGTTTG TGGCAGAGGT GACCTGCCTG 
GACCCCCTGA GGCGCAGCCG CCTGGAGGTG GCCAAGCTCC CGCTAACAGA GCATGAGCTG 
GAGAGTGAGA ATAAGAAGTG GGTGGAGTTT GCATGCGTGA CATTGAAAAA TGAGGTCTAC 
ATCTCAGGTG GCAAAGAAAC ACAGCATGAT GTTTGGAAAT ATAATTCTTC GATCAACAAG 
TGGATTCAGA TTGAGTATTT AAACATAGGC CGCTGGAGGC ATAAGATGGT GGTGTTGGGT 
GGCAAGGTCT ATGTGATCGG AGGCTTTGAC GGCTTACAGA GAATCAACAA TGTGGAGACC 
TACGACCCCT TTCACAACTG CTGGTCAGAG GCCGCACCCC TCCTTGTCCA TGTCAGTTCC 
TTTGCAGCCA CCAGCCATAA GAAGAAGCTG TATGTGATCG GGGGAGGGCC CAATGGGAAA 
CTGGCCACAG ACAAGACTCA GTGTTATGAC CCTTCCACCA ACAAGTGGAG TTTGAAGGCG 
GCCATGCCCG TGGAGGCTAA ATGCATCAAT GCAGTGAGTT TCCGGGACCG CATCTATGTC 
GTTGGTGGGG CCATGAGAGC GCTGTACGCC TACAGCCCGC TGGAAGACAG CTGGTGCCTG 
GTGACCCAGC TCAGCCACGA GCGGGCCAGC TGCGGTATCG CGCCCTGCAA CAACCGGCTC 
TACATCACCG GCGGGCGGGA CGAGAAGAAC GAGGTTATCG CCACGGTGCT GTGCTGGGAC 
CCCGAGGCCC AGAAACTGAC AGAGGAGTGC GTCCTGCCCC GGGGCGTGTC GCACCACGGC 
AGCGTCACCA TCAGGAAGTC GTACACCCAC ATCCGCAGGA TCGTGCCCGG AGCAGTGTCT 
GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_569713.2
CDS	60..1925
Translation	MLMAGQRGAWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRIVPGAVSV

Target ORF information:

RefSeq Version	NM_130446.3
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 6 (KLHL6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130446.3

ORF Insert Sequence:

ATGTTGATGG CAGGACAAAG GGGCGCCTGG ACCATGGGTG ATGTGGTCGA GAAGAGTTTG 
GAAGGGCCCC TGGCACCTTC TACAGATGAG CCCTCCCAGA AAACAGGAGA CTTGGTCGAG 
ATCTTAAATG GGGAAAAGGT CAAATTTGAC GACGCGGGAC TCTCCTTAAT TCTTCAGAAT 
GGCCTGGAAA CCCTGCGAAT GGAAAACGCT CTGACAGATG TCATCTTGTG TGTGGACATT 
CAGGAATTCT CCTGCCACCG CGTGGTGCTT GCCGCAGCCA GCAACTATTT CAGGGCCATG 
TTCTGCAACG ATTTAAAGGA AAAGTATGAG AAAAGGATCA TTATTAAAGG GGTTGATGCT 
GAGACCATGC ACACTCTGTT GGACTACACG TACACCAGCA AGGCGCTGAT CACCAAGCAG 
AATGTCCAGC GGGTCCTGGA GGCTGCTAAC CTCTTCCAGT TCCTGCGGAT GGTGGATGCC 
TGTGCCAGCT TCCTCACTGA AGCCTTGAAC CCAGAAAACT GCGTTGGAAT ACTGAGGCTG 
GCTGACACAC ACTCGCTGGA CAGTCTAAAG AAGCAGGTTC AGAGTTACAT CATTCAAAAC 
TTTGTGCAGA TTCTGAACTC TGAGGAGTTT CTTGACCTGC CCGTGGACAC TCTGCACCAC 
ATCTTGAAGA GTGATGACCT TTACGTGACC GAGGAGGCTC AGGTGTTTGA GACCGTGATG 
AGCTGGGTCC GGCACAAGCC ATCAGAACGA CTCTGCTTAC TCCCCTATGT CCTCGAGAAC 
GTGCGCTTAC CGCTTCTGGA CCCGTGGTAC TTTGTGGAGA CGGTGGAAGC AGATCCTCTC 
ATCAGGCAGT GCCCAGAGGT CTTCCCGCTG CTCCAGGAAG CCAGGATGTA CCACCTTTCT 
GGCAATGAGA TCATTTCGGA ACGCACCAAG CCCAGGATGC ATGAGTTCCA GTCTGAGGTG 
TTCATGATCA TTGGCGGCTG CACGAAGGAT GAACGGTTTG TGGCAGAGGT GACCTGCCTG 
GACCCCCTGA GGCGCAGCCG CCTGGAGGTG GCCAAGCTCC CGCTAACAGA GCATGAGCTG 
GAGAGTGAGA ATAAGAAGTG GGTGGAGTTT GCATGCGTGA CATTGAAAAA TGAGGTCTAC 
ATCTCAGGTG GCAAAGAAAC ACAGCATGAT GTTTGGAAAT ATAATTCTTC GATCAACAAG 
TGGATTCAGA TTGAGTATTT AAACATAGGC CGCTGGAGGC ATAAGATGGT GGTGTTGGGT 
GGCAAGGTCT ATGTGATCGG AGGCTTTGAC GGCTTACAGA GAATCAACAA TGTGGAGACC 
TACGACCCCT TTCACAACTG CTGGTCAGAG GCCGCACCCC TCCTTGTCCA TGTCAGTTCC 
TTTGCAGCCA CCAGCCATAA GAAGAAGCTG TATGTGATCG GGGGAGGGCC CAATGGGAAA 
CTGGCCACAG ACAAGACTCA GTGTTATGAC CCTTCCACCA ACAAGTGGAG TTTGAAGGCG 
GCCATGCCCG TGGAGGCTAA ATGCATCAAT GCAGTGAGTT TCCGGGACCG CATCTATGTC 
GTTGGTGGGG CCATGAGAGC GCTGTACGCC TACAGCCCGC TGGAAGACAG CTGGTGCCTG 
GTGACCCAGC TCAGCCACGA GCGGGCCAGC TGCGGTATCG CGCCCTGCAA CAACCGGCTC 
TACATCACCG GCGGGCGGGA CGAGAAGAAC GAGGTTATCG CCACGGTGCT GTGCTGGGAC 
CCCGAGGCCC AGAAACTGAC AGAGGAGTGC GTCCTGCCCC GGGGCGTGTC GCACCACGGC 
AGCGTCACCA TCAGGAAGTC GTACACCCAC ATCCGCAGGA TCGTGCCCGG AGCAGTGTCT 
GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLHL6 ( NM_130446.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_569713.2 Homo sapiens kelch like family member 6 (KLHL6), mRNA.

Price & Availability↑

CloneID	OHu05873
Clone ID Related Accession (Same CDS sequence)	NM_130446.3 , NM_130446.4
Accession Version	NM_130446.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1866bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	kelch-like protein 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP284594.1, BC032348.1, AK097125.1 and AC092960.3. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_130446.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.155198.1, BC032348.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000341319.8/ ENSP00000341342.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGATGG CAGGACAAAG GGGCGCCTGG ACCATGGGTG ATGTGGTCGA GAAGAGTTTG 
GAAGGGCCCC TGGCACCTTC TACAGATGAG CCCTCCCAGA AAACAGGAGA CTTGGTCGAG 
ATCTTAAATG GGGAAAAGGT CAAATTTGAC GACGCGGGAC TCTCCTTAAT TCTTCAGAAT 
GGCCTGGAAA CCCTGCGAAT GGAAAACGCT CTGACAGATG TCATCTTGTG TGTGGACATT 
CAGGAATTCT CCTGCCACCG CGTGGTGCTT GCCGCAGCCA GCAACTATTT CAGGGCCATG 
TTCTGCAACG ATTTAAAGGA AAAGTATGAG AAAAGGATCA TTATTAAAGG GGTTGATGCT 
GAGACCATGC ACACTCTGTT GGACTACACG TACACCAGCA AGGCGCTGAT CACCAAGCAG 
AATGTCCAGC GGGTCCTGGA GGCTGCTAAC CTCTTCCAGT TCCTGCGGAT GGTGGATGCC 
TGTGCCAGCT TCCTCACTGA AGCCTTGAAC CCAGAAAACT GCGTTGGAAT ACTGAGGCTG 
GCTGACACAC ACTCGCTGGA CAGTCTAAAG AAGCAGGTTC AGAGTTACAT CATTCAAAAC 
TTTGTGCAGA TTCTGAACTC TGAGGAGTTT CTTGACCTGC CCGTGGACAC TCTGCACCAC 
ATCTTGAAGA GTGATGACCT TTACGTGACC GAGGAGGCTC AGGTGTTTGA GACCGTGATG 
AGCTGGGTCC GGCACAAGCC ATCAGAACGA CTCTGCTTAC TCCCCTATGT CCTCGAGAAC 
GTGCGCTTAC CGCTTCTGGA CCCGTGGTAC TTTGTGGAGA CGGTGGAAGC AGATCCTCTC 
ATCAGGCAGT GCCCAGAGGT CTTCCCGCTG CTCCAGGAAG CCAGGATGTA CCACCTTTCT 
GGCAATGAGA TCATTTCGGA ACGCACCAAG CCCAGGATGC ATGAGTTCCA GTCTGAGGTG 
TTCATGATCA TTGGCGGCTG CACGAAGGAT GAACGGTTTG TGGCAGAGGT GACCTGCCTG 
GACCCCCTGA GGCGCAGCCG CCTGGAGGTG GCCAAGCTCC CGCTAACAGA GCATGAGCTG 
GAGAGTGAGA ATAAGAAGTG GGTGGAGTTT GCATGCGTGA CATTGAAAAA TGAGGTCTAC 
ATCTCAGGTG GCAAAGAAAC ACAGCATGAT GTTTGGAAAT ATAATTCTTC GATCAACAAG 
TGGATTCAGA TTGAGTATTT AAACATAGGC CGCTGGAGGC ATAAGATGGT GGTGTTGGGT 
GGCAAGGTCT ATGTGATCGG AGGCTTTGAC GGCTTACAGA GAATCAACAA TGTGGAGACC 
TACGACCCCT TTCACAACTG CTGGTCAGAG GCCGCACCCC TCCTTGTCCA TGTCAGTTCC 
TTTGCAGCCA CCAGCCATAA GAAGAAGCTG TATGTGATCG GGGGAGGGCC CAATGGGAAA 
CTGGCCACAG ACAAGACTCA GTGTTATGAC CCTTCCACCA ACAAGTGGAG TTTGAAGGCG 
GCCATGCCCG TGGAGGCTAA ATGCATCAAT GCAGTGAGTT TCCGGGACCG CATCTATGTC 
GTTGGTGGGG CCATGAGAGC GCTGTACGCC TACAGCCCGC TGGAAGACAG CTGGTGCCTG 
GTGACCCAGC TCAGCCACGA GCGGGCCAGC TGCGGTATCG CGCCCTGCAA CAACCGGCTC 
TACATCACCG GCGGGCGGGA CGAGAAGAAC GAGGTTATCG CCACGGTGCT GTGCTGGGAC 
CCCGAGGCCC AGAAACTGAC AGAGGAGTGC GTCCTGCCCC GGGGCGTGTC GCACCACGGC 
AGCGTCACCA TCAGGAAGTC GTACACCCAC ATCCGCAGGA TCGTGCCCGG AGCAGTGTCT 
GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_569713.2
CDS	54..1919
Translation	MLMAGQRGAWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRIVPGAVSV

Target ORF information:

RefSeq Version	NM_130446.4
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 6 (KLHL6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130446.4

ORF Insert Sequence:

ATGTTGATGG CAGGACAAAG GGGCGCCTGG ACCATGGGTG ATGTGGTCGA GAAGAGTTTG 
GAAGGGCCCC TGGCACCTTC TACAGATGAG CCCTCCCAGA AAACAGGAGA CTTGGTCGAG 
ATCTTAAATG GGGAAAAGGT CAAATTTGAC GACGCGGGAC TCTCCTTAAT TCTTCAGAAT 
GGCCTGGAAA CCCTGCGAAT GGAAAACGCT CTGACAGATG TCATCTTGTG TGTGGACATT 
CAGGAATTCT CCTGCCACCG CGTGGTGCTT GCCGCAGCCA GCAACTATTT CAGGGCCATG 
TTCTGCAACG ATTTAAAGGA AAAGTATGAG AAAAGGATCA TTATTAAAGG GGTTGATGCT 
GAGACCATGC ACACTCTGTT GGACTACACG TACACCAGCA AGGCGCTGAT CACCAAGCAG 
AATGTCCAGC GGGTCCTGGA GGCTGCTAAC CTCTTCCAGT TCCTGCGGAT GGTGGATGCC 
TGTGCCAGCT TCCTCACTGA AGCCTTGAAC CCAGAAAACT GCGTTGGAAT ACTGAGGCTG 
GCTGACACAC ACTCGCTGGA CAGTCTAAAG AAGCAGGTTC AGAGTTACAT CATTCAAAAC 
TTTGTGCAGA TTCTGAACTC TGAGGAGTTT CTTGACCTGC CCGTGGACAC TCTGCACCAC 
ATCTTGAAGA GTGATGACCT TTACGTGACC GAGGAGGCTC AGGTGTTTGA GACCGTGATG 
AGCTGGGTCC GGCACAAGCC ATCAGAACGA CTCTGCTTAC TCCCCTATGT CCTCGAGAAC 
GTGCGCTTAC CGCTTCTGGA CCCGTGGTAC TTTGTGGAGA CGGTGGAAGC AGATCCTCTC 
ATCAGGCAGT GCCCAGAGGT CTTCCCGCTG CTCCAGGAAG CCAGGATGTA CCACCTTTCT 
GGCAATGAGA TCATTTCGGA ACGCACCAAG CCCAGGATGC ATGAGTTCCA GTCTGAGGTG 
TTCATGATCA TTGGCGGCTG CACGAAGGAT GAACGGTTTG TGGCAGAGGT GACCTGCCTG 
GACCCCCTGA GGCGCAGCCG CCTGGAGGTG GCCAAGCTCC CGCTAACAGA GCATGAGCTG 
GAGAGTGAGA ATAAGAAGTG GGTGGAGTTT GCATGCGTGA CATTGAAAAA TGAGGTCTAC 
ATCTCAGGTG GCAAAGAAAC ACAGCATGAT GTTTGGAAAT ATAATTCTTC GATCAACAAG 
TGGATTCAGA TTGAGTATTT AAACATAGGC CGCTGGAGGC ATAAGATGGT GGTGTTGGGT 
GGCAAGGTCT ATGTGATCGG AGGCTTTGAC GGCTTACAGA GAATCAACAA TGTGGAGACC 
TACGACCCCT TTCACAACTG CTGGTCAGAG GCCGCACCCC TCCTTGTCCA TGTCAGTTCC 
TTTGCAGCCA CCAGCCATAA GAAGAAGCTG TATGTGATCG GGGGAGGGCC CAATGGGAAA 
CTGGCCACAG ACAAGACTCA GTGTTATGAC CCTTCCACCA ACAAGTGGAG TTTGAAGGCG 
GCCATGCCCG TGGAGGCTAA ATGCATCAAT GCAGTGAGTT TCCGGGACCG CATCTATGTC 
GTTGGTGGGG CCATGAGAGC GCTGTACGCC TACAGCCCGC TGGAAGACAG CTGGTGCCTG 
GTGACCCAGC TCAGCCACGA GCGGGCCAGC TGCGGTATCG CGCCCTGCAA CAACCGGCTC 
TACATCACCG GCGGGCGGGA CGAGAAGAAC GAGGTTATCG CCACGGTGCT GTGCTGGGAC 
CCCGAGGCCC AGAAACTGAC AGAGGAGTGC GTCCTGCCCC GGGGCGTGTC GCACCACGGC 
AGCGTCACCA TCAGGAAGTC GTACACCCAC ATCCGCAGGA TCGTGCCCGG AGCAGTGTCT 
GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLHL6 ( XM_011513273.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511575.1 Homo sapiens kelch like family member 6 (KLHL6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu74104
Clone ID Related Accession (Same CDS sequence)	XM_011513273.2 , XM_011513273.3
Accession Version	XM_011513273.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1485bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	kelch-like protein 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011513273.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGCG GGTCCTGGAG GCTGCTAACC TCTTCCAGGT GTGTGAACAA ACTGGCTCAG 
TGCTCTTCTC TGAAGCAGTT CCTGCGGATG GTGGATGCCT GTGCCAGCTT CCTCACTGAA 
GCCTTGAACC CAGAAAACTG CGTTGGAATA CTGAGGCTGG CTGACACACA CTCGCTGGAC 
AGTCTAAAGA AGCAGGTTCA GAGTTACATC ATTCAAAACT TTGTGCAGAT TCTGAACTCT 
GAGGAGTTTC TTGACCTGCC CGTGGACACT CTGCACCACA TCTTGAAGAG TGATGACCTT 
TACGTGACCG AGGAGGCTCA GGTGTTTGAG ACCGTGATGA GCTGGGTCCG GCACAAGCCA 
TCAGAACGAC TCTGCTTACT CCCCTATGTC CTCGAGAACG TGCGCTTACC GCTTCTGGAC 
CCGTGGTACT TTGTGGAGAC GGTGGAAGCA GATCCTCTCA TCAGGCAGTG CCCAGAGGTC 
TTCCCGCTGC TCCAGGAAGC CAGGATGTAC CACCTTTCTG GCAATGAGAT CATTTCGGAA 
CGCACCAAGC CCAGGATGCA TGAGTTCCAG TCTGAGGTGT TCATGATCAT TGGCGGCTGC 
ACGAAGGATG AACGGTTTGT GGCAGAGGTG ACCTGCCTGG ACCCCCTGAG GCGCAGCCGC 
CTGGAGGTGG CCAAGCTCCC GCTAACAGAG CATGAGCTGG AGAGTGAGAA TAAGAAGTGG 
GTGGAGTTTG CATGCGTGAC ATTGAAAAAT GAGGTCTACA TCTCAGGTGG CAAAGAAACA 
CAGCATGATG TTTGGAAATA TAATTCTTCG ATCAACAAGT GGATTCAGAT TGAGTATTTA 
AACATAGGCC GCTGGAGGCA TAAGATGGTG GTGTTGGGTG GCAAGGTCTA TGTGATCGGA 
GGCTTTGACG GCTTACAGAG AATCAACAAT GTGGAGACCT ACGACCCCTT TCACAACTGC 
TGGTCAGAGG CCGCACCCCT CCTTGTCCAT GTCAGTTCCT TTGCAGCCAC CAGCCATAAG 
AAGAAGCTGT ATGTGATCGG GGGAGGGCCC AATGGGAAAC TGGCCACAGA CAAGACTCAG 
TGTTATGACC CTTCCACCAA CAAGTGGAGT TTGAAGGCGG CCATGCCCGT GGAGGCTAAA 
TGCATCAATG CAGTGAGTTT CCGGGACCGC ATCTATGTCG TTGGTGGGGC CATGAGAGCG 
CTGTACGCCT ACAGCCCGCT GGAAGACAGC TGGTGCCTGG TGACCCAGCT CAGCCACGAG 
CGGGCCAGCT GCGGTATCGC GCCCTGCAAC AACCGGCTCT ACATCACCGG CGGGCGGGAC 
GAGAAGAACG AGGTTATCGC CACGGTGCTG TGCTGGGACC CCGAGGCCCA GAAACTGACA 
GAGGAGTGCG TCCTGCCCCG GGGCGTGTCG CACCACGGCA GCGTCACCAT CAGGAAGTCG 
TACACCCACA TCCGCAGGAT CGTGCCCGGA GCAGTGTCTG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511575.1
CDS	95..1579
Translation	MSSGSWRLLTSSRCVNKLAQCSSLKQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRIVPGAVSV

Target ORF information:

RefSeq Version	XM_011513273.2
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 6 (KLHL6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513273.2

ORF Insert Sequence:

ATGTCCAGCG GGTCCTGGAG GCTGCTAACC TCTTCCAGGT GTGTGAACAA ACTGGCTCAG 
TGCTCTTCTC TGAAGCAGTT CCTGCGGATG GTGGATGCCT GTGCCAGCTT CCTCACTGAA 
GCCTTGAACC CAGAAAACTG CGTTGGAATA CTGAGGCTGG CTGACACACA CTCGCTGGAC 
AGTCTAAAGA AGCAGGTTCA GAGTTACATC ATTCAAAACT TTGTGCAGAT TCTGAACTCT 
GAGGAGTTTC TTGACCTGCC CGTGGACACT CTGCACCACA TCTTGAAGAG TGATGACCTT 
TACGTGACCG AGGAGGCTCA GGTGTTTGAG ACCGTGATGA GCTGGGTCCG GCACAAGCCA 
TCAGAACGAC TCTGCTTACT CCCCTATGTC CTCGAGAACG TGCGCTTACC GCTTCTGGAC 
CCGTGGTACT TTGTGGAGAC GGTGGAAGCA GATCCTCTCA TCAGGCAGTG CCCAGAGGTC 
TTCCCGCTGC TCCAGGAAGC CAGGATGTAC CACCTTTCTG GCAATGAGAT CATTTCGGAA 
CGCACCAAGC CCAGGATGCA TGAGTTCCAG TCTGAGGTGT TCATGATCAT TGGCGGCTGC 
ACGAAGGATG AACGGTTTGT GGCAGAGGTG ACCTGCCTGG ACCCCCTGAG GCGCAGCCGC 
CTGGAGGTGG CCAAGCTCCC GCTAACAGAG CATGAGCTGG AGAGTGAGAA TAAGAAGTGG 
GTGGAGTTTG CATGCGTGAC ATTGAAAAAT GAGGTCTACA TCTCAGGTGG CAAAGAAACA 
CAGCATGATG TTTGGAAATA TAATTCTTCG ATCAACAAGT GGATTCAGAT TGAGTATTTA 
AACATAGGCC GCTGGAGGCA TAAGATGGTG GTGTTGGGTG GCAAGGTCTA TGTGATCGGA 
GGCTTTGACG GCTTACAGAG AATCAACAAT GTGGAGACCT ACGACCCCTT TCACAACTGC 
TGGTCAGAGG CCGCACCCCT CCTTGTCCAT GTCAGTTCCT TTGCAGCCAC CAGCCATAAG 
AAGAAGCTGT ATGTGATCGG GGGAGGGCCC AATGGGAAAC TGGCCACAGA CAAGACTCAG 
TGTTATGACC CTTCCACCAA CAAGTGGAGT TTGAAGGCGG CCATGCCCGT GGAGGCTAAA 
TGCATCAATG CAGTGAGTTT CCGGGACCGC ATCTATGTCG TTGGTGGGGC CATGAGAGCG 
CTGTACGCCT ACAGCCCGCT GGAAGACAGC TGGTGCCTGG TGACCCAGCT CAGCCACGAG 
CGGGCCAGCT GCGGTATCGC GCCCTGCAAC AACCGGCTCT ACATCACCGG CGGGCGGGAC 
GAGAAGAACG AGGTTATCGC CACGGTGCTG TGCTGGGACC CCGAGGCCCA GAAACTGACA 
GAGGAGTGCG TCCTGCCCCG GGGCGTGTCG CACCACGGCA GCGTCACCAT CAGGAAGTCG 
TACACCCACA TCCGCAGGAT CGTGCCCGGA GCAGTGTCTG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLHL6 ( XM_011513273.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511575.1 Homo sapiens kelch like family member 6 (KLHL6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu74104
Clone ID Related Accession (Same CDS sequence)	XM_011513273.2 , XM_011513273.3
Accession Version	XM_011513273.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1485bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	kelch-like protein 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011513273.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGCG GGTCCTGGAG GCTGCTAACC TCTTCCAGGT GTGTGAACAA ACTGGCTCAG 
TGCTCTTCTC TGAAGCAGTT CCTGCGGATG GTGGATGCCT GTGCCAGCTT CCTCACTGAA 
GCCTTGAACC CAGAAAACTG CGTTGGAATA CTGAGGCTGG CTGACACACA CTCGCTGGAC 
AGTCTAAAGA AGCAGGTTCA GAGTTACATC ATTCAAAACT TTGTGCAGAT TCTGAACTCT 
GAGGAGTTTC TTGACCTGCC CGTGGACACT CTGCACCACA TCTTGAAGAG TGATGACCTT 
TACGTGACCG AGGAGGCTCA GGTGTTTGAG ACCGTGATGA GCTGGGTCCG GCACAAGCCA 
TCAGAACGAC TCTGCTTACT CCCCTATGTC CTCGAGAACG TGCGCTTACC GCTTCTGGAC 
CCGTGGTACT TTGTGGAGAC GGTGGAAGCA GATCCTCTCA TCAGGCAGTG CCCAGAGGTC 
TTCCCGCTGC TCCAGGAAGC CAGGATGTAC CACCTTTCTG GCAATGAGAT CATTTCGGAA 
CGCACCAAGC CCAGGATGCA TGAGTTCCAG TCTGAGGTGT TCATGATCAT TGGCGGCTGC 
ACGAAGGATG AACGGTTTGT GGCAGAGGTG ACCTGCCTGG ACCCCCTGAG GCGCAGCCGC 
CTGGAGGTGG CCAAGCTCCC GCTAACAGAG CATGAGCTGG AGAGTGAGAA TAAGAAGTGG 
GTGGAGTTTG CATGCGTGAC ATTGAAAAAT GAGGTCTACA TCTCAGGTGG CAAAGAAACA 
CAGCATGATG TTTGGAAATA TAATTCTTCG ATCAACAAGT GGATTCAGAT TGAGTATTTA 
AACATAGGCC GCTGGAGGCA TAAGATGGTG GTGTTGGGTG GCAAGGTCTA TGTGATCGGA 
GGCTTTGACG GCTTACAGAG AATCAACAAT GTGGAGACCT ACGACCCCTT TCACAACTGC 
TGGTCAGAGG CCGCACCCCT CCTTGTCCAT GTCAGTTCCT TTGCAGCCAC CAGCCATAAG 
AAGAAGCTGT ATGTGATCGG GGGAGGGCCC AATGGGAAAC TGGCCACAGA CAAGACTCAG 
TGTTATGACC CTTCCACCAA CAAGTGGAGT TTGAAGGCGG CCATGCCCGT GGAGGCTAAA 
TGCATCAATG CAGTGAGTTT CCGGGACCGC ATCTATGTCG TTGGTGGGGC CATGAGAGCG 
CTGTACGCCT ACAGCCCGCT GGAAGACAGC TGGTGCCTGG TGACCCAGCT CAGCCACGAG 
CGGGCCAGCT GCGGTATCGC GCCCTGCAAC AACCGGCTCT ACATCACCGG CGGGCGGGAC 
GAGAAGAACG AGGTTATCGC CACGGTGCTG TGCTGGGACC CCGAGGCCCA GAAACTGACA 
GAGGAGTGCG TCCTGCCCCG GGGCGTGTCG CACCACGGCA GCGTCACCAT CAGGAAGTCG 
TACACCCACA TCCGCAGGAT CGTGCCCGGA GCAGTGTCTG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511575.1
CDS	95..1579
Translation	MSSGSWRLLTSSRCVNKLAQCSSLKQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRIVPGAVSV

Target ORF information:

RefSeq Version	XM_011513273.3
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 6 (KLHL6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513273.3

ORF Insert Sequence:

ATGTCCAGCG GGTCCTGGAG GCTGCTAACC TCTTCCAGGT GTGTGAACAA ACTGGCTCAG 
TGCTCTTCTC TGAAGCAGTT CCTGCGGATG GTGGATGCCT GTGCCAGCTT CCTCACTGAA 
GCCTTGAACC CAGAAAACTG CGTTGGAATA CTGAGGCTGG CTGACACACA CTCGCTGGAC 
AGTCTAAAGA AGCAGGTTCA GAGTTACATC ATTCAAAACT TTGTGCAGAT TCTGAACTCT 
GAGGAGTTTC TTGACCTGCC CGTGGACACT CTGCACCACA TCTTGAAGAG TGATGACCTT 
TACGTGACCG AGGAGGCTCA GGTGTTTGAG ACCGTGATGA GCTGGGTCCG GCACAAGCCA 
TCAGAACGAC TCTGCTTACT CCCCTATGTC CTCGAGAACG TGCGCTTACC GCTTCTGGAC 
CCGTGGTACT TTGTGGAGAC GGTGGAAGCA GATCCTCTCA TCAGGCAGTG CCCAGAGGTC 
TTCCCGCTGC TCCAGGAAGC CAGGATGTAC CACCTTTCTG GCAATGAGAT CATTTCGGAA 
CGCACCAAGC CCAGGATGCA TGAGTTCCAG TCTGAGGTGT TCATGATCAT TGGCGGCTGC 
ACGAAGGATG AACGGTTTGT GGCAGAGGTG ACCTGCCTGG ACCCCCTGAG GCGCAGCCGC 
CTGGAGGTGG CCAAGCTCCC GCTAACAGAG CATGAGCTGG AGAGTGAGAA TAAGAAGTGG 
GTGGAGTTTG CATGCGTGAC ATTGAAAAAT GAGGTCTACA TCTCAGGTGG CAAAGAAACA 
CAGCATGATG TTTGGAAATA TAATTCTTCG ATCAACAAGT GGATTCAGAT TGAGTATTTA 
AACATAGGCC GCTGGAGGCA TAAGATGGTG GTGTTGGGTG GCAAGGTCTA TGTGATCGGA 
GGCTTTGACG GCTTACAGAG AATCAACAAT GTGGAGACCT ACGACCCCTT TCACAACTGC 
TGGTCAGAGG CCGCACCCCT CCTTGTCCAT GTCAGTTCCT TTGCAGCCAC CAGCCATAAG 
AAGAAGCTGT ATGTGATCGG GGGAGGGCCC AATGGGAAAC TGGCCACAGA CAAGACTCAG 
TGTTATGACC CTTCCACCAA CAAGTGGAGT TTGAAGGCGG CCATGCCCGT GGAGGCTAAA 
TGCATCAATG CAGTGAGTTT CCGGGACCGC ATCTATGTCG TTGGTGGGGC CATGAGAGCG 
CTGTACGCCT ACAGCCCGCT GGAAGACAGC TGGTGCCTGG TGACCCAGCT CAGCCACGAG 
CGGGCCAGCT GCGGTATCGC GCCCTGCAAC AACCGGCTCT ACATCACCGG CGGGCGGGAC 
GAGAAGAACG AGGTTATCGC CACGGTGCTG TGCTGGGACC CCGAGGCCCA GAAACTGACA 
GAGGAGTGCG TCCTGCCCCG GGGCGTGTCG CACCACGGCA GCGTCACCAT CAGGAAGTCG 
TACACCCACA TCCGCAGGAT CGTGCCCGGA GCAGTGTCTG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLHL6 ( XM_011513274.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511576.1 Homo sapiens kelch like family member 6 (KLHL6), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu74105
Clone ID Related Accession (Same CDS sequence)	XM_011513274.2 , XM_011513274.3
Accession Version	XM_011513274.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	kelch-like protein 6 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011513274.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGATGG CAGGACAAAG GGGCGCCTGG ACCATGGGTG ATGTGGTCGA GAAGAGTTTG 
GAAGGGCCCC TGGCACCTTC TACAGATGAG CCCTCCCAGA AAACAGGAGA CTTGGTCGAG 
ATCTTAAATG GGGAAAAGGT CAAATTTGAC GACGCGGGAC TCTCCTTAAT TCTTCAGAAT 
GGCCTGGAAA CCCTGCGAAT GGAAAACGCT CTGACAGATG TCATCTTGTG TGTGGACATT 
CAGGAATTCT CCTGCCACCG CGTGGTGCTT GCCGCAGCCA GCAACTATTT CAGGGCCATG 
TTCTGCAACG ATTTAAAGGA AAAGTATGAG AAAAGGATCA TTATTAAAGG GGTTGATGCT 
GAGACCATGC ACACTCTGTT GGACTACACG TACACCAGCA AGGCGCTGAT CACCAAGCAG 
AATGTCCAGC GGGTCCTGGA GGCTGCTAAC CTCTTCCAGT TCCTGCGGAT GGTGGATGCC 
TGTGCCAGCT TCCTCACTGA AGCCTTGAAC CCAGAAAACT GCGTTGGAAT ACTGAGGCTG 
GCTGACACAC ACTCGCTGGA CAGTCTAAAG AAGCAGGTTC AGAGTTACAT CATTCAAAAC 
TTTGTGCAGA TTCTGAACTC TGAGGAGTTT CTTGACCTGC CCGTGGACAC TCTGCACCAC 
ATCTTGAAGA GTGATGACCT TTACGTGACC GAGGAGGCTC AGGTGTTTGA GACCGTGATG 
AGCTGGGTCC GGCACAAGCC ATCAGAACGA CTCTGCTTAC TCCCCTATGT CCTCGAGAAC 
GTGCGCTTAC CGCTTCTGGA CCCGTGGTAC TTTGTGGAGA CGGTGGAAGC AGATCCTCTC 
ATCAGGCAGT GCCCAGAGGT CTTCCCGCTG CTCCAGGAAG CCAGGATGTA CCACCTTTCT 
GGCAATGAGG TGGCAAAGAA ACACAGCATG ATGTTTGGAA ATATAATTCT TCGATCAACA 
AGTGGATTCA GATTGAGTAT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511576.1
CDS	60..1043
Translation	MLMAGQRGAWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNEVAKKHSMMFGNIILRSTSGFRLSI

Target ORF information:

RefSeq Version	XM_011513274.2
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 6 (KLHL6), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513274.2

ORF Insert Sequence:

ATGTTGATGG CAGGACAAAG GGGCGCCTGG ACCATGGGTG ATGTGGTCGA GAAGAGTTTG 
GAAGGGCCCC TGGCACCTTC TACAGATGAG CCCTCCCAGA AAACAGGAGA CTTGGTCGAG 
ATCTTAAATG GGGAAAAGGT CAAATTTGAC GACGCGGGAC TCTCCTTAAT TCTTCAGAAT 
GGCCTGGAAA CCCTGCGAAT GGAAAACGCT CTGACAGATG TCATCTTGTG TGTGGACATT 
CAGGAATTCT CCTGCCACCG CGTGGTGCTT GCCGCAGCCA GCAACTATTT CAGGGCCATG 
TTCTGCAACG ATTTAAAGGA AAAGTATGAG AAAAGGATCA TTATTAAAGG GGTTGATGCT 
GAGACCATGC ACACTCTGTT GGACTACACG TACACCAGCA AGGCGCTGAT CACCAAGCAG 
AATGTCCAGC GGGTCCTGGA GGCTGCTAAC CTCTTCCAGT TCCTGCGGAT GGTGGATGCC 
TGTGCCAGCT TCCTCACTGA AGCCTTGAAC CCAGAAAACT GCGTTGGAAT ACTGAGGCTG 
GCTGACACAC ACTCGCTGGA CAGTCTAAAG AAGCAGGTTC AGAGTTACAT CATTCAAAAC 
TTTGTGCAGA TTCTGAACTC TGAGGAGTTT CTTGACCTGC CCGTGGACAC TCTGCACCAC 
ATCTTGAAGA GTGATGACCT TTACGTGACC GAGGAGGCTC AGGTGTTTGA GACCGTGATG 
AGCTGGGTCC GGCACAAGCC ATCAGAACGA CTCTGCTTAC TCCCCTATGT CCTCGAGAAC 
GTGCGCTTAC CGCTTCTGGA CCCGTGGTAC TTTGTGGAGA CGGTGGAAGC AGATCCTCTC 
ATCAGGCAGT GCCCAGAGGT CTTCCCGCTG CTCCAGGAAG CCAGGATGTA CCACCTTTCT 
GGCAATGAGG TGGCAAAGAA ACACAGCATG ATGTTTGGAA ATATAATTCT TCGATCAACA 
AGTGGATTCA GATTGAGTAT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLHL6 ( XM_011513274.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511576.1 Homo sapiens kelch like family member 6 (KLHL6), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu74105
Clone ID Related Accession (Same CDS sequence)	XM_011513274.2 , XM_011513274.3
Accession Version	XM_011513274.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	kelch-like protein 6 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011513274.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGATGG CAGGACAAAG GGGCGCCTGG ACCATGGGTG ATGTGGTCGA GAAGAGTTTG 
GAAGGGCCCC TGGCACCTTC TACAGATGAG CCCTCCCAGA AAACAGGAGA CTTGGTCGAG 
ATCTTAAATG GGGAAAAGGT CAAATTTGAC GACGCGGGAC TCTCCTTAAT TCTTCAGAAT 
GGCCTGGAAA CCCTGCGAAT GGAAAACGCT CTGACAGATG TCATCTTGTG TGTGGACATT 
CAGGAATTCT CCTGCCACCG CGTGGTGCTT GCCGCAGCCA GCAACTATTT CAGGGCCATG 
TTCTGCAACG ATTTAAAGGA AAAGTATGAG AAAAGGATCA TTATTAAAGG GGTTGATGCT 
GAGACCATGC ACACTCTGTT GGACTACACG TACACCAGCA AGGCGCTGAT CACCAAGCAG 
AATGTCCAGC GGGTCCTGGA GGCTGCTAAC CTCTTCCAGT TCCTGCGGAT GGTGGATGCC 
TGTGCCAGCT TCCTCACTGA AGCCTTGAAC CCAGAAAACT GCGTTGGAAT ACTGAGGCTG 
GCTGACACAC ACTCGCTGGA CAGTCTAAAG AAGCAGGTTC AGAGTTACAT CATTCAAAAC 
TTTGTGCAGA TTCTGAACTC TGAGGAGTTT CTTGACCTGC CCGTGGACAC TCTGCACCAC 
ATCTTGAAGA GTGATGACCT TTACGTGACC GAGGAGGCTC AGGTGTTTGA GACCGTGATG 
AGCTGGGTCC GGCACAAGCC ATCAGAACGA CTCTGCTTAC TCCCCTATGT CCTCGAGAAC 
GTGCGCTTAC CGCTTCTGGA CCCGTGGTAC TTTGTGGAGA CGGTGGAAGC AGATCCTCTC 
ATCAGGCAGT GCCCAGAGGT CTTCCCGCTG CTCCAGGAAG CCAGGATGTA CCACCTTTCT 
GGCAATGAGG TGGCAAAGAA ACACAGCATG ATGTTTGGAA ATATAATTCT TCGATCAACA 
AGTGGATTCA GATTGAGTAT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511576.1
CDS	59..1042
Translation	MLMAGQRGAWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNEVAKKHSMMFGNIILRSTSGFRLSI

Target ORF information:

RefSeq Version	XM_011513274.3
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 6 (KLHL6), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513274.3

ORF Insert Sequence:

ATGTTGATGG CAGGACAAAG GGGCGCCTGG ACCATGGGTG ATGTGGTCGA GAAGAGTTTG 
GAAGGGCCCC TGGCACCTTC TACAGATGAG CCCTCCCAGA AAACAGGAGA CTTGGTCGAG 
ATCTTAAATG GGGAAAAGGT CAAATTTGAC GACGCGGGAC TCTCCTTAAT TCTTCAGAAT 
GGCCTGGAAA CCCTGCGAAT GGAAAACGCT CTGACAGATG TCATCTTGTG TGTGGACATT 
CAGGAATTCT CCTGCCACCG CGTGGTGCTT GCCGCAGCCA GCAACTATTT CAGGGCCATG 
TTCTGCAACG ATTTAAAGGA AAAGTATGAG AAAAGGATCA TTATTAAAGG GGTTGATGCT 
GAGACCATGC ACACTCTGTT GGACTACACG TACACCAGCA AGGCGCTGAT CACCAAGCAG 
AATGTCCAGC GGGTCCTGGA GGCTGCTAAC CTCTTCCAGT TCCTGCGGAT GGTGGATGCC 
TGTGCCAGCT TCCTCACTGA AGCCTTGAAC CCAGAAAACT GCGTTGGAAT ACTGAGGCTG 
GCTGACACAC ACTCGCTGGA CAGTCTAAAG AAGCAGGTTC AGAGTTACAT CATTCAAAAC 
TTTGTGCAGA TTCTGAACTC TGAGGAGTTT CTTGACCTGC CCGTGGACAC TCTGCACCAC 
ATCTTGAAGA GTGATGACCT TTACGTGACC GAGGAGGCTC AGGTGTTTGA GACCGTGATG 
AGCTGGGTCC GGCACAAGCC ATCAGAACGA CTCTGCTTAC TCCCCTATGT CCTCGAGAAC 
GTGCGCTTAC CGCTTCTGGA CCCGTGGTAC TTTGTGGAGA CGGTGGAAGC AGATCCTCTC 
ATCAGGCAGT GCCCAGAGGT CTTCCCGCTG CTCCAGGAAG CCAGGATGTA CCACCTTTCT 
GGCAATGAGG TGGCAAAGAA ACACAGCATG ATGTTTGGAA ATATAATTCT TCGATCAACA 
AGTGGATTCA GATTGAGTAT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prognostic value of the cancer oncogene Kelch-like 6 in gastric cancer.
The British journal of surgery104(13)1847-1856(2017 Dec)
Deng J,Guo J,Ma G,Zhang H,Sun D,Hou Y,Xie X,Guo X,Nie Y,Liang H

KLHL6 Is Preferentially Expressed in Germinal Center-Derived B-Cell Lymphomas.
American journal of clinical pathology148(6)465-476(2017 Nov)
Kunder CA,Roncador G,Advani RH,Gualco G,Bacchi CE,Sabile JM,Lossos IS,Nie K,Tibshirani RJ,Green MR,Alizadeh AA,Natkunam Y

Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation.
Journal of immunology (Baltimore, Md. : 1950)199(7)2408-2420(2017 Oct)
Bertocci B,Lecoeuche D,Sterlin D,K?hn J,Gaillard B,De Smet A,Lembo F,Bole-Feysot C,Cagnard N,Fadeev T,Dahan A,Weill JC,Reynaud CA

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

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KLHL6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム