ORAI1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ORAI1
Entrez Gene ID	84876
Full Name	ORAI calcium release-activated calcium modulator 1
Synonyms	CRACM1,IMD9,ORAT1,TAM2,TMEM142A
General protein information	Preferred Names ORAI calcium release-activated calcium modulator 1 Names calcium release-activated calcium channel protein 1 calcium release-activated calcium modulator 1 protein orai-1 transmembrane protein 142A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.31
Summary	The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011].
Disorder MIM:	610277
Disorder Html:	Immunodeficiency 9, 612782 (3); Myopathy, tubular aggregate, 2, 615883 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_032790.3	NP_116179.2	calcium release-activated calcium channel protein 1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	LOC566671	XP_695046.4
Xenopus tropicalis (tropical clawed frog)	orai2	XP_002937739.1
Canis lupus familiaris (dog)	ORAI1	XP_543386.4
	ORAI1	XP_001095850.1
Gallus gallus (chicken)	ORAI1	NP_001025829.1
Pan troglodytes (chimpanzee)	ORAI1	XP_528664.2
Bos taurus (cattle)	ORAI1	NP_001092472.1
Rattus norvegicus (Norway rat)	Orai1	NP_001014004.1
Homo sapiens (human)	ORAI1	NP_116179.2
Mus musculus (house mouse)	Orai1	NP_780632.1

Gene Ontology

The following ORAI1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ORAI1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu27317	NM_032790.3 Latest version!	Homo sapiens ORAI calcium release-activated calcium modulator 1 (ORAI1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ORAI1 ( NM_032790.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_116179.2 Homo sapiens ORAI calcium release-activated calcium modulator 1 (ORAI1), mRNA.

Price & Availability↑

CloneID	OHu27317
Clone ID Related Accession (Same CDS sequence)	NM_032790.3
Accession Version	NM_032790.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	calcium release-activated calcium channel protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC075831.1, BC013386.1, BG574128.1 and AK027372.1. This sequence is a reference standard in the RefSeqGene project. On Mar 27, 2008 this sequence version replaced NM_032790.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC075831.1, SRR1163657.291016.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCATCCGG AGCCCGCCCC GCCCCCGAGC CGCAGCAGTC CCGAGCTTCC CCCAAGCGGC 
GGCAGCACCA CCAGCGGCAG CCGCCGGAGC CGCCGCCGCA GCGGGGACGG GGAGCCCCCG 
GGGGCCCCGC CACCGCCGCC GTCCGCCGTC ACCTACCCGG ACTGGATCGG CCAGAGTTAC 
TCCGAGGTGA TGAGCCTCAA CGAGCACTCC ATGCAGGCGC TGTCCTGGCG CAAGCTCTAC 
TTGAGCCGCG CCAAGCTTAA AGCCTCCAGC CGGACCTCGG CTCTGCTCTC CGGCTTCGCC 
ATGGTGGCAA TGGTGGAGGT GCAGCTGGAC GCTGACCACG ACTACCCACC GGGGCTGCTC 
ATCGCCTTCA GTGCCTGCAC CACAGTGCTG GTGGCTGTGC ACCTGTTTGC GCTCATGATC 
AGCACCTGCA TCCTGCCCAA CATCGAGGCG GTGAGCAACG TGCACAATCT CAACTCGGTC 
AAGGAGTCCC CCCATGAGCG CATGCACCGC CACATCGAGC TGGCCTGGGC CTTCTCCACC 
GTCATCGGCA CGCTGCTCTT CCTAGCTGAG GTGGTGCTGC TCTGCTGGGT CAAGTTCTTG 
CCCCTCAAGA AGCAGCCAGG CCAGCCAAGG CCCACCAGCA AGCCCCCCGC CAGTGGCGCA 
GCAGCCAACG TCAGCACCAG CGGCATCACC CCGGGCCAGG CAGCTGCCAT CGCCTCGACC 
ACCATCATGG TGCCCTTCGG CCTGATCTTT ATCGTCTTCG CCGTCCACTT CTACCGCTCA 
CTGGTTAGCC ATAAGACTGA CCGACAGTTC CAGGAGCTCA ACGAGCTGGC GGAGTTTGCC 
CGCTTACAGG ACCAGCTGGA CCACAGAGGG GACCACCCCC TGACGCCCGG CAGCCACTAT 
GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116179.2
CDS	194..1099
Translation	MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA

Target ORF information:

RefSeq Version	NM_032790.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ORAI calcium release-activated calcium modulator 1 (ORAI1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032790.3

ORF Insert Sequence:

ATGCATCCGG AGCCCGCCCC GCCCCCGAGC CGCAGCAGTC CCGAGCTTCC CCCAAGCGGC 
GGCAGCACCA CCAGCGGCAG CCGCCGGAGC CGCCGCCGCA GCGGGGACGG GGAGCCCCCG 
GGGGCCCCGC CACCGCCGCC GTCCGCCGTC ACCTACCCGG ACTGGATCGG CCAGAGTTAC 
TCCGAGGTGA TGAGCCTCAA CGAGCACTCC ATGCAGGCGC TGTCCTGGCG CAAGCTCTAC 
TTGAGCCGCG CCAAGCTTAA AGCCTCCAGC CGGACCTCGG CTCTGCTCTC CGGCTTCGCC 
ATGGTGGCAA TGGTGGAGGT GCAGCTGGAC GCTGACCACG ACTACCCACC GGGGCTGCTC 
ATCGCCTTCA GTGCCTGCAC CACAGTGCTG GTGGCTGTGC ACCTGTTTGC GCTCATGATC 
AGCACCTGCA TCCTGCCCAA CATCGAGGCG GTGAGCAACG TGCACAATCT CAACTCGGTC 
AAGGAGTCCC CCCATGAGCG CATGCACCGC CACATCGAGC TGGCCTGGGC CTTCTCCACC 
GTCATCGGCA CGCTGCTCTT CCTAGCTGAG GTGGTGCTGC TCTGCTGGGT CAAGTTCTTG 
CCCCTCAAGA AGCAGCCAGG CCAGCCAAGG CCCACCAGCA AGCCCCCCGC CAGTGGCGCA 
GCAGCCAACG TCAGCACCAG CGGCATCACC CCGGGCCAGG CAGCTGCCAT CGCCTCGACC 
ACCATCATGG TGCCCTTCGG CCTGATCTTT ATCGTCTTCG CCGTCCACTT CTACCGCTCA 
CTGGTTAGCC ATAAGACTGA CCGACAGTTC CAGGAGCTCA ACGAGCTGGC GGAGTTTGCC 
CGCTTACAGG ACCAGCTGGA CCACAGAGGG GACCACCCCC TGACGCCCGG CAGCCACTAT 
GCCTAG