MOB3B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MOB3B
Entrez Gene ID	79817
Full Name	MOB kinase activator 3B
Synonyms	C9orf35,MOB1D,MOBKL2B
General protein information	Preferred Names MOB kinase activator 3B Names MOB kinase activator 3B MOB kinase activator-like 2B MOB1, Mps One Binder kinase activator-like 2B mob1 homolog 2b monopolar spindle 1 binding, MOB1, domain containing mps one binder kinase activator-like 2B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.2
Summary	The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the interferon kappa precursor (IFNK) gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	617652

mRNA and Protein(s)

mRNA	Protein	Name
NM_024761.5	NP_079037.3	MOB kinase activator 3B
NM_024761.4	NP_079037.3	MOB kinase activator 3B

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Mob3b	NP_835162.1
Gallus gallus (chicken)	MOBKL2B	XP_004949651.1
Pan troglodytes (chimpanzee)	MOBKL2B	XP_001154635.1
	MOB3B	XP_001104813.1
Bos taurus (cattle)	MOB3B	NP_001039956.1
Homo sapiens (human)	MOB3B	NP_079037.3
Canis lupus familiaris (dog)	MOB3B	XP_531966.3
Rattus norvegicus (Norway rat)	Mob3b	NP_001102440.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood.
Joung J, Engreitz JM, Konermann S, Abudayyeh OO, Verdine VK, Aguet F, Gootenberg JS, Sanjana NE, Wright JB, Fulco CP, Tseng YY, Yoon CH, Boehm JS, Lander ES, Zhang F
Nature548(7667)343-346(2017 08)

Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics.
Kim EA, Kim YH, Kang HW, Yoon HY, Kim WT, Kim YJ, Yun SJ, Moon SK, Choi YH, Kim IY, Lee SC, Kim WJ
Journal of Korean medical science30(7)937-42(2015 Jul)

A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer.
Kerns SL, Stone NN, Stock RG, Rath L, Ostrer H, Rosenstein BS
The Journal of urology190(1)102-8(2013 07)

New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes and immunity11(3)232-8(2010 Apr)

Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study.
Suarez-Gestal M, Perez-Pampin E, Calaza M, Gomez-Reino JJ, Gonzalez A
Arthritis research & therapy12(2)R72(2010)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

low levels of hMOB3B are closely associated with aggressive clinicopathologic features in patients with prostate cancer. The results suggest that hMOB3B may act as a tumor suppressor in human prostate cancer.
Title: Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

The following MOB3B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MOB3B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07673	NM_024761.5 Latest version!	Homo sapiens MOB kinase activator 3B (MOB3B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu07673	NM_024761.4	Homo sapiens MOB kinase activator 3B (MOB3B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MOB3B ( NM_024761.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_079037.3 Homo sapiens MOB kinase activator 3B (MOB3B), mRNA.

Price & Availability↑

CloneID	OHu07673
Clone ID Related Accession (Same CDS sequence)	NM_024761.5 , NM_024761.4
Accession Version	NM_024761.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	MOB kinase activator 3B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF511468.1, DB266074.1, AK023266.1, AL163192.6 and CN260547.1. On Nov 23, 2018 this sequence version replaced NM_024761.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.192260.1, SRR1803611.67106.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153946, SAMN03267773 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262244.6/ ENSP00000262244.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCATAG CCCTGAAGCA GGTATTCAAC AAGGACAAGA CCTTCCGACC CAAGAGGAAA 
TTTGAACCTG GCACACAGAG GTTTGAGCTG CACAAACGGG CTCAGGCATC CCTCAACTCG 
GGTGTGGACC TGAAGGCGGC TGTGCAGTTG CCCAGTGGGG AGGACCAGAA TGACTGGGTG 
GCAGTACATG TGGTGGACTT CTTCAATCGG ATCAACCTCA TCTATGGCAC CATCTGTGAG 
TTCTGCACCG AGCGGACCTG TCCTGTGATG TCAGGGGGCC CCAAATATGA GTATCGGTGG 
CAGGATGATC TCAAGTATAA GAAGCCAACA GCGCTGCCAG CTCCCCAGTA CATGAACCTT 
CTTATGGATT GGATTGAGGT TCAGATCAAC AACGAGGAAA TATTTCCAAC ATGCGTGGGT 
GTTCCCTTCC CAAAGAACTT CCTTCAGATC TGCAAGAAGA TCCTGTGCCG CCTTTTCCGG 
GTCTTTGTCC ACGTCTATAT CCACCACTTC GACCGGGTCA TTGTGATGGG TGCAGAGGCC 
CATGTCAACA CCTGCTACAA ACACTTCTAT TACTTTGTCA CAGAGATGAA CCTCATAGAC 
CGCAAGGAGC TAGAGCCTTT GAAAGAAATG ACGAGCAGGA TGTGTCACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079037.3
CDS	459..1109
Translation	MSIALKQVFNKDKTFRPKRKFEPGTQRFELHKRAQASLNSGVDLKAAVQLPSGEDQNDWVAVHVVDFFNRINLIYGTICEFCTERTCPVMSGGPKYEYRWQDDLKYKKPTALPAPQYMNLLMDWIEVQINNEEIFPTCVGVPFPKNFLQICKKILCRLFRVFVHVYIHHFDRVIVMGAEAHVNTCYKHFYYFVTEMNLIDRKELEPLKEMTSRMCH

Target ORF information:

RefSeq Version	NM_024761.5
Organism	Homo sapiens(human)
Definition	Homo sapiens MOB kinase activator 3B (MOB3B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024761.5

ORF Insert Sequence:

ATGTCCATAG CCCTGAAGCA GGTATTCAAC AAGGACAAGA CCTTCCGACC CAAGAGGAAA 
TTTGAACCTG GCACACAGAG GTTTGAGCTG CACAAACGGG CTCAGGCATC CCTCAACTCG 
GGTGTGGACC TGAAGGCGGC TGTGCAGTTG CCCAGTGGGG AGGACCAGAA TGACTGGGTG 
GCAGTACATG TGGTGGACTT CTTCAATCGG ATCAACCTCA TCTATGGCAC CATCTGTGAG 
TTCTGCACCG AGCGGACCTG TCCTGTGATG TCAGGGGGCC CCAAATATGA GTATCGGTGG 
CAGGATGATC TCAAGTATAA GAAGCCAACA GCGCTGCCAG CTCCCCAGTA CATGAACCTT 
CTTATGGATT GGATTGAGGT TCAGATCAAC AACGAGGAAA TATTTCCAAC ATGCGTGGGT 
GTTCCCTTCC CAAAGAACTT CCTTCAGATC TGCAAGAAGA TCCTGTGCCG CCTTTTCCGG 
GTCTTTGTCC ACGTCTATAT CCACCACTTC GACCGGGTCA TTGTGATGGG TGCAGAGGCC 
CATGTCAACA CCTGCTACAA ACACTTCTAT TACTTTGTCA CAGAGATGAA CCTCATAGAC 
CGCAAGGAGC TAGAGCCTTT GAAAGAAATG ACGAGCAGGA TGTGTCACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MOB3B ( NM_024761.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_079037.3 Homo sapiens MOB kinase activator 3B (MOB3B), mRNA.

Price & Availability↑

CloneID	OHu07673
Clone ID Related Accession (Same CDS sequence)	NM_024761.5 , NM_024761.4
Accession Version	NM_024761.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-29
Organism	Homo sapiens(human)
Product	MOB kinase activator 3B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF511468.1, DB266074.1, AK023266.1, AL163192.6 and CN260547.1. On Jan 22, 2011 this sequence version replaced NM_024761.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.192260.1, SRR1803614.222941.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153946, SAMN03267773 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCATAG CCCTGAAGCA GGTATTCAAC AAGGACAAGA CCTTCCGACC CAAGAGGAAA 
TTTGAACCTG GCACACAGAG GTTTGAGCTG CACAAACGGG CTCAGGCATC CCTCAACTCG 
GGTGTGGACC TGAAGGCGGC TGTGCAGTTG CCCAGTGGGG AGGACCAGAA TGACTGGGTG 
GCAGTACATG TGGTGGACTT CTTCAATCGG ATCAACCTCA TCTATGGCAC CATCTGTGAG 
TTCTGCACCG AGCGGACCTG TCCTGTGATG TCAGGGGGCC CCAAATATGA GTATCGGTGG 
CAGGATGATC TCAAGTATAA GAAGCCAACA GCGCTGCCAG CTCCCCAGTA CATGAACCTT 
CTTATGGATT GGATTGAGGT TCAGATCAAC AACGAGGAAA TATTTCCAAC ATGCGTGGGT 
GTTCCCTTCC CAAAGAACTT CCTTCAGATC TGCAAGAAGA TCCTGTGCCG CCTTTTCCGG 
GTCTTTGTCC ACGTCTATAT CCACCACTTC GACCGGGTCA TTGTGATGGG TGCAGAGGCC 
CATGTCAACA CCTGCTACAA ACACTTCTAT TACTTTGTCA CAGAGATGAA CCTCATAGAC 
CGCAAGGAGC TAGAGCCTTT GAAAGAAATG ACGAGCAGGA TGTGTCACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079037.3
CDS	497..1147
Translation	MSIALKQVFNKDKTFRPKRKFEPGTQRFELHKRAQASLNSGVDLKAAVQLPSGEDQNDWVAVHVVDFFNRINLIYGTICEFCTERTCPVMSGGPKYEYRWQDDLKYKKPTALPAPQYMNLLMDWIEVQINNEEIFPTCVGVPFPKNFLQICKKILCRLFRVFVHVYIHHFDRVIVMGAEAHVNTCYKHFYYFVTEMNLIDRKELEPLKEMTSRMCH

Target ORF information:

RefSeq Version	NM_024761.4
Organism	Homo sapiens(human)
Definition	Homo sapiens MOB kinase activator 3B (MOB3B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024761.4

ORF Insert Sequence:

ATGTCCATAG CCCTGAAGCA GGTATTCAAC AAGGACAAGA CCTTCCGACC CAAGAGGAAA 
TTTGAACCTG GCACACAGAG GTTTGAGCTG CACAAACGGG CTCAGGCATC CCTCAACTCG 
GGTGTGGACC TGAAGGCGGC TGTGCAGTTG CCCAGTGGGG AGGACCAGAA TGACTGGGTG 
GCAGTACATG TGGTGGACTT CTTCAATCGG ATCAACCTCA TCTATGGCAC CATCTGTGAG 
TTCTGCACCG AGCGGACCTG TCCTGTGATG TCAGGGGGCC CCAAATATGA GTATCGGTGG 
CAGGATGATC TCAAGTATAA GAAGCCAACA GCGCTGCCAG CTCCCCAGTA CATGAACCTT 
CTTATGGATT GGATTGAGGT TCAGATCAAC AACGAGGAAA TATTTCCAAC ATGCGTGGGT 
GTTCCCTTCC CAAAGAACTT CCTTCAGATC TGCAAGAAGA TCCTGTGCCG CCTTTTCCGG 
GTCTTTGTCC ACGTCTATAT CCACCACTTC GACCGGGTCA TTGTGATGGG TGCAGAGGCC 
CATGTCAACA CCTGCTACAA ACACTTCTAT TACTTTGTCA CAGAGATGAA CCTCATAGAC 
CGCAAGGAGC TAGAGCCTTT GAAAGAAATG ACGAGCAGGA TGTGTCACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood.
Nature548(7667)343-346(2017 08)
Joung J,Engreitz JM,Konermann S,Abudayyeh OO,Verdine VK,Aguet F,Gootenberg JS,Sanjana NE,Wright JB,Fulco CP,Tseng YY,Yoon CH,Boehm JS,Lander ES,Zhang F

Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics.
Journal of Korean medical science30(7)937-42(2015 Jul)
Kim EA,Kim YH,Kang HW,Yoon HY,Kim WT,Kim YJ,Yun SJ,Moon SK,Choi YH,Kim IY,Lee SC,Kim WJ

A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer.
The Journal of urology190(1)102-8(2013 07)
Kerns SL,Stone NN,Stock RG,Rath L,Ostrer H,Rosenstein BS

New genetic associations detected in a host response study to hepatitis B vaccine.
Genes and immunity11(3)232-8(2010 Apr)
Davila S,Froeling FE,Tan A,Bonnard C,Boland GJ,Snippe H,Hibberd ML,Seielstad M

Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study.
Arthritis research & therapy12(2)R72(2010)
Suarez-Gestal M,Perez-Pampin E,Calaza M,Gomez-Reino JJ,Gonzalez A