TMEM109 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMEM109
Entrez Gene ID	79073
Full Name	transmembrane protein 109
General protein information	Preferred Names transmembrane protein 109 Names transmembrane protein 109 mg23 mitsugumin-23
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_024092.2	NP_076997.1	transmembrane protein 109 precursor
NM_024092.3	NP_076997.1	transmembrane protein 109 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TMEM109	NP_076997.1
Pan troglodytes (chimpanzee)	TMEM109	XP_003951937.1
Canis lupus familiaris (dog)	TMEM109	XP_005631755.1
Rattus norvegicus (Norway rat)	Tmem109	NP_001007737.1
Mus musculus (house mouse)	Tmem109	NP_598903.1
Bos taurus (cattle)	TMEM109	NP_001039935.1

Gene Ontology
Bibliography

Related articles in PubMed

Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death.
Yamashita A, Taniwaki T, Kaikoi Y, Yamazaki T
FEBS letters587(9)1299-303(2013 May)

Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration.
Kato U, Inadome H, Yamamoto M, Emoto K, Kobayashi T, Umeda M
The Journal of biological chemistry288(7)4922-34(2013 Feb)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin23.
Yamazaki T, Sasaki N, Nishi M, Takeshima H
Biochemical and biophysical research communications392(2)196-200(2010 Feb)

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal of proteome research8(3)1304-14(2009 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MG23 plays a protective role against UVC by accumulating alphaBC in the close vicinity of the ER
Title: Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death.

MG23 is an essential component of ER-generated lethal signals provoked upon DNA damage, specifying cell fate under pathophysiological conditions.
Title: Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin23.

The following TMEM109 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM109 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09037	NM_024092.3 Latest version!	Homo sapiens transmembrane protein 109 (TMEM109), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09037	NM_024092.2	Homo sapiens transmembrane protein 109 (TMEM109), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMEM109 ( NM_024092.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_076997.1 Homo sapiens transmembrane protein 109 (TMEM109), mRNA.

Price & Availability↑

CloneID	OHu09037
Clone ID Related Accession (Same CDS sequence)	NM_024092.2 , NM_024092.3
Accession Version	NM_024092.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	transmembrane protein 109 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI463800.1, BC001309.1 and AF131803.1. On Dec 5, 2008 this sequence version replaced NM_024092.1. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.404596.1, SRR1660803.197189.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCCT CCAGCATCAG TTCACCATGG GGAAAGCATG TGTTCAAAGC CATTCTGATG 
GTCCTAGTGG CCCTTATCCT CCTCCACTCA GCATTGGCCC AGTCCCGTCG AGACTTTGCA 
CCACCAGGCC AACAGAAGAG AGAAGCCCCA GTTGATGTCT TGACCCAGAT AGGTCGATCT 
GTGCGAGGGA CACTGGATGC CTGGATTGGG CCAGAGACCA TGCACCTGGT GTCAGAGTCT 
TCGTCCCAAG TGTTGTGGGC CATCTCATCA GCCATTTCTG TGGCCTTCTT TGCTCTGTCT 
GGGATCGCCG CACAGCTGCT GAATGCCTTG GGACTAGCTG GTGATTACCT CGCCCAGGGC 
CTGAAGCTCA GCCCTGGCCA GGTCCAGACC TTCCTGCTGT GGGGAGCAGG GGCCCTGGTC 
GTCTACTGGC TGCTGTCTCT GCTCCTCGGC TTGGTCTTGG CCTTGCTGGG GCGGATCCTG 
TGGGGCCTGA AGCTTGTCAT CTTCCTGGCC GGCTTCGTGG CCCTGATGAG GTCGGTGCCT 
GACCCTTCCA CCCGGGCCCT GCTACTCCTG GCCTTGCTGA TCCTCTACGC CCTGCTGAGC 
CGGCTCACTG GCTCCCGAGC CTCTGGGGCC CAACTCGAGG CCAAGGTGCG AGGGCTGGAA 
CGCCAGGTGG AGGAGCTGCG CTGGCGCCAG AGGCGAGCGG CCAAGGGGGC CCGCAGTGTG 
GAGGAGGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076997.1
CDS	379..1110
Translation	MAASSISSPWGKHVFKAILMVLVALILLHSALAQSRRDFAPPGQQKREAPVDVLTQIGRSVRGTLDAWIGPETMHLVSESSSQVLWAISSAISVAFFALSGIAAQLLNALGLAGDYLAQGLKLSPGQVQTFLLWGAGALVVYWLLSLLLGLVLALLGRILWGLKLVIFLAGFVALMRSVPDPSTRALLLLALLILYALLSRLTGSRASGAQLEAKVRGLERQVEELRWRQRRAAKGARSVEEE

Target ORF information:

RefSeq Version	NM_024092.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 109 (TMEM109), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024092.2

ORF Insert Sequence:

ATGGCAGCCT CCAGCATCAG TTCACCATGG GGAAAGCATG TGTTCAAAGC CATTCTGATG 
GTCCTAGTGG CCCTTATCCT CCTCCACTCA GCATTGGCCC AGTCCCGTCG AGACTTTGCA 
CCACCAGGCC AACAGAAGAG AGAAGCCCCA GTTGATGTCT TGACCCAGAT AGGTCGATCT 
GTGCGAGGGA CACTGGATGC CTGGATTGGG CCAGAGACCA TGCACCTGGT GTCAGAGTCT 
TCGTCCCAAG TGTTGTGGGC CATCTCATCA GCCATTTCTG TGGCCTTCTT TGCTCTGTCT 
GGGATCGCCG CACAGCTGCT GAATGCCTTG GGACTAGCTG GTGATTACCT CGCCCAGGGC 
CTGAAGCTCA GCCCTGGCCA GGTCCAGACC TTCCTGCTGT GGGGAGCAGG GGCCCTGGTC 
GTCTACTGGC TGCTGTCTCT GCTCCTCGGC TTGGTCTTGG CCTTGCTGGG GCGGATCCTG 
TGGGGCCTGA AGCTTGTCAT CTTCCTGGCC GGCTTCGTGG CCCTGATGAG GTCGGTGCCT 
GACCCTTCCA CCCGGGCCCT GCTACTCCTG GCCTTGCTGA TCCTCTACGC CCTGCTGAGC 
CGGCTCACTG GCTCCCGAGC CTCTGGGGCC CAACTCGAGG CCAAGGTGCG AGGGCTGGAA 
CGCCAGGTGG AGGAGCTGCG CTGGCGCCAG AGGCGAGCGG CCAAGGGGGC CCGCAGTGTG 
GAGGAGGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM109 ( NM_024092.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_076997.1 Homo sapiens transmembrane protein 109 (TMEM109), mRNA.

Price & Availability↑

CloneID	OHu09037
Clone ID Related Accession (Same CDS sequence)	NM_024092.2 , NM_024092.3
Accession Version	NM_024092.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	transmembrane protein 109 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI463800.1, BC001309.1 and AF131803.1. On Nov 23, 2018 this sequence version replaced NM_024092.2. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.38900.1, SRR3476690.1155531.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000227525.8/ ENSP00000227525.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGCCT CCAGCATCAG TTCACCATGG GGAAAGCATG TGTTCAAAGC CATTCTGATG 
GTCCTAGTGG CCCTTATCCT CCTCCACTCA GCATTGGCCC AGTCCCGTCG AGACTTTGCA 
CCACCAGGCC AACAGAAGAG AGAAGCCCCA GTTGATGTCT TGACCCAGAT AGGTCGATCT 
GTGCGAGGGA CACTGGATGC CTGGATTGGG CCAGAGACCA TGCACCTGGT GTCAGAGTCT 
TCGTCCCAAG TGTTGTGGGC CATCTCATCA GCCATTTCTG TGGCCTTCTT TGCTCTGTCT 
GGGATCGCCG CACAGCTGCT GAATGCCTTG GGACTAGCTG GTGATTACCT CGCCCAGGGC 
CTGAAGCTCA GCCCTGGCCA GGTCCAGACC TTCCTGCTGT GGGGAGCAGG GGCCCTGGTC 
GTCTACTGGC TGCTGTCTCT GCTCCTCGGC TTGGTCTTGG CCTTGCTGGG GCGGATCCTG 
TGGGGCCTGA AGCTTGTCAT CTTCCTGGCC GGCTTCGTGG CCCTGATGAG GTCGGTGCCT 
GACCCTTCCA CCCGGGCCCT GCTACTCCTG GCCTTGCTGA TCCTCTACGC CCTGCTGAGC 
CGGCTCACTG GCTCCCGAGC CTCTGGGGCC CAACTCGAGG CCAAGGTGCG AGGGCTGGAA 
CGCCAGGTGG AGGAGCTGCG CTGGCGCCAG AGGCGAGCGG CCAAGGGGGC CCGCAGTGTG 
GAGGAGGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076997.1
CDS	120..851
Translation	MAASSISSPWGKHVFKAILMVLVALILLHSALAQSRRDFAPPGQQKREAPVDVLTQIGRSVRGTLDAWIGPETMHLVSESSSQVLWAISSAISVAFFALSGIAAQLLNALGLAGDYLAQGLKLSPGQVQTFLLWGAGALVVYWLLSLLLGLVLALLGRILWGLKLVIFLAGFVALMRSVPDPSTRALLLLALLILYALLSRLTGSRASGAQLEAKVRGLERQVEELRWRQRRAAKGARSVEEE

Target ORF information:

RefSeq Version	NM_024092.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 109 (TMEM109), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024092.3

ORF Insert Sequence:

ATGGCAGCCT CCAGCATCAG TTCACCATGG GGAAAGCATG TGTTCAAAGC CATTCTGATG 
GTCCTAGTGG CCCTTATCCT CCTCCACTCA GCATTGGCCC AGTCCCGTCG AGACTTTGCA 
CCACCAGGCC AACAGAAGAG AGAAGCCCCA GTTGATGTCT TGACCCAGAT AGGTCGATCT 
GTGCGAGGGA CACTGGATGC CTGGATTGGG CCAGAGACCA TGCACCTGGT GTCAGAGTCT 
TCGTCCCAAG TGTTGTGGGC CATCTCATCA GCCATTTCTG TGGCCTTCTT TGCTCTGTCT 
GGGATCGCCG CACAGCTGCT GAATGCCTTG GGACTAGCTG GTGATTACCT CGCCCAGGGC 
CTGAAGCTCA GCCCTGGCCA GGTCCAGACC TTCCTGCTGT GGGGAGCAGG GGCCCTGGTC 
GTCTACTGGC TGCTGTCTCT GCTCCTCGGC TTGGTCTTGG CCTTGCTGGG GCGGATCCTG 
TGGGGCCTGA AGCTTGTCAT CTTCCTGGCC GGCTTCGTGG CCCTGATGAG GTCGGTGCCT 
GACCCTTCCA CCCGGGCCCT GCTACTCCTG GCCTTGCTGA TCCTCTACGC CCTGCTGAGC 
CGGCTCACTG GCTCCCGAGC CTCTGGGGCC CAACTCGAGG CCAAGGTGCG AGGGCTGGAA 
CGCCAGGTGG AGGAGCTGCG CTGGCGCCAG AGGCGAGCGG CCAAGGGGGC CCGCAGTGTG 
GAGGAGGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death.
FEBS letters587(9)1299-303(2013 May)
Yamashita A,Taniwaki T,Kaikoi Y,Yamazaki T

Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration.
The Journal of biological chemistry288(7)4922-34(2013 Feb)
Kato U,Inadome H,Yamamoto M,Emoto K,Kobayashi T,Umeda M

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin23.
Biochemical and biophysical research communications392(2)196-200(2010 Feb)
Yamazaki T,Sasaki N,Nishi M,Takeshima H

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Journal of proteome research8(3)1304-14(2009 Mar)
Gonzalez-Begne M,Lu B,Han X,Hagen FK,Hand AR,Melvin JE,Yates JR