TIMP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TIMP3
Entrez Gene ID	7078
Full Name	TIMP metallopeptidase inhibitor 3
Synonyms	HSMRK222,K222,K222TA2,SFD
General protein information	Preferred Names TIMP metallopeptidase inhibitor 3 Names metalloproteinase inhibitor 3 MIG-5 protein TIMP-3 protein MIG-5 tissue inhibitor of metalloproteinases 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q12.3
Summary	This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008].
Disorder MIM:	188826
Disorder Html:	Sorsby fundus dystrophy, 136900 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000362.4	NP_000353.1	metalloproteinase inhibitor 3 precursor
NM_000362.5	NP_000353.1	metalloproteinase inhibitor 3 precursor

Pathways from BioSystems

Homologies

	TIMP3	NP_001028128.1
Canis lupus familiaris (dog)	TIMP3	XP_538410.2
Rattus norvegicus (Norway rat)	Timp3	NP_037018.2
Gallus gallus (chicken)	TIMP3	NP_990818.1
Homo sapiens (human)	TIMP3	NP_000353.1
Pan troglodytes (chimpanzee)	TIMP3	XP_515097.2
Bos taurus (cattle)	TIMP3	NP_776898.2
Mus musculus (house mouse)	Timp3	NP_035725.1
Xenopus tropicalis (tropical clawed frog)	timp3	XP_002940366.1

Gene Ontology

The following TIMP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TIMP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18861	NM_000362.5 Latest version!	Homo sapiens TIMP metallopeptidase inhibitor 3 (TIMP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18861	NM_000362.4	Homo sapiens TIMP metallopeptidase inhibitor 3 (TIMP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TIMP3 ( NM_000362.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000353.1 Homo sapiens TIMP metallopeptidase inhibitor 3 (TIMP3), mRNA.

Price & Availability↑

CloneID	OHu18861
Clone ID Related Accession (Same CDS sequence)	NM_000362.4 , NM_000362.5
Accession Version	NM_000362.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	metalloproteinase inhibitor 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL023282.1, BC014277.2, Z98256.1 and AF035289.1. This sequence is a reference standard in the RefSeqGene project. On Sep 20, 2005 this sequence version replaced NM_000362.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U14394.1, SRR1660805.2148.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACCCCTT GGCTCGGGCT CATCGTGCTC CTGGGCAGCT GGAGCCTGGG GGACTGGGGC 
GCCGAGGCGT GCACATGCTC GCCCAGCCAC CCCCAGGACG CCTTCTGCAA CTCCGACATC 
GTGATCCGGG CCAAGGTGGT GGGGAAGAAG CTGGTAAAGG AGGGGCCCTT CGGCACGCTG 
GTCTACACCA TCAAGCAGAT GAAGATGTAC CGAGGCTTCA CCAAGATGCC CCATGTGCAG 
TACATCCATA CGGAAGCTTC CGAGAGTCTC TGTGGCCTTA AGCTGGAGGT CAACAAGTAC 
CAGTACCTGC TGACAGGTCG CGTCTATGAT GGCAAGATGT ACACGGGGCT GTGCAACTTC 
GTGGAGAGGT GGGACCAGCT CACCCTCTCC CAGCGCAAGG GGCTGAACTA TCGGTATCAC 
CTGGGTTGTA ACTGCAAGAT CAAGTCCTGC TACTACCTGC CTTGCTTTGT GACTTCCAAG 
AACGAGTGTC TCTGGACCGA CATGCTCTCC AATTTCGGTT ACCCTGGCTA CCAGTCCAAA 
CACTACGCCT GCATCCGGCA GAAGGGCGGC TACTGCAGCT GGTACCGAGG ATGGGCCCCC 
CCGGATAAAA GCATCATCAA TGCCACAGAC CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000353.1
CDS	1187..1822
Translation	MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEGPFGTLVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVNKYQYLLTGRVYDGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP

Target ORF information:

RefSeq Version	NM_000362.4
Organism	Homo sapiens(human)
Definition	Homo sapiens TIMP metallopeptidase inhibitor 3 (TIMP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000362.4

ORF Insert Sequence:

ATGACCCCTT GGCTCGGGCT CATCGTGCTC CTGGGCAGCT GGAGCCTGGG GGACTGGGGC 
GCCGAGGCGT GCACATGCTC GCCCAGCCAC CCCCAGGACG CCTTCTGCAA CTCCGACATC 
GTGATCCGGG CCAAGGTGGT GGGGAAGAAG CTGGTAAAGG AGGGGCCCTT CGGCACGCTG 
GTCTACACCA TCAAGCAGAT GAAGATGTAC CGAGGCTTCA CCAAGATGCC CCATGTGCAG 
TACATCCATA CGGAAGCTTC CGAGAGTCTC TGTGGCCTTA AGCTGGAGGT CAACAAGTAC 
CAGTACCTGC TGACAGGTCG CGTCTATGAT GGCAAGATGT ACACGGGGCT GTGCAACTTC 
GTGGAGAGGT GGGACCAGCT CACCCTCTCC CAGCGCAAGG GGCTGAACTA TCGGTATCAC 
CTGGGTTGTA ACTGCAAGAT CAAGTCCTGC TACTACCTGC CTTGCTTTGT GACTTCCAAG 
AACGAGTGTC TCTGGACCGA CATGCTCTCC AATTTCGGTT ACCCTGGCTA CCAGTCCAAA 
CACTACGCCT GCATCCGGCA GAAGGGCGGC TACTGCAGCT GGTACCGAGG ATGGGCCCCC 
CCGGATAAAA GCATCATCAA TGCCACAGAC CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIMP3 ( NM_000362.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000353.1 Homo sapiens TIMP metallopeptidase inhibitor 3 (TIMP3), mRNA.

Price & Availability↑

CloneID	OHu18861
Clone ID Related Accession (Same CDS sequence)	NM_000362.4 , NM_000362.5
Accession Version	NM_000362.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-22
Organism	Homo sapiens(human)
Product	metalloproteinase inhibitor 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL023282.1, BC014277.2, Z98256.1 and AF035289.1. This sequence is a reference standard in the RefSeqGene project. On Dec 23, 2019 this sequence version replaced NM_000362.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U14394.1, DRR138527.734011.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACCCCTT GGCTCGGGCT CATCGTGCTC CTGGGCAGCT GGAGCCTGGG GGACTGGGGC 
GCCGAGGCGT GCACATGCTC GCCCAGCCAC CCCCAGGACG CCTTCTGCAA CTCCGACATC 
GTGATCCGGG CCAAGGTGGT GGGGAAGAAG CTGGTAAAGG AGGGGCCCTT CGGCACGCTG 
GTCTACACCA TCAAGCAGAT GAAGATGTAC CGAGGCTTCA CCAAGATGCC CCATGTGCAG 
TACATCCATA CGGAAGCTTC CGAGAGTCTC TGTGGCCTTA AGCTGGAGGT CAACAAGTAC 
CAGTACCTGC TGACAGGTCG CGTCTATGAT GGCAAGATGT ACACGGGGCT GTGCAACTTC 
GTGGAGAGGT GGGACCAGCT CACCCTCTCC CAGCGCAAGG GGCTGAACTA TCGGTATCAC 
CTGGGTTGTA ACTGCAAGAT CAAGTCCTGC TACTACCTGC CTTGCTTTGT GACTTCCAAG 
AACGAGTGTC TCTGGACCGA CATGCTCTCC AATTTCGGTT ACCCTGGCTA CCAGTCCAAA 
CACTACGCCT GCATCCGGCA GAAGGGCGGC TACTGCAGCT GGTACCGAGG ATGGGCCCCC 
CCGGATAAAA GCATCATCAA TGCCACAGAC CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000353.1
CDS	298..933
Translation	MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEGPFGTLVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVNKYQYLLTGRVYDGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP

Target ORF information:

RefSeq Version	NM_000362.5
Organism	Homo sapiens(human)
Definition	Homo sapiens TIMP metallopeptidase inhibitor 3 (TIMP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000362.5

ORF Insert Sequence:

ATGACCCCTT GGCTCGGGCT CATCGTGCTC CTGGGCAGCT GGAGCCTGGG GGACTGGGGC 
GCCGAGGCGT GCACATGCTC GCCCAGCCAC CCCCAGGACG CCTTCTGCAA CTCCGACATC 
GTGATCCGGG CCAAGGTGGT GGGGAAGAAG CTGGTAAAGG AGGGGCCCTT CGGCACGCTG 
GTCTACACCA TCAAGCAGAT GAAGATGTAC CGAGGCTTCA CCAAGATGCC CCATGTGCAG 
TACATCCATA CGGAAGCTTC CGAGAGTCTC TGTGGCCTTA AGCTGGAGGT CAACAAGTAC 
CAGTACCTGC TGACAGGTCG CGTCTATGAT GGCAAGATGT ACACGGGGCT GTGCAACTTC 
GTGGAGAGGT GGGACCAGCT CACCCTCTCC CAGCGCAAGG GGCTGAACTA TCGGTATCAC 
CTGGGTTGTA ACTGCAAGAT CAAGTCCTGC TACTACCTGC CTTGCTTTGT GACTTCCAAG 
AACGAGTGTC TCTGGACCGA CATGCTCTCC AATTTCGGTT ACCCTGGCTA CCAGTCCAAA 
CACTACGCCT GCATCCGGCA GAAGGGCGGC TACTGCAGCT GGTACCGAGG ATGGGCCCCC 
CCGGATAAAA GCATCATCAA TGCCACAGAC CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.