CCL19 cDNA ORF clone, Homo sapiens(human)

CCL19/CCR7 contributes to the pathogenesis of endometriosis via PI3K/Akt pathway by regulating the proliferation and invasion of ESCs.
Diao R, Wei W, Zhao J, Tian F, Cai X, Duan YG
American journal of reproductive immunology (New York, N.Y. : 1989)78(5)(2017 Nov)

findings connect NOTCH1, DUSP22, and CCL19-driven chemotaxis within a single functional network, suggesting that modulation of the homing process may provide a relevant contribution to the unfavorable prognosis associated with NOTCH1 mutations in CLL.
Title: Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22.

CCL19 is significantly overexpressed in patients with unstable carotid atherosclerotic plaques and may be a possible novel biomarker for identifying high-risk patients in whom more urgent intervention may be indicated.
Title: Gene and Protein Expression of Chemokine (C-C-Motif) Ligand 19 is Upregulated in Unstable Carotid Atherosclerotic Plaques.

Deletion of this extended C-terminus reduces CCL21's affinity for heparin and transferring the CCL21 C-terminus to CCL19 enhances heparin binding mainly through non-specific, electrostatic interactions
Title: Transferring the C-terminus of the chemokine CCL21 to CCL19 confers enhanced heparin binding.

The solution structure of CCL19 is reported. It contains a canonical chemokine domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19 and binding is competitive.
Title: Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.

observed significantly higher concentrations of IL-8 (p < 0.001), MCP-1 (p = 0.014), and MIP-3beta (p = 0.022) in the PF of women with endometriosis than in the controls.
Title: Addition of MCP-1 and MIP-3? to the IL-8 appraisal in peritoneal fluid enhances the probability of identifying women with endometriosis.