PPM1H cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PPM1H
Entrez Gene ID	57460
Full Name	protein phosphatase, Mg2+/Mn2+ dependent 1H
Synonyms	ARHCL1,NERPP-2C,URCC2
General protein information	Preferred Names protein phosphatase, Mg2+/Mn2+ dependent 1H Names protein phosphatase 1H neurite extension-related protein phosphatase related to PP2C protein phosphatase 1H (PP2C domain containing) ras homolog gene family, member C like 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q14.1-q14.2
Disorder MIM:	616016

mRNA and Protein(s)

mRNA	Protein	Name
XM_017019676.2	XP_016875165.1	protein phosphatase 1H isoform X2
XM_011538579.1	XP_011536881.1	protein phosphatase 1H isoform X3
XM_011538578.2	XP_011536880.1	protein phosphatase 1H isoform X1
XM_017019676.1	XP_016875165.1	protein phosphatase 1H isoform X2
NM_020700.1	NP_065751.1	protein phosphatase 1H
NM_020700.2	NP_065751.1	protein phosphatase 1H

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ppm1h	NP_001258008.1
Bos taurus (cattle)	PPM1H	NP_001179978.1
Caenorhabditis elegans (roundworm)	C42C1.2	NP_502329.3
Xenopus tropicalis (tropical clawed frog)	ppm1h	NP_001017305.1
Danio rerio (zebrafish)	ppm1h	NP_001070923.1
Homo sapiens (human)	PPM1H	NP_065751.1
Pan troglodytes (chimpanzee)	PPM1H	XP_509184.2
	PPM1H	XP_001116776.1
Canis lupus familiaris (dog)	PPM1H	XP_531656.3
Mus musculus (house mouse)	Ppm1h	NP_001103688.1
Gallus gallus (chicken)	PPM1H	XP_004937615.1

Gene Ontology
Bibliography

Related articles in PubMed

Effect of PPM1H on malignant phenotype of human pancreatic cancer cells.
Zhu H, Qin H, Li DM, Liu J, Zhao Q
Oncology reports36(5)2926-2934(2016 Nov)

Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H.
Shen T, Sun C, Zhang Z, Xu N, Duan X, Feng XH, Lin X
Cell research24(6)727-41(2014 Jun)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

PPM1H is a p27 phosphatase implicated in trastuzumab resistance.
Lee-Hoeflich ST, Pham TQ, Dowbenko D, Munroe X, Lee J, Li L, Zhou W, Haverty PM, Pujara K, Stinson J, Chan SM, Eastham-Anderson J, Pandita A, Seshagiri S, Hoeflich KP, Turashvili G, Gelmon KA, Aparicio SA, Davis DP, Sliwkowski MX, Stern HM
Cancer discovery1(4)326-37(2011 Sep)

Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
Croteau-Chonka DC, Marvelle AF, Lange EM, Lee NR, Adair LS, Lange LA, Mohlke KL
Obesity (Silver Spring, Md.)19(5)1019-27(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PPM1H may be a new tumor-suppressor factor for pancreatic cancer and provides new insight into molecular targets for gene therapy of pancreatic cancer
Title: Effect of PPM1H on malignant phenotype of human pancreatic cancer cells.

PPM1H acts as a gatekeeper to prevent excessive BMP signaling through dephosphorylation and subsequent nuclear exclusion of P-Smad1/5/8 proteins.
Title: Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H.

Knockdown of the serine/threonine phosphatase PPM1H confers trastuzumab resistance via reduction in protein levels of the tumor suppressor p27.
Title: PPM1H is a p27 phosphatase implicated in trastuzumab resistance.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Case-control genome-wide association study of attention-deficit/hyperactivity disorder.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus.

The following PPM1H gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPM1H cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03422	NM_020700.2 Latest version!	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu70473	XM_011538579.1 Latest version!	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu70472	XM_011538578.2 Latest version!	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu84002	XM_017019676.2 Latest version!	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu84002	XM_017019676.1	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu03422	NM_020700.1	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PPM1H ( NM_020700.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_065751.1 Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), mRNA.

Price & Availability↑

CloneID	OHu03422
Clone ID Related Accession (Same CDS sequence)	NM_020700.1 , NM_020700.2
Accession Version	NM_020700.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1545bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein phosphatase 1H
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA396561.1, AB032983.1 and AC048341.22. On or before Jun 29, 2007 this sequence version replaced XM_350880.5, XM_939302.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AB084258.1, SRR1660805.19399.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGCTCACTC GAGTGAAATC TGCCGTGGCC AATTTCATGG GCGGCATCAT GGCTGGCAGC 
TCAGGCTCCG AGCACGGCGG CGGCAGCTGC GGAGGCTCGG ACCTGCCCCT GCGTTTCCCC 
TACGGGCGGC CAGAGTTCCT GGGGCTGTCT CAGGACGAGG TGGAGTGCAG CGCCGACCAC 
ATCGCCCGCC CCATCCTCAT CCTCAAGGAG ACTCGGCGGC TGCCCTGGGC CACTGGCTAC 
GCAGAGGTTA TCAATGCCGG GAAGAGCACA CACAATGAAG ACCAAGCCAG CTGTGAGGTG 
CTCACTGTGA AGAAGAAGGC AGGGGCCGTG ACCTCAACCC CAAACAGGAA CTCATCCAAG 
AGACGGTCCT CCCTTCCCAA TGGGGAAGGG CTGCAGCTGA AGGAGAACTC GGAATCCGAG 
GGTGTTTCCT GCCACTATTG GTCGCTGTTT GACGGGCACG CGGGGTCCGG GGCCGCGGTG 
GTGGCGTCAC GCCTGCTGCA GCACCACATC ACGGAGCAGC TGCAGGACAT CGTGGACATC 
CTGAAGAACT CCGCCGTCCT GCCCCCTACC TGCCTGGGGG AGGAGCCTGA GAACACGCCC 
GCCAACAGCC GGACTCTGAC CCGGGCAGCC TCCCTGCGCG GAGGGGTGGG GGCCCCGGGC 
TCCCCCAGCA CGCCCCCCAC ACGCTTCTTT ACCGAGAAGA AGATTCCCCA TGAGTGCCTG 
GTCATCGGAG CGCTTGAAAG TGCATTCAAG GAAATGGACC TACAGATAGA ACGAGAGAGG 
AGTTCATATA ATATATCTGG TGGCTGCACG GCCCTCATTG TGATTTGCCT TTTGGGGAAG 
CTGTATGTTG CAAATGCTGG GGATAGCAGG GCCATAATCA TCAGAAATGG AGAAATTATC 
CCCATGTCTT CAGAATTTAC CCCCGAGACG GAGCGCCAGC GACTTCAGTA CCTGGCATTC 
ATGCAGCCTC ACTTGCTGGG AAATGAGTTC ACACATTTGG AGTTTCCAAG GAGAGTACAG 
AGAAAGGAGC TTGGAAAGAA GATGCTCTAC AGGGACTTTA ATATGACAGG CTGGGCATAC 
AAAACCATTG AGGATGAGGA CTTGAAGTTC CCCCTTATAT ATGGAGAAGG CAAGAAGGCC 
CGGGTAATGG CAACTATTGG AGTGACCAGG GGACTTGGGG ACCATGACCT GAAGGTGCAT 
GACTCCAACA TCTACATTAA ACCATTCCTG TCTTCAGCTC CAGAGGTAAG AATCTACGAT 
CTTTCAAAAT ATGATCATGG ATCAGATGAT GTGCTGATCT TGGCCACTGA TGGACTCTGG 
GACGTTTTAT CAAATGAAGA AGTAGCAGAA GCAATCACTC AGTTTCTTCC TAACTGTGAT 
CCAGATGATC CTCACAGGTA CACACTGGCA GCTCAGGACC TGGTGATGCG TGCCCGGGGT 
GTGCTGAAGG ACAGAGGATG GCGGATATCT AATGACCGAC TGGGCTCAGG AGACGACATT 
TCTGTATATG TCATTCCTTT AATACATGGA AACAAGCTGT CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065751.1
CDS	150..1694
Translation	MLTRVKSAVANFMGGIMAGSSGSEHGGGSCGGSDLPLRFPYGRPEFLGLSQDEVECSADHIARPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLTVKKKAGAVTSTPNRNSSKRRSSLPNGEGLQLKENSESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIHGNKLS

Target ORF information:

RefSeq Version	NM_020700.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020700.1

ORF Insert Sequence:

ATGCTCACTC GAGTGAAATC TGCCGTGGCC AATTTCATGG GCGGCATCAT GGCTGGCAGC 
TCAGGCTCCG AGCACGGCGG CGGCAGCTGC GGAGGCTCGG ACCTGCCCCT GCGTTTCCCC 
TACGGGCGGC CAGAGTTCCT GGGGCTGTCT CAGGACGAGG TGGAGTGCAG CGCCGACCAC 
ATCGCCCGCC CCATCCTCAT CCTCAAGGAG ACTCGGCGGC TGCCCTGGGC CACTGGCTAC 
GCAGAGGTTA TCAATGCCGG GAAGAGCACA CACAATGAAG ACCAAGCCAG CTGTGAGGTG 
CTCACTGTGA AGAAGAAGGC AGGGGCCGTG ACCTCAACCC CAAACAGGAA CTCATCCAAG 
AGACGGTCCT CCCTTCCCAA TGGGGAAGGG CTGCAGCTGA AGGAGAACTC GGAATCCGAG 
GGTGTTTCCT GCCACTATTG GTCGCTGTTT GACGGGCACG CGGGGTCCGG GGCCGCGGTG 
GTGGCGTCAC GCCTGCTGCA GCACCACATC ACGGAGCAGC TGCAGGACAT CGTGGACATC 
CTGAAGAACT CCGCCGTCCT GCCCCCTACC TGCCTGGGGG AGGAGCCTGA GAACACGCCC 
GCCAACAGCC GGACTCTGAC CCGGGCAGCC TCCCTGCGCG GAGGGGTGGG GGCCCCGGGC 
TCCCCCAGCA CGCCCCCCAC ACGCTTCTTT ACCGAGAAGA AGATTCCCCA TGAGTGCCTG 
GTCATCGGAG CGCTTGAAAG TGCATTCAAG GAAATGGACC TACAGATAGA ACGAGAGAGG 
AGTTCATATA ATATATCTGG TGGCTGCACG GCCCTCATTG TGATTTGCCT TTTGGGGAAG 
CTGTATGTTG CAAATGCTGG GGATAGCAGG GCCATAATCA TCAGAAATGG AGAAATTATC 
CCCATGTCTT CAGAATTTAC CCCCGAGACG GAGCGCCAGC GACTTCAGTA CCTGGCATTC 
ATGCAGCCTC ACTTGCTGGG AAATGAGTTC ACACATTTGG AGTTTCCAAG GAGAGTACAG 
AGAAAGGAGC TTGGAAAGAA GATGCTCTAC AGGGACTTTA ATATGACAGG CTGGGCATAC 
AAAACCATTG AGGATGAGGA CTTGAAGTTC CCCCTTATAT ATGGAGAAGG CAAGAAGGCC 
CGGGTAATGG CAACTATTGG AGTGACCAGG GGACTTGGGG ACCATGACCT GAAGGTGCAT 
GACTCCAACA TCTACATTAA ACCATTCCTG TCTTCAGCTC CAGAGGTAAG AATCTACGAT 
CTTTCAAAAT ATGATCATGG ATCAGATGAT GTGCTGATCT TGGCCACTGA TGGACTCTGG 
GACGTTTTAT CAAATGAAGA AGTAGCAGAA GCAATCACTC AGTTTCTTCC TAACTGTGAT 
CCAGATGATC CTCACAGGTA CACACTGGCA GCTCAGGACC TGGTGATGCG TGCCCGGGGT 
GTGCTGAAGG ACAGAGGATG GCGGATATCT AATGACCGAC TGGGCTCAGG AGACGACATT 
TCTGTATATG TCATTCCTTT AATACATGGA AACAAGCTGT CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPM1H ( NM_020700.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_065751.1 Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), mRNA.

Price & Availability↑

CloneID	OHu03422
Clone ID Related Accession (Same CDS sequence)	NM_020700.1 , NM_020700.2
Accession Version	NM_020700.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1545bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	protein phosphatase 1H
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC078814.23, DA396561.1, AB032983.1 and AC048341.22. On Nov 23, 2018 this sequence version replaced NM_020700.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AB084258.1, SRR1660805.19399.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000228705.7/ ENSP00000228705.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCACTC GAGTGAAATC TGCCGTGGCC AATTTCATGG GCGGCATCAT GGCTGGCAGC 
TCAGGCTCCG AGCACGGCGG CGGCAGCTGC GGAGGCTCGG ACCTGCCCCT GCGTTTCCCC 
TACGGGCGGC CAGAGTTCCT GGGGCTGTCT CAGGACGAGG TGGAGTGCAG CGCCGACCAC 
ATCGCCCGCC CCATCCTCAT CCTCAAGGAG ACTCGGCGGC TGCCCTGGGC CACTGGCTAC 
GCAGAGGTTA TCAATGCCGG GAAGAGCACA CACAATGAAG ACCAAGCCAG CTGTGAGGTG 
CTCACTGTGA AGAAGAAGGC AGGGGCCGTG ACCTCAACCC CAAACAGGAA CTCATCCAAG 
AGACGGTCCT CCCTTCCCAA TGGGGAAGGG CTGCAGCTGA AGGAGAACTC GGAATCCGAG 
GGTGTTTCCT GCCACTATTG GTCGCTGTTT GACGGGCACG CGGGGTCCGG GGCCGCGGTG 
GTGGCGTCAC GCCTGCTGCA GCACCACATC ACGGAGCAGC TGCAGGACAT CGTGGACATC 
CTGAAGAACT CCGCCGTCCT GCCCCCTACC TGCCTGGGGG AGGAGCCTGA GAACACGCCC 
GCCAACAGCC GGACTCTGAC CCGGGCAGCC TCCCTGCGCG GAGGGGTGGG GGCCCCGGGC 
TCCCCCAGCA CGCCCCCCAC ACGCTTCTTT ACCGAGAAGA AGATTCCCCA TGAGTGCCTG 
GTCATCGGAG CGCTTGAAAG TGCATTCAAG GAAATGGACC TACAGATAGA ACGAGAGAGG 
AGTTCATATA ATATATCTGG TGGCTGCACG GCCCTCATTG TGATTTGCCT TTTGGGGAAG 
CTGTATGTTG CAAATGCTGG GGATAGCAGG GCCATAATCA TCAGAAATGG AGAAATTATC 
CCCATGTCTT CAGAATTTAC CCCCGAGACG GAGCGCCAGC GACTTCAGTA CCTGGCATTC 
ATGCAGCCTC ACTTGCTGGG AAATGAGTTC ACACATTTGG AGTTTCCAAG GAGAGTACAG 
AGAAAGGAGC TTGGAAAGAA GATGCTCTAC AGGGACTTTA ATATGACAGG CTGGGCATAC 
AAAACCATTG AGGATGAGGA CTTGAAGTTC CCCCTTATAT ATGGAGAAGG CAAGAAGGCC 
CGGGTAATGG CAACTATTGG AGTGACCAGG GGACTTGGGG ACCATGACCT GAAGGTGCAT 
GACTCCAACA TCTACATTAA ACCATTCCTG TCTTCAGCTC CAGAGGTAAG AATCTACGAT 
CTTTCAAAAT ATGATCATGG ATCAGATGAT GTGCTGATCT TGGCCACTGA TGGACTCTGG 
GACGTTTTAT CAAATGAAGA AGTAGCAGAA GCAATCACTC AGTTTCTTCC TAACTGTGAT 
CCAGATGATC CTCACAGGTA CACACTGGCA GCTCAGGACC TGGTGATGCG TGCCCGGGGT 
GTGCTGAAGG ACAGAGGATG GCGGATATCT AATGACCGAC TGGGCTCAGG AGACGACATT 
TCTGTATATG TCATTCCTTT AATACATGGA AACAAGCTGT CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065751.1
CDS	415..1959
Translation	MLTRVKSAVANFMGGIMAGSSGSEHGGGSCGGSDLPLRFPYGRPEFLGLSQDEVECSADHIARPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLTVKKKAGAVTSTPNRNSSKRRSSLPNGEGLQLKENSESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIHGNKLS

Target ORF information:

RefSeq Version	NM_020700.2
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020700.2

ORF Insert Sequence:

ATGCTCACTC GAGTGAAATC TGCCGTGGCC AATTTCATGG GCGGCATCAT GGCTGGCAGC 
TCAGGCTCCG AGCACGGCGG CGGCAGCTGC GGAGGCTCGG ACCTGCCCCT GCGTTTCCCC 
TACGGGCGGC CAGAGTTCCT GGGGCTGTCT CAGGACGAGG TGGAGTGCAG CGCCGACCAC 
ATCGCCCGCC CCATCCTCAT CCTCAAGGAG ACTCGGCGGC TGCCCTGGGC CACTGGCTAC 
GCAGAGGTTA TCAATGCCGG GAAGAGCACA CACAATGAAG ACCAAGCCAG CTGTGAGGTG 
CTCACTGTGA AGAAGAAGGC AGGGGCCGTG ACCTCAACCC CAAACAGGAA CTCATCCAAG 
AGACGGTCCT CCCTTCCCAA TGGGGAAGGG CTGCAGCTGA AGGAGAACTC GGAATCCGAG 
GGTGTTTCCT GCCACTATTG GTCGCTGTTT GACGGGCACG CGGGGTCCGG GGCCGCGGTG 
GTGGCGTCAC GCCTGCTGCA GCACCACATC ACGGAGCAGC TGCAGGACAT CGTGGACATC 
CTGAAGAACT CCGCCGTCCT GCCCCCTACC TGCCTGGGGG AGGAGCCTGA GAACACGCCC 
GCCAACAGCC GGACTCTGAC CCGGGCAGCC TCCCTGCGCG GAGGGGTGGG GGCCCCGGGC 
TCCCCCAGCA CGCCCCCCAC ACGCTTCTTT ACCGAGAAGA AGATTCCCCA TGAGTGCCTG 
GTCATCGGAG CGCTTGAAAG TGCATTCAAG GAAATGGACC TACAGATAGA ACGAGAGAGG 
AGTTCATATA ATATATCTGG TGGCTGCACG GCCCTCATTG TGATTTGCCT TTTGGGGAAG 
CTGTATGTTG CAAATGCTGG GGATAGCAGG GCCATAATCA TCAGAAATGG AGAAATTATC 
CCCATGTCTT CAGAATTTAC CCCCGAGACG GAGCGCCAGC GACTTCAGTA CCTGGCATTC 
ATGCAGCCTC ACTTGCTGGG AAATGAGTTC ACACATTTGG AGTTTCCAAG GAGAGTACAG 
AGAAAGGAGC TTGGAAAGAA GATGCTCTAC AGGGACTTTA ATATGACAGG CTGGGCATAC 
AAAACCATTG AGGATGAGGA CTTGAAGTTC CCCCTTATAT ATGGAGAAGG CAAGAAGGCC 
CGGGTAATGG CAACTATTGG AGTGACCAGG GGACTTGGGG ACCATGACCT GAAGGTGCAT 
GACTCCAACA TCTACATTAA ACCATTCCTG TCTTCAGCTC CAGAGGTAAG AATCTACGAT 
CTTTCAAAAT ATGATCATGG ATCAGATGAT GTGCTGATCT TGGCCACTGA TGGACTCTGG 
GACGTTTTAT CAAATGAAGA AGTAGCAGAA GCAATCACTC AGTTTCTTCC TAACTGTGAT 
CCAGATGATC CTCACAGGTA CACACTGGCA GCTCAGGACC TGGTGATGCG TGCCCGGGGT 
GTGCTGAAGG ACAGAGGATG GCGGATATCT AATGACCGAC TGGGCTCAGG AGACGACATT 
TCTGTATATG TCATTCCTTT AATACATGGA AACAAGCTGT CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPM1H ( XM_011538579.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011536881.1 Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu70473
Clone ID Related Accession (Same CDS sequence)	XM_011538579.1
Accession Version	XM_011538579.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein phosphatase 1H isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACCTAC AGATAGAACG AGAGAGGAGT TCATATAATA TATCTGGTGG CTGCACGGCC 
CTCATTGTGA TTTGCCTTTT GGGGAAGCTG TATGTTGCAA ATGCTGGGGA TAGCAGGGCC 
ATAATCATCA GAAATGGAGA AATTATCCCC ATGTCTTCAG AATTTACCCC CGAGACGGAG 
CGCCAGCGAC TTCAGTACCT GGCATTCATG CAGCCTCACT TGCTGGGAAA TGAGTTCACA 
CATTTGGAGT TTCCAAGGAG AGTACAGAGA AAGGAGCTTG GAAAGAAGAT GCTCTACAGG 
GACTTTAATA TGACAGGCTG GGCATACAAA ACCATTGAGG ATGAGGACTT GAAGTTCCCC 
CTTATATATG GAGAAGGCAA GAAGGCCCGG GTAATGGCAA CTATTGGAGT GACCAGGGGA 
CTTGGGGACC ATGACCTGAA GGTGCATGAC TCCAACATCT ACATTAAACC ATTCCTGTCT 
TCAGCTCCAG AGGTAAGAAT CTACGATCTT TCAAAATATG ATCATGGATC AGATGATGTG 
CTGATCTTGG CCACTGATGG ACTCTGGGAC GTTTTATCAA ATGAAGAAGT AGCAGAAGCA 
ATCACTCAGT TTCTTCCTAA CTGTGATCCA GATGATCCTC ACAGGTACAC ACTGGCAGCT 
CAGGACCTGG TGATGCGTGC CCGGGGTGTG CTGAAGGACA GAGGATGGCG GATATCTAAT 
GACCGACTGG GCTCAGGAGA CGACATTTCT GTATATGTCA TTCCTTTAAT ACATGGAAAC 
AAGCTGTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011536881.1
CDS	591..1382
Translation	MDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIHGNKLS

Target ORF information:

RefSeq Version	XM_011538579.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011538579.1

ORF Insert Sequence:

ATGGACCTAC AGATAGAACG AGAGAGGAGT TCATATAATA TATCTGGTGG CTGCACGGCC 
CTCATTGTGA TTTGCCTTTT GGGGAAGCTG TATGTTGCAA ATGCTGGGGA TAGCAGGGCC 
ATAATCATCA GAAATGGAGA AATTATCCCC ATGTCTTCAG AATTTACCCC CGAGACGGAG 
CGCCAGCGAC TTCAGTACCT GGCATTCATG CAGCCTCACT TGCTGGGAAA TGAGTTCACA 
CATTTGGAGT TTCCAAGGAG AGTACAGAGA AAGGAGCTTG GAAAGAAGAT GCTCTACAGG 
GACTTTAATA TGACAGGCTG GGCATACAAA ACCATTGAGG ATGAGGACTT GAAGTTCCCC 
CTTATATATG GAGAAGGCAA GAAGGCCCGG GTAATGGCAA CTATTGGAGT GACCAGGGGA 
CTTGGGGACC ATGACCTGAA GGTGCATGAC TCCAACATCT ACATTAAACC ATTCCTGTCT 
TCAGCTCCAG AGGTAAGAAT CTACGATCTT TCAAAATATG ATCATGGATC AGATGATGTG 
CTGATCTTGG CCACTGATGG ACTCTGGGAC GTTTTATCAA ATGAAGAAGT AGCAGAAGCA 
ATCACTCAGT TTCTTCCTAA CTGTGATCCA GATGATCCTC ACAGGTACAC ACTGGCAGCT 
CAGGACCTGG TGATGCGTGC CCGGGGTGTG CTGAAGGACA GAGGATGGCG GATATCTAAT 
GACCGACTGG GCTCAGGAGA CGACATTTCT GTATATGTCA TTCCTTTAAT ACATGGAAAC 
AAGCTGTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPM1H ( XM_011538578.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011536880.1 Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu70472
Clone ID Related Accession (Same CDS sequence)	XM_011538578.2
Accession Version	XM_011538578.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein phosphatase 1H isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011538578.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCACTGC GCCTGGGAGC TTGTGTCCGA TTCCGGGAGG TGGCCGTGTC CGAGTGCGTG 
GTTGTACATT TCCGAAGGTC TCAGTTTCTC TCACTTTCAG CCCGCGAGTT CCTCCGCTTC 
TCCTTTAGCA GGGTTATCAA TGCCGGGAAG AGCACACACA ATGAAGACCA AGCCAGCTGT 
GAGGTGCTCA CTGTGAAGAA GAAGGCAGGG GCCGTGACCT CAACCCCAAA CAGGAACTCA 
TCCAAGAGAC GGTCCTCCCT TCCCAATGGG GAAGGGCTGC AGCTGAAGGA GAACTCGGAA 
TCCGAGGGTG TTTCCTGCCA CTATTGGTCG CTGTTTGACG GGCACGCGGG GTCCGGGGCC 
GCGGTGGTGG CGTCACGCCT GCTGCAGCAC CACATCACGG AGCAGCTGCA GGACATCGTG 
GACATCCTGA AGAACTCCGC CGTCCTGCCC CCTACCTGCC TGGGGGAGGA GCCTGAGAAC 
ACGCCCGCCA ACAGCCGGAC TCTGACCCGG GCAGCCTCCC TGCGCGGAGG GGTGGGGGCC 
CCGGGCTCCC CCAGCACGCC CCCCACACGC TTCTTTACCG AGAAGAAGAT TCCCCATGAG 
TGCCTGGTCA TCGGAGCGCT TGAAAGTGCA TTCAAGGAAA TGGACCTACA GATAGAACGA 
GAGAGGAGTT CATATAATAT ATCTGGTGGC TGCACGGCCC TCATTGTGAT TTGCCTTTTG 
GGGAAGCTGT ATGTTGCAAA TGCTGGGGAT AGCAGGGCCA TAATCATCAG AAATGGAGAA 
ATTATCCCCA TGTCTTCAGA ATTTACCCCC GAGACGGAGC GCCAGCGACT TCAGTACCTG 
GCATTCATGC AGCCTCACTT GCTGGGAAAT GAGTTCACAC ATTTGGAGTT TCCAAGGAGA 
GTACAGAGAA AGGAGCTTGG AAAGAAGATG CTCTACAGGG ACTTTAATAT GACAGGCTGG 
GCATACAAAA CCATTGAGGA TGAGGACTTG AAGTTCCCCC TTATATATGG AGAAGGCAAG 
AAGGCCCGGG TAATGGCAAC TATTGGAGTG ACCAGGGGAC TTGGGGACCA TGACCTGAAG 
GTGCATGACT CCAACATCTA CATTAAACCA TTCCTGTCTT CAGCTCCAGA GGTAAGAATC 
TACGATCTTT CAAAATATGA TCATGGATCA GATGATGTGC TGATCTTGGC CACTGATGGA 
CTCTGGGACG TTTTATCAAA TGAAGAAGTA GCAGAAGCAA TCACTCAGTT TCTTCCTAAC 
TGTGATCCAG ATGATCCTCA CAGGTACACA CTGGCAGCTC AGGACCTGGT GATGCGTGCC 
CGGGGTGTGC TGAAGGACAG AGGATGGCGG ATATCTAATG ACCGACTGGG CTCAGGAGAC 
GACATTTCTG TATATGTCAT TCCTTTAATA CATGGAAACA AGCTGTCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011536880.1
CDS	400..1830
Translation	MSLRLGACVRFREVAVSECVVVHFRRSQFLSLSAREFLRFSFSRVINAGKSTHNEDQASCEVLTVKKKAGAVTSTPNRNSSKRRSSLPNGEGLQLKENSESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIHGNKLS

Target ORF information:

RefSeq Version	XM_011538578.2
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011538578.2

ORF Insert Sequence:

ATGTCACTGC GCCTGGGAGC TTGTGTCCGA TTCCGGGAGG TGGCCGTGTC CGAGTGCGTG 
GTTGTACATT TCCGAAGGTC TCAGTTTCTC TCACTTTCAG CCCGCGAGTT CCTCCGCTTC 
TCCTTTAGCA GGGTTATCAA TGCCGGGAAG AGCACACACA ATGAAGACCA AGCCAGCTGT 
GAGGTGCTCA CTGTGAAGAA GAAGGCAGGG GCCGTGACCT CAACCCCAAA CAGGAACTCA 
TCCAAGAGAC GGTCCTCCCT TCCCAATGGG GAAGGGCTGC AGCTGAAGGA GAACTCGGAA 
TCCGAGGGTG TTTCCTGCCA CTATTGGTCG CTGTTTGACG GGCACGCGGG GTCCGGGGCC 
GCGGTGGTGG CGTCACGCCT GCTGCAGCAC CACATCACGG AGCAGCTGCA GGACATCGTG 
GACATCCTGA AGAACTCCGC CGTCCTGCCC CCTACCTGCC TGGGGGAGGA GCCTGAGAAC 
ACGCCCGCCA ACAGCCGGAC TCTGACCCGG GCAGCCTCCC TGCGCGGAGG GGTGGGGGCC 
CCGGGCTCCC CCAGCACGCC CCCCACACGC TTCTTTACCG AGAAGAAGAT TCCCCATGAG 
TGCCTGGTCA TCGGAGCGCT TGAAAGTGCA TTCAAGGAAA TGGACCTACA GATAGAACGA 
GAGAGGAGTT CATATAATAT ATCTGGTGGC TGCACGGCCC TCATTGTGAT TTGCCTTTTG 
GGGAAGCTGT ATGTTGCAAA TGCTGGGGAT AGCAGGGCCA TAATCATCAG AAATGGAGAA 
ATTATCCCCA TGTCTTCAGA ATTTACCCCC GAGACGGAGC GCCAGCGACT TCAGTACCTG 
GCATTCATGC AGCCTCACTT GCTGGGAAAT GAGTTCACAC ATTTGGAGTT TCCAAGGAGA 
GTACAGAGAA AGGAGCTTGG AAAGAAGATG CTCTACAGGG ACTTTAATAT GACAGGCTGG 
GCATACAAAA CCATTGAGGA TGAGGACTTG AAGTTCCCCC TTATATATGG AGAAGGCAAG 
AAGGCCCGGG TAATGGCAAC TATTGGAGTG ACCAGGGGAC TTGGGGACCA TGACCTGAAG 
GTGCATGACT CCAACATCTA CATTAAACCA TTCCTGTCTT CAGCTCCAGA GGTAAGAATC 
TACGATCTTT CAAAATATGA TCATGGATCA GATGATGTGC TGATCTTGGC CACTGATGGA 
CTCTGGGACG TTTTATCAAA TGAAGAAGTA GCAGAAGCAA TCACTCAGTT TCTTCCTAAC 
TGTGATCCAG ATGATCCTCA CAGGTACACA CTGGCAGCTC AGGACCTGGT GATGCGTGCC 
CGGGGTGTGC TGAAGGACAG AGGATGGCGG ATATCTAATG ACCGACTGGG CTCAGGAGAC 
GACATTTCTG TATATGTCAT TCCTTTAATA CATGGAAACA AGCTGTCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPM1H ( XM_017019676.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016875165.1 Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu84002
Clone ID Related Accession (Same CDS sequence)	XM_017019676.2 , XM_017019676.1
Accession Version	XM_017019676.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1296bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein phosphatase 1H isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017019676.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCACTC GAGTGAAATC TGCCGTGGCC AATTTCATGG GCGGCATCAT GGCTGGCAGC 
TCAGGCTCCG AGCACGGCGG CGGCAGCTGC GGAGGCTCGG ACCTGCCCCT GCGTTTCCCC 
TACGGGCGGC CAGAGTTCCT GGGGCTGTCT CAGGACGAGG TGGAGTGCAG CGCCGACCAC 
ATCGCCCGCC CCATCCTCAT CCTCAAGGAG ACTCGGCGGC TGCCCTGGGC CACTGGCTAC 
GCAGAGGTTA TCAATGCCGG GAAGAGCACA CACAATGAAG ACCAAGCCAG CTGTGAGGTG 
CTCACTGTGA AGAAGAAGGC AGGGGCCGTG ACCTCAACCC CAAACAGGAA CTCATCCAAG 
AGACGGTCCT CCCTTCCCAA TGGGGAAGGG CTGCAGCTGA AGGAGAACTC GGAATCCGAG 
GGTGTTTCCT GCCACTATTG GTCGCTGTTT GACGGGCACG CGGGGTCCGG GGCCGCGGTG 
GTGGCGTCAC GCCTGCTGCA GCACCACATC ACGGAGCAGC TGCAGGACAT CGTGGACATC 
CTGAAGAACT CCGCCGTCCT GCCCCCTACC TGCCTGGGGG AGGAGCCTGA GAACACGCCC 
GCCAACAGCC GGACTCTGAC CCGGGCAGCC TCCCTGCGCG GAGGGGTGGG GGCCCCGGGC 
TCCCCCAGCA CGCCCCCCAC ACGCTTCTTT ACCGAGAAGA AGATTCCCCA TGAGTGCCTG 
GTCATCGGAG CGCTTGAAAG TGCATTCAAG GAAATGGACC TACAGATAGA ACGAGAGAGG 
AGTTCATATA ATATATCTGG TGGCTGCACG GCCCTCATTG TGATTTGCCT TTTGGGGAAG 
CTGTATGTTG CAAATGCTGG GGATAGCAGG GCCATAATCA TCAGAAATGG AGAAATTATC 
CCCATGTCTT CAGAATTTAC CCCCGAGACG GAGCGCCAGC GACTTCAGTA CCTGGCATTC 
ATGCAGCCTC ACTTGCTGGG AAATGAGTTC ACACATTTGG AGTTTCCAAG GAGAGTACAG 
AGAAAGGAGC TTGGAAAGAA GATGCTCTAC AGGGACTTTA ATATGACAGG CTGGGCATAC 
AAAACCATTG AGGATGAGGA CTTGAAGTTC CCCCTTATAT ATGGAGAAGG CAAGAAGGCC 
CGGGTAATGG CAACTATTGG AGTGACCAGG GGACTTGGGG ACCATGACCT GAAGGTGCAT 
GACTCCAACA TCTACATTAA ACCATTCCTG TCTTCAGCTC CAGAGCCCAA TGTTCTGAAG 
TCCTGTGATC AGTTACATCA AGGCCTGATG CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016875165.1
CDS	150..1445
Translation	MLTRVKSAVANFMGGIMAGSSGSEHGGGSCGGSDLPLRFPYGRPEFLGLSQDEVECSADHIARPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLTVKKKAGAVTSTPNRNSSKRRSSLPNGEGLQLKENSESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEPNVLKSCDQLHQGLML

Target ORF information:

RefSeq Version	XM_017019676.2
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017019676.2

ORF Insert Sequence:

ATGCTCACTC GAGTGAAATC TGCCGTGGCC AATTTCATGG GCGGCATCAT GGCTGGCAGC 
TCAGGCTCCG AGCACGGCGG CGGCAGCTGC GGAGGCTCGG ACCTGCCCCT GCGTTTCCCC 
TACGGGCGGC CAGAGTTCCT GGGGCTGTCT CAGGACGAGG TGGAGTGCAG CGCCGACCAC 
ATCGCCCGCC CCATCCTCAT CCTCAAGGAG ACTCGGCGGC TGCCCTGGGC CACTGGCTAC 
GCAGAGGTTA TCAATGCCGG GAAGAGCACA CACAATGAAG ACCAAGCCAG CTGTGAGGTG 
CTCACTGTGA AGAAGAAGGC AGGGGCCGTG ACCTCAACCC CAAACAGGAA CTCATCCAAG 
AGACGGTCCT CCCTTCCCAA TGGGGAAGGG CTGCAGCTGA AGGAGAACTC GGAATCCGAG 
GGTGTTTCCT GCCACTATTG GTCGCTGTTT GACGGGCACG CGGGGTCCGG GGCCGCGGTG 
GTGGCGTCAC GCCTGCTGCA GCACCACATC ACGGAGCAGC TGCAGGACAT CGTGGACATC 
CTGAAGAACT CCGCCGTCCT GCCCCCTACC TGCCTGGGGG AGGAGCCTGA GAACACGCCC 
GCCAACAGCC GGACTCTGAC CCGGGCAGCC TCCCTGCGCG GAGGGGTGGG GGCCCCGGGC 
TCCCCCAGCA CGCCCCCCAC ACGCTTCTTT ACCGAGAAGA AGATTCCCCA TGAGTGCCTG 
GTCATCGGAG CGCTTGAAAG TGCATTCAAG GAAATGGACC TACAGATAGA ACGAGAGAGG 
AGTTCATATA ATATATCTGG TGGCTGCACG GCCCTCATTG TGATTTGCCT TTTGGGGAAG 
CTGTATGTTG CAAATGCTGG GGATAGCAGG GCCATAATCA TCAGAAATGG AGAAATTATC 
CCCATGTCTT CAGAATTTAC CCCCGAGACG GAGCGCCAGC GACTTCAGTA CCTGGCATTC 
ATGCAGCCTC ACTTGCTGGG AAATGAGTTC ACACATTTGG AGTTTCCAAG GAGAGTACAG 
AGAAAGGAGC TTGGAAAGAA GATGCTCTAC AGGGACTTTA ATATGACAGG CTGGGCATAC 
AAAACCATTG AGGATGAGGA CTTGAAGTTC CCCCTTATAT ATGGAGAAGG CAAGAAGGCC 
CGGGTAATGG CAACTATTGG AGTGACCAGG GGACTTGGGG ACCATGACCT GAAGGTGCAT 
GACTCCAACA TCTACATTAA ACCATTCCTG TCTTCAGCTC CAGAGCCCAA TGTTCTGAAG 
TCCTGTGATC AGTTACATCA AGGCCTGATG CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPM1H ( XM_017019676.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016875165.1 Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu84002
Clone ID Related Accession (Same CDS sequence)	XM_017019676.2 , XM_017019676.1
Accession Version	XM_017019676.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1296bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	protein phosphatase 1H isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCACTC GAGTGAAATC TGCCGTGGCC AATTTCATGG GCGGCATCAT GGCTGGCAGC 
TCAGGCTCCG AGCACGGCGG CGGCAGCTGC GGAGGCTCGG ACCTGCCCCT GCGTTTCCCC 
TACGGGCGGC CAGAGTTCCT GGGGCTGTCT CAGGACGAGG TGGAGTGCAG CGCCGACCAC 
ATCGCCCGCC CCATCCTCAT CCTCAAGGAG ACTCGGCGGC TGCCCTGGGC CACTGGCTAC 
GCAGAGGTTA TCAATGCCGG GAAGAGCACA CACAATGAAG ACCAAGCCAG CTGTGAGGTG 
CTCACTGTGA AGAAGAAGGC AGGGGCCGTG ACCTCAACCC CAAACAGGAA CTCATCCAAG 
AGACGGTCCT CCCTTCCCAA TGGGGAAGGG CTGCAGCTGA AGGAGAACTC GGAATCCGAG 
GGTGTTTCCT GCCACTATTG GTCGCTGTTT GACGGGCACG CGGGGTCCGG GGCCGCGGTG 
GTGGCGTCAC GCCTGCTGCA GCACCACATC ACGGAGCAGC TGCAGGACAT CGTGGACATC 
CTGAAGAACT CCGCCGTCCT GCCCCCTACC TGCCTGGGGG AGGAGCCTGA GAACACGCCC 
GCCAACAGCC GGACTCTGAC CCGGGCAGCC TCCCTGCGCG GAGGGGTGGG GGCCCCGGGC 
TCCCCCAGCA CGCCCCCCAC ACGCTTCTTT ACCGAGAAGA AGATTCCCCA TGAGTGCCTG 
GTCATCGGAG CGCTTGAAAG TGCATTCAAG GAAATGGACC TACAGATAGA ACGAGAGAGG 
AGTTCATATA ATATATCTGG TGGCTGCACG GCCCTCATTG TGATTTGCCT TTTGGGGAAG 
CTGTATGTTG CAAATGCTGG GGATAGCAGG GCCATAATCA TCAGAAATGG AGAAATTATC 
CCCATGTCTT CAGAATTTAC CCCCGAGACG GAGCGCCAGC GACTTCAGTA CCTGGCATTC 
ATGCAGCCTC ACTTGCTGGG AAATGAGTTC ACACATTTGG AGTTTCCAAG GAGAGTACAG 
AGAAAGGAGC TTGGAAAGAA GATGCTCTAC AGGGACTTTA ATATGACAGG CTGGGCATAC 
AAAACCATTG AGGATGAGGA CTTGAAGTTC CCCCTTATAT ATGGAGAAGG CAAGAAGGCC 
CGGGTAATGG CAACTATTGG AGTGACCAGG GGACTTGGGG ACCATGACCT GAAGGTGCAT 
GACTCCAACA TCTACATTAA ACCATTCCTG TCTTCAGCTC CAGAGCCCAA TGTTCTGAAG 
TCCTGTGATC AGTTACATCA AGGCCTGATG CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016875165.1
CDS	400..1695
Translation	MLTRVKSAVANFMGGIMAGSSGSEHGGGSCGGSDLPLRFPYGRPEFLGLSQDEVECSADHIARPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLTVKKKAGAVTSTPNRNSSKRRSSLPNGEGLQLKENSESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEPNVLKSCDQLHQGLML

Target ORF information:

RefSeq Version	XM_017019676.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017019676.1

ORF Insert Sequence:

ATGCTCACTC GAGTGAAATC TGCCGTGGCC AATTTCATGG GCGGCATCAT GGCTGGCAGC 
TCAGGCTCCG AGCACGGCGG CGGCAGCTGC GGAGGCTCGG ACCTGCCCCT GCGTTTCCCC 
TACGGGCGGC CAGAGTTCCT GGGGCTGTCT CAGGACGAGG TGGAGTGCAG CGCCGACCAC 
ATCGCCCGCC CCATCCTCAT CCTCAAGGAG ACTCGGCGGC TGCCCTGGGC CACTGGCTAC 
GCAGAGGTTA TCAATGCCGG GAAGAGCACA CACAATGAAG ACCAAGCCAG CTGTGAGGTG 
CTCACTGTGA AGAAGAAGGC AGGGGCCGTG ACCTCAACCC CAAACAGGAA CTCATCCAAG 
AGACGGTCCT CCCTTCCCAA TGGGGAAGGG CTGCAGCTGA AGGAGAACTC GGAATCCGAG 
GGTGTTTCCT GCCACTATTG GTCGCTGTTT GACGGGCACG CGGGGTCCGG GGCCGCGGTG 
GTGGCGTCAC GCCTGCTGCA GCACCACATC ACGGAGCAGC TGCAGGACAT CGTGGACATC 
CTGAAGAACT CCGCCGTCCT GCCCCCTACC TGCCTGGGGG AGGAGCCTGA GAACACGCCC 
GCCAACAGCC GGACTCTGAC CCGGGCAGCC TCCCTGCGCG GAGGGGTGGG GGCCCCGGGC 
TCCCCCAGCA CGCCCCCCAC ACGCTTCTTT ACCGAGAAGA AGATTCCCCA TGAGTGCCTG 
GTCATCGGAG CGCTTGAAAG TGCATTCAAG GAAATGGACC TACAGATAGA ACGAGAGAGG 
AGTTCATATA ATATATCTGG TGGCTGCACG GCCCTCATTG TGATTTGCCT TTTGGGGAAG 
CTGTATGTTG CAAATGCTGG GGATAGCAGG GCCATAATCA TCAGAAATGG AGAAATTATC 
CCCATGTCTT CAGAATTTAC CCCCGAGACG GAGCGCCAGC GACTTCAGTA CCTGGCATTC 
ATGCAGCCTC ACTTGCTGGG AAATGAGTTC ACACATTTGG AGTTTCCAAG GAGAGTACAG 
AGAAAGGAGC TTGGAAAGAA GATGCTCTAC AGGGACTTTA ATATGACAGG CTGGGCATAC 
AAAACCATTG AGGATGAGGA CTTGAAGTTC CCCCTTATAT ATGGAGAAGG CAAGAAGGCC 
CGGGTAATGG CAACTATTGG AGTGACCAGG GGACTTGGGG ACCATGACCT GAAGGTGCAT 
GACTCCAACA TCTACATTAA ACCATTCCTG TCTTCAGCTC CAGAGCCCAA TGTTCTGAAG 
TCCTGTGATC AGTTACATCA AGGCCTGATG CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effect of PPM1H on malignant phenotype of human pancreatic cancer cells.
Oncology reports36(5)2926-2934(2016 Nov)
Zhu H,Qin H,Li DM,Liu J,Zhao Q

Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H.
Cell research24(6)727-41(2014 Jun)
Shen T,Sun C,Zhang Z,Xu N,Duan X,Feng XH,Lin X

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

PPM1H is a p27 phosphatase implicated in trastuzumab resistance.
Cancer discovery1(4)326-37(2011 Sep)
Lee-Hoeflich ST,Pham TQ,Dowbenko D,Munroe X,Lee J,Li L,Zhou W,Haverty PM,Pujara K,Stinson J,Chan SM,Eastham-Anderson J,Pandita A,Seshagiri S,Hoeflich KP,Turashvili G,Gelmon KA,Aparicio SA,Davis DP,Sliwkowski MX,Stern HM

Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
Obesity (Silver Spring, Md.)19(5)1019-27(2011 May)
Croteau-Chonka DC,Marvelle AF,Lange EM,Lee NR,Adair LS,Lange LA,Mohlke KL

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PPM1H cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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