KCNC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNC1
Entrez Gene ID	3746
Full Name	potassium voltage-gated channel subfamily C member 1
Synonyms	EPM7,KV3.1,KV4,NGK2
General protein information	Preferred Names potassium voltage-gated channel subfamily C member 1 Names potassium voltage-gated channel subfamily C member 1 potassium channel, voltage gated Shaw related subfamily C, member 1 voltage-gated potassium channel protein KV3.1 voltage-gated potassium channel subunit Kv4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.1
Summary	This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both 'b' and 'alpha', while the shorter isoform has been called both 'a' and 'beta' (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014].
Disorder MIM:	176258
Disorder Html:	Epilepsy, progressive myoclonic 7, 616187 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011520080.2	XP_011518382.1	potassium voltage-gated channel subfamily C member 1 isoform X1
NM_001112741.1	NP_001106212.1	potassium voltage-gated channel subfamily C member 1 isoform 1
NM_001112741.2	NP_001106212.1	potassium voltage-gated channel subfamily C member 1 isoform 1
NM_004976.4	NP_004967.1	potassium voltage-gated channel subfamily C member 1 isoform 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KCNC1	NP_001003113.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008201	XP_317267.4
Homo sapiens (human)	KCNC1	NP_001106212.1
Gallus gallus (chicken)	KCNC1	XP_004941483.1
Pan troglodytes (chimpanzee)	KCNC1	XP_001172719.2
Rattus norvegicus (Norway rat)	Kcnc1	NP_036988.1
Caenorhabditis elegans (roundworm)	egl-36	NP_509795.1
Bos taurus (cattle)	KCNC1	NP_001106752.1
Danio rerio (zebrafish)	kcnc1a	NP_001122197.1
	KCNC1	XP_001087915.1
Mus musculus (house mouse)	Kcnc1	NP_001106210.1

Gene Ontology
Bibliography

Related articles in PubMed

Loss of Function of KCNC1 is associated with intellectual disability without seizures.
Poirier K, Viot G, Lombardi L, Jauny C, Billuart P, Bienvenu T
European journal of human genetics : EJHG25(5)560-564(2017 05)

Myoclonus epilepsy and ataxia due to KCNC1 mutation: Analysis of 20 cases and K
Oliver KL, Franceschetti S, Milligan CJ, Muona M, Mandelstam SA, Canafoglia L, Boguszewska-Chachulska AM, Korczyn AD, Bisulli F, Di Bonaventura C, Ragona F, Michelucci R, Ben-Zeev B, Straussberg R, Panzica F, Massano J, Friedman D, Crespel A, Engelsen BA, Andermann F, Andermann E, Spodar K, Lasek-Bal A, Riguzzi P, Pasini E, Tinuper P, Licchetta L, Gardella E, Lindenau M, Wulf A, M?ller RS, Benninger F, Afawi Z, Rubboli G, Reid CA, Maljevic S, Lerche H, Lehesjoki AE, Petrou S, Berkovic SF
Annals of neurology81(5)677-689(2017 May)

Myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK) is caused by heterozygous KCNC1 mutations.
Nascimento FA, Andrade DM
Epileptic disorders : international epilepsy journal with videotape18(S2)135-138(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A nonsense variant in KCNC1 gene was identified in three family members with intellectual disability without seizures.
Title: Loss of Function of KCNC1 is associated with intellectual disability without seizures.

KNCN1 p.R320H mutation causes MEAK syndrome.
Title: Myoclonus epilepsy and ataxia due to KCNC1 mutation: Analysis of 20 cases and K

reviews the phenotype/genotype of progressive myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK)associated with KCNC1 mutations [review]
Title: Myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK) is caused by heterozygous KCNC1 mutations.

KCNC1 produces a resurgent current during repolarization, ensuring enough repolarizing power to terminate each action potential. The current results from a combination of steep voltage-dependent gating kinetics and ultra-fast voltage-sensor relaxation.
Title: Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization.

A recurrent KCNC1 de novo mutation, c.959G>A (p.Arg320His), is a new major cause for progressive myoclonus epilepsy. It has a dominant-negative loss-of-function effect.
Title: A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy.

The following KCNC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21972	NM_004976.4 Latest version!	Homo sapiens potassium voltage-gated channel subfamily C member 1 (KCNC1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$214.50-$300.30 $429.00
OHu21978	NM_001112741.2 Latest version!	Homo sapiens potassium voltage-gated channel subfamily C member 1 (KCNC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$244.50-$342.30 $489.00
OHu58549	XM_011520080.2 Latest version!	Homo sapiens potassium voltage-gated channel subfamily C member 1 (KCNC1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu21978	NM_001112741.1	Homo sapiens potassium voltage-gated channel subfamily C member 1 (KCNC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$244.50-$342.30 $489.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNC1 ( NM_004976.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004967.1 Homo sapiens potassium voltage-gated channel subfamily C member 1 (KCNC1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21972
Clone ID Related Accession (Same CDS sequence)	NM_004976.4
Accession Version	NM_004976.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1536bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily C member 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN993192.1, BC107129.2, AC124056.8, AK125480.1 and AW452561.1. On Dec 20, 2007 this sequence version replaced NM_004976.3. Transcript Variant: This variant (2) lacks two exons and its 3' exon extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.250966.1, SRR1803614.44334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCAAG GGGACGAGAG CGAGCGCATC GTGATCAACG TGGGCGGCAC GCGCCACCAG 
ACGTACCGCT CGACCCTGCG CACGCTGCCC GGCACGCGGC TCGCCTGGCT GGCGGAGCCC 
GACGCCCACA GCCACTTCGA CTATGACCCG CGTGCTGACG AGTTCTTCTT CGACCGCCAC 
CCCGGCGTCT TCGCGCACAT CCTGAACTAC TACCGCACGG GCAAGCTGCA CTGCCCAGCC 
GACGTGTGCG GGCCGCTCTA CGAGGAGGAG CTGGCCTTCT GGGGCATCGA CGAGACCGAC 
GTGGAGCCCT GCTGCTGGAT GACGTACCGC CAGCACCGCG ACGCCGAGGA GGCTCTGGAC 
AGCTTCGGCG GCGCTCCTCT GGACAACAGC GCCGACGACG CGGACGCCGA CGGCCCTGGC 
GACTCGGGCG ACGGCGAGGA CGAGCTGGAG ATGACCAAGC GCCTGGCGCT CAGTGACTCC 
CCGGATGGCC GGCCTGGCGG CTTTTGGCGC CGCTGGCAGC CGCGCATCTG GGCGCTCTTC 
GAGGACCCGT ACTCGTCCCG CTACGCGCGG TATGTGGCCT TCGCTTCCCT CTTCTTCATC 
CTGGTCTCCA TCACCACCTT CTGCCTGGAG ACCCACGAGC GCTTCAACCC CATCGTGAAC 
AAGACGGAGA TCGAGAACGT TCGCAATGGC ACGCAAGTGC GCTACTACCG GGAGGCCGAG 
ACGGAGGCCT TCCTTACCTA CATCGAGGGC GTCTGTGTGG TCTGGTTCAC CTTCGAGTTC 
CTCATGCGTG TCATCTTCTG CCCCAACAAG GTAGAGTTCA TCAAGAACTC GCTCAACATC 
ATTGACTTTG TGGCCATCCT GCCCTTCTAC CTGGAGGTGG GGCTGAGCGG CCTGTCCTCC 
AAGGCAGCCA AGGACGTGCT GGGCTTCCTG CGCGTCGTCC GCTTCGTGCG CATCTTGCGC 
ATCTTTAAGC TGACCCGCCA CTTTGTGGGC CTGCGGGTCC TGGGCCACAC GCTCCGAGCC 
AGCACCAACG AGTTCCTGCT GCTCATCATC TTCCTGGCCT TGGGCGTGCT GATCTTCGCC 
ACCATGATCT ACTACGCCGA GAGGATAGGG GCACAGCCCA ATGACCCCAG CGCCAGTGAG 
CACACGCACT TTAAGAACAT CCCCATCGGC TTCTGGTGGG CCGTGGTCAC CATGACGACC 
CTGGGCTATG GAGACATGTA CCCGCAGACG TGGTCCGGCA TGCTGGTGGG GGCTCTGTGT 
GCGCTGGCGG GCGTGCTCAC CATCGCCATG CCCGTGCCCG TCATCGTGAA CAATTTCGGG 
ATGTATTACT CCTTAGCCAT GGCTAAGCAG AAACTACCAA AGAAAAAAAA GAAGCATATT 
CCGCGGCCAC CGCAGCTGGG ATCTCCCAAT TATTGTAAAT CTGTCGTAAA CTCTCCACAC 
CACAGTACTC AGAGTGACAC ATGTCCGCTG GCCCAGGAAG AAATTTTAGA AATTAACAGA 
GCAGGTAGGA AACCTCTTAG AGGCATGTCG ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004967.1
CDS	56..1591
Translation	MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRAGRKPLRGMSI

Target ORF information:

RefSeq Version	NM_004976.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily C member 1 (KCNC1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004976.4

ORF Insert Sequence:

ATGGGCCAAG GGGACGAGAG CGAGCGCATC GTGATCAACG TGGGCGGCAC GCGCCACCAG 
ACGTACCGCT CGACCCTGCG CACGCTGCCC GGCACGCGGC TCGCCTGGCT GGCGGAGCCC 
GACGCCCACA GCCACTTCGA CTATGACCCG CGTGCTGACG AGTTCTTCTT CGACCGCCAC 
CCCGGCGTCT TCGCGCACAT CCTGAACTAC TACCGCACGG GCAAGCTGCA CTGCCCAGCC 
GACGTGTGCG GGCCGCTCTA CGAGGAGGAG CTGGCCTTCT GGGGCATCGA CGAGACCGAC 
GTGGAGCCCT GCTGCTGGAT GACGTACCGC CAGCACCGCG ACGCCGAGGA GGCTCTGGAC 
AGCTTCGGCG GCGCTCCTCT GGACAACAGC GCCGACGACG CGGACGCCGA CGGCCCTGGC 
GACTCGGGCG ACGGCGAGGA CGAGCTGGAG ATGACCAAGC GCCTGGCGCT CAGTGACTCC 
CCGGATGGCC GGCCTGGCGG CTTTTGGCGC CGCTGGCAGC CGCGCATCTG GGCGCTCTTC 
GAGGACCCGT ACTCGTCCCG CTACGCGCGG TATGTGGCCT TCGCTTCCCT CTTCTTCATC 
CTGGTCTCCA TCACCACCTT CTGCCTGGAG ACCCACGAGC GCTTCAACCC CATCGTGAAC 
AAGACGGAGA TCGAGAACGT TCGCAATGGC ACGCAAGTGC GCTACTACCG GGAGGCCGAG 
ACGGAGGCCT TCCTTACCTA CATCGAGGGC GTCTGTGTGG TCTGGTTCAC CTTCGAGTTC 
CTCATGCGTG TCATCTTCTG CCCCAACAAG GTAGAGTTCA TCAAGAACTC GCTCAACATC 
ATTGACTTTG TGGCCATCCT GCCCTTCTAC CTGGAGGTGG GGCTGAGCGG CCTGTCCTCC 
AAGGCAGCCA AGGACGTGCT GGGCTTCCTG CGCGTCGTCC GCTTCGTGCG CATCTTGCGC 
ATCTTTAAGC TGACCCGCCA CTTTGTGGGC CTGCGGGTCC TGGGCCACAC GCTCCGAGCC 
AGCACCAACG AGTTCCTGCT GCTCATCATC TTCCTGGCCT TGGGCGTGCT GATCTTCGCC 
ACCATGATCT ACTACGCCGA GAGGATAGGG GCACAGCCCA ATGACCCCAG CGCCAGTGAG 
CACACGCACT TTAAGAACAT CCCCATCGGC TTCTGGTGGG CCGTGGTCAC CATGACGACC 
CTGGGCTATG GAGACATGTA CCCGCAGACG TGGTCCGGCA TGCTGGTGGG GGCTCTGTGT 
GCGCTGGCGG GCGTGCTCAC CATCGCCATG CCCGTGCCCG TCATCGTGAA CAATTTCGGG 
ATGTATTACT CCTTAGCCAT GGCTAAGCAG AAACTACCAA AGAAAAAAAA GAAGCATATT 
CCGCGGCCAC CGCAGCTGGG ATCTCCCAAT TATTGTAAAT CTGTCGTAAA CTCTCCACAC 
CACAGTACTC AGAGTGACAC ATGTCCGCTG GCCCAGGAAG AAATTTTAGA AATTAACAGA 
GCAGGTAGGA AACCTCTTAG AGGCATGTCG ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNC1 ( NM_001112741.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001106212.1 Homo sapiens potassium voltage-gated channel subfamily C member 1 (KCNC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21978
Clone ID Related Accession (Same CDS sequence)	NM_001112741.1 , NM_001112741.2
Accession Version	NM_001112741.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1758bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-27
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily C member 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC124301.6, AC124056.8 and AC124078.5. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.879985.1, SRR1803617.159507.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGGCCAAG GGGACGAGAG CGAGCGCATC GTGATCAACG TGGGCGGCAC GCGCCACCAG 
ACGTACCGCT CGACCCTGCG CACGCTGCCC GGCACGCGGC TCGCCTGGCT GGCGGAGCCC 
GACGCCCACA GCCACTTCGA CTATGACCCG CGTGCTGACG AGTTCTTCTT CGACCGCCAC 
CCCGGCGTCT TCGCGCACAT CCTGAACTAC TACCGCACGG GCAAGCTGCA CTGCCCAGCC 
GACGTGTGCG GGCCGCTCTA CGAGGAGGAG CTGGCCTTCT GGGGCATCGA CGAGACCGAC 
GTGGAGCCCT GCTGCTGGAT GACGTACCGC CAGCACCGCG ACGCCGAGGA GGCTCTGGAC 
AGCTTCGGCG GCGCTCCTCT GGACAACAGC GCCGACGACG CGGACGCCGA CGGCCCTGGC 
GACTCGGGCG ACGGCGAGGA CGAGCTGGAG ATGACCAAGC GCCTGGCGCT CAGTGACTCC 
CCGGATGGCC GGCCTGGCGG CTTTTGGCGC CGCTGGCAGC CGCGCATCTG GGCGCTCTTC 
GAGGACCCGT ACTCGTCCCG CTACGCGCGG TATGTGGCCT TCGCTTCCCT CTTCTTCATC 
CTGGTCTCCA TCACCACCTT CTGCCTGGAG ACCCACGAGC GCTTCAACCC CATCGTGAAC 
AAGACGGAGA TCGAGAACGT TCGCAATGGC ACGCAAGTGC GCTACTACCG GGAGGCCGAG 
ACGGAGGCCT TCCTTACCTA CATCGAGGGC GTCTGTGTGG TCTGGTTCAC CTTCGAGTTC 
CTCATGCGTG TCATCTTCTG CCCCAACAAG GTAGAGTTCA TCAAGAACTC GCTCAACATC 
ATTGACTTTG TGGCCATCCT GCCCTTCTAC CTGGAGGTGG GGCTGAGCGG CCTGTCCTCC 
AAGGCAGCCA AGGACGTGCT GGGCTTCCTG CGCGTCGTCC GCTTCGTGCG CATCTTGCGC 
ATCTTTAAGC TGACCCGCCA CTTTGTGGGC CTGCGGGTCC TGGGCCACAC GCTCCGAGCC 
AGCACCAACG AGTTCCTGCT GCTCATCATC TTCCTGGCCT TGGGCGTGCT GATCTTCGCC 
ACCATGATCT ACTACGCCGA GAGGATAGGG GCACAGCCCA ATGACCCCAG CGCCAGTGAG 
CACACGCACT TTAAGAACAT CCCCATCGGC TTCTGGTGGG CCGTGGTCAC CATGACGACC 
CTGGGCTATG GAGACATGTA CCCGCAGACG TGGTCCGGCA TGCTGGTGGG GGCTCTGTGT 
GCGCTGGCGG GCGTGCTCAC CATCGCCATG CCCGTGCCCG TCATCGTGAA CAATTTCGGG 
ATGTATTACT CCTTAGCCAT GGCTAAGCAG AAACTACCAA AGAAAAAAAA GAAGCATATT 
CCGCGGCCAC CGCAGCTGGG ATCTCCCAAT TATTGTAAAT CTGTCGTAAA CTCTCCACAC 
CACAGTACTC AGAGTGACAC ATGTCCGCTG GCCCAGGAAG AAATTTTAGA AATTAACAGA 
GCAGATTCCA AACTGAATGG GGAGGTGGCG AAGGCCGCGC TGGCGAACGA AGACTGCCCC 
CACATAGACC AGGCCCTCAC TCCCGATGAG GGCCTGCCCT TTACGCGCTC GGGCACCCGC 
GAGAGATACG GACCCTGCTT CCTCTTATCA ACCGGGGAGT ACGCGTGCCC ACCTGGTGGA 
GGAATGAGAA AGGATCTTTG CAAAGAAAGC CCTGTCATTG CTAAGTATAT GCCGACAGAG 
GCTGTGAGAG TGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001106212.1
CDS	56..1813
Translation	MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALTPDEGLPFTRSGTRERYGPCFLLSTGEYACPPGGGMRKDLCKESPVIAKYMPTEAVRVT

Target ORF information:

RefSeq Version	NM_001112741.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily C member 1 (KCNC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001112741.1

ORF Insert Sequence:

ATGGGCCAAG GGGACGAGAG CGAGCGCATC GTGATCAACG TGGGCGGCAC GCGCCACCAG 
ACGTACCGCT CGACCCTGCG CACGCTGCCC GGCACGCGGC TCGCCTGGCT GGCGGAGCCC 
GACGCCCACA GCCACTTCGA CTATGACCCG CGTGCTGACG AGTTCTTCTT CGACCGCCAC 
CCCGGCGTCT TCGCGCACAT CCTGAACTAC TACCGCACGG GCAAGCTGCA CTGCCCAGCC 
GACGTGTGCG GGCCGCTCTA CGAGGAGGAG CTGGCCTTCT GGGGCATCGA CGAGACCGAC 
GTGGAGCCCT GCTGCTGGAT GACGTACCGC CAGCACCGCG ACGCCGAGGA GGCTCTGGAC 
AGCTTCGGCG GCGCTCCTCT GGACAACAGC GCCGACGACG CGGACGCCGA CGGCCCTGGC 
GACTCGGGCG ACGGCGAGGA CGAGCTGGAG ATGACCAAGC GCCTGGCGCT CAGTGACTCC 
CCGGATGGCC GGCCTGGCGG CTTTTGGCGC CGCTGGCAGC CGCGCATCTG GGCGCTCTTC 
GAGGACCCGT ACTCGTCCCG CTACGCGCGG TATGTGGCCT TCGCTTCCCT CTTCTTCATC 
CTGGTCTCCA TCACCACCTT CTGCCTGGAG ACCCACGAGC GCTTCAACCC CATCGTGAAC 
AAGACGGAGA TCGAGAACGT TCGCAATGGC ACGCAAGTGC GCTACTACCG GGAGGCCGAG 
ACGGAGGCCT TCCTTACCTA CATCGAGGGC GTCTGTGTGG TCTGGTTCAC CTTCGAGTTC 
CTCATGCGTG TCATCTTCTG CCCCAACAAG GTAGAGTTCA TCAAGAACTC GCTCAACATC 
ATTGACTTTG TGGCCATCCT GCCCTTCTAC CTGGAGGTGG GGCTGAGCGG CCTGTCCTCC 
AAGGCAGCCA AGGACGTGCT GGGCTTCCTG CGCGTCGTCC GCTTCGTGCG CATCTTGCGC 
ATCTTTAAGC TGACCCGCCA CTTTGTGGGC CTGCGGGTCC TGGGCCACAC GCTCCGAGCC 
AGCACCAACG AGTTCCTGCT GCTCATCATC TTCCTGGCCT TGGGCGTGCT GATCTTCGCC 
ACCATGATCT ACTACGCCGA GAGGATAGGG GCACAGCCCA ATGACCCCAG CGCCAGTGAG 
CACACGCACT TTAAGAACAT CCCCATCGGC TTCTGGTGGG CCGTGGTCAC CATGACGACC 
CTGGGCTATG GAGACATGTA CCCGCAGACG TGGTCCGGCA TGCTGGTGGG GGCTCTGTGT 
GCGCTGGCGG GCGTGCTCAC CATCGCCATG CCCGTGCCCG TCATCGTGAA CAATTTCGGG 
ATGTATTACT CCTTAGCCAT GGCTAAGCAG AAACTACCAA AGAAAAAAAA GAAGCATATT 
CCGCGGCCAC CGCAGCTGGG ATCTCCCAAT TATTGTAAAT CTGTCGTAAA CTCTCCACAC 
CACAGTACTC AGAGTGACAC ATGTCCGCTG GCCCAGGAAG AAATTTTAGA AATTAACAGA 
GCAGATTCCA AACTGAATGG GGAGGTGGCG AAGGCCGCGC TGGCGAACGA AGACTGCCCC 
CACATAGACC AGGCCCTCAC TCCCGATGAG GGCCTGCCCT TTACGCGCTC GGGCACCCGC 
GAGAGATACG GACCCTGCTT CCTCTTATCA ACCGGGGAGT ACGCGTGCCC ACCTGGTGGA 
GGAATGAGAA AGGATCTTTG CAAAGAAAGC CCTGTCATTG CTAAGTATAT GCCGACAGAG 
GCTGTGAGAG TGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNC1 ( NM_001112741.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001106212.1 Homo sapiens potassium voltage-gated channel subfamily C member 1 (KCNC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21978
Clone ID Related Accession (Same CDS sequence)	NM_001112741.1 , NM_001112741.2
Accession Version	NM_001112741.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1758bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily C member 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC124301.6, AC124056.8 and AC124078.5. On Sep 19, 2019 this sequence version replaced NM_001112741.1. Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGGCCAAG GGGACGAGAG CGAGCGCATC GTGATCAACG TGGGCGGCAC GCGCCACCAG 
ACGTACCGCT CGACCCTGCG CACGCTGCCC GGCACGCGGC TCGCCTGGCT GGCGGAGCCC 
GACGCCCACA GCCACTTCGA CTATGACCCG CGTGCTGACG AGTTCTTCTT CGACCGCCAC 
CCCGGCGTCT TCGCGCACAT CCTGAACTAC TACCGCACGG GCAAGCTGCA CTGCCCAGCC 
GACGTGTGCG GGCCGCTCTA CGAGGAGGAG CTGGCCTTCT GGGGCATCGA CGAGACCGAC 
GTGGAGCCCT GCTGCTGGAT GACGTACCGC CAGCACCGCG ACGCCGAGGA GGCTCTGGAC 
AGCTTCGGCG GCGCTCCTCT GGACAACAGC GCCGACGACG CGGACGCCGA CGGCCCTGGC 
GACTCGGGCG ACGGCGAGGA CGAGCTGGAG ATGACCAAGC GCCTGGCGCT CAGTGACTCC 
CCGGATGGCC GGCCTGGCGG CTTTTGGCGC CGCTGGCAGC CGCGCATCTG GGCGCTCTTC 
GAGGACCCGT ACTCGTCCCG CTACGCGCGG TATGTGGCCT TCGCTTCCCT CTTCTTCATC 
CTGGTCTCCA TCACCACCTT CTGCCTGGAG ACCCACGAGC GCTTCAACCC CATCGTGAAC 
AAGACGGAGA TCGAGAACGT TCGCAATGGC ACGCAAGTGC GCTACTACCG GGAGGCCGAG 
ACGGAGGCCT TCCTTACCTA CATCGAGGGC GTCTGTGTGG TCTGGTTCAC CTTCGAGTTC 
CTCATGCGTG TCATCTTCTG CCCCAACAAG GTAGAGTTCA TCAAGAACTC GCTCAACATC 
ATTGACTTTG TGGCCATCCT GCCCTTCTAC CTGGAGGTGG GGCTGAGCGG CCTGTCCTCC 
AAGGCAGCCA AGGACGTGCT GGGCTTCCTG CGCGTCGTCC GCTTCGTGCG CATCTTGCGC 
ATCTTTAAGC TGACCCGCCA CTTTGTGGGC CTGCGGGTCC TGGGCCACAC GCTCCGAGCC 
AGCACCAACG AGTTCCTGCT GCTCATCATC TTCCTGGCCT TGGGCGTGCT GATCTTCGCC 
ACCATGATCT ACTACGCCGA GAGGATAGGG GCACAGCCCA ATGACCCCAG CGCCAGTGAG 
CACACGCACT TTAAGAACAT CCCCATCGGC TTCTGGTGGG CCGTGGTCAC CATGACGACC 
CTGGGCTATG GAGACATGTA CCCGCAGACG TGGTCCGGCA TGCTGGTGGG GGCTCTGTGT 
GCGCTGGCGG GCGTGCTCAC CATCGCCATG CCCGTGCCCG TCATCGTGAA CAATTTCGGG 
ATGTATTACT CCTTAGCCAT GGCTAAGCAG AAACTACCAA AGAAAAAAAA GAAGCATATT 
CCGCGGCCAC CGCAGCTGGG ATCTCCCAAT TATTGTAAAT CTGTCGTAAA CTCTCCACAC 
CACAGTACTC AGAGTGACAC ATGTCCGCTG GCCCAGGAAG AAATTTTAGA AATTAACAGA 
GCAGATTCCA AACTGAATGG GGAGGTGGCG AAGGCCGCGC TGGCGAACGA AGACTGCCCC 
CACATAGACC AGGCCCTCAC TCCCGATGAG GGCCTGCCCT TTACGCGCTC GGGCACCCGC 
GAGAGATACG GACCCTGCTT CCTCTTATCA ACCGGGGAGT ACGCGTGCCC ACCTGGTGGA 
GGAATGAGAA AGGATCTTTG CAAAGAAAGC CCTGTCATTG CTAAGTATAT GCCGACAGAG 
GCTGTGAGAG TGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001106212.1
CDS	1223..2980
Translation	MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALTPDEGLPFTRSGTRERYGPCFLLSTGEYACPPGGGMRKDLCKESPVIAKYMPTEAVRVT

Target ORF information:

RefSeq Version	NM_001112741.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily C member 1 (KCNC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001112741.2

ORF Insert Sequence:

ATGGGCCAAG GGGACGAGAG CGAGCGCATC GTGATCAACG TGGGCGGCAC GCGCCACCAG 
ACGTACCGCT CGACCCTGCG CACGCTGCCC GGCACGCGGC TCGCCTGGCT GGCGGAGCCC 
GACGCCCACA GCCACTTCGA CTATGACCCG CGTGCTGACG AGTTCTTCTT CGACCGCCAC 
CCCGGCGTCT TCGCGCACAT CCTGAACTAC TACCGCACGG GCAAGCTGCA CTGCCCAGCC 
GACGTGTGCG GGCCGCTCTA CGAGGAGGAG CTGGCCTTCT GGGGCATCGA CGAGACCGAC 
GTGGAGCCCT GCTGCTGGAT GACGTACCGC CAGCACCGCG ACGCCGAGGA GGCTCTGGAC 
AGCTTCGGCG GCGCTCCTCT GGACAACAGC GCCGACGACG CGGACGCCGA CGGCCCTGGC 
GACTCGGGCG ACGGCGAGGA CGAGCTGGAG ATGACCAAGC GCCTGGCGCT CAGTGACTCC 
CCGGATGGCC GGCCTGGCGG CTTTTGGCGC CGCTGGCAGC CGCGCATCTG GGCGCTCTTC 
GAGGACCCGT ACTCGTCCCG CTACGCGCGG TATGTGGCCT TCGCTTCCCT CTTCTTCATC 
CTGGTCTCCA TCACCACCTT CTGCCTGGAG ACCCACGAGC GCTTCAACCC CATCGTGAAC 
AAGACGGAGA TCGAGAACGT TCGCAATGGC ACGCAAGTGC GCTACTACCG GGAGGCCGAG 
ACGGAGGCCT TCCTTACCTA CATCGAGGGC GTCTGTGTGG TCTGGTTCAC CTTCGAGTTC 
CTCATGCGTG TCATCTTCTG CCCCAACAAG GTAGAGTTCA TCAAGAACTC GCTCAACATC 
ATTGACTTTG TGGCCATCCT GCCCTTCTAC CTGGAGGTGG GGCTGAGCGG CCTGTCCTCC 
AAGGCAGCCA AGGACGTGCT GGGCTTCCTG CGCGTCGTCC GCTTCGTGCG CATCTTGCGC 
ATCTTTAAGC TGACCCGCCA CTTTGTGGGC CTGCGGGTCC TGGGCCACAC GCTCCGAGCC 
AGCACCAACG AGTTCCTGCT GCTCATCATC TTCCTGGCCT TGGGCGTGCT GATCTTCGCC 
ACCATGATCT ACTACGCCGA GAGGATAGGG GCACAGCCCA ATGACCCCAG CGCCAGTGAG 
CACACGCACT TTAAGAACAT CCCCATCGGC TTCTGGTGGG CCGTGGTCAC CATGACGACC 
CTGGGCTATG GAGACATGTA CCCGCAGACG TGGTCCGGCA TGCTGGTGGG GGCTCTGTGT 
GCGCTGGCGG GCGTGCTCAC CATCGCCATG CCCGTGCCCG TCATCGTGAA CAATTTCGGG 
ATGTATTACT CCTTAGCCAT GGCTAAGCAG AAACTACCAA AGAAAAAAAA GAAGCATATT 
CCGCGGCCAC CGCAGCTGGG ATCTCCCAAT TATTGTAAAT CTGTCGTAAA CTCTCCACAC 
CACAGTACTC AGAGTGACAC ATGTCCGCTG GCCCAGGAAG AAATTTTAGA AATTAACAGA 
GCAGATTCCA AACTGAATGG GGAGGTGGCG AAGGCCGCGC TGGCGAACGA AGACTGCCCC 
CACATAGACC AGGCCCTCAC TCCCGATGAG GGCCTGCCCT TTACGCGCTC GGGCACCCGC 
GAGAGATACG GACCCTGCTT CCTCTTATCA ACCGGGGAGT ACGCGTGCCC ACCTGGTGGA 
GGAATGAGAA AGGATCTTTG CAAAGAAAGC CCTGTCATTG CTAAGTATAT GCCGACAGAG 
GCTGTGAGAG TGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNC1 ( XM_011520080.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518382.1 Homo sapiens potassium voltage-gated channel subfamily C member 1 (KCNC1), transcript variant X1, mRNA.

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CloneID	OHu58549
Clone ID Related Accession (Same CDS sequence)	XM_011520080.2
Accession Version	XM_011520080.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily C member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011520080.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCCAAG GGGACGAGAG CGAGCGCATC GTGATCAACG TGGGCGGCAC GCGCCACCAG 
ACGTACCGCT CGACCCTGCG CACGCTGCCC GGCACGCGGC TCGCCTGGCT GGCGGAGCCC 
GACGCCCACA GCCACTTCGA CTATGACCCG CGTGCTGACG AGTTCTTCTT CGACCGCCAC 
CCCGGCGTCT TCGCGCACAT CCTGAACTAC TACCGCACGG GCAAGCTGCA CTGCCCAGCC 
GACGTGTGCG GGCCGCTCTA CGAGGAGGAG CTGGCCTTCT GGGGCATCGA CGAGACCGAC 
GTGGAGCCCT GCTGCTGGAT GACGTACCGC CAGCACCGCG ACGCCGAGGA GGCTCTGGAC 
AGCTTCGGCG GCGCTCCTCT GGACAACAGC GCCGACGACG CGGACGCCGA CGGCCCTGGC 
GACTCGGGCG ACGGCGAGGA CGAGCTGGAG ATGACCAAGC GCCTGGCGCT CAGTGACTCC 
CCGGATGGCC GGCCTGGCGG CTTTTGGCGC CGCTGGCAGC CGCGCATCTG GGCGCTCTTC 
GAGGACCCGT ACTCGTCCCG CTACGCGCGG TATGTGGCCT TCGCTTCCCT CTTCTTCATC 
CTGGTCTCCA TCACCACCTT CTGCCTGGAG ACCCACGAGC GCTTCAACCC CATCGTGAAC 
AAGACGGAGA TCGAGAACGT TCGCAATGGC ACGCAAGTGC GCTACTACCG GGAGGCCGAG 
ACGGAGGCCT TCCTTACCTA CATCGAGGGC GTCTGTGTGG TCTGGTTCAC CTTCGAGTTC 
CTCATGCGTG TCATCTTCTG CCCCAACAAG GTAGAGTTCA TCAAGAACTC GCTCAACATC 
ATTGACTTTG TGGCCATCCT GCCCTTCTAC CTGGAGGTGG GGCTGAGCGG CCTGTCCTCC 
AAGGCAGCCA AGGACGTGCT GGGCTTCCTG CGCGTCGTCC GCTTCGTGCG CATCTTGCGC 
ATCTTTAAGC TGACCCGCCA CTTTGTGGGC CTGCGGGTCC TGGGCCACAC GCTCCGAGCC 
AGCACCAACG AGTTCCTGCT GCTCATCATC TTCCTGGCCT TGGGCGTGCT GATCTTCGCC 
ACCATGATCT ACTACGCCGA GAGGATAGGG GCACAGCCCA ATGACCCCAG CGCCAGTGAG 
CACACGCACT TTAAGAACAT CCCCATCGGC TTCTGGTGGG CCGTGGTCAC CATGACGACC 
CTGGGCTATG GAGACATGTA CCCGCAGACG TGGTCCGGCA TGCTGGTGGG GGCTCTGTGT 
GCGCTGGCGG GCGTGCTCAC CATCGCCATG CCCGTGCCCG TCATCGTGAA CAATTTCGGG 
ATGTATTACT CCTTAGCCAT GGCTAAGCAG AAACTACCAA AGAAAAAAAA GAAGCATATT 
CCGCGGCCAC CGCAGCTGGG ATCTCCCAAT TATTGTAAAT CTGTCGTAAA CTCTCCACAC 
CACAGTACTC AGAGTGACAC ATGTCCGCTG GCCCAGGAAG AAATTTTAGA AATTAACAGA 
GCAGGGATTT CAAAGGAACA GATGACCCAG AGAAGAATGA CAGCACTGAG TAAGAAGGAG 
TGCCAGATGC TCATCTCAGC CCATTTCAAG CCTGGAAACC ATCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518382.1
CDS	1194..2801
Translation	MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRAGISKEQMTQRRMTALSKKECQMLISAHFKPGNHL

Target ORF information:

RefSeq Version	XM_011520080.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily C member 1 (KCNC1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520080.2

ORF Insert Sequence:

ATGGGCCAAG GGGACGAGAG CGAGCGCATC GTGATCAACG TGGGCGGCAC GCGCCACCAG 
ACGTACCGCT CGACCCTGCG CACGCTGCCC GGCACGCGGC TCGCCTGGCT GGCGGAGCCC 
GACGCCCACA GCCACTTCGA CTATGACCCG CGTGCTGACG AGTTCTTCTT CGACCGCCAC 
CCCGGCGTCT TCGCGCACAT CCTGAACTAC TACCGCACGG GCAAGCTGCA CTGCCCAGCC 
GACGTGTGCG GGCCGCTCTA CGAGGAGGAG CTGGCCTTCT GGGGCATCGA CGAGACCGAC 
GTGGAGCCCT GCTGCTGGAT GACGTACCGC CAGCACCGCG ACGCCGAGGA GGCTCTGGAC 
AGCTTCGGCG GCGCTCCTCT GGACAACAGC GCCGACGACG CGGACGCCGA CGGCCCTGGC 
GACTCGGGCG ACGGCGAGGA CGAGCTGGAG ATGACCAAGC GCCTGGCGCT CAGTGACTCC 
CCGGATGGCC GGCCTGGCGG CTTTTGGCGC CGCTGGCAGC CGCGCATCTG GGCGCTCTTC 
GAGGACCCGT ACTCGTCCCG CTACGCGCGG TATGTGGCCT TCGCTTCCCT CTTCTTCATC 
CTGGTCTCCA TCACCACCTT CTGCCTGGAG ACCCACGAGC GCTTCAACCC CATCGTGAAC 
AAGACGGAGA TCGAGAACGT TCGCAATGGC ACGCAAGTGC GCTACTACCG GGAGGCCGAG 
ACGGAGGCCT TCCTTACCTA CATCGAGGGC GTCTGTGTGG TCTGGTTCAC CTTCGAGTTC 
CTCATGCGTG TCATCTTCTG CCCCAACAAG GTAGAGTTCA TCAAGAACTC GCTCAACATC 
ATTGACTTTG TGGCCATCCT GCCCTTCTAC CTGGAGGTGG GGCTGAGCGG CCTGTCCTCC 
AAGGCAGCCA AGGACGTGCT GGGCTTCCTG CGCGTCGTCC GCTTCGTGCG CATCTTGCGC 
ATCTTTAAGC TGACCCGCCA CTTTGTGGGC CTGCGGGTCC TGGGCCACAC GCTCCGAGCC 
AGCACCAACG AGTTCCTGCT GCTCATCATC TTCCTGGCCT TGGGCGTGCT GATCTTCGCC 
ACCATGATCT ACTACGCCGA GAGGATAGGG GCACAGCCCA ATGACCCCAG CGCCAGTGAG 
CACACGCACT TTAAGAACAT CCCCATCGGC TTCTGGTGGG CCGTGGTCAC CATGACGACC 
CTGGGCTATG GAGACATGTA CCCGCAGACG TGGTCCGGCA TGCTGGTGGG GGCTCTGTGT 
GCGCTGGCGG GCGTGCTCAC CATCGCCATG CCCGTGCCCG TCATCGTGAA CAATTTCGGG 
ATGTATTACT CCTTAGCCAT GGCTAAGCAG AAACTACCAA AGAAAAAAAA GAAGCATATT 
CCGCGGCCAC CGCAGCTGGG ATCTCCCAAT TATTGTAAAT CTGTCGTAAA CTCTCCACAC 
CACAGTACTC AGAGTGACAC ATGTCCGCTG GCCCAGGAAG AAATTTTAGA AATTAACAGA 
GCAGGGATTT CAAAGGAACA GATGACCCAG AGAAGAATGA CAGCACTGAG TAAGAAGGAG 
TGCCAGATGC TCATCTCAGC CCATTTCAAG CCTGGAAACC ATCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of Function of KCNC1 is associated with intellectual disability without seizures.
European journal of human genetics : EJHG25(5)560-564(2017 05)
Poirier K,Viot G,Lombardi L,Jauny C,Billuart P,Bienvenu T

Myoclonus epilepsy and ataxia due to KCNC1 mutation: Analysis of 20 cases and K
Annals of neurology81(5)677-689(2017 May)
Oliver KL,Franceschetti S,Milligan CJ,Muona M,Mandelstam SA,Canafoglia L,Boguszewska-Chachulska AM,Korczyn AD,Bisulli F,Di Bonaventura C,Ragona F,Michelucci R,Ben-Zeev B,Straussberg R,Panzica F,Massano J,Friedman D,Crespel A,Engelsen BA,Andermann F,Andermann E,Spodar K,Lasek-Bal A,Riguzzi P,Pasini E,Tinuper P,Licchetta L,Gardella E,Lindenau M,Wulf A,M?ller RS,Benninger F,Afawi Z,Rubboli G,Reid CA,Maljevic S,Lerche H,Lehesjoki AE,Petrou S,Berkovic SF

Myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK) is caused by heterozygous KCNC1 mutations.
Epileptic disorders : international epilepsy journal with videotape18(S2)135-138(2016 Sep)
Nascimento FA,Andrade DM

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KCNC1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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