NOP53 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NOP53
Entrez Gene ID	29997
Full Name	NOP53 ribosome biogenesis factor
Synonyms	GLTSCR2,PICT-1,PICT1
General protein information	Preferred Names NOP53 ribosome biogenesis factor Names ribosome biogenesis protein NOP53 glioma tumor suppressor candidate region gene 2 protein p60 protein interacting with carboxyl terminus 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Disorder MIM:	605691

mRNA and Protein(s)

mRNA	Protein	Name
NM_015710.5	NP_056525.2	ribosome biogenesis protein NOP53
NM_015710.4	NP_056525.2	ribosome biogenesis protein NOP53

Pathways from BioSystems

Homologies

	GLTSCR2	XP_001113326.1
Drosophila melanogaster (fruit fly)	CG1785	NP_572502.1
Saccharomyces cerevisiae (baker's yeast)	NOP53	NP_015179.1
Neurospora crassa	NCU05233	XP_961893.1
Xenopus tropicalis (tropical clawed frog)	gltscr2	XP_002939289.2
Homo sapiens (human)	GLTSCR2	NP_056525.2
Canis lupus familiaris (dog)	GLTSCR2	XP_005616435.1
Rattus norvegicus (Norway rat)	Gltscr2	NP_997474.1
Eremothecium gossypii	AGOS_ACR126W	NP_983528.1
Schizosaccharomyces pombe (fission yeast)	rrp16	NP_594732.1
Mus musculus (house mouse)	Gltscr2	NP_598592.2
Danio rerio (zebrafish)	gltscr2	NP_001073415.1
Magnaporthe oryzae (rice blast fungus)	MGG_04142	XP_003719688.1
Pan troglodytes (chimpanzee)	GLTSCR2	XP_001169866.2
Bos taurus (cattle)	GLTSCR2	NP_001033596.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000270	XP_310849.4
Caenorhabditis elegans (roundworm)	CELE_Y39B6A.33	NP_741664.1
Kluyveromyces lactis	KLLA0F11506g	XP_455604.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

The protein interacting with carboxyl terminus-1 codon 389 polymorphism impairs protein interacting with carboxyl terminus-1 function and is a risk factor for uterine cervical cancer.
Yoshimoto M, Tokuda A, Nishiwaki K, Sengoku K, Yaginuma Y
Molecular carcinogenesis56(5)1484-1492(2017 May)

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
Chen H, Han L, Tsai H, Wang Z, Wu Y, Duo Y, Cao W, Chen L, Tan Z, Xu N, Huang X, Zhuang J, Huang L
Oncotarget7(50)83241-83257(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Codon 389 polymorphism in PICT-1 is a risk factor for uterine cervical cancers.PICT-1 counteracts HPV-induced p53 degradation.
Title: The protein interacting with carboxyl terminus-1 codon 389 polymorphism impairs protein interacting with carboxyl terminus-1 function and is a risk factor for uterine cervical cancer.

GLTSCR2 is a crucially involved in the positive regulation of telomerase and chromosome stability.
Title: Role of GLTSCR2 in the regulation of telomerase activity and chromosome stability.

GLTSCR2 is crucial for normal cellular function as well as for preventing the development or progression of cancer. The JNK-c-jun axis is indispensible for regulating the activities of GLTSCR2.
Title: c-Jun N-terminal kinase regulates the nucleoplasmic translocation and stability of nucleolar GLTSCR2 protein.

The expression of GLTSCR2 was suppressed in renal cell carcinomas, accentuating the malignant phenotype.
Title: Suppression of GLTSCR2 expression in renal cell carcinomas.

GLTSCR2 was an upstream negative regulator of the nucleophosmin (NPM)-MYC axis involved in controlling the transcriptional activity of MYC. GLTSCR2 may be a candidate for suppressing the growth of cancer cells stimulated by MYC hyperactivation.
Title: The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis.

The following NOP53 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOP53 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23339	NM_015710.5 Latest version!	Homo sapiens NOP53 ribosome biogenesis factor (NOP53), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$204.50-$286.30 $409.00
View Old Accession Versions >>
OHu23339	NM_015710.4	Homo sapiens NOP53 ribosome biogenesis factor (NOP53), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$204.50-$286.30 $409.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NOP53 ( NM_015710.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_056525.2 Homo sapiens NOP53 ribosome biogenesis factor (NOP53), mRNA.

Price & Availability↑

CloneID	OHu23339
Clone ID Related Accession (Same CDS sequence)	NM_015710.5 , NM_015710.4
Accession Version	NM_015710.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	ribosome biogenesis protein NOP53
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX866974.1, BC004229.2 and BC006311.2. On Nov 23, 2018 this sequence version replaced NM_015710.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.813476.1, SRR3476690.594152.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000246802.10/ ENSP00000246802.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCAG GAGGCAGTGG CGTTGGTGGG AAGCGCAGCT CGAAAAGCGA TGCCGATTCT 
GGTTTCCTGG GGCTGCGGCC CACTTCGGTG GACCCAGCGC TGAGGCGGCG GCGGCGAGGC 
CCAAGAAATA AGAAGCGGGG CTGGCGGCGG CTTGCTCAGG AGCCGCTGGG GCTGGAGGTT 
GACCAGTTCC TGGAAGACGT GCGGCTACAG GAGCGCACGA GCGGTGGCTT GTTGTCAGAG 
GCCCCAAATG AAAAACTCTT CTTCGTGGAC ACTGGCTCCA AGGAAAAAGG GCTGACAAAG 
AAGAGAACCA AAGTCCAGAA GAAGTCACTG CTTCTCAAGA AACCCCTTCG GGTTGACCTC 
ATCCTCGAGA ACACATCCAA AGTCCCTGCC CCCAAAGACG TCCTCGCCCA CCAGGTCCCC 
AACGCCAAGA AGCTCAGGCG GAAGGAGCAG CTATGGGAGA AGCTGGCCAA GCAGGGCGAG 
CTGCCCCGGG AGGTGCGCAG GGCCCAGGCC CGGCTCCTCA ACCCTTCTGC AACAAGGGCC 
AAGCCCGGGC CCCAGGACAC CGTAGAGCGG CCCTTCTACG ACCTCTGGGC CTCAGACAAC 
CCCCTGGACA GGCCGTTGGT TGGCCAGGAT GAGTTTTTCC TGGAGCAGAC CAAGAAGAAA 
GGAGTGAAGC GGCCAGCACG CCTGCACACC AAGCCGTCCC AGGCACCCGC CGTGGAGGTG 
GCGCCTGCCG GAGCTTCCTA CAATCCATCC TTTGAAGACC ACCAGACCCT GCTCTCAGCG 
GCCCACGAGG TGGAGTTGCA GCGGCAGAAG GAGGCGGAGA AGCTGGAGCG GCAGCTGGCC 
CTGCCCGCCA CGGAGCAGGC CGCCACCCAG GAGTCCACAT TCCAGGAGCT GTGCGAGGGG 
CTGCTGGAGG AGTCGGATGG TGAGGGGGAG CCAGGCCAGG GCGAGGGGCC GGAGGCTGGG 
GATGCCGAGG TCTGTCCCAC GCCCGCCCGC CTGGCCACCA CAGAGAAGAA GACGGAGCAG 
CAGCGGCGGC GGGAGAAGGC TGTGCACAGG CTGCGGGTAC AGCAGGCCGC GTTGCGGGCC 
GCCCGGCTCC GGCACCAGGA GCTGTTCCGG CTGCGCGGGA TCAAGGCCCA GGTGGCCCTG 
AGGCTGGCGG AGCTGGCGCG GCGGCAGAGG CGGCGGCAGG CGCGGCGGGA GGCTGAGGCT 
GACAAGCCCC GAAGGCTGGG GCGGCTCAAG TACCAGGCAC CTGACATCGA CGTGCAGCTG 
AGCTCGGAGC TGACAGACTC GCTCAGGACC CTGAAGCCCG AGGGCAACAT CCTTCGAGAC 
CGGTTCAAGA GCTTCCAGAG GAGGAATATG ATCGAGCCTC GAGAGAGAGC CAAGTTCAAA 
CGCAAGTACA AGGTGAAGCT GGTGGAGAAG CGGGCGTTCC GTGAGATCCA GTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056525.2
CDS	15..1451
Translation	MAAGGSGVGGKRSSKSDADSGFLGLRPTSVDPALRRRRRGPRNKKRGWRRLAQEPLGLEVDQFLEDVRLQERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQKKSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQL

Target ORF information:

RefSeq Version	NM_015710.5
Organism	Homo sapiens(human)
Definition	Homo sapiens NOP53 ribosome biogenesis factor (NOP53), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015710.5

ORF Insert Sequence:

ATGGCGGCAG GAGGCAGTGG CGTTGGTGGG AAGCGCAGCT CGAAAAGCGA TGCCGATTCT 
GGTTTCCTGG GGCTGCGGCC CACTTCGGTG GACCCAGCGC TGAGGCGGCG GCGGCGAGGC 
CCAAGAAATA AGAAGCGGGG CTGGCGGCGG CTTGCTCAGG AGCCGCTGGG GCTGGAGGTT 
GACCAGTTCC TGGAAGACGT GCGGCTACAG GAGCGCACGA GCGGTGGCTT GTTGTCAGAG 
GCCCCAAATG AAAAACTCTT CTTCGTGGAC ACTGGCTCCA AGGAAAAAGG GCTGACAAAG 
AAGAGAACCA AAGTCCAGAA GAAGTCACTG CTTCTCAAGA AACCCCTTCG GGTTGACCTC 
ATCCTCGAGA ACACATCCAA AGTCCCTGCC CCCAAAGACG TCCTCGCCCA CCAGGTCCCC 
AACGCCAAGA AGCTCAGGCG GAAGGAGCAG CTATGGGAGA AGCTGGCCAA GCAGGGCGAG 
CTGCCCCGGG AGGTGCGCAG GGCCCAGGCC CGGCTCCTCA ACCCTTCTGC AACAAGGGCC 
AAGCCCGGGC CCCAGGACAC CGTAGAGCGG CCCTTCTACG ACCTCTGGGC CTCAGACAAC 
CCCCTGGACA GGCCGTTGGT TGGCCAGGAT GAGTTTTTCC TGGAGCAGAC CAAGAAGAAA 
GGAGTGAAGC GGCCAGCACG CCTGCACACC AAGCCGTCCC AGGCACCCGC CGTGGAGGTG 
GCGCCTGCCG GAGCTTCCTA CAATCCATCC TTTGAAGACC ACCAGACCCT GCTCTCAGCG 
GCCCACGAGG TGGAGTTGCA GCGGCAGAAG GAGGCGGAGA AGCTGGAGCG GCAGCTGGCC 
CTGCCCGCCA CGGAGCAGGC CGCCACCCAG GAGTCCACAT TCCAGGAGCT GTGCGAGGGG 
CTGCTGGAGG AGTCGGATGG TGAGGGGGAG CCAGGCCAGG GCGAGGGGCC GGAGGCTGGG 
GATGCCGAGG TCTGTCCCAC GCCCGCCCGC CTGGCCACCA CAGAGAAGAA GACGGAGCAG 
CAGCGGCGGC GGGAGAAGGC TGTGCACAGG CTGCGGGTAC AGCAGGCCGC GTTGCGGGCC 
GCCCGGCTCC GGCACCAGGA GCTGTTCCGG CTGCGCGGGA TCAAGGCCCA GGTGGCCCTG 
AGGCTGGCGG AGCTGGCGCG GCGGCAGAGG CGGCGGCAGG CGCGGCGGGA GGCTGAGGCT 
GACAAGCCCC GAAGGCTGGG GCGGCTCAAG TACCAGGCAC CTGACATCGA CGTGCAGCTG 
AGCTCGGAGC TGACAGACTC GCTCAGGACC CTGAAGCCCG AGGGCAACAT CCTTCGAGAC 
CGGTTCAAGA GCTTCCAGAG GAGGAATATG ATCGAGCCTC GAGAGAGAGC CAAGTTCAAA 
CGCAAGTACA AGGTGAAGCT GGTGGAGAAG CGGGCGTTCC GTGAGATCCA GTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOP53 ( NM_015710.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056525.2 Homo sapiens NOP53 ribosome biogenesis factor (NOP53), mRNA.

Price & Availability↑

CloneID	OHu23339
Clone ID Related Accession (Same CDS sequence)	NM_015710.5 , NM_015710.4
Accession Version	NM_015710.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	ribosome biogenesis protein NOP53
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX866974.1, BC004229.2, BC006311.2 and AI540063.1. On Jun 11, 2009 this sequence version replaced NM_015710.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.177821.1, SRR1163655.87819.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCAG GAGGCAGTGG CGTTGGTGGG AAGCGCAGCT CGAAAAGCGA TGCCGATTCT 
GGTTTCCTGG GGCTGCGGCC CACTTCGGTG GACCCAGCGC TGAGGCGGCG GCGGCGAGGC 
CCAAGAAATA AGAAGCGGGG CTGGCGGCGG CTTGCTCAGG AGCCGCTGGG GCTGGAGGTT 
GACCAGTTCC TGGAAGACGT GCGGCTACAG GAGCGCACGA GCGGTGGCTT GTTGTCAGAG 
GCCCCAAATG AAAAACTCTT CTTCGTGGAC ACTGGCTCCA AGGAAAAAGG GCTGACAAAG 
AAGAGAACCA AAGTCCAGAA GAAGTCACTG CTTCTCAAGA AACCCCTTCG GGTTGACCTC 
ATCCTCGAGA ACACATCCAA AGTCCCTGCC CCCAAAGACG TCCTCGCCCA CCAGGTCCCC 
AACGCCAAGA AGCTCAGGCG GAAGGAGCAG CTATGGGAGA AGCTGGCCAA GCAGGGCGAG 
CTGCCCCGGG AGGTGCGCAG GGCCCAGGCC CGGCTCCTCA ACCCTTCTGC AACAAGGGCC 
AAGCCCGGGC CCCAGGACAC CGTAGAGCGG CCCTTCTACG ACCTCTGGGC CTCAGACAAC 
CCCCTGGACA GGCCGTTGGT TGGCCAGGAT GAGTTTTTCC TGGAGCAGAC CAAGAAGAAA 
GGAGTGAAGC GGCCAGCACG CCTGCACACC AAGCCGTCCC AGGCACCCGC CGTGGAGGTG 
GCGCCTGCCG GAGCTTCCTA CAATCCATCC TTTGAAGACC ACCAGACCCT GCTCTCAGCG 
GCCCACGAGG TGGAGTTGCA GCGGCAGAAG GAGGCGGAGA AGCTGGAGCG GCAGCTGGCC 
CTGCCCGCCA CGGAGCAGGC CGCCACCCAG GAGTCCACAT TCCAGGAGCT GTGCGAGGGG 
CTGCTGGAGG AGTCGGATGG TGAGGGGGAG CCAGGCCAGG GCGAGGGGCC GGAGGCTGGG 
GATGCCGAGG TCTGTCCCAC GCCCGCCCGC CTGGCCACCA CAGAGAAGAA GACGGAGCAG 
CAGCGGCGGC GGGAGAAGGC TGTGCACAGG CTGCGGGTAC AGCAGGCCGC GTTGCGGGCC 
GCCCGGCTCC GGCACCAGGA GCTGTTCCGG CTGCGCGGGA TCAAGGCCCA GGTGGCCCTG 
AGGCTGGCGG AGCTGGCGCG GCGGCAGAGG CGGCGGCAGG CGCGGCGGGA GGCTGAGGCT 
GACAAGCCCC GAAGGCTGGG GCGGCTCAAG TACCAGGCAC CTGACATCGA CGTGCAGCTG 
AGCTCGGAGC TGACAGACTC GCTCAGGACC CTGAAGCCCG AGGGCAACAT CCTTCGAGAC 
CGGTTCAAGA GCTTCCAGAG GAGGAATATG ATCGAGCCTC GAGAGAGAGC CAAGTTCAAA 
CGCAAGTACA AGGTGAAGCT GGTGGAGAAG CGGGCGTTCC GTGAGATCCA GTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056525.2
CDS	25..1461
Translation	MAAGGSGVGGKRSSKSDADSGFLGLRPTSVDPALRRRRRGPRNKKRGWRRLAQEPLGLEVDQFLEDVRLQERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQKKSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQL

Target ORF information:

RefSeq Version	NM_015710.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NOP53 ribosome biogenesis factor (NOP53), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015710.4

ORF Insert Sequence:

ATGGCGGCAG GAGGCAGTGG CGTTGGTGGG AAGCGCAGCT CGAAAAGCGA TGCCGATTCT 
GGTTTCCTGG GGCTGCGGCC CACTTCGGTG GACCCAGCGC TGAGGCGGCG GCGGCGAGGC 
CCAAGAAATA AGAAGCGGGG CTGGCGGCGG CTTGCTCAGG AGCCGCTGGG GCTGGAGGTT 
GACCAGTTCC TGGAAGACGT GCGGCTACAG GAGCGCACGA GCGGTGGCTT GTTGTCAGAG 
GCCCCAAATG AAAAACTCTT CTTCGTGGAC ACTGGCTCCA AGGAAAAAGG GCTGACAAAG 
AAGAGAACCA AAGTCCAGAA GAAGTCACTG CTTCTCAAGA AACCCCTTCG GGTTGACCTC 
ATCCTCGAGA ACACATCCAA AGTCCCTGCC CCCAAAGACG TCCTCGCCCA CCAGGTCCCC 
AACGCCAAGA AGCTCAGGCG GAAGGAGCAG CTATGGGAGA AGCTGGCCAA GCAGGGCGAG 
CTGCCCCGGG AGGTGCGCAG GGCCCAGGCC CGGCTCCTCA ACCCTTCTGC AACAAGGGCC 
AAGCCCGGGC CCCAGGACAC CGTAGAGCGG CCCTTCTACG ACCTCTGGGC CTCAGACAAC 
CCCCTGGACA GGCCGTTGGT TGGCCAGGAT GAGTTTTTCC TGGAGCAGAC CAAGAAGAAA 
GGAGTGAAGC GGCCAGCACG CCTGCACACC AAGCCGTCCC AGGCACCCGC CGTGGAGGTG 
GCGCCTGCCG GAGCTTCCTA CAATCCATCC TTTGAAGACC ACCAGACCCT GCTCTCAGCG 
GCCCACGAGG TGGAGTTGCA GCGGCAGAAG GAGGCGGAGA AGCTGGAGCG GCAGCTGGCC 
CTGCCCGCCA CGGAGCAGGC CGCCACCCAG GAGTCCACAT TCCAGGAGCT GTGCGAGGGG 
CTGCTGGAGG AGTCGGATGG TGAGGGGGAG CCAGGCCAGG GCGAGGGGCC GGAGGCTGGG 
GATGCCGAGG TCTGTCCCAC GCCCGCCCGC CTGGCCACCA CAGAGAAGAA GACGGAGCAG 
CAGCGGCGGC GGGAGAAGGC TGTGCACAGG CTGCGGGTAC AGCAGGCCGC GTTGCGGGCC 
GCCCGGCTCC GGCACCAGGA GCTGTTCCGG CTGCGCGGGA TCAAGGCCCA GGTGGCCCTG 
AGGCTGGCGG AGCTGGCGCG GCGGCAGAGG CGGCGGCAGG CGCGGCGGGA GGCTGAGGCT 
GACAAGCCCC GAAGGCTGGG GCGGCTCAAG TACCAGGCAC CTGACATCGA CGTGCAGCTG 
AGCTCGGAGC TGACAGACTC GCTCAGGACC CTGAAGCCCG AGGGCAACAT CCTTCGAGAC 
CGGTTCAAGA GCTTCCAGAG GAGGAATATG ATCGAGCCTC GAGAGAGAGC CAAGTTCAAA 
CGCAAGTACA AGGTGAAGCT GGTGGAGAAG CGGGCGTTCC GTGAGATCCA GTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

The protein interacting with carboxyl terminus-1 codon 389 polymorphism impairs protein interacting with carboxyl terminus-1 function and is a risk factor for uterine cervical cancer.
Molecular carcinogenesis56(5)1484-1492(2017 May)
Yoshimoto M,Tokuda A,Nishiwaki K,Sengoku K,Yaginuma Y

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
Oncotarget7(50)83241-83257(2016 Dec)
Chen H,Han L,Tsai H,Wang Z,Wu Y,Duo Y,Cao W,Chen L,Tan Z,Xu N,Huang X,Zhuang J,Huang L