AMBN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AMBN
Entrez Gene ID	258
Full Name	ameloblastin
Synonyms	AI1F
General protein information	Preferred Names ameloblastin Names ameloblastin enamel matrix protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q13.3
Summary	This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. [provided by RefSeq, Aug 2011].
Disorder MIM:	601259
Disorder Html:	Amelogenesis imperfecta, type IF, 616270 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016519.6	NP_057603.1	ameloblastin precursor
NM_016519.5	NP_057603.1	ameloblastin precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ambn	NP_033794.1
	AMBN	XP_001105992.1
Homo sapiens (human)	AMBN	NP_057603.1
Canis lupus familiaris (dog)	AMBN	XP_539304.3
Rattus norvegicus (Norway rat)	Ambn	NP_037032.1
Bos taurus (cattle)	AMBN	NP_776413.1
Pan troglodytes (chimpanzee)	AMBN	XP_001160377.1
Xenopus tropicalis (tropical clawed frog)	ambn	XP_002938667.2

Gene Ontology
Bibliography

Related articles in PubMed

Significance of genetic variations in developmental enamel defects of primary dentition in Polish children.
Gerreth K, Zaorska K, Zabel M, Nowicki M, Borysewicz-Lewicka M
Clinical oral investigations22(1)321-329(2018 Jan)

Ameloblastin Upregulates Inflammatory Response Through Induction of IL-1? in Human Macrophages.
Otsuka M, Okinaga T, Ariyoshi W, Kitamura C, Nishihara T
Journal of cellular biochemistry118(10)3308-3317(2017 Oct)

Genes Involved in the Enamel Development Are Associated with Calcium and Phosphorus Level in Saliva.
K?chler EC, Pecharki GD, Castro ML, Ramos J, Barbosa F Jr, Brancher JA, Vieira AR, Gerlach RF, Trevilatto PC
Caries research51(3)225-230(2017)

Protein Interaction between Ameloblastin and Proteasome Subunit ? Type 3 Can Facilitate Redistribution of Ameloblastin Domains within Forming Enamel.
Geng S, White SN, Paine ML, Snead ML
The Journal of biological chemistry290(34)20661-73(2015 Aug)

Evolutionary analysis of selective constraints identifies ameloblastin (AMBN) as a potential candidate for amelogenesis imperfecta.
Delsuc F, Gasse B, Sire JY
BMC evolutionary biology15148(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results indicate that AMBN enhances IL-1beta production in LPS-treated U937 cells through ERK1/2 phosphorylation and caspase-1 activation, suggesting that AMBN upregulates the inflammatory response in human macrophages and plays an important role in innate immunity.
Title: Ameloblastin Upregulates Inflammatory Response Through Induction of IL-1? in Human Macrophages.

Protein interaction between Ambn and Psma3 can facilitate redistribution of ameloblastin domains within forming enamel.
Title: Protein Interaction between Ameloblastin and Proteasome Subunit ? Type 3 Can Facilitate Redistribution of Ameloblastin Domains within Forming Enamel.

Authors perform an evolutionary analysis of mammalian AMBN sequences in order to predict functionally important sites of the protein and to identify candidate disease-associated mutations responsible for the protein function and identify AMBN as a candidate for amelogenesis imperfect in humans.
Title: Evolutionary analysis of selective constraints identifies ameloblastin (AMBN) as a potential candidate for amelogenesis imperfecta.

two genetic variants (rs2337359 upstream of TUFT1 and missense rs7439186 in AMBN) involved in gene-by-fluoride interactions.
Title: Effects of enamel matrix genes on dental caries are moderated by fluoride exposures.

Report shows for the first time that AMBN mutations cause non-syndromic human amelogenesis imperfecta and confirms that mouse models with disrupted Ambn function are valid.
Title: Deletion of ameloblastin exon 6 is associated with amelogenesis imperfecta.

The following AMBN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AMBN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20479	NM_016519.6 Latest version!	Homo sapiens ameloblastin (AMBN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
View Old Accession Versions >>
OHu20479	NM_016519.5	Homo sapiens ameloblastin (AMBN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AMBN ( NM_016519.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_057603.1 Homo sapiens ameloblastin (AMBN), mRNA.

Price & Availability↑

CloneID	OHu20479
Clone ID Related Accession (Same CDS sequence)	NM_016519.6 , NM_016519.5
Accession Version	NM_016519.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	ameloblastin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC134919.3, BP248666.1, AJ537437.1, BC106931.1 and AF209780.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_016519.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF209780.1, BC106931.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2145743 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000322937.10/ ENSP00000313809.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCAGCAT CTAAGATTCC ACTTTTCAAA ATGAAGGACC TGATACTGAT CCTATGCCTC 
CTGGAAATGA GTTTTGCAGT GCCGTTCTTT CCTCAGCAAT CTGGAACACC GGGTATGGCT 
AGTTTGAGCC TTGAGACAAT GAGACAGTTG GGAAGTCTGC AGAGATTAAA CACACTTTCT 
CAGTATTCTA GATACGGCTT TGGAAAATCA TTTAATTCTT TGTGGATGCA CGGTCTCCTC 
CCACCACATT CCTCTCTTCC ATGGATGAGG CCAAGAGAAC ATGAAACTCA ACAGTATGAA 
TATTCTTTGC CTGTGCATCC CCCACCTCTC CCATCACAGC CATCCTTGAA GCCTCAACAG 
CCAGGACTGA AACCTTTTCT CCAGTCTGCT GCTGCAACCA CCAACCAGGC CACAGCACTG 
AAAGAAGCAC TTCAGCCTCC AATTCACCTG GGACATCTGC CCTTGCAGGA AGGAGAACTG 
CCTCTGGTTC AGCAGCAGGT GGCACCATCA GATAAGCCAC CAAAGCCTGA GCTCCCAGGA 
GTAGATTTTG CTGATCCACA AGGTCCATCA CTCCCAGGAA TGGATTTTCC TGATCCACAA 
GGTCCATCAC TCCCAGGATT GGATTTTGCT GATCCACAAG GTTCAACAAT TTTCCAAATA 
GCCCGTTTGA TTTCTCACGG ACCAATGCCA CAAAATAAAC AATCTCCACT TTATCCAGGA 
ATGTTGTACG TGCCTTTTGG AGCAAATCAA TTGAATGCCC CTGCCAGACT TGGCATCATG 
AGTTCAGAAG AAGTGGCAGG CGGGAGAGAA GACCCAATGG CCTATGGAGC CATGTTTCCA 
GGATTTGGAG GCATGAGGCC CGGCTTTGAG GGAATGCCCC ACAACCCAGC TATGGGCGGT 
GACTTCACTC TGGAATTTGA CTCCCCAGTG GCTGCCACCA AAGGCCCTGA GAACGAAGAA 
GGAGGTGCAC AAGGCTCCCC TATGCCGGAG GCCAACCCAG ACAATCTAGA AAACCCAGCT 
TTCCTTACAG AGCTAGAACC TGCTCCCCAC GCAGGGCTCC TTGCTCTCCC TAAGGATGAC 
ATTCCCGGCC TGCCAAGGAG CCCTTCAGGG AAGATGAAGG GACTCCCCAG CGTCACCCCA 
GCAGCTGCTG ACCCACTGAT GACCCCTGAA TTAGCTGATG TTTATAGGAC CTACGATGCT 
GACATGACCA CATCCGTGGA TTTCCAGGAA GAAGCAACCA TGGATACCAC GATGGCCCCA 
AACTCTCTGC AAACATCCAT GCCAGGAAAC AAAGCCCAGG AGCCCGAGAT GATGCATGAC 
GCATGGCATT TCCAAGAGCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057603.1
CDS	104..1447
Translation	MSASKIPLFKMKDLILILCLLEMSFAVPFFPQQSGTPGMASLSLETMRQLGSLQRLNTLSQYSRYGFGKSFNSLWMHGLLPPHSSLPWMRPREHETQQYEYSLPVHPPPLPSQPSLKPQQPGLKPFLQSAAATTNQATALKEALQPPIHLGHLPLQEGELPLVQQQVAPSDKPPKPELPGVDFADPQGPSLPGMDFPDPQGPSLPGLDFADPQGSTIFQIARLISHGPMPQNKQSPLYPGMLYVPFGANQLNAPARLGIMSSEEVAGGREDPMAYGAMFPGFGGMRPGFEGMPHNPAMGGDFTLEFDSPVAATKGPENEEGGAQGSPMPEANPDNLENPAFLTELEPAPHAGLLALPKDDIPGLPRSPSGKMKGLPSVTPAAADPLMTPELADVYRTYDADMTTSVDFQEEATMDTTMAPNSLQTSMPGNKAQEPEMMHDAWHFQEP

Target ORF information:

RefSeq Version	NM_016519.6
Organism	Homo sapiens(human)
Definition	Homo sapiens ameloblastin (AMBN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016519.6

ORF Insert Sequence:

ATGTCAGCAT CTAAGATTCC ACTTTTCAAA ATGAAGGACC TGATACTGAT CCTATGCCTC 
CTGGAAATGA GTTTTGCAGT GCCGTTCTTT CCTCAGCAAT CTGGAACACC GGGTATGGCT 
AGTTTGAGCC TTGAGACAAT GAGACAGTTG GGAAGTCTGC AGAGATTAAA CACACTTTCT 
CAGTATTCTA GATACGGCTT TGGAAAATCA TTTAATTCTT TGTGGATGCA CGGTCTCCTC 
CCACCACATT CCTCTCTTCC ATGGATGAGG CCAAGAGAAC ATGAAACTCA ACAGTATGAA 
TATTCTTTGC CTGTGCATCC CCCACCTCTC CCATCACAGC CATCCTTGAA GCCTCAACAG 
CCAGGACTGA AACCTTTTCT CCAGTCTGCT GCTGCAACCA CCAACCAGGC CACAGCACTG 
AAAGAAGCAC TTCAGCCTCC AATTCACCTG GGACATCTGC CCTTGCAGGA AGGAGAACTG 
CCTCTGGTTC AGCAGCAGGT GGCACCATCA GATAAGCCAC CAAAGCCTGA GCTCCCAGGA 
GTAGATTTTG CTGATCCACA AGGTCCATCA CTCCCAGGAA TGGATTTTCC TGATCCACAA 
GGTCCATCAC TCCCAGGATT GGATTTTGCT GATCCACAAG GTTCAACAAT TTTCCAAATA 
GCCCGTTTGA TTTCTCACGG ACCAATGCCA CAAAATAAAC AATCTCCACT TTATCCAGGA 
ATGTTGTACG TGCCTTTTGG AGCAAATCAA TTGAATGCCC CTGCCAGACT TGGCATCATG 
AGTTCAGAAG AAGTGGCAGG CGGGAGAGAA GACCCAATGG CCTATGGAGC CATGTTTCCA 
GGATTTGGAG GCATGAGGCC CGGCTTTGAG GGAATGCCCC ACAACCCAGC TATGGGCGGT 
GACTTCACTC TGGAATTTGA CTCCCCAGTG GCTGCCACCA AAGGCCCTGA GAACGAAGAA 
GGAGGTGCAC AAGGCTCCCC TATGCCGGAG GCCAACCCAG ACAATCTAGA AAACCCAGCT 
TTCCTTACAG AGCTAGAACC TGCTCCCCAC GCAGGGCTCC TTGCTCTCCC TAAGGATGAC 
ATTCCCGGCC TGCCAAGGAG CCCTTCAGGG AAGATGAAGG GACTCCCCAG CGTCACCCCA 
GCAGCTGCTG ACCCACTGAT GACCCCTGAA TTAGCTGATG TTTATAGGAC CTACGATGCT 
GACATGACCA CATCCGTGGA TTTCCAGGAA GAAGCAACCA TGGATACCAC GATGGCCCCA 
AACTCTCTGC AAACATCCAT GCCAGGAAAC AAAGCCCAGG AGCCCGAGAT GATGCATGAC 
GCATGGCATT TCCAAGAGCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AMBN ( NM_016519.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057603.1 Homo sapiens ameloblastin (AMBN), mRNA.

Price & Availability↑

CloneID	OHu20479
Clone ID Related Accession (Same CDS sequence)	NM_016519.6 , NM_016519.5
Accession Version	NM_016519.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	ameloblastin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP248666.1, AJ537437.1, BC106931.1, AF209780.1 and AC134919.3. This sequence is a reference standard in the RefSeqGene project. On Sep 1, 2011 this sequence version replaced NM_016519.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF209780.1, BC106931.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2145743 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGCAT CTAAGATTCC ACTTTTCAAA ATGAAGGACC TGATACTGAT CCTATGCCTC 
CTGGAAATGA GTTTTGCAGT GCCGTTCTTT CCTCAGCAAT CTGGAACACC GGGTATGGCT 
AGTTTGAGCC TTGAGACAAT GAGACAGTTG GGAAGTCTGC AGAGATTAAA CACACTTTCT 
CAGTATTCTA GATACGGCTT TGGAAAATCA TTTAATTCTT TGTGGATGCA CGGTCTCCTC 
CCACCACATT CCTCTCTTCC ATGGATGAGG CCAAGAGAAC ATGAAACTCA ACAGTATGAA 
TATTCTTTGC CTGTGCATCC CCCACCTCTC CCATCACAGC CATCCTTGAA GCCTCAACAG 
CCAGGACTGA AACCTTTTCT CCAGTCTGCT GCTGCAACCA CCAACCAGGC CACAGCACTG 
AAAGAAGCAC TTCAGCCTCC AATTCACCTG GGACATCTGC CCTTGCAGGA AGGAGAACTG 
CCTCTGGTTC AGCAGCAGGT GGCACCATCA GATAAGCCAC CAAAGCCTGA GCTCCCAGGA 
GTAGATTTTG CTGATCCACA AGGTCCATCA CTCCCAGGAA TGGATTTTCC TGATCCACAA 
GGTCCATCAC TCCCAGGATT GGATTTTGCT GATCCACAAG GTTCAACAAT TTTCCAAATA 
GCCCGTTTGA TTTCTCACGG ACCAATGCCA CAAAATAAAC AATCTCCACT TTATCCAGGA 
ATGTTGTACG TGCCTTTTGG AGCAAATCAA TTGAATGCCC CTGCCAGACT TGGCATCATG 
AGTTCAGAAG AAGTGGCAGG CGGGAGAGAA GACCCAATGG CCTATGGAGC CATGTTTCCA 
GGATTTGGAG GCATGAGGCC CGGCTTTGAG GGAATGCCCC ACAACCCAGC TATGGGCGGT 
GACTTCACTC TGGAATTTGA CTCCCCAGTG GCTGCCACCA AAGGCCCTGA GAACGAAGAA 
GGAGGTGCAC AAGGCTCCCC TATGCCGGAG GCCAACCCAG ACAATCTAGA AAACCCAGCT 
TTCCTTACAG AGCTAGAACC TGCTCCCCAC GCAGGGCTCC TTGCTCTCCC TAAGGATGAC 
ATTCCCGGCC TGCCAAGGAG CCCTTCAGGG AAGATGAAGG GACTCCCCAG CGTCACCCCA 
GCAGCTGCTG ACCCACTGAT GACCCCTGAA TTAGCTGATG TTTATAGGAC CTACGATGCT 
GACATGACCA CATCCGTGGA TTTCCAGGAA GAAGCAACCA TGGATACCAC GATGGCCCCA 
AACTCTCTGC AAACATCCAT GCCAGGAAAC AAAGCCCAGG AGCCCGAGAT GATGCATGAC 
GCATGGCATT TCCAAGAGCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057603.1
CDS	102..1445
Translation	MSASKIPLFKMKDLILILCLLEMSFAVPFFPQQSGTPGMASLSLETMRQLGSLQRLNTLSQYSRYGFGKSFNSLWMHGLLPPHSSLPWMRPREHETQQYEYSLPVHPPPLPSQPSLKPQQPGLKPFLQSAAATTNQATALKEALQPPIHLGHLPLQEGELPLVQQQVAPSDKPPKPELPGVDFADPQGPSLPGMDFPDPQGPSLPGLDFADPQGSTIFQIARLISHGPMPQNKQSPLYPGMLYVPFGANQLNAPARLGIMSSEEVAGGREDPMAYGAMFPGFGGMRPGFEGMPHNPAMGGDFTLEFDSPVAATKGPENEEGGAQGSPMPEANPDNLENPAFLTELEPAPHAGLLALPKDDIPGLPRSPSGKMKGLPSVTPAAADPLMTPELADVYRTYDADMTTSVDFQEEATMDTTMAPNSLQTSMPGNKAQEPEMMHDAWHFQEP

Target ORF information:

RefSeq Version	NM_016519.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ameloblastin (AMBN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016519.5

ORF Insert Sequence:

ATGTCAGCAT CTAAGATTCC ACTTTTCAAA ATGAAGGACC TGATACTGAT CCTATGCCTC 
CTGGAAATGA GTTTTGCAGT GCCGTTCTTT CCTCAGCAAT CTGGAACACC GGGTATGGCT 
AGTTTGAGCC TTGAGACAAT GAGACAGTTG GGAAGTCTGC AGAGATTAAA CACACTTTCT 
CAGTATTCTA GATACGGCTT TGGAAAATCA TTTAATTCTT TGTGGATGCA CGGTCTCCTC 
CCACCACATT CCTCTCTTCC ATGGATGAGG CCAAGAGAAC ATGAAACTCA ACAGTATGAA 
TATTCTTTGC CTGTGCATCC CCCACCTCTC CCATCACAGC CATCCTTGAA GCCTCAACAG 
CCAGGACTGA AACCTTTTCT CCAGTCTGCT GCTGCAACCA CCAACCAGGC CACAGCACTG 
AAAGAAGCAC TTCAGCCTCC AATTCACCTG GGACATCTGC CCTTGCAGGA AGGAGAACTG 
CCTCTGGTTC AGCAGCAGGT GGCACCATCA GATAAGCCAC CAAAGCCTGA GCTCCCAGGA 
GTAGATTTTG CTGATCCACA AGGTCCATCA CTCCCAGGAA TGGATTTTCC TGATCCACAA 
GGTCCATCAC TCCCAGGATT GGATTTTGCT GATCCACAAG GTTCAACAAT TTTCCAAATA 
GCCCGTTTGA TTTCTCACGG ACCAATGCCA CAAAATAAAC AATCTCCACT TTATCCAGGA 
ATGTTGTACG TGCCTTTTGG AGCAAATCAA TTGAATGCCC CTGCCAGACT TGGCATCATG 
AGTTCAGAAG AAGTGGCAGG CGGGAGAGAA GACCCAATGG CCTATGGAGC CATGTTTCCA 
GGATTTGGAG GCATGAGGCC CGGCTTTGAG GGAATGCCCC ACAACCCAGC TATGGGCGGT 
GACTTCACTC TGGAATTTGA CTCCCCAGTG GCTGCCACCA AAGGCCCTGA GAACGAAGAA 
GGAGGTGCAC AAGGCTCCCC TATGCCGGAG GCCAACCCAG ACAATCTAGA AAACCCAGCT 
TTCCTTACAG AGCTAGAACC TGCTCCCCAC GCAGGGCTCC TTGCTCTCCC TAAGGATGAC 
ATTCCCGGCC TGCCAAGGAG CCCTTCAGGG AAGATGAAGG GACTCCCCAG CGTCACCCCA 
GCAGCTGCTG ACCCACTGAT GACCCCTGAA TTAGCTGATG TTTATAGGAC CTACGATGCT 
GACATGACCA CATCCGTGGA TTTCCAGGAA GAAGCAACCA TGGATACCAC GATGGCCCCA 
AACTCTCTGC AAACATCCAT GCCAGGAAAC AAAGCCCAGG AGCCCGAGAT GATGCATGAC 
GCATGGCATT TCCAAGAGCC CTGA