EIF2S3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EIF2S3
Entrez Gene ID	1968
Full Name	eukaryotic translation initiation factor 2 subunit gamma
Synonyms	EIF2,EIF2G,EIF2gamma,MEHMO,MRXSBRK,eIF-2gA
General protein information	Preferred Names eukaryotic translation initiation factor 2 subunit gamma Names eukaryotic translation initiation factor 2 subunit 3 eIF-2-gamma X eIF-2gX eukaryotic translation initiation factor 2 subunit gamma X eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa eukaryotic translation initiation factor 2G
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp22.11
Summary	The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010].
Disorder MIM:	300161
Disorder Html:	Mental retardation, X-linked, syndromic, Borck type, 300987 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001415.4	NP_001406.1	eukaryotic translation initiation factor 2 subunit 3
NM_001415.3	NP_001406.1	eukaryotic translation initiation factor 2 subunit 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	EIF2S3	XP_003952163.1
Danio rerio (zebrafish)	eif2s3	NP_997876.1
Rattus norvegicus (Norway rat)	Eif2s3x	NP_001094012.1
Gallus gallus (chicken)	EIF2S3	NP_001006260.1
Caenorhabditis elegans (roundworm)	CELE_Y39G10AR.8	NP_490960.1
Arabidopsis thaliana (thale cress)	EIF2 GAMMA	NP_171913.1
Xenopus tropicalis (tropical clawed frog)	eif2s3	NP_001011456.1
Homo sapiens (human)	EIF2S3	NP_001406.1
Canis lupus familiaris (dog)	EIF2S3	XP_537983.2
Drosophila melanogaster (fruit fly)	eIF-2gamma	NP_731993.1
Oryza sativa (rice)	Os12g0176800	NP_001066299.1
Bos taurus (cattle)	EIF2S3	NP_001039582.1
Mus musculus (house mouse)	Eif2s3x	NP_036140.1
	EIF2S3	XP_001089902.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003597	XP_003436534.1
Oryza sativa (rice)	Os12g0607100	NP_001067233.1

Gene Ontology
Bibliography

Related articles in PubMed

Neonatal hypoglycemia, early-onset diabetes and hypopituitarism due to the mutation in EIF2S3 gene causing MEHMO syndrome.
Stanik J, Skopkova M, Stanikova D, Brennerova K, Barak L, Ticha L, Hornova J, Klimes I, Gasperikova D
Physiological research(2018 Jan)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

EIF2S3 Mutations Associated with Severe X-Linked Intellectual Disability Syndrome MEHMO.
Skopkova M, Hennig F, Shin BS, Turner CE, Stanikova D, Brennerova K, Stanik J, Fischer U, Henden L, M?ller U, Steinberger D, Leshinsky-Silver E, Bottani A, Kurdiova T, Ukropec J, Nyitrayova O, Kolnikova M, Klimes I, Borck G, Bahlo M, Haas SA, Kim JR, Lotspeich-Cole LE, Gasperikova D, Dever TE, Kalscheuer VM
Human mutation38(4)409-425(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that more severe EIF2S3 mutations cause the full MEHMO phenotype, while less deleterious mutations cause a milder form of the syndrome with only a subset of the symptoms.
Title: EIF2S3 Mutations Associated with Severe X-Linked Intellectual Disability Syndrome MEHMO.

Our data confirm that EIF2S3 mutation is implicated in a rare, but recognizable, form of syndromic intellectual disability.
Title: Two novel EIF2S3 mutations associated with syndromic intellectual disability with severe microcephaly, growth retardation, and epilepsy.

The human X-chromosomal neurological disorder characterized by intellectual disability and microcephaly is caused by a missense mutation in eIF2gamma (encoded by EIF2S3), the core subunit of the heterotrimeric eIF2 complex.
Title: eIF2? mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis.

The following EIF2S3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EIF2S3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17824	NM_001415.4 Latest version!	Homo sapiens eukaryotic translation initiation factor 2 subunit gamma (EIF2S3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OHu17824	NM_001415.3	Homo sapiens eukaryotic translation initiation factor 2 subunit gamma (EIF2S3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EIF2S3 ( NM_001415.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001406.1 Homo sapiens eukaryotic translation initiation factor 2 subunit gamma (EIF2S3), mRNA.

Price & Availability↑

CloneID	OHu17824
Clone ID Related Accession (Same CDS sequence)	NM_001415.4 , NM_001415.3
Accession Version	NM_001415.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1419bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 2 subunit 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BC019906.1, BC011945.1, AI133612.1, BF435665.1 and CB150474.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001415.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.218577.1, SRR1660807.237157.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000253039.9/ ENSP00000253039.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGGCG GAGAAGCTGG AGTGACTCTA GGGCAGCCGC ATCTTTCGCG TCAGGATCTC 
ACCACCTTGG ATGTTACCAA GTTGACGCCA CTTTCACACG AAGTTATCAG CAGACAAGCC 
ACAATTAACA TAGGTACAAT TGGTCATGTA GCTCATGGGA AATCCACAGT CGTCAAAGCT 
ATTTCTGGAG TTCATACTGT CAGGTTCAAA AATGAACTAG AAAGAAATAT TACAATCAAG 
CTTGGATATG CTAATGCTAA GATTTATAAG CTTGATGACC CAAGTTGCCC TCGGCCAGAA 
TGTTATAGAT CTTGTGGGAG CAGTACACCT GACGAGTTTC CTACGGACAT TCCAGGGACC 
AAAGGGAACT TCAAATTAGT CAGACATGTT TCCTTTGTTG ACTGTCCTGG CCACGATATT 
TTGATGGCTA CTATGCTGAA CGGTGCAGCA GTGATGGATG CAGCTCTTCT GTTGATAGCT 
GGTAATGAAT CTTGCCCTCA GCCTCAGACA TCGGAACACC TGGCTGCTAT AGAGATCATG 
AAACTGAAGC ATATTTTGAT TCTACAAAAT AAAATTGATT TGGTAAAAGA AAGTCAGGCT 
AAAGAACAAT ACGAGCAGAT CCTTGCATTT GTCCAAGGTA CAGTAGCAGA GGGAGCTCCC 
ATTATTCCAA TTTCAGCTCA GCTGAAATAC AATATTGAAG TTGTTTGTGA GTACATAGTA 
AAGAAAATTC CAGTACCCCC AAGAGACTTT ACTTCAGAGC CCCGGCTTAT TGTTATTAGA 
TCTTTTGATG TCAACAAACC TGGCTGTGAA GTTGATGACC TTAAGGGAGG TGTAGCTGGT 
GGTAGTATCC TAAAAGGAGT ATTAAAGGTG GGCCAGGAGA TAGAAGTAAG ACCTGGTATT 
GTTTCCAAAG ATAGTGAAGG AAAACTCATG TGTAAACCAA TCTTTTCCAA AATTGTATCA 
CTTTTTGCGG AGCATAATGA TCTGCAATAT GCTGCTCCAG GCGGTCTTAT TGGAGTTGGA 
ACAAAAATTG ACCCCACTTT GTGCCGGGCT GACAGAATGG TGGGGCAAGT ACTTGGTGCA 
GTCGGAGCTT TACCTGAGAT ATTCACAGAA TTGGAAATTT CCTATTTCCT GCTTAGACGG 
CTTCTAGGTG TACGCACTGA AGGAGACAAG AAAGCAGCAA AGGTTCAAAA GCTGTCTAAG 
AATGAAGTGC TCATGGTGAA CATAGGATCC CTGTCAACAG GAGGGAGAGT TAGTGCTGTC 
AAGGCCGATT TGGGTAAAAT TGTTTTGACC AATCCAGTGT GCACAGAGGT AGGAGAAAAA 
ATTGCCCTTA GCCGAAGAGT TGAAAAACAC TGGCGTTTAA TTGGTTGGGG TCAGATAAGA 
AGAGGAGTGA CAATCAAGCC AACAGTAGAT GATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001406.1
CDS	14..1432
Translation	MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD

Target ORF information:

RefSeq Version	NM_001415.4
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 2 subunit gamma (EIF2S3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001415.4

ORF Insert Sequence:

ATGGCGGGCG GAGAAGCTGG AGTGACTCTA GGGCAGCCGC ATCTTTCGCG TCAGGATCTC 
ACCACCTTGG ATGTTACCAA GTTGACGCCA CTTTCACACG AAGTTATCAG CAGACAAGCC 
ACAATTAACA TAGGTACAAT TGGTCATGTA GCTCATGGGA AATCCACAGT CGTCAAAGCT 
ATTTCTGGAG TTCATACTGT CAGGTTCAAA AATGAACTAG AAAGAAATAT TACAATCAAG 
CTTGGATATG CTAATGCTAA GATTTATAAG CTTGATGACC CAAGTTGCCC TCGGCCAGAA 
TGTTATAGAT CTTGTGGGAG CAGTACACCT GACGAGTTTC CTACGGACAT TCCAGGGACC 
AAAGGGAACT TCAAATTAGT CAGACATGTT TCCTTTGTTG ACTGTCCTGG CCACGATATT 
TTGATGGCTA CTATGCTGAA CGGTGCAGCA GTGATGGATG CAGCTCTTCT GTTGATAGCT 
GGTAATGAAT CTTGCCCTCA GCCTCAGACA TCGGAACACC TGGCTGCTAT AGAGATCATG 
AAACTGAAGC ATATTTTGAT TCTACAAAAT AAAATTGATT TGGTAAAAGA AAGTCAGGCT 
AAAGAACAAT ACGAGCAGAT CCTTGCATTT GTCCAAGGTA CAGTAGCAGA GGGAGCTCCC 
ATTATTCCAA TTTCAGCTCA GCTGAAATAC AATATTGAAG TTGTTTGTGA GTACATAGTA 
AAGAAAATTC CAGTACCCCC AAGAGACTTT ACTTCAGAGC CCCGGCTTAT TGTTATTAGA 
TCTTTTGATG TCAACAAACC TGGCTGTGAA GTTGATGACC TTAAGGGAGG TGTAGCTGGT 
GGTAGTATCC TAAAAGGAGT ATTAAAGGTG GGCCAGGAGA TAGAAGTAAG ACCTGGTATT 
GTTTCCAAAG ATAGTGAAGG AAAACTCATG TGTAAACCAA TCTTTTCCAA AATTGTATCA 
CTTTTTGCGG AGCATAATGA TCTGCAATAT GCTGCTCCAG GCGGTCTTAT TGGAGTTGGA 
ACAAAAATTG ACCCCACTTT GTGCCGGGCT GACAGAATGG TGGGGCAAGT ACTTGGTGCA 
GTCGGAGCTT TACCTGAGAT ATTCACAGAA TTGGAAATTT CCTATTTCCT GCTTAGACGG 
CTTCTAGGTG TACGCACTGA AGGAGACAAG AAAGCAGCAA AGGTTCAAAA GCTGTCTAAG 
AATGAAGTGC TCATGGTGAA CATAGGATCC CTGTCAACAG GAGGGAGAGT TAGTGCTGTC 
AAGGCCGATT TGGGTAAAAT TGTTTTGACC AATCCAGTGT GCACAGAGGT AGGAGAAAAA 
ATTGCCCTTA GCCGAAGAGT TGAAAAACAC TGGCGTTTAA TTGGTTGGGG TCAGATAAGA 
AGAGGAGTGA CAATCAAGCC AACAGTAGAT GATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF2S3 ( NM_001415.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001406.1 Homo sapiens eukaryotic translation initiation factor 2 subunit gamma (EIF2S3), mRNA.

Price & Availability↑

CloneID	OHu17824
Clone ID Related Accession (Same CDS sequence)	NM_001415.4 , NM_001415.3
Accession Version	NM_001415.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1419bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 2 subunit 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BC019906.1, BC011945.1, AI133612.1, BF435665.1 and CB150474.1. This sequence is a reference standard in the RefSeqGene project. On Dec 15, 2005 this sequence version replaced NM_001415.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.218577.1, SRR1660807.237157.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGGGCG GAGAAGCTGG AGTGACTCTA GGGCAGCCGC ATCTTTCGCG TCAGGATCTC 
ACCACCTTGG ATGTTACCAA GTTGACGCCA CTTTCACACG AAGTTATCAG CAGACAAGCC 
ACAATTAACA TAGGTACAAT TGGTCATGTA GCTCATGGGA AATCCACAGT CGTCAAAGCT 
ATTTCTGGAG TTCATACTGT CAGGTTCAAA AATGAACTAG AAAGAAATAT TACAATCAAG 
CTTGGATATG CTAATGCTAA GATTTATAAG CTTGATGACC CAAGTTGCCC TCGGCCAGAA 
TGTTATAGAT CTTGTGGGAG CAGTACACCT GACGAGTTTC CTACGGACAT TCCAGGGACC 
AAAGGGAACT TCAAATTAGT CAGACATGTT TCCTTTGTTG ACTGTCCTGG CCACGATATT 
TTGATGGCTA CTATGCTGAA CGGTGCAGCA GTGATGGATG CAGCTCTTCT GTTGATAGCT 
GGTAATGAAT CTTGCCCTCA GCCTCAGACA TCGGAACACC TGGCTGCTAT AGAGATCATG 
AAACTGAAGC ATATTTTGAT TCTACAAAAT AAAATTGATT TGGTAAAAGA AAGTCAGGCT 
AAAGAACAAT ACGAGCAGAT CCTTGCATTT GTCCAAGGTA CAGTAGCAGA GGGAGCTCCC 
ATTATTCCAA TTTCAGCTCA GCTGAAATAC AATATTGAAG TTGTTTGTGA GTACATAGTA 
AAGAAAATTC CAGTACCCCC AAGAGACTTT ACTTCAGAGC CCCGGCTTAT TGTTATTAGA 
TCTTTTGATG TCAACAAACC TGGCTGTGAA GTTGATGACC TTAAGGGAGG TGTAGCTGGT 
GGTAGTATCC TAAAAGGAGT ATTAAAGGTG GGCCAGGAGA TAGAAGTAAG ACCTGGTATT 
GTTTCCAAAG ATAGTGAAGG AAAACTCATG TGTAAACCAA TCTTTTCCAA AATTGTATCA 
CTTTTTGCGG AGCATAATGA TCTGCAATAT GCTGCTCCAG GCGGTCTTAT TGGAGTTGGA 
ACAAAAATTG ACCCCACTTT GTGCCGGGCT GACAGAATGG TGGGGCAAGT ACTTGGTGCA 
GTCGGAGCTT TACCTGAGAT ATTCACAGAA TTGGAAATTT CCTATTTCCT GCTTAGACGG 
CTTCTAGGTG TACGCACTGA AGGAGACAAG AAAGCAGCAA AGGTTCAAAA GCTGTCTAAG 
AATGAAGTGC TCATGGTGAA CATAGGATCC CTGTCAACAG GAGGGAGAGT TAGTGCTGTC 
AAGGCCGATT TGGGTAAAAT TGTTTTGACC AATCCAGTGT GCACAGAGGT AGGAGAAAAA 
ATTGCCCTTA GCCGAAGAGT TGAAAAACAC TGGCGTTTAA TTGGTTGGGG TCAGATAAGA 
AGAGGAGTGA CAATCAAGCC AACAGTAGAT GATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001406.1
CDS	22..1440
Translation	MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD

Target ORF information:

RefSeq Version	NM_001415.3
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 2 subunit gamma (EIF2S3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001415.3

ORF Insert Sequence:

ATGGCGGGCG GAGAAGCTGG AGTGACTCTA GGGCAGCCGC ATCTTTCGCG TCAGGATCTC 
ACCACCTTGG ATGTTACCAA GTTGACGCCA CTTTCACACG AAGTTATCAG CAGACAAGCC 
ACAATTAACA TAGGTACAAT TGGTCATGTA GCTCATGGGA AATCCACAGT CGTCAAAGCT 
ATTTCTGGAG TTCATACTGT CAGGTTCAAA AATGAACTAG AAAGAAATAT TACAATCAAG 
CTTGGATATG CTAATGCTAA GATTTATAAG CTTGATGACC CAAGTTGCCC TCGGCCAGAA 
TGTTATAGAT CTTGTGGGAG CAGTACACCT GACGAGTTTC CTACGGACAT TCCAGGGACC 
AAAGGGAACT TCAAATTAGT CAGACATGTT TCCTTTGTTG ACTGTCCTGG CCACGATATT 
TTGATGGCTA CTATGCTGAA CGGTGCAGCA GTGATGGATG CAGCTCTTCT GTTGATAGCT 
GGTAATGAAT CTTGCCCTCA GCCTCAGACA TCGGAACACC TGGCTGCTAT AGAGATCATG 
AAACTGAAGC ATATTTTGAT TCTACAAAAT AAAATTGATT TGGTAAAAGA AAGTCAGGCT 
AAAGAACAAT ACGAGCAGAT CCTTGCATTT GTCCAAGGTA CAGTAGCAGA GGGAGCTCCC 
ATTATTCCAA TTTCAGCTCA GCTGAAATAC AATATTGAAG TTGTTTGTGA GTACATAGTA 
AAGAAAATTC CAGTACCCCC AAGAGACTTT ACTTCAGAGC CCCGGCTTAT TGTTATTAGA 
TCTTTTGATG TCAACAAACC TGGCTGTGAA GTTGATGACC TTAAGGGAGG TGTAGCTGGT 
GGTAGTATCC TAAAAGGAGT ATTAAAGGTG GGCCAGGAGA TAGAAGTAAG ACCTGGTATT 
GTTTCCAAAG ATAGTGAAGG AAAACTCATG TGTAAACCAA TCTTTTCCAA AATTGTATCA 
CTTTTTGCGG AGCATAATGA TCTGCAATAT GCTGCTCCAG GCGGTCTTAT TGGAGTTGGA 
ACAAAAATTG ACCCCACTTT GTGCCGGGCT GACAGAATGG TGGGGCAAGT ACTTGGTGCA 
GTCGGAGCTT TACCTGAGAT ATTCACAGAA TTGGAAATTT CCTATTTCCT GCTTAGACGG 
CTTCTAGGTG TACGCACTGA AGGAGACAAG AAAGCAGCAA AGGTTCAAAA GCTGTCTAAG 
AATGAAGTGC TCATGGTGAA CATAGGATCC CTGTCAACAG GAGGGAGAGT TAGTGCTGTC 
AAGGCCGATT TGGGTAAAAT TGTTTTGACC AATCCAGTGT GCACAGAGGT AGGAGAAAAA 
ATTGCCCTTA GCCGAAGAGT TGAAAAACAC TGGCGTTTAA TTGGTTGGGG TCAGATAAGA 
AGAGGAGTGA CAATCAAGCC AACAGTAGAT GATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neonatal hypoglycemia, early-onset diabetes and hypopituitarism due to the mutation in EIF2S3 gene causing MEHMO syndrome.
Physiological research(2018 Jan)
Stanik J,Skopkova M,Stanikova D,Brennerova K,Barak L,Ticha L,Hornova J,Klimes I,Gasperikova D

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

EIF2S3 Mutations Associated with Severe X-Linked Intellectual Disability Syndrome MEHMO.
Human mutation38(4)409-425(2017 Apr)
Skopkova M,Hennig F,Shin BS,Turner CE,Stanikova D,Brennerova K,Stanik J,Fischer U,Henden L,M?ller U,Steinberger D,Leshinsky-Silver E,Bottani A,Kurdiova T,Ukropec J,Nyitrayova O,Kolnikova M,Klimes I,Borck G,Bahlo M,Haas SA,Kim JR,Lotspeich-Cole LE,Gasperikova D,Dever TE,Kalscheuer VM

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EIF2S3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

Eメール

電話

FAX

オンラインフォーム