COMTD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COMTD1
Entrez Gene ID	118881
Full Name	catechol-O-methyltransferase domain containing 1
General protein information	Preferred Names catechol-O-methyltransferase domain containing 1 Names catechol O-methyltransferase domain-containing protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q22.2

mRNA and Protein(s)

mRNA	Protein	Name
XM_024447791.1	XP_024303559.1	catechol O-methyltransferase domain-containing protein 1 isoform X1
NM_144589.3	NP_653190.2	catechol O-methyltransferase domain-containing protein 1
NM_144589.2	NP_653190.2	catechol O-methyltransferase domain-containing protein 1
NM_144589.4	NP_653190.2	catechol O-methyltransferase domain-containing protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	COMTD1	NP_653190.2
Mus musculus (house mouse)	Comtd1	NP_081241.1
Caenorhabditis elegans (roundworm)	comt-4	NP_503558.1
Rattus norvegicus (Norway rat)	Comtd1	NP_001100719.1
Caenorhabditis elegans (roundworm)	comt-5	NP_503559.2
Canis lupus familiaris (dog)	COMTD1	XP_546175.3
Danio rerio (zebrafish)	comtd1	NP_001157280.1
Caenorhabditis elegans (roundworm)	comt-3	NP_503560.2
Pan troglodytes (chimpanzee)	COMTD1	XP_001149486.1
Gallus gallus (chicken)	COMTD1	XP_421605.4
Caenorhabditis elegans (roundworm)	CELE_Y32B12A.3	NP_507175.2
Arabidopsis thaliana (thale cress)	AT3G62000	NP_191759.1
	COMTD1	XP_001096124.1
Bos taurus (cattle)	COMTD1	NP_001098838.1
Arabidopsis thaliana (thale cress)	AT3G61990	NP_191758.1
Oryza sativa (rice)	Os08g0154000	NP_001061012.1

Gene Ontology
Bibliography

Related articles in PubMed

De Novo 1.77-Mb Microdeletion of 10q22.2q22.3 in a Girl With Developmental Delay, Speech Delay, Congenital Cleft Palate, and Bilateral Hearing Impairment.
Lei TY, Wang HT, Li F, Cui YQ, Fu F, Li R, Liao C
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association54(3)343-350(2017 May)

Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia.
Nishioka M, Bundo M, Koike S, Takizawa R, Kakiuchi C, Araki T, Kasai K, Iwamoto K
Journal of human genetics58(2)91-7(2013 Feb)

Genetic variants associated with breast size also influence breast cancer risk.
Eriksson N, Benton GM, Do CB, Kiefer AK, Mountain JL, Hinds DA, Francke U, Tung JY
BMC medical genetics1353(2012 Jun)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vri?ze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A
American journal of human genetics78(1)78-88(2006 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

The following COMTD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COMTD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06331	NM_144589.4 Latest version!	Homo sapiens catechol-O-methyltransferase domain containing 1 (COMTD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu75086	XM_024447791.1 Latest version!	Homo sapiens catechol-O-methyltransferase domain containing 1 (COMTD1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu06331	NM_144589.2	Homo sapiens catechol-O-methyltransferase domain containing 1 (COMTD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu06331	NM_144589.3	Homo sapiens catechol-O-methyltransferase domain containing 1 (COMTD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COMTD1 ( NM_144589.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_653190.2 Homo sapiens catechol-O-methyltransferase domain containing 1 (COMTD1), mRNA.

Price & Availability↑

CloneID	OHu06331
Clone ID Related Accession (Same CDS sequence)	NM_144589.3 , NM_144589.2 , NM_144589.4
Accession Version	NM_144589.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-26
Organism	Homo sapiens(human)
Product	catechol O-methyltransferase domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK290452.1, BC047774.1 and AK302283.1. On Jul 4, 2017 this sequence version replaced NM_144589.2. ##Evidence-Data-START## Transcript exon combination :: AK290452.1, SRR1163657.18586.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGACCCAGC CGGTGCCCCG GCTCTCCGTG CCCGCCGCGC TGGCCCTGGG CTCAGCCGCA 
CTGGGCGCCG CCTTCGCCAC TGGCCTCTTC CTGGGGAGGC GGTGCCCCCC ATGGCGAGGC 
CGGCGAGAGC AGTGCCTGCT TCCCCCCGAG GACAGCCGCC TGTGGCAGTA TCTTCTGAGC 
CGCTCCATGC GGGAGCACCC GGCGCTGCGA AGCCTGAGGC TGCTGACCCT GGAGCAGCCG 
CAGGGGGATT CTATGATGAC CTGCGAGCAG GCCCAGCTCT TGGCCAACCT GGCGCGGCTC 
ATCCAGGCCA AGAAGGCGCT GGACCTGGGC ACCTTCACGG GCTACTCCGC CCTGGCCCTG 
GCCCTGGCGC TGCCCGCGGA CGGGCGCGTG GTGACCTGCG AGGTGGACGC GCAGCCCCCG 
GAGCTGGGAC GGCCCCTGTG GAGGCAGGCC GAGGCGGAGC ACAAGATCGA CCTCCGGCTG 
AAGCCCGCCT TGGAGACCCT GGACGAGCTG CTGGCGGCGG GCGAGGCCGG CACCTTCGAC 
GTGGCCGTGG TGGATGCGGA CAAGGAGAAC TGCTCCGCCT ACTACGAGCG CTGCCTGCAG 
CTGCTGCGAC CCGGAGGCAT CCTCGCCGTC CTCAGAGTCC TGTGGCGCGG GAAGGTGCTG 
CAACCTCCGA AAGGGGACGT GGCGGCCGAG TGTGTGCGAA ACCTAAACGA ACGCATCCGG 
CGGGACGTCA GGGTCTACAT CAGCCTCCTG CCCCTGGGCG ATGGACTCAC CTTGGCCTTC 
AAGATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653190.2
CDS	139..927
Translation	MTQPVPRLSVPAALALGSAALGAAFATGLFLGRRCPPWRGRREQCLLPPEDSRLWQYLLSRSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIQAKKALDLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIRRDVRVYISLLPLGDGLTLAFKI

Target ORF information:

RefSeq Version	NM_144589.3
Organism	Homo sapiens(human)
Definition	Homo sapiens catechol-O-methyltransferase domain containing 1 (COMTD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144589.3

ORF Insert Sequence:

ATGACCCAGC CGGTGCCCCG GCTCTCCGTG CCCGCCGCGC TGGCCCTGGG CTCAGCCGCA 
CTGGGCGCCG CCTTCGCCAC TGGCCTCTTC CTGGGGAGGC GGTGCCCCCC ATGGCGAGGC 
CGGCGAGAGC AGTGCCTGCT TCCCCCCGAG GACAGCCGCC TGTGGCAGTA TCTTCTGAGC 
CGCTCCATGC GGGAGCACCC GGCGCTGCGA AGCCTGAGGC TGCTGACCCT GGAGCAGCCG 
CAGGGGGATT CTATGATGAC CTGCGAGCAG GCCCAGCTCT TGGCCAACCT GGCGCGGCTC 
ATCCAGGCCA AGAAGGCGCT GGACCTGGGC ACCTTCACGG GCTACTCCGC CCTGGCCCTG 
GCCCTGGCGC TGCCCGCGGA CGGGCGCGTG GTGACCTGCG AGGTGGACGC GCAGCCCCCG 
GAGCTGGGAC GGCCCCTGTG GAGGCAGGCC GAGGCGGAGC ACAAGATCGA CCTCCGGCTG 
AAGCCCGCCT TGGAGACCCT GGACGAGCTG CTGGCGGCGG GCGAGGCCGG CACCTTCGAC 
GTGGCCGTGG TGGATGCGGA CAAGGAGAAC TGCTCCGCCT ACTACGAGCG CTGCCTGCAG 
CTGCTGCGAC CCGGAGGCAT CCTCGCCGTC CTCAGAGTCC TGTGGCGCGG GAAGGTGCTG 
CAACCTCCGA AAGGGGACGT GGCGGCCGAG TGTGTGCGAA ACCTAAACGA ACGCATCCGG 
CGGGACGTCA GGGTCTACAT CAGCCTCCTG CCCCTGGGCG ATGGACTCAC CTTGGCCTTC 
AAGATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COMTD1 ( NM_144589.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_653190.2 Homo sapiens catechol-O-methyltransferase domain containing 1 (COMTD1), mRNA.

Price & Availability↑

CloneID	OHu06331
Clone ID Related Accession (Same CDS sequence)	NM_144589.3 , NM_144589.2 , NM_144589.4
Accession Version	NM_144589.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-04-24
Organism	Homo sapiens(Human)
Product	catechol O-methyltransferase domain-containing protein 1
Comment	PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC047774.1. On Jun 9, 2003 this sequence version replaced NM_144589.1. ##Evidence-Data-START## Transcript exon combination :: BC047774.1, SRR1163657.18586.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGACCCAGC CGGTGCCCCG GCTCTCCGTG CCCGCCGCGC TGGCCCTGGG CTCAGCCGCA 
CTGGGCGCCG CCTTCGCCAC TGGCCTCTTC CTGGGGAGGC GGTGCCCCCC ATGGCGAGGC 
CGGCGAGAGC AGTGCCTGCT TCCCCCCGAG GACAGCCGCC TGTGGCAGTA TCTTCTGAGC 
CGCTCCATGC GGGAGCACCC GGCGCTGCGA AGCCTGAGGC TGCTGACCCT GGAGCAGCCG 
CAGGGGGATT CTATGATGAC CTGCGAGCAG GCCCAGCTCT TGGCCAACCT GGCGCGGCTC 
ATCCAGGCCA AGAAGGCGCT GGACCTGGGC ACCTTCACGG GCTACTCCGC CCTGGCCCTG 
GCCCTGGCGC TGCCCGCGGA CGGGCGCGTG GTGACCTGCG AGGTGGACGC GCAGCCCCCG 
GAGCTGGGAC GGCCCCTGTG GAGGCAGGCC GAGGCGGAGC ACAAGATCGA CCTCCGGCTG 
AAGCCCGCCT TGGAGACCCT GGACGAGCTG CTGGCGGCGG GCGAGGCCGG CACCTTCGAC 
GTGGCCGTGG TGGATGCGGA CAAGGAGAAC TGCTCCGCCT ACTACGAGCG CTGCCTGCAG 
CTGCTGCGAC CCGGAGGCAT CCTCGCCGTC CTCAGAGTCC TGTGGCGCGG GAAGGTGCTG 
CAACCTCCGA AAGGGGACGT GGCGGCCGAG TGTGTGCGAA ACCTAAACGA ACGCATCCGG 
CGGGACGTCA GGGTCTACAT CAGCCTCCTG CCCCTGGGCG ATGGACTCAC CTTGGCCTTC 
AAGATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653190.2
CDS	85..873
Translation	MTQPVPRLSVPAALALGSAALGAAFATGLFLGRRCPPWRGRREQCLLPPEDSRLWQYLLSRSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIQAKKALDLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIRRDVRVYISLLPLGDGLTLAFKI

Target ORF information:

RefSeq Version	NM_144589.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens catechol-O-methyltransferase domain containing 1 (COMTD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144589.2

ORF Insert Sequence:

ATGACCCAGC CGGTGCCCCG GCTCTCCGTG CCCGCCGCGC TGGCCCTGGG CTCAGCCGCA 
CTGGGCGCCG CCTTCGCCAC TGGCCTCTTC CTGGGGAGGC GGTGCCCCCC ATGGCGAGGC 
CGGCGAGAGC AGTGCCTGCT TCCCCCCGAG GACAGCCGCC TGTGGCAGTA TCTTCTGAGC 
CGCTCCATGC GGGAGCACCC GGCGCTGCGA AGCCTGAGGC TGCTGACCCT GGAGCAGCCG 
CAGGGGGATT CTATGATGAC CTGCGAGCAG GCCCAGCTCT TGGCCAACCT GGCGCGGCTC 
ATCCAGGCCA AGAAGGCGCT GGACCTGGGC ACCTTCACGG GCTACTCCGC CCTGGCCCTG 
GCCCTGGCGC TGCCCGCGGA CGGGCGCGTG GTGACCTGCG AGGTGGACGC GCAGCCCCCG 
GAGCTGGGAC GGCCCCTGTG GAGGCAGGCC GAGGCGGAGC ACAAGATCGA CCTCCGGCTG 
AAGCCCGCCT TGGAGACCCT GGACGAGCTG CTGGCGGCGG GCGAGGCCGG CACCTTCGAC 
GTGGCCGTGG TGGATGCGGA CAAGGAGAAC TGCTCCGCCT ACTACGAGCG CTGCCTGCAG 
CTGCTGCGAC CCGGAGGCAT CCTCGCCGTC CTCAGAGTCC TGTGGCGCGG GAAGGTGCTG 
CAACCTCCGA AAGGGGACGT GGCGGCCGAG TGTGTGCGAA ACCTAAACGA ACGCATCCGG 
CGGGACGTCA GGGTCTACAT CAGCCTCCTG CCCCTGGGCG ATGGACTCAC CTTGGCCTTC 
AAGATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COMTD1 ( NM_144589.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_653190.2 Homo sapiens catechol-O-methyltransferase domain containing 1 (COMTD1), mRNA.

Price & Availability↑

CloneID	OHu06331
Clone ID Related Accession (Same CDS sequence)	NM_144589.3 , NM_144589.2 , NM_144589.4
Accession Version	NM_144589.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	catechol O-methyltransferase domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC047774.1, AK302283.1 and AL390034.23. On May 17, 2019 this sequence version replaced NM_144589.3. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.702838.1, AK290452.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372538.8/ ENSP00000361616.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGACCCAGC CGGTGCCCCG GCTCTCCGTG CCCGCCGCGC TGGCCCTGGG CTCAGCCGCA 
CTGGGCGCCG CCTTCGCCAC TGGCCTCTTC CTGGGGAGGC GGTGCCCCCC ATGGCGAGGC 
CGGCGAGAGC AGTGCCTGCT TCCCCCCGAG GACAGCCGCC TGTGGCAGTA TCTTCTGAGC 
CGCTCCATGC GGGAGCACCC GGCGCTGCGA AGCCTGAGGC TGCTGACCCT GGAGCAGCCG 
CAGGGGGATT CTATGATGAC CTGCGAGCAG GCCCAGCTCT TGGCCAACCT GGCGCGGCTC 
ATCCAGGCCA AGAAGGCGCT GGACCTGGGC ACCTTCACGG GCTACTCCGC CCTGGCCCTG 
GCCCTGGCGC TGCCCGCGGA CGGGCGCGTG GTGACCTGCG AGGTGGACGC GCAGCCCCCG 
GAGCTGGGAC GGCCCCTGTG GAGGCAGGCC GAGGCGGAGC ACAAGATCGA CCTCCGGCTG 
AAGCCCGCCT TGGAGACCCT GGACGAGCTG CTGGCGGCGG GCGAGGCCGG CACCTTCGAC 
GTGGCCGTGG TGGATGCGGA CAAGGAGAAC TGCTCCGCCT ACTACGAGCG CTGCCTGCAG 
CTGCTGCGAC CCGGAGGCAT CCTCGCCGTC CTCAGAGTCC TGTGGCGCGG GAAGGTGCTG 
CAACCTCCGA AAGGGGACGT GGCGGCCGAG TGTGTGCGAA ACCTAAACGA ACGCATCCGG 
CGGGACGTCA GGGTCTACAT CAGCCTCCTG CCCCTGGGCG ATGGACTCAC CTTGGCCTTC 
AAGATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653190.2
CDS	30..818
Translation	MTQPVPRLSVPAALALGSAALGAAFATGLFLGRRCPPWRGRREQCLLPPEDSRLWQYLLSRSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIQAKKALDLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIRRDVRVYISLLPLGDGLTLAFKI

Target ORF information:

RefSeq Version	NM_144589.4
Organism	Homo sapiens(human)
Definition	Homo sapiens catechol-O-methyltransferase domain containing 1 (COMTD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144589.4

ORF Insert Sequence:

ATGACCCAGC CGGTGCCCCG GCTCTCCGTG CCCGCCGCGC TGGCCCTGGG CTCAGCCGCA 
CTGGGCGCCG CCTTCGCCAC TGGCCTCTTC CTGGGGAGGC GGTGCCCCCC ATGGCGAGGC 
CGGCGAGAGC AGTGCCTGCT TCCCCCCGAG GACAGCCGCC TGTGGCAGTA TCTTCTGAGC 
CGCTCCATGC GGGAGCACCC GGCGCTGCGA AGCCTGAGGC TGCTGACCCT GGAGCAGCCG 
CAGGGGGATT CTATGATGAC CTGCGAGCAG GCCCAGCTCT TGGCCAACCT GGCGCGGCTC 
ATCCAGGCCA AGAAGGCGCT GGACCTGGGC ACCTTCACGG GCTACTCCGC CCTGGCCCTG 
GCCCTGGCGC TGCCCGCGGA CGGGCGCGTG GTGACCTGCG AGGTGGACGC GCAGCCCCCG 
GAGCTGGGAC GGCCCCTGTG GAGGCAGGCC GAGGCGGAGC ACAAGATCGA CCTCCGGCTG 
AAGCCCGCCT TGGAGACCCT GGACGAGCTG CTGGCGGCGG GCGAGGCCGG CACCTTCGAC 
GTGGCCGTGG TGGATGCGGA CAAGGAGAAC TGCTCCGCCT ACTACGAGCG CTGCCTGCAG 
CTGCTGCGAC CCGGAGGCAT CCTCGCCGTC CTCAGAGTCC TGTGGCGCGG GAAGGTGCTG 
CAACCTCCGA AAGGGGACGT GGCGGCCGAG TGTGTGCGAA ACCTAAACGA ACGCATCCGG 
CGGGACGTCA GGGTCTACAT CAGCCTCCTG CCCCTGGGCG ATGGACTCAC CTTGGCCTTC 
AAGATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COMTD1 ( XM_024447791.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024303559.1 Homo sapiens catechol-O-methyltransferase domain containing 1 (COMTD1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu75086
Clone ID Related Accession (Same CDS sequence)	XM_024447791.1
Accession Version	XM_024447791.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	catechol O-methyltransferase domain-containing protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCCAGC CGGTGCCCCG GCTCTCCGTG CCCGCCGCGC TGGCCCTGGG CTCAGCCGCA 
CTGGGCGCCG CCTTCGCCAC TGGCCTCTTC CTGGGCACCT TCACGGGCTA CTCCGCCCTG 
GCCCTGGCCC TGGCGCTGCC CGCGGACGGG CGCGTGGTGA CCTGCGAGGT GGACGCGCAG 
CCCCCGGAGC TGGGACGGCC CCTGTGGAGG CAGGCCGAGG CGGAGCACAA GATCGACCTC 
CGGCTGAAGC CCGCCTTGGA GACCCTGGAC GAGCTGCTGG CGGCGGGCGA GGCCGGCACC 
TTCGACGTGG CCGTGGTGGA TGCGGACAAG GAGAACTGCT CCGCCTACTA CGAGCGCTGC 
CTGCAGCTGC TGCGACCCGG AGGCATCCTC GCCGTCCTCA GAGTCCTGTG GCGCGGGAAG 
GTGCTGCAAC CTCCGAAAGG GGACGTGGCG GCCGAGTGTG TGCGAAACCT AAACGAACGC 
ATCCGGCGGG ACGTCAGGGT CTACATCAGC CTCCTGCCCC TGGGCGATGG ACTCACCTTG 
GCCTTCAAGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024303559.1
CDS	100..654
Translation	MTQPVPRLSVPAALALGSAALGAAFATGLFLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIRRDVRVYISLLPLGDGLTLAFKI

Target ORF information:

RefSeq Version	XM_024447791.1
Organism	Homo sapiens(human)
Definition	Homo sapiens catechol-O-methyltransferase domain containing 1 (COMTD1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447791.1

ORF Insert Sequence:

ATGACCCAGC CGGTGCCCCG GCTCTCCGTG CCCGCCGCGC TGGCCCTGGG CTCAGCCGCA 
CTGGGCGCCG CCTTCGCCAC TGGCCTCTTC CTGGGCACCT TCACGGGCTA CTCCGCCCTG 
GCCCTGGCCC TGGCGCTGCC CGCGGACGGG CGCGTGGTGA CCTGCGAGGT GGACGCGCAG 
CCCCCGGAGC TGGGACGGCC CCTGTGGAGG CAGGCCGAGG CGGAGCACAA GATCGACCTC 
CGGCTGAAGC CCGCCTTGGA GACCCTGGAC GAGCTGCTGG CGGCGGGCGA GGCCGGCACC 
TTCGACGTGG CCGTGGTGGA TGCGGACAAG GAGAACTGCT CCGCCTACTA CGAGCGCTGC 
CTGCAGCTGC TGCGACCCGG AGGCATCCTC GCCGTCCTCA GAGTCCTGTG GCGCGGGAAG 
GTGCTGCAAC CTCCGAAAGG GGACGTGGCG GCCGAGTGTG TGCGAAACCT AAACGAACGC 
ATCCGGCGGG ACGTCAGGGT CTACATCAGC CTCCTGCCCC TGGGCGATGG ACTCACCTTG 
GCCTTCAAGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

De Novo 1.77-Mb Microdeletion of 10q22.2q22.3 in a Girl With Developmental Delay, Speech Delay, Congenital Cleft Palate, and Bilateral Hearing Impairment.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association54(3)343-350(2017 May)
Lei TY,Wang HT,Li F,Cui YQ,Fu F,Li R,Liao C

Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia.
Journal of human genetics58(2)91-7(2013 Feb)
Nishioka M,Bundo M,Koike S,Takizawa R,Kakiuchi C,Araki T,Kasai K,Iwamoto K

Genetic variants associated with breast size also influence breast cancer risk.
BMC medical genetics1353(2012 Jun)
Eriksson N,Benton GM,Do CB,Kiefer AK,Mountain JL,Hinds DA,Francke U,Tung JY

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
American journal of human genetics78(1)78-88(2006 Jan)
Grupe A,Li Y,Rowland C,Nowotny P,Hinrichs AL,Smemo S,Kauwe JS,Maxwell TJ,Cherny S,Doil L,Tacey K,van Luchene R,Myers A,Wavrant-De Vri?ze F,Kaleem M,Hollingworth P,Jehu L,Foy C,Archer N,Hamilton G,Holmans P,Morris CM,Catanese J,Sninsky J,White TJ,Powell J,Hardy J,O'Donovan M,Lovestone S,Jones L,Morris JC,Thal L,Owen M,Williams J,Goate A

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COMTD1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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