RLN3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RLN3
Entrez Gene ID	117579
Full Name	relaxin 3
Synonyms	H3,RXN3,ZINS4,insl7
General protein information	Preferred Names relaxin 3 Names relaxin-3 insulin-like peptide 7 insulin-like peptide INSL7 prorelaxin H3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.12
Summary	This gene encodes a member of the relaxin family of insulin-like hormones that is expressed predominantly in the brain and plays a role in physiological processes such as stress, memory and appetite regulation. The encoded protein is a precursor that is proteolytically processed to generate a heterodimeric mature form consisting A and B chains interlinked by disulfide bonds. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015].
Disorder MIM:	606855

mRNA and Protein(s)

mRNA	Protein	Name
NM_080864.4	NP_543140.1	relaxin-3 preproprotein
NM_001311197.1	NP_001298126.1	relaxin-3 precursor
NM_080864.3	NP_543140.1	relaxin-3 preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RLN3	XP_853484.2
Homo sapiens (human)	RLN3	NP_543140.1
	RLN3	NP_001098046.1
Mus musculus (house mouse)	Rln3	NP_775276.1
Pan troglodytes (chimpanzee)	RLN3	XP_001171356.2
Bos taurus (cattle)	RLN3	XP_002688796.1
Rattus norvegicus (Norway rat)	Rln3	NP_733767.1

Gene Ontology
Bibliography

Related articles in PubMed

Serum relaxin-3 hormone relationship to male delayed puberty.
Hanafy S, Sabry JH, Akl EM, Elethy RA, Mostafa T
Andrologia(2017 Aug)

Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload.
Pintalhao M, Castro-Chaves P, Vasques-Novoa F, Gon?alves F, Mendon?a L, Fontes-Carvalho R, Louren?o P, Almeida P, Leite-Moreira A, Bettencourt P
European journal of heart failure19(2)218-225(2017 Feb)

The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.
Ang SY, Hutchinson DS, Evans BA, Hossain MA, Patil N, Bathgate RA, Kocan M, Summers RJ
Naunyn-Schmiedeberg's archives of pharmacology390(1)105-111(2017 Jan)

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.
Jayakody T, Marwari S, Lakshminarayanan R, Tan FC, Johannes CW, Dymock BW, Poulsen A, Herr DR, Dawe GS
Peptides8444-57(2016 Oct)

A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.
Liu Y, Zhang L, Shao XX, Hu MJ, Liu YL, Xu ZG, Guo ZY
Archives of biochemistry and biophysics604113-20(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting.
Title: Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload.

Relaxin-3 is a high-efficacy agonist at RXFP4 with a comparable signal transduction profile to INSL5.
Title: The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.

the relaxin-3 B-chain C-terminus changes from the original folding-back conformation to an extended conformation during binding with RXFP3, to allow its B27Trp and B26Arg residues to interact with the Trp138 and Glu141 residues of RXFP3, respectively.
Title: Identification of hydrophobic interactions between relaxin-3 and its receptor RXFP3: implication for a conformational change in the B-chain C-terminus during receptor binding.

the negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3
Title: A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.

Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour.
Title: Physical fitness, serum relaxin and duration of gestation.

The following RLN3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RLN3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30820	NM_080864.4 Latest version!	Homo sapiens relaxin 3 (RLN3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu75049	NM_001311197.1 Latest version!	Homo sapiens relaxin 3 (RLN3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu30820	NM_080864.3	Homo sapiens relaxin 3 (RLN3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RLN3 ( NM_080864.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_543140.1 Homo sapiens relaxin 3 (RLN3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30820
Clone ID Related Accession (Same CDS sequence)	NM_080864.4 , NM_080864.3
Accession Version	NM_080864.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	relaxin-3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC140935.1, AC022098.9 and AY358181.1. On May 17, 2019 this sequence version replaced NM_080864.3. Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC140935.1, AB076563.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000431365.3/ ENSP00000397415.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGGT ACATGCTGCT GCTGCTCCTG GCGGTATGGG TGCTGACCGG GGAGCTGTGG 
CCGGGAGCTG AGGCCCGGGC AGCGCCTTAC GGGGTCAGGC TTTGCGGCCG AGAATTCATC 
CGAGCAGTCA TCTTCACCTG CGGGGGCTCC CGGTGGAGAC GATCAGACAT CCTGGCCCAC 
GAGGCTATGG GAGATACCTT CCCGGATGCA GATGCTGATG AAGACAGTCT GGCAGGCGAG 
CTGGATGAGG CCATGGGGTC CAGCGAGTGG CTGGCCCTGA CCAAGTCACC CCAGGCCTTT 
TACAGGGGGC GACCCAGCTG GCAAGGAACC CCTGGGGTTC TTCGGGGCAG CCGAGATGTC 
CTGGCTGGCC TTTCCAGCAG CTGCTGCAAG TGGGGGTGTA GCAAAAGTGA AATCAGTAGC 
CTTTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_543140.1
CDS	58..486
Translation	MARYMLLLLLAVWVLTGELWPGAEARAAPYGVRLCGREFIRAVIFTCGGSRWRRSDILAHEAMGDTFPDADADEDSLAGELDEAMGSSEWLALTKSPQAFYRGRPSWQGTPGVLRGSRDVLAGLSSSCCKWGCSKSEISSLC

Target ORF information:

RefSeq Version	NM_080864.4
Organism	Homo sapiens(human)
Definition	Homo sapiens relaxin 3 (RLN3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080864.4

ORF Insert Sequence:

ATGGCCAGGT ACATGCTGCT GCTGCTCCTG GCGGTATGGG TGCTGACCGG GGAGCTGTGG 
CCGGGAGCTG AGGCCCGGGC AGCGCCTTAC GGGGTCAGGC TTTGCGGCCG AGAATTCATC 
CGAGCAGTCA TCTTCACCTG CGGGGGCTCC CGGTGGAGAC GATCAGACAT CCTGGCCCAC 
GAGGCTATGG GAGATACCTT CCCGGATGCA GATGCTGATG AAGACAGTCT GGCAGGCGAG 
CTGGATGAGG CCATGGGGTC CAGCGAGTGG CTGGCCCTGA CCAAGTCACC CCAGGCCTTT 
TACAGGGGGC GACCCAGCTG GCAAGGAACC CCTGGGGTTC TTCGGGGCAG CCGAGATGTC 
CTGGCTGGCC TTTCCAGCAG CTGCTGCAAG TGGGGGTGTA GCAAAAGTGA AATCAGTAGC 
CTTTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RLN3 ( NM_080864.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_543140.1 Homo sapiens relaxin 3 (RLN3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30820
Clone ID Related Accession (Same CDS sequence)	NM_080864.4 , NM_080864.3
Accession Version	NM_080864.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-23
Organism	Homo sapiens(human)
Product	relaxin-3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC140935.1, AC022098.9 and AY358181.1. On Aug 1, 2015 this sequence version replaced NM_080864.2. Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC140935.1, AB076563.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGGT ACATGCTGCT GCTGCTCCTG GCGGTATGGG TGCTGACCGG GGAGCTGTGG 
CCGGGAGCTG AGGCCCGGGC AGCGCCTTAC GGGGTCAGGC TTTGCGGCCG AGAATTCATC 
CGAGCAGTCA TCTTCACCTG CGGGGGCTCC CGGTGGAGAC GATCAGACAT CCTGGCCCAC 
GAGGCTATGG GAGATACCTT CCCGGATGCA GATGCTGATG AAGACAGTCT GGCAGGCGAG 
CTGGATGAGG CCATGGGGTC CAGCGAGTGG CTGGCCCTGA CCAAGTCACC CCAGGCCTTT 
TACAGGGGGC GACCCAGCTG GCAAGGAACC CCTGGGGTTC TTCGGGGCAG CCGAGATGTC 
CTGGCTGGCC TTTCCAGCAG CTGCTGCAAG TGGGGGTGTA GCAAAAGTGA AATCAGTAGC 
CTTTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_543140.1
CDS	58..486
Translation	MARYMLLLLLAVWVLTGELWPGAEARAAPYGVRLCGREFIRAVIFTCGGSRWRRSDILAHEAMGDTFPDADADEDSLAGELDEAMGSSEWLALTKSPQAFYRGRPSWQGTPGVLRGSRDVLAGLSSSCCKWGCSKSEISSLC

Target ORF information:

RefSeq Version	NM_080864.3
Organism	Homo sapiens(human)
Definition	Homo sapiens relaxin 3 (RLN3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080864.3

ORF Insert Sequence:

ATGGCCAGGT ACATGCTGCT GCTGCTCCTG GCGGTATGGG TGCTGACCGG GGAGCTGTGG 
CCGGGAGCTG AGGCCCGGGC AGCGCCTTAC GGGGTCAGGC TTTGCGGCCG AGAATTCATC 
CGAGCAGTCA TCTTCACCTG CGGGGGCTCC CGGTGGAGAC GATCAGACAT CCTGGCCCAC 
GAGGCTATGG GAGATACCTT CCCGGATGCA GATGCTGATG AAGACAGTCT GGCAGGCGAG 
CTGGATGAGG CCATGGGGTC CAGCGAGTGG CTGGCCCTGA CCAAGTCACC CCAGGCCTTT 
TACAGGGGGC GACCCAGCTG GCAAGGAACC CCTGGGGTTC TTCGGGGCAG CCGAGATGTC 
CTGGCTGGCC TTTCCAGCAG CTGCTGCAAG TGGGGGTGTA GCAAAAGTGA AATCAGTAGC 
CTTTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RLN3 ( NM_001311197.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001298126.1 Homo sapiens relaxin 3 (RLN3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu75049
Clone ID Related Accession (Same CDS sequence)	NM_001311197.1
Accession Version	NM_001311197.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	relaxin-3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC140935.1, AC022098.9, BC110069.1 and AY358181.1. Transcript Variant: This variant (2) contains an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC110069.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGGT ACATGCTGCT GCTGCTCCTG GCGGTATGGG TGCTGACCGG GGAGCTGTGG 
CCGGGAGCTG AGGCCCGGGC AGCGCCTTAC GGGGTCAGGC TTTGCGGCCG AGAATTCATC 
CGAGCAGTCA TCTTCACCTG CGGGGGCTCC CGGTGGAGAC GATCAGACAT CCTGGCCCAC 
GAGGCTATGG AAAAGAACAT TGAGGCTCCA AGAAGTAAAT TTACTTGCTC ACGATTAGAG 
AAGCTGGATT CATGCTCAGT CAGCCCAGCT CCCAAATGTA CCAGGTCCTC AATTAATAAA 
GAGAGATACC TTCCCGGATG CAGATGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001298126.1
CDS	58..387
Translation	MARYMLLLLLAVWVLTGELWPGAEARAAPYGVRLCGREFIRAVIFTCGGSRWRRSDILAHEAMEKNIEAPRSKFTCSRLEKLDSCSVSPAPKCTRSSINKERYLPGCRC

Target ORF information:

RefSeq Version	NM_001311197.1
Organism	Homo sapiens(human)
Definition	Homo sapiens relaxin 3 (RLN3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311197.1

ORF Insert Sequence:

ATGGCCAGGT ACATGCTGCT GCTGCTCCTG GCGGTATGGG TGCTGACCGG GGAGCTGTGG 
CCGGGAGCTG AGGCCCGGGC AGCGCCTTAC GGGGTCAGGC TTTGCGGCCG AGAATTCATC 
CGAGCAGTCA TCTTCACCTG CGGGGGCTCC CGGTGGAGAC GATCAGACAT CCTGGCCCAC 
GAGGCTATGG AAAAGAACAT TGAGGCTCCA AGAAGTAAAT TTACTTGCTC ACGATTAGAG 
AAGCTGGATT CATGCTCAGT CAGCCCAGCT CCCAAATGTA CCAGGTCCTC AATTAATAAA 
GAGAGATACC TTCCCGGATG CAGATGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Serum relaxin-3 hormone relationship to male delayed puberty.
Andrologia(2017 Aug)
Hanafy S,Sabry JH,Akl EM,Elethy RA,Mostafa T

Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload.
European journal of heart failure19(2)218-225(2017 Feb)
Pintalhao M,Castro-Chaves P,Vasques-Novoa F,Gon?alves F,Mendon?a L,Fontes-Carvalho R,Louren?o P,Almeida P,Leite-Moreira A,Bettencourt P

The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.
Naunyn-Schmiedeberg's archives of pharmacology390(1)105-111(2017 Jan)
Ang SY,Hutchinson DS,Evans BA,Hossain MA,Patil N,Bathgate RA,Kocan M,Summers RJ

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.
Peptides8444-57(2016 Oct)
Jayakody T,Marwari S,Lakshminarayanan R,Tan FC,Johannes CW,Dymock BW,Poulsen A,Herr DR,Dawe GS

A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.
Archives of biochemistry and biophysics604113-20(2016 Aug)
Liu Y,Zhang L,Shao XX,Hu MJ,Liu YL,Xu ZG,Guo ZY

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RLN3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Services & Products

見積依頼

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電話

FAX

オンラインフォーム