CD52 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CD52
Entrez Gene ID	1043
Full Name	CD52 molecule
Synonyms	CDW52,EDDM5
General protein information	Preferred Names CD52 molecule Names CAMPATH-1 antigen CD52 antigen (CAMPATH-1 antigen) CDW52 antigen (CAMPATH-1 antigen) HEL-S-171mP cambridge pathology 1 antigen epididymal secretory protein E5 epididymis secretory sperm binding protein Li 171mP he5 human epididymis-specific protein 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.11
Disorder MIM:	114280

mRNA and Protein(s)

mRNA	Protein	Name
NM_001803.2	NP_001794.2	CAMPATH-1 antigen precursor
NM_001803.3	NP_001794.2	CAMPATH-1 antigen precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CD52	NP_001794.2
Pan troglodytes (chimpanzee)	CD52	XP_001142336.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of campath-1 (CD52) as novel drug target in neoplastic stem cells in 5q-patients with MDS and AML.
Blatt K, Herrmann H, Hoermann G, Willmann M, Cerny-Reiterer S, Sadovnik I, Herndlhofer S, Streubel B, Rabitsch W, Sperr WR, Mayerhofer M, R?licke T, Valent P
Clinical cancer research : an official journal of the American Association for Cancer Research20(13)3589-602(2014 Jul)

A molecular and computational diagnostic approach identifies FOXP3, ICOS, CD52 and CASP1 as the most informative biomarkers in acute graft-versus-host disease.
Cuzzola M, Fiasch? M, Iacopino P, Messina G, Martino M, Console G, Fedele R, Massi D, Recchia AG, Irrera G, Morabito F
Haematologica97(10)1532-8(2012 Oct)

The N-linked carbohydrate moiety of male reproductive tract CD52 (mrt-CD52) interferes with the complement system via binding to C1q.
Hardiyanto L, Hasegawa A, Komori S
Journal of reproductive immunology94(2)142-50(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CD52 is a novel prognostic NSC marker and a potential NSC target in a subset of patients with MDS and AML, which may have clinical implications and may explain clinical effects produced by alemtuzumab in these patients.
Title: Identification of campath-1 (CD52) as novel drug target in neoplastic stem cells in 5q-patients with MDS and AML.

A molecular and computational diagnostic approach identifies FOXP3, ICOS, CD52 and CASP1 as the most informative biomarkers in acute graft-versus-host disease.
Title: A molecular and computational diagnostic approach identifies FOXP3, ICOS, CD52 and CASP1 as the most informative biomarkers in acute graft-versus-host disease.

carbohydrate moiety of sperm protein interferes with the complement system via binding to C1q
Title: The N-linked carbohydrate moiety of male reproductive tract CD52 (mrt-CD52) interferes with the complement system via binding to C1q.

CT60 single-nucleotide polymorphism of CTLA4 is a surrogate marker for donor lymphocyte infusion outcome after allogeneic cell transplantation for acute leukemia
Title: CT60 single-nucleotide polymorphism as a surrogate marker for donor lymphocyte infusion outcome after allogeneic cell transplantation for acute leukemia.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: CD52 gene polymorphism and its potential effect on the response to alemtuzumab in renal transplant recipients.

The following CD52 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD52 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29789	NM_001803.3 Latest version!	Homo sapiens CD52 molecule (CD52), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29789	NM_001803.2	Homo sapiens CD52 molecule (CD52), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CD52 ( NM_001803.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001794.2 Homo sapiens CD52 molecule (CD52), mRNA.

Price & Availability↑

CloneID	OHu29789
Clone ID Related Accession (Same CDS sequence)	NM_001803.2 , NM_001803.3
Accession Version	NM_001803.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	CAMPATH-1 antigen precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI835519.1, BC000644.2 and X62466.1. On Jun 30, 2005 this sequence version replaced NM_001803.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FJ460513.1, SRR1163658.129714.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCGCT TCCTCTTCCT CCTACTCACC ATCAGCCTCC TGGTTATGGT ACAGATACAA 
ACTGGACTCT CAGGACAAAA CGACACCAGC CAAACCAGCA GCCCCTCAGC ATCCAGCAAC 
ATAAGCGGAG GCATTTTCCT TTTCTTCGTG GCCAATGCCA TAATCCACCT CTTCTGCTTC 
AGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001794.2
CDS	99..284
Translation	MKRFLFLLLTISLLVMVQIQTGLSGQNDTSQTSSPSASSNISGGIFLFFVANAIIHLFCFS

Target ORF information:

RefSeq Version	NM_001803.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CD52 molecule (CD52), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001803.2

ORF Insert Sequence:

ATGAAGCGCT TCCTCTTCCT CCTACTCACC ATCAGCCTCC TGGTTATGGT ACAGATACAA 
ACTGGACTCT CAGGACAAAA CGACACCAGC CAAACCAGCA GCCCCTCAGC ATCCAGCAAC 
ATAAGCGGAG GCATTTTCCT TTTCTTCGTG GCCAATGCCA TAATCCACCT CTTCTGCTTC 
AGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD52 ( NM_001803.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001794.2 Homo sapiens CD52 molecule (CD52), mRNA.

Price & Availability↑

CloneID	OHu29789
Clone ID Related Accession (Same CDS sequence)	NM_001803.2 , NM_001803.3
Accession Version	NM_001803.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	CAMPATH-1 antigen precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI835519.1, BC000644.2 and X62466.1. On Nov 22, 2018 this sequence version replaced NM_001803.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.327494.1, BG535652.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000374213.3/ ENSP00000363330.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCGCT TCCTCTTCCT CCTACTCACC ATCAGCCTCC TGGTTATGGT ACAGATACAA 
ACTGGACTCT CAGGACAAAA CGACACCAGC CAAACCAGCA GCCCCTCAGC ATCCAGCAAC 
ATAAGCGGAG GCATTTTCCT TTTCTTCGTG GCCAATGCCA TAATCCACCT CTTCTGCTTC 
AGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001794.2
CDS	61..246
Translation	MKRFLFLLLTISLLVMVQIQTGLSGQNDTSQTSSPSASSNISGGIFLFFVANAIIHLFCFS

Target ORF information:

RefSeq Version	NM_001803.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CD52 molecule (CD52), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001803.3

ORF Insert Sequence:

ATGAAGCGCT TCCTCTTCCT CCTACTCACC ATCAGCCTCC TGGTTATGGT ACAGATACAA 
ACTGGACTCT CAGGACAAAA CGACACCAGC CAAACCAGCA GCCCCTCAGC ATCCAGCAAC 
ATAAGCGGAG GCATTTTCCT TTTCTTCGTG GCCAATGCCA TAATCCACCT CTTCTGCTTC 
AGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of campath-1 (CD52) as novel drug target in neoplastic stem cells in 5q-patients with MDS and AML.
Clinical cancer research : an official journal of the American Association for Cancer Research20(13)3589-602(2014 Jul)
Blatt K,Herrmann H,Hoermann G,Willmann M,Cerny-Reiterer S,Sadovnik I,Herndlhofer S,Streubel B,Rabitsch W,Sperr WR,Mayerhofer M,R?licke T,Valent P

A molecular and computational diagnostic approach identifies FOXP3, ICOS, CD52 and CASP1 as the most informative biomarkers in acute graft-versus-host disease.
Haematologica97(10)1532-8(2012 Oct)
Cuzzola M,Fiasch? M,Iacopino P,Messina G,Martino M,Console G,Fedele R,Massi D,Recchia AG,Irrera G,Morabito F

The N-linked carbohydrate moiety of male reproductive tract CD52 (mrt-CD52) interferes with the complement system via binding to C1q.
Journal of reproductive immunology94(2)142-50(2012 Jun)
Hardiyanto L,Hasegawa A,Komori S