IL21 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL21
Entrez Gene ID	554218
Full Name	interleukin 21
Synonyms	interleukin-21
General protein information	Preferred Names interleukin 21 Names interleukin-21
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001024835.1	NP_001020006.1	interleukin-21 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

IFN-?, IL-21, and IL-10 co-expression in evolving autoimmune vitiligo lesions of Smyth line chickens.
Shi F, Erf GF
The Journal of investigative dermatology132(3 Pt 1)642-9(2012 Mar)

Chicken interleukin-21 is costimulatory for T cells and blocks maturation of dendritic cells.
Rothwell L, Hu T, Wu Z, Kaiser P
Developmental and comparative immunology36(2)475-82(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Vitiligo in Smyth line chickens appears to be a Th1-polarized autoimmune disease, whereby IFN-gamma expression is strongly associated with parallel increases in IL-10 and IL-21, particularly during the early and active stages of vitiligo.
Title: IFN-?, IL-21, and IL-10 co-expression in evolving autoimmune vitiligo lesions of Smyth line chickens.

Chicken il-21 synergistically enhances T-cell proliferation and inhibits maturation of dendritic cells.
Title: Chicken interleukin-21 is costimulatory for T cells and blocks maturation of dendritic cells.

The following IL21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa24420	NM_001024835.1 Latest version!	Gallus gallus interleukin 21 (IL21), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL21 ( NM_001024835.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001020006.1 Gallus gallus interleukin 21 (IL21), mRNA.

Price & Availability↑

CloneID	OGa24420
Clone ID Related Accession (Same CDS sequence)	NM_001024835.1
Accession Version	NM_001024835.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-20
Organism	Gallus gallus(chicken)
Product	interleukin-21 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY943833.1. ##Evidence-Data-START## Transcript exon combination :: AM773757.1, AY943833.1 [ECO:0000332] ##Evidence-Data-END##

ATGGAGAGGA TGATTATTTT CTGTATGCTC TTCTTCTGTT TCAGTATGGT GCTGACTGCA 
ACTTCACCAA AAGCAATGAA ATACAAGCAG CTTTCAAAGA CAATTGACCA TCTAAAAGAT 
GTGGTGAAAG ATAAGGATGT CGAATTGCTG CATACACCAG AAAACCCTGG GGATGGATGC 
CTGCTCACAG CTGTAACCTG CTTCCAGAAT GGCATACTGA AATTACAGCC AAAAAACAGC 
CAAGTAAATG CTACATTCGC CAAAACTGTG AAGATCTTGA GAAGACCTTT TCTCCCAGTC 
TCTGAAGAGC ACTGTGAGTC TTCATGTGAA TCCTACGAGA GAAAAAAACC CCAAGAGTTT 
CTGAACAGCT TTTCAAAACT GATGCAAAAG TTATTCAAGA ACTCCACAGC TGAACGCTAC 
GGAAAATCTA CTATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020006.1
CDS	1..438
Translation	MERMIIFCMLFFCFSMVLTATSPKAMKYKQLSKTIDHLKDVVKDKDVELLHTPENPGDGCLLTAVTCFQNGILKLQPKNSQVNATFAKTVKILRRPFLPVSEEHCESSCESYERKKPQEFLNSFSKLMQKLFKNSTAERYGKSTI

Target ORF information:

RefSeq Version	NM_001024835.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus interleukin 21 (IL21), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024835.1

ORF Insert Sequence:

ATGGAGAGGA TGATTATTTT CTGTATGCTC TTCTTCTGTT TCAGTATGGT GCTGACTGCA 
ACTTCACCAA AAGCAATGAA ATACAAGCAG CTTTCAAAGA CAATTGACCA TCTAAAAGAT 
GTGGTGAAAG ATAAGGATGT CGAATTGCTG CATACACCAG AAAACCCTGG GGATGGATGC 
CTGCTCACAG CTGTAACCTG CTTCCAGAAT GGCATACTGA AATTACAGCC AAAAAACAGC 
CAAGTAAATG CTACATTCGC CAAAACTGTG AAGATCTTGA GAAGACCTTT TCTCCCAGTC 
TCTGAAGAGC ACTGTGAGTC TTCATGTGAA TCCTACGAGA GAAAAAAACC CCAAGAGTTT 
CTGAACAGCT TTTCAAAACT GATGCAAAAG TTATTCAAGA ACTCCACAGC TGAACGCTAC 
GGAAAATCTA CTATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IFN-?, IL-21, and IL-10 co-expression in evolving autoimmune vitiligo lesions of Smyth line chickens.
The Journal of investigative dermatology132(3 Pt 1)642-9(2012 Mar)
Shi F,Erf GF

Chicken interleukin-21 is costimulatory for T cells and blocks maturation of dendritic cells.
Developmental and comparative immunology36(2)475-82(2012 Feb)
Rothwell L,Hu T,Wu Z,Kaiser P