psen2 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	psen2
Entrez Gene ID	58026
Full Name	presenilin 2
Synonyms	pre2,zf-PS2
General protein information	Preferred Names presenilin 2 Names presenilin-2 PS-2
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_131514.2	NP_571589.2	presenilin-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PSEN2	NP_000438.2
	PSEN2	XP_002801954.1
Canis lupus familiaris (dog)	PSEN2	XP_005622685.1
Danio rerio (zebrafish)	psen2	NP_571589.2
Xenopus tropicalis (tropical clawed frog)	psen2	NP_001017181.1
Bos taurus (cattle)	PSEN2	NP_776865.2
Rattus norvegicus (Norway rat)	Psen2	NP_112349.2
Drosophila melanogaster (fruit fly)	Psn	NP_001137988.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002957	XP_311942.4
Gallus gallus (chicken)	PSEN2	NP_989633.1
Oryza sativa (rice)	Os01g0276400	NP_001042728.2
Pan troglodytes (chimpanzee)	PSEN2	XP_003949755.1
Mus musculus (house mouse)	Psen2	NP_001122077.1

Gene Ontology
Bibliography

Related articles in PubMed

Sex-specific characterization and evaluation of the Alzheimer's disease genetic risk factor sorl1 in zebrafish during aging and in the adult brain following a 100?ppb embryonic lead exposure.
Lee J, Peterson SM, Freeman JL
Journal of applied toxicology : JAT37(4)400-407(2017 Apr)

Mitochondrion to endoplasmic reticulum apposition length in zebrafish embryo spinal progenitors is unchanged in response to perturbations associated with Alzheimer's disease.
Newman M, Halter L, Lim A, Lardelli M
PloS one12(6)e0179859(2017)

Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95.
Frank DF, Miller GW, Connon RE, Geist J, Lein PJ
PeerJ5e4106(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that Psen2 plays a more prominent role in Notch signalling and embryo development in zebrafish than in mammals, and that the effect of reduced Psen2 can be ameliorated by Psen1 loss.
Title: Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos.

Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation.
Title: Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2.

The following psen2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the psen2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa37590	NM_131514.2 Latest version!	Danio rerio presenilin 2 (psen2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

psen2 ( NM_131514.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_571589.2 Danio rerio presenilin 2 (psen2), mRNA.

Price & Availability↑

CloneID	ODa37590
Clone ID Related Accession (Same CDS sequence)	NM_131514.2
Accession Version	NM_131514.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1326bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Danio rerio(zebrafish)
Product	presenilin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF178539.1. On Dec 20, 2003 this sequence version replaced NM_131514.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF178539.1, BC065382.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGAATACCT CAGACAGTGA AGAGGACTCC TACAACGAGA GGTCCGCTCT GGTCCAGTCC 
GAAAGCCCAA CCGTGCCCTC ATACAACCAA GACAATGCCA TGTCTCTCCC CCAGGACACA 
GACAGCAAAC GGAGCGGTGC GGTCCGCTCG AGGTCCGCCT CGGGCTCTGG AGATGCCGGG 
CCGGTGGACA GAGAGCGCGC AGACACCCCT GATGGAGAGG AAGAGGAGCT CACACTCAAA 
TACGGCGCGA AACACGTCAT CATGCTCTTC ATCCCTGTCA CGCTCTGCAT GGTGGTCGTA 
GTGGCCACGA TCAAGTCCGT CAGTTTCTAC ACCGAGAAGA GCGGACAGCG GCTCATCTAT 
ACCCCATTTG AAGAAGACCC GAACTCAGTG GGCCAGCGTC TGCTGAATTC TGTGCTCAAC 
ACTCTGGTCA TGATCAGTGT GATTGTCTTC ATGACCATCA TCCTGGTGCT GCTCTACAAG 
TACCGCTGCT ATAAATTTAT TCACGGCTGG CTGATTCTAT CCTCGCTGAT GCTGCTCTTC 
TGGTTTAGCT TCATGTATCT GGGAGAGGTC TTCAAGACAT ATAATGTGGC GATGGATTAT 
CCGACGCTGG TGATGATCAT CTGGAACTTC GGTGTGGTGG GAATGATCTG CATCCACTGG 
AAGGGTCCGC TGCGGCTCCA GCAGGCGTAT CTCATCGTCA TCAGTGCCCT CATGGCCCTC 
ATCTTCATTA AATACCTGCC CGAGTGGTCC GCCTGGGTCA TCCTGGGAGC CATCTCTATA 
TACGATCTGA TTGCGGTGTT GTGTCCGAAA GGCCCGTTGA GGATGCTGGT GGAAACAGCT 
CAAGAAAGAA ATGAGCCCAT TTTCCCTGCG CTCATATATT CATCTGCCAT GGTCTGGATG 
GTTGGAATGG CTGACTCTAA TAATCCAGAT TCAGCTGGTG AAAGGCGGCG CAGTGGGGGC 
GGAGTAAGGA CACAGGAAGG GGTGGAGTCA GAGGATGATG CGCCTCAGGC AGGGAGGAGG 
CAGTATTCAG CAGAAGAGGA CCTGGAGGAA GACCGAGGAG TGAAGCTGGG GCTGGGAGAC 
TTCATCTTCT ACAGTGTACT GGTGGGTAAA GCAGCGGCGA CTGGAGGAGA CTGGAACACC 
ACACTGGCCT GCTTTGTGGC CATCCTCATC GGTCTGTGTC TGACGCTCCT CCTGCTGGCC 
ATCTTCAAGA AGGCTCTTCC GGCTCTGCCC ATCTCCATCA CCTTCGGCCT GGTCTTCTAC 
TTCTCCACAG ATAATCTGGT GCGGCCCTTC ATGGACAGCC TGGCAGCACA TCAGTACTAC 
ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_571589.2
CDS	115..1440
Translation	MNTSDSEEDSYNERSALVQSESPTVPSYNQDNAMSLPQDTDSKRSGAVRSRSASGSGDAGPVDRERADTPDGEEEELTLKYGAKHVIMLFIPVTLCMVVVVATIKSVSFYTEKSGQRLIYTPFEEDPNSVGQRLLNSVLNTLVMISVIVFMTIILVLLYKYRCYKFIHGWLILSSLMLLFWFSFMYLGEVFKTYNVAMDYPTLVMIIWNFGVVGMICIHWKGPLRLQQAYLIVISALMALIFIKYLPEWSAWVILGAISIYDLIAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWMVGMADSNNPDSAGERRRSGGGVRTQEGVESEDDAPQAGRRQYSAEEDLEEDRGVKLGLGDFIFYSVLVGKAAATGGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFSTDNLVRPFMDSLAAHQYYI

Target ORF information:

RefSeq Version	NM_131514.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio presenilin 2 (psen2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_131514.2

ORF Insert Sequence:

ATGAATACCT CAGACAGTGA AGAGGACTCC TACAACGAGA GGTCCGCTCT GGTCCAGTCC 
GAAAGCCCAA CCGTGCCCTC ATACAACCAA GACAATGCCA TGTCTCTCCC CCAGGACACA 
GACAGCAAAC GGAGCGGTGC GGTCCGCTCG AGGTCCGCCT CGGGCTCTGG AGATGCCGGG 
CCGGTGGACA GAGAGCGCGC AGACACCCCT GATGGAGAGG AAGAGGAGCT CACACTCAAA 
TACGGCGCGA AACACGTCAT CATGCTCTTC ATCCCTGTCA CGCTCTGCAT GGTGGTCGTA 
GTGGCCACGA TCAAGTCCGT CAGTTTCTAC ACCGAGAAGA GCGGACAGCG GCTCATCTAT 
ACCCCATTTG AAGAAGACCC GAACTCAGTG GGCCAGCGTC TGCTGAATTC TGTGCTCAAC 
ACTCTGGTCA TGATCAGTGT GATTGTCTTC ATGACCATCA TCCTGGTGCT GCTCTACAAG 
TACCGCTGCT ATAAATTTAT TCACGGCTGG CTGATTCTAT CCTCGCTGAT GCTGCTCTTC 
TGGTTTAGCT TCATGTATCT GGGAGAGGTC TTCAAGACAT ATAATGTGGC GATGGATTAT 
CCGACGCTGG TGATGATCAT CTGGAACTTC GGTGTGGTGG GAATGATCTG CATCCACTGG 
AAGGGTCCGC TGCGGCTCCA GCAGGCGTAT CTCATCGTCA TCAGTGCCCT CATGGCCCTC 
ATCTTCATTA AATACCTGCC CGAGTGGTCC GCCTGGGTCA TCCTGGGAGC CATCTCTATA 
TACGATCTGA TTGCGGTGTT GTGTCCGAAA GGCCCGTTGA GGATGCTGGT GGAAACAGCT 
CAAGAAAGAA ATGAGCCCAT TTTCCCTGCG CTCATATATT CATCTGCCAT GGTCTGGATG 
GTTGGAATGG CTGACTCTAA TAATCCAGAT TCAGCTGGTG AAAGGCGGCG CAGTGGGGGC 
GGAGTAAGGA CACAGGAAGG GGTGGAGTCA GAGGATGATG CGCCTCAGGC AGGGAGGAGG 
CAGTATTCAG CAGAAGAGGA CCTGGAGGAA GACCGAGGAG TGAAGCTGGG GCTGGGAGAC 
TTCATCTTCT ACAGTGTACT GGTGGGTAAA GCAGCGGCGA CTGGAGGAGA CTGGAACACC 
ACACTGGCCT GCTTTGTGGC CATCCTCATC GGTCTGTGTC TGACGCTCCT CCTGCTGGCC 
ATCTTCAAGA AGGCTCTTCC GGCTCTGCCC ATCTCCATCA CCTTCGGCCT GGTCTTCTAC 
TTCTCCACAG ATAATCTGGT GCGGCCCTTC ATGGACAGCC TGGCAGCACA TCAGTACTAC 
ATCTGA