PSEN2 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSEN2
Entrez Gene ID	490382
Full Name	presenilin 2
General protein information	Preferred Names presenilin 2 Names presenilin-2 presenilin 2 (Alzheimer disease 4)
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001284465.1	NP_001271394.1	presenilin-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PSEN2	NP_000438.2
	PSEN2	XP_002801954.1
Canis lupus familiaris (dog)	PSEN2	XP_005622685.1
Danio rerio (zebrafish)	psen2	NP_571589.2
Xenopus tropicalis (tropical clawed frog)	psen2	NP_001017181.1
Bos taurus (cattle)	PSEN2	NP_776865.2
Rattus norvegicus (Norway rat)	Psen2	NP_112349.2
Drosophila melanogaster (fruit fly)	Psn	NP_001137988.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002957	XP_311942.4
Gallus gallus (chicken)	PSEN2	NP_989633.1
Oryza sativa (rice)	Os01g0276400	NP_001042728.2
Pan troglodytes (chimpanzee)	PSEN2	XP_003949755.1
Mus musculus (house mouse)	Psen2	NP_001122077.1

Gene Ontology
Bibliography

Related articles in PubMed

Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing.
Sarasa L, Gallego C, Monle?n I, Olvera A, Canudas J, Monta??s M, Pesini P, Sarasa M
Neuroscience171(4)1091-101(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PSEN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSEN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe33815	NM_001284465.1 Latest version!	Canis lupus familiaris presenilin 2 (PSEN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSEN2 ( NM_001284465.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001271394.1 Canis lupus familiaris presenilin 2 (PSEN2), mRNA.

Price & Availability↑

CloneID	OCe33815
Clone ID Related Accession (Same CDS sequence)	NM_001284465.1
Accession Version	NM_001284465.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-22
Organism	Canis lupus familiaris(dog)
Product	presenilin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB793318.1. ##Evidence-Data-START## Transcript exon combination :: AB793318.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA103936001, SAMEA103936002 [ECO:0000350] ##Evidence-Data-END##

ATGCTCACAT TCATGGCCTC TGACAGTGAG GAAGAAGTGT GTGACGAGAG GACATCCCTG 
ATGTCGGCTG AGAGCCCCCC GCCACGCTGC TGCCAGGAGG CCAGGCAGGG CCTGGAGGAT 
GGAGAAAATG CTGCCCAGTG GAGAAGCCAG GACAGCGAGG AGGACTTTGA GGATGATGCT 
GACCACTACG TCTGCGGCGG GGTACCTGGG CAGCCGTCGG GCCTGGAGGA GGAGCTGACC 
CTCAAGTATG GGGCAAAGCA CGTGATCATG CTCTTTGTGC CGGTCACCCT GTGCATGATT 
GTGGTGGTGG CCACCATCAA GTCCGTGCGC TTCTACACAG AGAAGAACGG ACAGCTCATC 
TACACACCAT TCACCGAGGA CACGCCCTCT GTGGGCCAGC GCCTCCTCAA CTCTGTGCTC 
AACACCCTCA TCATGATCAG CGTCATTGTG GCCATGACCA TCTTCTTGGT CGTGCTCTAC 
AAGTACCGCT GCTACAAGTT TATCCATGGC TGGTTGATCA TGTCATCCTT GATGCTCCTG 
TTCCTTTTCA CCTATATCTA CCTCGGGGAA GTGCTTAAGA CCTACAACGT GGCCATGGAC 
TACCCTACCC TGTTCCTGAC TGTCTGGAAC TTTGGGGCAG TGGGCATGGT GTGCATCCAT 
TGGAAAGGCC CCTTGGTGTT GCAGCAAGCC TACCTCATCA TGATCAGTGC CCTCATGGCC 
TTGGTGTTCA TCAAGTACCT CCCCGAATGG TCTGCCTGGG TCATTCTGGG CGCCATCTCT 
GTGTACGATC TAGTGGCTGT GCTGTGCCCC AAAGGGCCTC TGAGGATGCT GGTGGAGACC 
GCCCAGGAGA GAAACGAGCC CATATTTCCT GCCCTGATAT ACTCCTCTGC CATGGTGTGG 
ACAGTGGGCA TGGCCAAGCT GGACCCCTCC TCCCAGGGAG CCCTGCAGCT GCCCTACGAC 
CCAGAGATGG AAGAAGACTC GTATGACAGT TTTAGGGAGC CCTCGTACCC GGAAGTCTTT 
GAGCCCCCCC TGCCTGGTTA CCCAGGGGAC GAACTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTCGGCC TGGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC AGCGGCCACA 
GGCAGCGGGG ACTGGAACAC CACGCTGGCG TGCTTCGTGG CCATCCTCAT TGGTTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCACTGC CTGCCCTCCC CATTTCCATC 
ACATTTGGGC TCATCTTTTA CTTCTCCACG GACAACTTGG TGCGTCCGTT CATGGATACC 
TTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001271394.1
CDS	56..1402
Translation	MLTFMASDSEEEVCDERTSLMSAESPPPRCCQEARQGLEDGENAAQWRSQDSEEDFEDDADHYVCGGVPGQPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVAMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFREPSYPEVFEPPLPGYPGDELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	NM_001284465.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris presenilin 2 (PSEN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001284465.1

ORF Insert Sequence:

ATGCTCACAT TCATGGCCTC TGACAGTGAG GAAGAAGTGT GTGACGAGAG GACATCCCTG 
ATGTCGGCTG AGAGCCCCCC GCCACGCTGC TGCCAGGAGG CCAGGCAGGG CCTGGAGGAT 
GGAGAAAATG CTGCCCAGTG GAGAAGCCAG GACAGCGAGG AGGACTTTGA GGATGATGCT 
GACCACTACG TCTGCGGCGG GGTACCTGGG CAGCCGTCGG GCCTGGAGGA GGAGCTGACC 
CTCAAGTATG GGGCAAAGCA CGTGATCATG CTCTTTGTGC CGGTCACCCT GTGCATGATT 
GTGGTGGTGG CCACCATCAA GTCCGTGCGC TTCTACACAG AGAAGAACGG ACAGCTCATC 
TACACACCAT TCACCGAGGA CACGCCCTCT GTGGGCCAGC GCCTCCTCAA CTCTGTGCTC 
AACACCCTCA TCATGATCAG CGTCATTGTG GCCATGACCA TCTTCTTGGT CGTGCTCTAC 
AAGTACCGCT GCTACAAGTT TATCCATGGC TGGTTGATCA TGTCATCCTT GATGCTCCTG 
TTCCTTTTCA CCTATATCTA CCTCGGGGAA GTGCTTAAGA CCTACAACGT GGCCATGGAC 
TACCCTACCC TGTTCCTGAC TGTCTGGAAC TTTGGGGCAG TGGGCATGGT GTGCATCCAT 
TGGAAAGGCC CCTTGGTGTT GCAGCAAGCC TACCTCATCA TGATCAGTGC CCTCATGGCC 
TTGGTGTTCA TCAAGTACCT CCCCGAATGG TCTGCCTGGG TCATTCTGGG CGCCATCTCT 
GTGTACGATC TAGTGGCTGT GCTGTGCCCC AAAGGGCCTC TGAGGATGCT GGTGGAGACC 
GCCCAGGAGA GAAACGAGCC CATATTTCCT GCCCTGATAT ACTCCTCTGC CATGGTGTGG 
ACAGTGGGCA TGGCCAAGCT GGACCCCTCC TCCCAGGGAG CCCTGCAGCT GCCCTACGAC 
CCAGAGATGG AAGAAGACTC GTATGACAGT TTTAGGGAGC CCTCGTACCC GGAAGTCTTT 
GAGCCCCCCC TGCCTGGTTA CCCAGGGGAC GAACTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTCGGCC TGGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC AGCGGCCACA 
GGCAGCGGGG ACTGGAACAC CACGCTGGCG TGCTTCGTGG CCATCCTCAT TGGTTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCACTGC CTGCCCTCCC CATTTCCATC 
ACATTTGGGC TCATCTTTTA CTTCTCCACG GACAACTTGG TGCGTCCGTT CATGGATACC 
TTGGCCTCCC ATCAGCTCTA CATCTGA