| Gene Symbol | pkd-2 |
| Entrez Gene ID | 178424 |
| Full Name | Polycystin-2 |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » pkd-2 cDNA ORF clone
| Gene Symbol | pkd-2 |
| Entrez Gene ID | 178424 |
| Full Name | Polycystin-2 |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
| mRNA | Protein | Name |
|---|---|---|
| NM_070437.4 | NP_502838.3 | Polycystin-2 |
| NM_070437.5 | NP_502838.3 | Polycystin-2 |
| Pan troglodytes (chimpanzee) | PKD2 | XP_003310458.1 |
| PKD2 | XP_001099242.1 | |
| Mus musculus (house mouse) | Pkd2 | NP_032887.3 |
| Bos taurus (cattle) | PKD2 | NP_001039777.1 |
| Gallus gallus (chicken) | PKD2 | NP_001026311.1 |
| Canis lupus familiaris (dog) | PKD2 | XP_544974.2 |
| Xenopus tropicalis (tropical clawed frog) | pkd2 | XP_002938673.2 |
| Homo sapiens (human) | PKD2 | NP_000288.1 |
| Rattus norvegicus (Norway rat) | Pkd2 | NP_001178863.1 |
| Danio rerio (zebrafish) | pkd2 | NP_001002310.1 |
| Caenorhabditis elegans (roundworm) | pkd-2 | NP_502838.3 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
expressed in male-specific neurons, required for mating
Title: Polycystic Kidney Disease: Lessons Learned from Caenorhabditis elegans Mating Behavior.
11 mutants found with defects in the ciliary localization (cil) of C. elegans PKD-2, a transient receptor potential polycystin (TRPP) channel
Title: Identification of genes involved in the ciliary trafficking of C. elegans PKD-2.
Results demonstrate that somatodendritic and ciliary targeting of PKD-2 requires the transmembrane region of PKD-2 and that the PKD-2 cytosolic termini regulate subcellular distribution and function.
Title: Distinct protein domains regulate ciliary targeting and function of C. elegans PKD-2.
These data reveal that the STAM-Hrs complex, which down-regulates ligand-activated growth factor receptors from the cell surface of yeast and mammalian cells, also regulates the localization and signaling of a ciliary PC1 receptor-TRPP2 complex.
Title: STAM and Hrs down-regulate ciliary TRP receptors.
Both general and cell-type-specific factors govern TRPP2/PKD-2 subcellular distribution by forming at least two steps involving somatodendritic and ciliary sorting decisions.
Title: General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia.
The following pkd-2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the pkd-2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OCa342463 | |
| Clone ID Related Accession (Same CDS sequence) | NM_070437.4 , NM_070437.5 | |
| Accession Version | NM_070437.4 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2151bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-08 | |
| Organism | Caenorhabditis elegans | |
| Product | Polycystin-2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003282). On Jun 26, 2012 this sequence version replaced NM_070437.3. COMPLETENESS: incomplete on both ends. | |
1 | ATGAACTACG GCGCTGCGGA CGAGCGATGG GCTAATCCAC CGCAGCCGGT CGCCGCTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_502838.3 |
| CDS | 1..2151 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_070437.4 |
1 | ATGAACTACG GCGCTGCGGA CGAGCGATGG GCTAATCCAC CGCAGCCGGT CGCCGCTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa342463 | |
| Clone ID Related Accession (Same CDS sequence) | NM_070437.4 , NM_070437.5 | |
| Accession Version | NM_070437.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2151bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-17 | |
| Organism | Caenorhabditis elegans | |
| Product | Polycystin-2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003282). On Sep 4, 2019 this sequence version replaced NM_070437.4. | |
1 | ATGAACTACG GCGCTGCGGA CGAGCGATGG GCTAATCCAC CGCAGCCGGT CGCCGCTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_502838.3 |
| CDS | 21..2171 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_070437.5 |
1 | ATGAACTACG GCGCTGCGGA CGAGCGATGG GCTAATCCAC CGCAGCCGGT CGCCGCTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |