nrg1.L cDNA ORF clone, Xenopus laevis(African clawed frog)

Gene
Clones
gRNAs

Summary

Gene Symbol	nrg1.L
Entrez Gene ID	373595
Full Name	neuregulin 1 L homeolog
Synonyms	NRG-1,heregulin,nrg1,nrg1-A
General protein information	Preferred Names neuregulin 1 L homeolog Names pro-neuregulin-1, membrane-bound isoform heregulin-alpha pro-NRG1
Gene Type	protein-coding
Organism	Xenopus laevis(African clawed frog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001085594.1	NP_001079063.1	pro-neuregulin-1, membrane-bound isoform

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

The immunoglobulin-like domain is involved in interaction of Neuregulin1 with ErbB.
Eto K, Eda K, Kanemoto S, Abe S
Biochemical and biophysical research communications350(2)263-71(2006 Nov)

A cysteine-rich form of Xenopus neuregulin induces the expression of acetylcholine receptors in cultured myotubes.
Yang JF, Zhou H, Choi RC, Ip NY, Peng HB, Tsim KW
Molecular and cellular neurosciences13(6)415-29(1999 Jun)

Cloning of cDNAs encoding xenopus neuregulin: expression in myotomal muscle during embryo development.
Yang JF, Zhou H, Pun S, Ip NY, Peng HB, Tsim KW
Brain research. Molecular brain research58(1-2)59-73(1998 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cloning of a novel isoform of NRG1 (IgNRG1beta2) containing an immunoglobulin-like domain which is probably essential for efficient interaction with ErbB receptors.
Title: The immunoglobulin-like domain is involved in interaction of Neuregulin1 with ErbB.

The following nrg1.L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the nrg1.L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OAf00030	NM_001085594.1 Latest version!	Xenopus laevis neuregulin 1 L homeolog (nrg1.L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

nrg1.L ( NM_001085594.1 ) cDNA ORF clone, Xenopus laevis(African clawed frog) -> NP_001079063.1 Xenopus laevis neuregulin 1 L homeolog (nrg1.L), mRNA.

Price & Availability↑

CloneID	OAf00030
Clone ID Related Accession (Same CDS sequence)	NM_001085594.1
Accession Version	NM_001085594.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Xenopus laevis(African clawed frog)
Product	pro-neuregulin-1, membrane-bound isoform
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF142632.1. ##Evidence-Data-START## Transcript exon combination :: AF142632.1 [ECO:0000332] ##Evidence-Data-END##

ATGTCTGAAG ATACTGCAGA GGGTTTGCAG AACCAGTGCT CTGAGCAGAG CTCAGACCCC 
CCCTCTGCTG AACTTCAGAA TGAAGAAAGC ATGCCAGAGA CTCAAGATGA GGAGGAAACG 
ACCCATGGGA TTACAGGCCT TGCTATTACC TGCTGTGTAT GTCTTGAGGC AGACAGGCTG 
AGAATCTGCC TTAACTCTGA GAAGATTTGC ATAATCCCTA TCTTGGCATG TCTGATTAGT 
CTGTGTCTCT GCATCGCGGG CCTTAAATGG GTGTTTGTAG ATAAAATATT TGAGTATGAC 
TCTCCTACAC ATTTGGACCC TGGCCATAGA GGCCAAGATC TTATCCTTTA TACTGACACA 
GCTCCATCTA CTTTGGTGCC ATCCTCTGTT CGTACTTTAC CTGTCATTAT TCCTACAACT 
GATTCTAAGG CTGCAGTTAC ATTCAAATTT GGAACTTCTC TTTTACCCAC AGAACCCACT 
TACAACCATT TACTTCTGAT GAAAATTTAC TTAAAAGTTA CATCAGTAGA AAAATCAGTT 
GAGCCTTCTA CCCTAAACCT ATTGGAATCA CAGAAAGAGG TTATTTTTGC TACAACCAAA 
AGGGGTGACA CCACAGCTGG GCCAGGTCAC CTTATTAAGT GTTCAGACAA AGAGAAGACC 
TACTGTGTCA ATGGAGGAGA GTGTTATGTA CTCAACGGTA TAACAAGCAG CAACCAGTTC 
ATGTGCAAGT GCCCAAATGA ATTTACTGGT GATCGCTGCC AAAACTACGT AATGGCCAGC 
TTCTACAAAG CTGAGGAGTT GTACCAAAAA AGAGTGTTGA CCATAACCGG CATCTGCATT 
GACCTTCTTG TAGTTGGCGA TATGTGTGTT GTGGACGCCT ACTGCAAAAC CAAGAAACAG 
AGAAAAAAGT TGAATGACCG TTTAAGACAA AGCCTCAGAG AGAGAAACAA AAACATAACA 
AACAAGGACA ACAGACCTCA CAACCCAAAG AACCCACCTC CCAGAAAAAA TGTCCAGCTG 
GTAAATCAGT ATGTCTCAAA AAATGTCATA TCAAGCGAAC ACGTGATTGA ACGGGAAACA 
GAAACATCTT TCTCTACAAG CCATTATACC TCGACAACAC ATCACTCAAC AACTGTTACA 
CAAACACCAA GTCACAGCTG GAGTAATGGT CTATCAGAAA GCATGATTTC AGAAAAAAGT 
TACTCAGTAA TAGTTACATC ATCGGTGGAA AACAGCAGGC ACACAAGCCC AACAGGGCCA 
AGGGGGCGTC TTAATGGTAT TGGAGGACCT AGAGACTGTA GTTATCTCAG GCATGCTAGA 
GATACTCCAG ACTCTTACAG AGATTCACCA CACAGTGAGA GATATGTTTC AGCTATGACT 
ACACCAGCCC GCATGTCACC AGTAGAATTC AAGACACCAA TCTCTCCTAA ATCGCCTTGT 
TTGGAAACGT CTCCACCTGA ATCTAGCTTA GCCGTTTCTG TTCCATCAGT GGCTGTGAGC 
CCCTTTATAG AAGAAGAAAG ACCTCTTCTT TTGGTGTCTC CACCAAGGTT ACGAGAAAAG 
AGATATGACA GAAAAACACC ACAAAAAACA CCACACAAGC AGCACAATTC CTACCATCAC 
AATCCTGGCC ATGACAGCAG CAGCTTACCG CCGAATCCTT TAAGAATAGT AGAAGATGAG 
GAGTATGAAA CCACACAGGA GTATGAACCG TCACTAGAGC CTGCAAAGAA ATTAGTCAAC 
AGCCGAAGGC AAAAAAGAAC AAAACCCAAT GGCCACATTT CCAATAGATT AGAACTGGAC 
AGTGACTCAA GCTCCGAGAG CAGTACATCT GAGAGTGAGA CAGAAGATGA AAGAATAGGC 
GAGGAAACAC CTTTTCTGAG TATACAGAAC CCACTGGCAG CCAGCTTAGA GTCCGCCAGT 
TTATACCGAC ATGCTGACAG CAGGACTAAC CCAACTAGCC GATTCTCAAC ACAGGAAGAA 
TTACAAGCAA GGTTGTCCAG CATAGCGAAT CAAGCCCTAT GCGATCAAAA GAAGCGAAAA 
ATGACCTGTA AAACTTTATT TATATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001079063.1
CDS	530..2596
Translation	MSEDTAEGLQNQCSEQSSDPPSAELQNEESMPETQDEEETTHGITGLAITCCVCLEADRLRICLNSEKICIIPILACLISLCLCIAGLKWVFVDKIFEYDSPTHLDPGHRGQDLILYTDTAPSTLVPSSVRTLPVIIPTTDSKAAVTFKFGTSLLPTEPTYNHLLLMKIYLKVTSVEKSVEPSTLNLLESQKEVIFATTKRGDTTAGPGHLIKCSDKEKTYCVNGGECYVLNGITSSNQFMCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIDLLVVGDMCVVDAYCKTKKQRKKLNDRLRQSLRERNKNITNKDNRPHNPKNPPPRKNVQLVNQYVSKNVISSEHVIERETETSFSTSHYTSTTHHSTTVTQTPSHSWSNGLSESMISEKSYSVIVTSSVENSRHTSPTGPRGRLNGIGGPRDCSYLRHARDTPDSYRDSPHSERYVSAMTTPARMSPVEFKTPISPKSPCLETSPPESSLAVSVPSVAVSPFIEEERPLLLVSPPRLREKRYDRKTPQKTPHKQHNSYHHNPGHDSSSLPPNPLRIVEDEEYETTQEYEPSLEPAKKLVNSRRQKRTKPNGHISNRLELDSDSSSESSTSESETEDERIGEETPFLSIQNPLAASLESASLYRHADSRTNPTSRFSTQEELQARLSSIANQALCDQKKRKMTCKTLFI

Target ORF information:

RefSeq Version	NM_001085594.1
Organism	Xenopus laevis(African clawed frog)
Definition	Xenopus laevis neuregulin 1 L homeolog (nrg1.L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001085594.1

ORF Insert Sequence:

ATGTCTGAAG ATACTGCAGA GGGTTTGCAG AACCAGTGCT CTGAGCAGAG CTCAGACCCC 
CCCTCTGCTG AACTTCAGAA TGAAGAAAGC ATGCCAGAGA CTCAAGATGA GGAGGAAACG 
ACCCATGGGA TTACAGGCCT TGCTATTACC TGCTGTGTAT GTCTTGAGGC AGACAGGCTG 
AGAATCTGCC TTAACTCTGA GAAGATTTGC ATAATCCCTA TCTTGGCATG TCTGATTAGT 
CTGTGTCTCT GCATCGCGGG CCTTAAATGG GTGTTTGTAG ATAAAATATT TGAGTATGAC 
TCTCCTACAC ATTTGGACCC TGGCCATAGA GGCCAAGATC TTATCCTTTA TACTGACACA 
GCTCCATCTA CTTTGGTGCC ATCCTCTGTT CGTACTTTAC CTGTCATTAT TCCTACAACT 
GATTCTAAGG CTGCAGTTAC ATTCAAATTT GGAACTTCTC TTTTACCCAC AGAACCCACT 
TACAACCATT TACTTCTGAT GAAAATTTAC TTAAAAGTTA CATCAGTAGA AAAATCAGTT 
GAGCCTTCTA CCCTAAACCT ATTGGAATCA CAGAAAGAGG TTATTTTTGC TACAACCAAA 
AGGGGTGACA CCACAGCTGG GCCAGGTCAC CTTATTAAGT GTTCAGACAA AGAGAAGACC 
TACTGTGTCA ATGGAGGAGA GTGTTATGTA CTCAACGGTA TAACAAGCAG CAACCAGTTC 
ATGTGCAAGT GCCCAAATGA ATTTACTGGT GATCGCTGCC AAAACTACGT AATGGCCAGC 
TTCTACAAAG CTGAGGAGTT GTACCAAAAA AGAGTGTTGA CCATAACCGG CATCTGCATT 
GACCTTCTTG TAGTTGGCGA TATGTGTGTT GTGGACGCCT ACTGCAAAAC CAAGAAACAG 
AGAAAAAAGT TGAATGACCG TTTAAGACAA AGCCTCAGAG AGAGAAACAA AAACATAACA 
AACAAGGACA ACAGACCTCA CAACCCAAAG AACCCACCTC CCAGAAAAAA TGTCCAGCTG 
GTAAATCAGT ATGTCTCAAA AAATGTCATA TCAAGCGAAC ACGTGATTGA ACGGGAAACA 
GAAACATCTT TCTCTACAAG CCATTATACC TCGACAACAC ATCACTCAAC AACTGTTACA 
CAAACACCAA GTCACAGCTG GAGTAATGGT CTATCAGAAA GCATGATTTC AGAAAAAAGT 
TACTCAGTAA TAGTTACATC ATCGGTGGAA AACAGCAGGC ACACAAGCCC AACAGGGCCA 
AGGGGGCGTC TTAATGGTAT TGGAGGACCT AGAGACTGTA GTTATCTCAG GCATGCTAGA 
GATACTCCAG ACTCTTACAG AGATTCACCA CACAGTGAGA GATATGTTTC AGCTATGACT 
ACACCAGCCC GCATGTCACC AGTAGAATTC AAGACACCAA TCTCTCCTAA ATCGCCTTGT 
TTGGAAACGT CTCCACCTGA ATCTAGCTTA GCCGTTTCTG TTCCATCAGT GGCTGTGAGC 
CCCTTTATAG AAGAAGAAAG ACCTCTTCTT TTGGTGTCTC CACCAAGGTT ACGAGAAAAG 
AGATATGACA GAAAAACACC ACAAAAAACA CCACACAAGC AGCACAATTC CTACCATCAC 
AATCCTGGCC ATGACAGCAG CAGCTTACCG CCGAATCCTT TAAGAATAGT AGAAGATGAG 
GAGTATGAAA CCACACAGGA GTATGAACCG TCACTAGAGC CTGCAAAGAA ATTAGTCAAC 
AGCCGAAGGC AAAAAAGAAC AAAACCCAAT GGCCACATTT CCAATAGATT AGAACTGGAC 
AGTGACTCAA GCTCCGAGAG CAGTACATCT GAGAGTGAGA CAGAAGATGA AAGAATAGGC 
GAGGAAACAC CTTTTCTGAG TATACAGAAC CCACTGGCAG CCAGCTTAGA GTCCGCCAGT 
TTATACCGAC ATGCTGACAG CAGGACTAAC CCAACTAGCC GATTCTCAAC ACAGGAAGAA 
TTACAAGCAA GGTTGTCCAG CATAGCGAAT CAAGCCCTAT GCGATCAAAA GAAGCGAAAA 
ATGACCTGTA AAACTTTATT TATATAA