| Gene Symbol | HSD3B1 |
| Entrez Gene ID | 445539 |
| Full Name | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
| Synonyms | 3B-HSD,HSD3B |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
| Genome |
ORF » Species Summary » Sus scrofa » HSD3B1 cDNA ORF clone
| Gene Symbol | HSD3B1 |
| Entrez Gene ID | 445539 |
| Full Name | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
| Synonyms | 3B-HSD,HSD3B |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
| Genome |
| mRNA | Protein | Name |
|---|---|---|
| NM_001004049.2 | NP_001004049.1 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase |
| XM_021088745.1 | XP_020944404.1 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase isoform X1 |
Altered expression of 3?-HSD, CYP17 and 17?-HSD in the foetal porcine gonads in response to anti-androgen flutamide exposure.
Knapczyk-Stwora K, Grzesiak M, Slomczynska M
Reproduction in domestic animals = Zuchthygiene49(5)725-33(2014 Oct)
Effects of hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 polymorphisms on fat androstenone level and gene expression in Duroc pigs.
Kim JM, Ahn JH, Lim KS, Lee EA, Chun T, Hong KC
Animal genetics44(5)592-5(2013 Aug)
Investigation on the transcription factors of porcine 3?-hydroxysteroid dehydrogenase and 17?-hydroxysteroid dehydrogenase genes.
Dong X, Bai Y, Xin Y, Xu Q, Chen G, Fang M
Gene499(1)186-90(2012 May)
In vitro exposure of porcine granulosa cells to the phytoestrogens genistein and daidzein: effects on the biosynthesis of reproductive steroid hormones.
Tiemann U, Schneider F, Vanselow J, Tomek W
Reproductive toxicology (Elmsford, N.Y.)24(3-4)317-25(2007 Nov-Dec)
The presence of 3beta-hydroxysteroid dehydrogenase in the ovarian follicles and corpora lutea of pregnant swine.
Knapczyk K, Duda M, Czaplicki D, Slomczynska M
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association115(7)411-6(2007 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
We found that adiponectin and insulin alone regulates the expression of StAR, CYP11A1 and HSD3B1 genes and secretion of P4 and A4 by the porcine endometrial and myometrial tissue explants during early pregnancy and the oestrous cycle.
Title: Effect of adiponectin on the steroidogenic acute regulatory protein, P450 side chain cleavage enzyme and 3?-hydroxysteroid dehydrogenase gene expression, progesterone and androstenedione production by the porcine uterus during early pregnancy.
The effects of androgen blockade on the expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD), CYP17, and 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) in the porcine fetus are reported.
Title: Altered expression of 3?-HSD, CYP17 and 17?-HSD in the foetal porcine gonads in response to anti-androgen flutamide exposure.
Study found that uncastrated Duroc pigs with the GG SNP5 genotype had significantly higher 3beta-HSD mRNA levels than did uncastrated Duroc pigs with other SNP5 genotypes.
Title: Effects of hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 polymorphisms on fat androstenone level and gene expression in Duroc pigs.
New insights to the transcriptional regulation of 3betaHSD1 and 17betaHSD7 and further hints to their involvement in steroid metabolism.
Title: Investigation on the transcription factors of porcine 3?-hydroxysteroid dehydrogenase and 17?-hydroxysteroid dehydrogenase genes.
Genistein and daidzein have direct effects on porcine granulosa cell progesterone synthesis involving the inhibition of 3-beta-HSD enzyme activity.
Title: In vitro exposure of porcine granulosa cells to the phytoestrogens genistein and daidzein: effects on the biosynthesis of reproductive steroid hormones.
The following HSD3B1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSD3B1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OSe00532 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001004049.2 | |
| Accession Version | NM_001004049.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-01-24 | |
| Organism | Sus scrofa(pig) | |
| Product | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK235739.1, AF232699.2 and CR938722.3. On Jan 25, 2017 this sequence version replaced NM_001004049.1. ##Evidence-Data-START## Transcript exon combination :: AK235739.1, AK348635.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03652802, SAMN03652803 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCTGGAT GGAGCTGCCT TGTGACAGGA GGAGGAGGGT TTCTGGGTCA GAGGATCGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001004049.1 |
| CDS | 143..1264 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001004049.2 |
1 | ATGGCTGGAT GGAGCTGCCT TGTGACAGGA GGAGGAGGGT TTCTGGGTCA GAGGATCGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe247262 | |
| Clone ID Related Accession (Same CDS sequence) | XM_021088745.1 | |
| Accession Version | XM_021088745.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-05-12 | |
| Organism | Sus scrofa(pig) | |
| Product | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_010446.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Sus scrofa Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGCTGGAT GGAGCTGCCT TGTGACAGGA GGAGGAGGGT TTCTGGGTCA GAGGATCGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_020944404.1 |
| CDS | 431..1630 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_021088745.1 |
1 | ATGGCTGGAT GGAGCTGCCT TGTGACAGGA GGAGGAGGGT TTCTGGGTCA GAGGATCGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Altered expression of 3?-HSD, CYP17 and 17?-HSD in the foetal porcine gonads in response to anti-androgen flutamide exposure. |
Effects of hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 polymorphisms on fat androstenone level and gene expression in Duroc pigs. |
Investigation on the transcription factors of porcine 3?-hydroxysteroid dehydrogenase and 17?-hydroxysteroid dehydrogenase genes. |
In vitro exposure of porcine granulosa cells to the phytoestrogens genistein and daidzein: effects on the biosynthesis of reproductive steroid hormones. |
The presence of 3beta-hydroxysteroid dehydrogenase in the ovarian follicles and corpora lutea of pregnant swine. |