| Gene Symbol | TNF |
| Entrez Gene ID | 397086 |
| Full Name | tumor necrosis factor |
| Synonyms | TNFa |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
| Genome |
ORF » Species Summary » Sus scrofa » TNF cDNA ORF clone
| Gene Symbol | TNF |
| Entrez Gene ID | 397086 |
| Full Name | tumor necrosis factor |
| Synonyms | TNFa |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
| Genome |
| mRNA | Protein | Name |
|---|---|---|
| NM_214022.1 | NP_999187.1 | tumor necrosis factor |
Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-?.
Mathis T, Housset M, Eandi C, Beguier F, Touhami S, Reichman S, Augustin S, Gondouin P, Sahel JA, Kodjikian L, Goureau O, Guillonneau X, Sennlaub F
Aging cell16(1)173-182(2017 Feb)
Effects of Trimetazidine on PDCD4/NF-?B/TNF-? Pathway in Coronary Microembolization.
Su Q, Li L, Zhao J, Sun Y, Yang H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(2)753-760(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
TNF-alpha induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle.
Title: Cyclic Tensile Strain Reduces TNF-? Induced Expression of MMP-13 by Condylar Temporomandibular Joint Cells.
TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 and essential retinal pigment epithelium genes.
Title: Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-?.
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB/ TNF-alpha pathway in cardiomyocytes.
Title: Effects of Trimetazidine on PDCD4/NF-?B/TNF-? Pathway in Coronary Microembolization.
This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 resistance.
Title: Effects of the -791(C?T) mutation in the promoter for tumor necrosis factor alpha on gene expression and resistance of Large White pigs to enterotoxigenic Escherichia coli F18.
TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.
Title: Effects of interleukin 6 and tumor necrosis factor-? on the proliferation of porcine theca interna cells: Possible role of these cytokines in the pathogenesis of polycystic ovary syndrome.
The following TNF gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNF cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OSe30520 | |
| Clone ID Related Accession (Same CDS sequence) | NM_214022.1 | |
| Accession Version | NM_214022.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-19 | |
| Organism | Sus scrofa(pig) | |
| Product | tumor necrosis factor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X54859.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN02904337 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGAGCACTG AGAGCATGAT CCGAGACGTG GAGCTGGCGG AGGAGGCGCT CGCCAAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_999187.1 |
| CDS | 184..882 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_214022.1 |
1 | ATGAGCACTG AGAGCATGAT CCGAGACGTG GAGCTGGCGG AGGAGGCGCT CGCCAAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-?. |
Effects of Trimetazidine on PDCD4/NF-?B/TNF-? Pathway in Coronary Microembolization. |