HMGCR cDNA ORF clone, Sus scrofa(pig)

Gene
Clones
gRNAs

Summary

Gene Symbol	HMGCR
Entrez Gene ID	100144446
Full Name	3-hydroxy-3-methylglutaryl-CoA reductase
Synonyms	HMGR
Gene Type	protein-coding
Organism	Sus scrofa(pig)
Genome	Chromosome: 2 Map Location: 2\|2q22

mRNA and Protein(s)

mRNA	Protein	Name
NM_001122988.1	NP_001116460.1	3-hydroxy-3-methylglutaryl-coenzyme A reductase

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

HMGCR inhibits the early stage of PCV2 infection, while PKC enhances the infection at the late stage.
Ma T, Chen X, Ouyang H, Liu X, Ouyang T, Peng Z, Yang X, Chen F, Pang D, Bai J, Ren L
Virus research22941-47(2017 Feb)

Molecular cloning, tissue expression and protein structure prediction of the porcine 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGR) gene.
Chen X, Wang X, Li Z, Kong L, Liu G, Fu J, Wang A
Gene495(2)170-7(2012 Mar)

Regulation of porcine granulosa cell 3-hydroxy-3-methylglutaryl coenzyme A reductase by insulin and insulin-like growth factor I: synergism with follicle-stimulating hormone or protein kinase A agonist.
Maitra A, LaVoie HA, Day RN, Garmey JC, Veldhuis JD
Endocrinology136(11)5111-7(1995 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HMGCR inhibits the early stage of PCV2 infection, while PKC enhances the infection at the late stage.
Title: HMGCR inhibits the early stage of PCV2 infection, while PKC enhances the infection at the late stage.

The relative expression level of HMGR was high in liver, heart, kidney, bladder and subcutaneous fat, medium in lung, uterus and large intestine, and low in cerebrum, spleen, spinal cord, stomach, ovary, longissimus muscle, and small intestine.
Title: Molecular cloning, tissue expression and protein structure prediction of the porcine 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGR) gene.

The following HMGCR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HMGCR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSe00448	NM_001122988.1 Latest version!	Sus scrofa 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HMGCR ( NM_001122988.1 ) cDNA ORF clone, Sus scrofa(pig) -> NP_001116460.1 Sus scrofa 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), mRNA.

Price & Availability↑

CloneID	OSe00448
Clone ID Related Accession (Same CDS sequence)	NM_001122988.1
Accession Version	NM_001122988.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2658bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Sus scrofa(pig)
Product	3-hydroxy-3-methylglutaryl-coenzyme A reductase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ432054.1. ##Evidence-Data-START## Transcript exon combination :: DQ432054.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1487420, SAMEA1876824 [ECO:0000348] ##Evidence-Data-END##

ATGTTGTCAA GACTCTTCCG AATGCATGGC CTCTTTGTGG CCTCCCATCC CTGGGAAGTC 
ATAGTGGGGA CAGTGACACT GACCATCTGT ATGATGTCCA TGAACATGTT TACTGGTAAC 
GATAAGATCT GTGGTTGGAA TTATGAATGT CCAAAGTTTG AAGAGGATGT TTTGAGCAGT 
GACATCATAA TTCTGACAAT AACACGATGC ATAGCAATCC TGTATATTTA CTTCCAGTTT 
CAGAATTTAC GTCAACTTGG ATCAAAATAT ATTTTGGGTA TTGCCGGCCT CTTCACAATT 
TTCTCAAGTT TTGTATTCAG TACAGTTGTT ATCCATTTCC TAGACAAAGA ATTGACAGGC 
TTGAATGAAG CTCTGCCCTT TTTCCTACTT TTGATTGACC TTTCCAGAGC AAGTGCACTG 
GCAAAGTTTG CCCTCAGCTC CAACTCACAG GATGAAGTAA GGGAGAATAT TGCTCGTGGA 
ATGGCAATTT TAGGTCCCAC ATTCACCCTC GATGCTCTTG TAGAATGCCT TGTGATTGGA 
GTTGGCACCA TGTCAGGGGT GCGTCAGCTT GAAATTATGT GCTGCTTTGG CTGCATGTCA 
GTTCTCGCCA CCTACTTCGT GTTCATGACT TTCTTCCCAG CTTGCGTGTC CTTGGTTTTA 
GAGCTTTCTC GGGAAAGCCG CGAGGGTCGT CCAATTTGGC AGCTCAGCCA TTTTGCCCGA 
GTTTTAGAAG GGGAAGAAAA TAAACCAAAT CCTGTTACTC AGAGAGTTAA AATAATTATG 
TCTCTAGGCT TGGTTCTTGT TCACGCGCAC AGTCGCTGGA TAGCCGATCC TTCTCCTCAA 
AACAGTACGG CAGACAATTC TAAGGTTTCG TTAGGATTGG ATGAAAATGT GTCCAAGAGA 
ATTGAACCAA GTGTTTCCCT CTGGCAGTTT TATCTGTCTA AAATGATCAG CATGGATATT 
GAACAAGTTA TTACCCTAAC TTTGGCTCTC CTTCTGGCTG TCAAGTATAT CTTCTTTGAA 
CAAGCAGAGA CGGAATCTAC ACTCTCATTA AAAAACCCTA TCACATCTCC GGTAGTGACC 
CAAAAGAAAG TCACAGATGA CTGTTGTAGA CGTGAACCAA CACTGGTCAG AAATGACCAG 
AAATTCCACA CAGTGGAGGA GGAGGCCAGG ATAAACAGAG AAAGAAAAGT TGAGGTTATA 
AAACCCTTGG TGGCAGAAAC TGACACCTCA AGCAGACCCA CGTTTGTGGT TGGTAACTCC 
ACACTTGATT CTTCGCTGGA ACTAGAGATG CAGGAACCTG AGATCCAGAT TCCCTCGGAG 
CCTCGGCCTA ATGAAGAATG TCTACAGATA CTTGGAAATG CAGAGAAAGG TGCAAAATTC 
CTTAGTGATG CTGAGATCAT CCAGTTGGTC AATGCTAAAC ATATCCCAGC TTACAAATTG 
GAAACTTTGA TGGAAACCCA TGAACGAGGT GTATCTATTC GCCGACAGTT ACTTTCCAAA 
AAACTTCCAG AACCTTCTTC CCTCCAGTAT CTACCCTACA GAGACTATAA TTACTCCTTG 
GTAATGGGCG CTTGCTGTGA GAATGTTATT GGATATATGC CCATCCCTGT TGGAGTGGCA 
GGACCCCTGT GCTTGGATGG AAAAGAATTT CAGGTTCCAA TGGCAACAAC AGAAGGTTGC 
CTCGTGGCCA GCACCAATAG AGGCTGCAGA GCAATTGGTC TTGGTGGAGG CGCCAGCAGC 
CGAATCCTCG CAGATGGCAT GACTCCAGTG GTACGTTTTC CACGTGCTTG TGACTCTGCA 
GAAGTAAAGG CCTGGCTCGA GACACCTGAA GGGTTTGCAG TGATAAAGGA GGCATTCGAC 
AGCACCAGCA GATTTGCTCG CCTACAGAAA CTTCAAATGA GTGTGGCCGG ACGCAACCTT 
TATATCCGTT TCCAGTCCAG GTCAGGTGAT GCCATGGGGA TGAACATGAT TTCAAAGGGT 
ACAGAGAAAG CCCTTTCGAA ACTTCATGAG TATTTCCCTG AAATGCAGAT TCTGGCAGTC 
AGTGGTAACT ATTGTACTGA CAAGAAACCT GCTGCTGTAA ACTGGATAGA GGGAAGAGGA 
AAGTCTGTTG TGTGTGAAGC TGTCATTCCA GCCAAGGTTG TCAGAGAAGT ATTAAAGACT 
ACTACAGAAG CGATGGTTGA GGTCAACATT AACAAAAATC TGGTGGGCTC GGCCATGGCC 
GGGAGCATCG GCGGCTACAA CGCCCATGCA GCCAACATCG TGACTGCCAT CTACATTGCC 
TGTGGTCAGG ATGCGGCACA GAACGTTGGC AGCTCCAACT GTATTACTTT AATGGAAGCG 
AGTGGTCCCA CAAATGAAGA CTTGTACATC AGCTGCACCA TGCCATCCAT AGAGATCGGG 
ACCGTGGGCG GGGGGACCAG CCTGCTCCCT CAGCAGGCCT GTTTGCAGAT GCTAGGGGTT 
CAAGGAGCGT GCAAAGACAA TCCTGGGGAA AACGCCCGGC AGCTCGCCCG AATTGTGTGC 
GGTACAGTGA TGGCTGGGGA GTTGTCCCTG ATGGCAGCTT TGGCAGCTGG ACATCTCGTC 
AGAAGTCACA TGATTCACAA CAGGTCAAAG ATAAATTTAC AAGACCTCCA AGGAACTTGC 
ACTAAGAAGG CAGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116460.1
CDS	104..2761
Translation	MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNDKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLATYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEGEENKPNPVTQRVKIIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLTLALLLAVKYIFFEQAETESTLSLKNPITSPVVTQKKVTDDCCRREPTLVRNDQKFHTVEEEARINRERKVEVIKPLVAETDTSSRPTFVVGNSTLDSSLELEMQEPEIQIPSEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRILADGMTPVVRFPRACDSAEVKAWLETPEGFAVIKEAFDSTSRFARLQKLQMSVAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAVNWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMVEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTSLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMIHNRSKINLQDLQGTCTKKAA

Target ORF information:

RefSeq Version	NM_001122988.1
Organism	Sus scrofa(pig)
Definition	Sus scrofa 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001122988.1

ORF Insert Sequence:

ATGTTGTCAA GACTCTTCCG AATGCATGGC CTCTTTGTGG CCTCCCATCC CTGGGAAGTC 
ATAGTGGGGA CAGTGACACT GACCATCTGT ATGATGTCCA TGAACATGTT TACTGGTAAC 
GATAAGATCT GTGGTTGGAA TTATGAATGT CCAAAGTTTG AAGAGGATGT TTTGAGCAGT 
GACATCATAA TTCTGACAAT AACACGATGC ATAGCAATCC TGTATATTTA CTTCCAGTTT 
CAGAATTTAC GTCAACTTGG ATCAAAATAT ATTTTGGGTA TTGCCGGCCT CTTCACAATT 
TTCTCAAGTT TTGTATTCAG TACAGTTGTT ATCCATTTCC TAGACAAAGA ATTGACAGGC 
TTGAATGAAG CTCTGCCCTT TTTCCTACTT TTGATTGACC TTTCCAGAGC AAGTGCACTG 
GCAAAGTTTG CCCTCAGCTC CAACTCACAG GATGAAGTAA GGGAGAATAT TGCTCGTGGA 
ATGGCAATTT TAGGTCCCAC ATTCACCCTC GATGCTCTTG TAGAATGCCT TGTGATTGGA 
GTTGGCACCA TGTCAGGGGT GCGTCAGCTT GAAATTATGT GCTGCTTTGG CTGCATGTCA 
GTTCTCGCCA CCTACTTCGT GTTCATGACT TTCTTCCCAG CTTGCGTGTC CTTGGTTTTA 
GAGCTTTCTC GGGAAAGCCG CGAGGGTCGT CCAATTTGGC AGCTCAGCCA TTTTGCCCGA 
GTTTTAGAAG GGGAAGAAAA TAAACCAAAT CCTGTTACTC AGAGAGTTAA AATAATTATG 
TCTCTAGGCT TGGTTCTTGT TCACGCGCAC AGTCGCTGGA TAGCCGATCC TTCTCCTCAA 
AACAGTACGG CAGACAATTC TAAGGTTTCG TTAGGATTGG ATGAAAATGT GTCCAAGAGA 
ATTGAACCAA GTGTTTCCCT CTGGCAGTTT TATCTGTCTA AAATGATCAG CATGGATATT 
GAACAAGTTA TTACCCTAAC TTTGGCTCTC CTTCTGGCTG TCAAGTATAT CTTCTTTGAA 
CAAGCAGAGA CGGAATCTAC ACTCTCATTA AAAAACCCTA TCACATCTCC GGTAGTGACC 
CAAAAGAAAG TCACAGATGA CTGTTGTAGA CGTGAACCAA CACTGGTCAG AAATGACCAG 
AAATTCCACA CAGTGGAGGA GGAGGCCAGG ATAAACAGAG AAAGAAAAGT TGAGGTTATA 
AAACCCTTGG TGGCAGAAAC TGACACCTCA AGCAGACCCA CGTTTGTGGT TGGTAACTCC 
ACACTTGATT CTTCGCTGGA ACTAGAGATG CAGGAACCTG AGATCCAGAT TCCCTCGGAG 
CCTCGGCCTA ATGAAGAATG TCTACAGATA CTTGGAAATG CAGAGAAAGG TGCAAAATTC 
CTTAGTGATG CTGAGATCAT CCAGTTGGTC AATGCTAAAC ATATCCCAGC TTACAAATTG 
GAAACTTTGA TGGAAACCCA TGAACGAGGT GTATCTATTC GCCGACAGTT ACTTTCCAAA 
AAACTTCCAG AACCTTCTTC CCTCCAGTAT CTACCCTACA GAGACTATAA TTACTCCTTG 
GTAATGGGCG CTTGCTGTGA GAATGTTATT GGATATATGC CCATCCCTGT TGGAGTGGCA 
GGACCCCTGT GCTTGGATGG AAAAGAATTT CAGGTTCCAA TGGCAACAAC AGAAGGTTGC 
CTCGTGGCCA GCACCAATAG AGGCTGCAGA GCAATTGGTC TTGGTGGAGG CGCCAGCAGC 
CGAATCCTCG CAGATGGCAT GACTCCAGTG GTACGTTTTC CACGTGCTTG TGACTCTGCA 
GAAGTAAAGG CCTGGCTCGA GACACCTGAA GGGTTTGCAG TGATAAAGGA GGCATTCGAC 
AGCACCAGCA GATTTGCTCG CCTACAGAAA CTTCAAATGA GTGTGGCCGG ACGCAACCTT 
TATATCCGTT TCCAGTCCAG GTCAGGTGAT GCCATGGGGA TGAACATGAT TTCAAAGGGT 
ACAGAGAAAG CCCTTTCGAA ACTTCATGAG TATTTCCCTG AAATGCAGAT TCTGGCAGTC 
AGTGGTAACT ATTGTACTGA CAAGAAACCT GCTGCTGTAA ACTGGATAGA GGGAAGAGGA 
AAGTCTGTTG TGTGTGAAGC TGTCATTCCA GCCAAGGTTG TCAGAGAAGT ATTAAAGACT 
ACTACAGAAG CGATGGTTGA GGTCAACATT AACAAAAATC TGGTGGGCTC GGCCATGGCC 
GGGAGCATCG GCGGCTACAA CGCCCATGCA GCCAACATCG TGACTGCCAT CTACATTGCC 
TGTGGTCAGG ATGCGGCACA GAACGTTGGC AGCTCCAACT GTATTACTTT AATGGAAGCG 
AGTGGTCCCA CAAATGAAGA CTTGTACATC AGCTGCACCA TGCCATCCAT AGAGATCGGG 
ACCGTGGGCG GGGGGACCAG CCTGCTCCCT CAGCAGGCCT GTTTGCAGAT GCTAGGGGTT 
CAAGGAGCGT GCAAAGACAA TCCTGGGGAA AACGCCCGGC AGCTCGCCCG AATTGTGTGC 
GGTACAGTGA TGGCTGGGGA GTTGTCCCTG ATGGCAGCTT TGGCAGCTGG ACATCTCGTC 
AGAAGTCACA TGATTCACAA CAGGTCAAAG ATAAATTTAC AAGACCTCCA AGGAACTTGC 
ACTAAGAAGG CAGCTTGA