Rgs2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rgs2
Entrez Gene ID	84583
Full Name	regulator of G-protein signaling 2
General protein information	Preferred Names regulator of G-protein signaling 2 Names regulator of G-protein signaling 2 regulator of G-protein signaling protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q21
Summary	member of a family of GTPase activating proteins that terminate G-protein coupled receptor signaling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053453.2	NP_445905.1	regulator of G-protein signaling 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RGS2	XP_005640987.1
Mus musculus (house mouse)	Rgs2	NP_033087.2
	RGS2	XP_001112788.1
Xenopus tropicalis (tropical clawed frog)	rgs2	NP_001025622.1
Pan troglodytes (chimpanzee)	RGS2	XP_001166601.1
Rattus norvegicus (Norway rat)	Rgs2	NP_445905.1
Gallus gallus (chicken)	RGS2	NP_989726.1
Homo sapiens (human)	RGS2	NP_002914.1

Gene Ontology
Bibliography

Related articles in PubMed

Chronic intermittent ethanol exposure selectively alters the expression of G? subunit isoforms and RGS subtypes in rat prefrontal cortex.
Luessen DJ, Sun H, McGinnis MM, McCool BA, Chen R
Brain research1672106-112(2017 Oct)

Impaired response of regulator of G?q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats.
Wu Y, Takahashi H, Suzuki E, Kruzliak P, Soucek M, Uehara Y
Hypertension research : official journal of the Japanese Society of Hypertension39(4)210-6(2016 Apr)

The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.
Sun H, Calipari ES, Beveridge TJ, Jones SR, Chen R
Neuroscience307253-61(2015 Oct)

The eIF2B-interacting domain of RGS2 protects against GPCR agonist-induced hypertrophy in neonatal rat cardiomyocytes.
Chidiac P, Sobiesiak AJ, Lee KN, Gros R, Nguyen CH
Cellular signalling26(6)1226-34(2014 Jun)

Stress-induced transcription of regulator of G protein signaling 2 (RGS2) by heat shock transcription factor HSF1.
Ota A, Sawai M, Sakurai H
Biochimie95(7)1432-6(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that Dahl S rats exhibit a blunted RGS2 response to Ang-II, and this blunted response may be partially responsible for the susceptibility to renal injury in Dahl S rats.
Title: Impaired response of regulator of G?q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats.

The protective effects of RGS2 in cardiac hypertrophy may derive at least in part from its ability to govern protein synthesis.
Title: The eIF2B-interacting domain of RGS2 protects against GPCR agonist-induced hypertrophy in neonatal rat cardiomyocytes.

Stress-induced transcription of regulator of G protein signaling 2 (RGS2) by heat shock transcription factor HSF1
Title: Stress-induced transcription of regulator of G protein signaling 2 (RGS2) by heat shock transcription factor HSF1.

RGS2 functions on a daily basis to negatively modulate melatonin production
Title: RGS2 is a feedback inhibitor of melatonin production in the pineal gland.

Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2
Title: Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured vascular smooth muscles.

The following Rgs2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rgs2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09609	NM_053453.2 Latest version!	Rattus norvegicus regulator of G-protein signaling 2 (Rgs2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rgs2 ( NM_053453.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445905.1 Rattus norvegicus regulator of G-protein signaling 2 (Rgs2), mRNA.

Price & Availability↑

CloneID	ORa09609
Clone ID Related Accession (Same CDS sequence)	NM_053453.2
Accession Version	NM_053453.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	regulator of G-protein signaling 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF321837.1. On Jun 10, 2007 this sequence version replaced NM_053453.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF321837.1, DY315773.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCAAAGTG CCATGTTCCT GGCTGTCCAG CACGACTGCG TACCCATGGA CAAGAGCGCA 
GGCAACGGCC CCAAGGTCGA GGAGAAGCGG GAGAAAATGA AGCGGACACT CTTAAAAGAT 
TGGAAGACCC GTTTGAGCTA TTTCTTGCAA AACTCCTCTA CTCCTGGGAA GCCCAAAACT 
GGCAAGAAAA GCAAACAGCA AACTTTTATC AAGCCTTCTC CTGAGGAAGC GCTGCTCTGG 
GCAGAAGCAT TTGATGAACT GCTGGCCAGC AAATATGGGC TTGCTGCATT CAGAGCGTTT 
TTAAAGTCCG AGTTCTGTGA AGAAAATATT GAATTCTGGT TGGCTTGCGA AGACTTCAAG 
AAAACCAAAT CACCACAGAA ACTGTCCTCA AAAGCAAGGA AAATATACAC CGACTTCATC 
GAGAAGGAAG CTCCCAAAGA GATAAACATA GACTTTCAAA CAAAAACTCT GATTGCCCAA 
AATATCCAAG AGGCTACAAG TGGCTGCTTC ACCACAGCGC AGAAGAGGGT GTACAGCCTG 
ATGGAGAACA ACTCTTATCC TCGTTTCTTG GAATCAGAAT TTTATCAGGA CTTGTGTAAA 
AAGCCACAGA TCACCACGGA GCCCCATGCT ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445905.1
CDS	1..636
Translation	MQSAMFLAVQHDCVPMDKSAGNGPKVEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQTFIKPSPEEALLWAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT

Target ORF information:

RefSeq Version	NM_053453.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus regulator of G-protein signaling 2 (Rgs2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053453.2

ORF Insert Sequence:

ATGCAAAGTG CCATGTTCCT GGCTGTCCAG CACGACTGCG TACCCATGGA CAAGAGCGCA 
GGCAACGGCC CCAAGGTCGA GGAGAAGCGG GAGAAAATGA AGCGGACACT CTTAAAAGAT 
TGGAAGACCC GTTTGAGCTA TTTCTTGCAA AACTCCTCTA CTCCTGGGAA GCCCAAAACT 
GGCAAGAAAA GCAAACAGCA AACTTTTATC AAGCCTTCTC CTGAGGAAGC GCTGCTCTGG 
GCAGAAGCAT TTGATGAACT GCTGGCCAGC AAATATGGGC TTGCTGCATT CAGAGCGTTT 
TTAAAGTCCG AGTTCTGTGA AGAAAATATT GAATTCTGGT TGGCTTGCGA AGACTTCAAG 
AAAACCAAAT CACCACAGAA ACTGTCCTCA AAAGCAAGGA AAATATACAC CGACTTCATC 
GAGAAGGAAG CTCCCAAAGA GATAAACATA GACTTTCAAA CAAAAACTCT GATTGCCCAA 
AATATCCAAG AGGCTACAAG TGGCTGCTTC ACCACAGCGC AGAAGAGGGT GTACAGCCTG 
ATGGAGAACA ACTCTTATCC TCGTTTCTTG GAATCAGAAT TTTATCAGGA CTTGTGTAAA 
AAGCCACAGA TCACCACGGA GCCCCATGCT ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chronic intermittent ethanol exposure selectively alters the expression of G? subunit isoforms and RGS subtypes in rat prefrontal cortex.
Brain research1672106-112(2017 Oct)
Luessen DJ,Sun H,McGinnis MM,McCool BA,Chen R

Impaired response of regulator of G?q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats.
Hypertension research : official journal of the Japanese Society of Hypertension39(4)210-6(2016 Apr)
Wu Y,Takahashi H,Suzuki E,Kruzliak P,Soucek M,Uehara Y

The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.
Neuroscience307253-61(2015 Oct)
Sun H,Calipari ES,Beveridge TJ,Jones SR,Chen R

The eIF2B-interacting domain of RGS2 protects against GPCR agonist-induced hypertrophy in neonatal rat cardiomyocytes.
Cellular signalling26(6)1226-34(2014 Jun)
Chidiac P,Sobiesiak AJ,Lee KN,Gros R,Nguyen CH

Stress-induced transcription of regulator of G protein signaling 2 (RGS2) by heat shock transcription factor HSF1.
Biochimie95(7)1432-6(2013 Jul)
Ota A,Sawai M,Sakurai H