Pirb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pirb
Entrez Gene ID	65146
Full Name	paired Ig-like receptor B
Synonyms	Lilrb3,NILR-1,Nilr1
General protein information	Preferred Names paired Ig-like receptor B Names neutrophil immunoglobulin-like receptor 1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 type 1 one-pass transmembrane Ig-like receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q12
Summary	immunoglobulin-like receptor expressed by neutrophilic granulocytes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031713.1	NP_113901.2	neutrophil immunoglobulin-like receptor 1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Changes in Expressions of Major Histocompatibility Complex Class I, Paired-Immunoglobulin-Like Receptor B, and Cluster of Differentiation 3? in Motor Cortical Representations of the Brachial Plexus After Avulsion in Rats.
Zhang J, Chen L, Gu YD
World neurosurgery106211-218(2017 Oct)

Electroacupuncture enhances rehabilitation through miR-181b targeting PirB after ischemic stroke.
Deng B, Bai F, Zhou H, Zhou D, Ma Z, Xiong L, Wang Q
Scientific reports638997(2016 Dec)

17?-estradiol suppresses hyperoxia-induced apoptosis of oligodendrocytes through paired-immunoglobulin-like receptor B.
Wang H, Wu J
Molecular medicine reports13(3)2892-8(2016 Mar)

[Neuroregeneration of newborn rats with hypoxic-ischemic brain damage following antibody-mediated neutralization of paired-immunoglobulin-like receptor B].
Wang H, Mu DZ
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics16(1)67-72(2014 Jan)

Human LilrB2 is a ?-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.
Kim T, Vidal GS, Djurisic M, William CM, Birnbaum ME, Garcia KC, Hyman BT, Shatz CJ
Science (New York, N.Y.)341(6152)1399-404(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In the original motor cortical representations of the brachial plexus, mRNA and protein expression levels of MHCI, PirB, and CD3zeta were down-regulated 7 days post brachial plexus injury compared with control. Interestingly, mRNA and protein expression levels of these factors were up-regulated at 3 months compared with 7 days, excepting PirB protein, whose expression was not increasing.
Title: Changes in Expressions of Major Histocompatibility Complex Class I, Paired-Immunoglobulin-Like Receptor B, and Cluster of Differentiation 3? in Motor Cortical Representations of the Brachial Plexus After Avulsion in Rats.

Estradiol protects oligodendrocyte precursor cells from hyperoxiainduced apoptosis, predominantly through the downregulation of PirB.
Title: 17?-estradiol suppresses hyperoxia-induced apoptosis of oligodendrocytes through paired-immunoglobulin-like receptor B.

PirB might be involved in hypoxic-ischemic brain damage (HIBD) through a Rho-ROCK-dependent mechanism.
Title: [Neuroregeneration of newborn rats with hypoxic-ischemic brain damage following antibody-mediated neutralization of paired-immunoglobulin-like receptor B].

Protein expression of major histocompatibity complex was elevated with aging in synaptosomes, hippocampal CA1, and dentate gyrus, while PirB protein expression was induced in both CA1 and DG.
Title: Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging.

PirB mRNA and protein expression increased in the cortical neurons of newborn rats following hypoxia-ischemia damage. PirB is able to improve axonal regeneration following HI damage.
Title: PirB restricts neuronal regeneration in developing rat brain following hypoxia-ischemia.

The following Pirb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pirb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08552	NM_031713.1 Latest version!	Rattus norvegicus paired Ig-like receptor B (Pirb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pirb ( NM_031713.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113901.2 Rattus norvegicus paired Ig-like receptor B (Pirb), mRNA.

Price & Availability↑

CloneID	ORa08552
Clone ID Related Accession (Same CDS sequence)	NM_031713.1
Accession Version	NM_031713.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1749bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	neutrophil immunoglobulin-like receptor 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF082534.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF082534.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGGACTG CCCTGCCTCC AGGGCCATAC CCTCTTCCCA AACCCTTCAG AAAGGCTCTG 
TATCTCTGTT CTCAAGCAGA GTTGCAGCCT CTCAGAAGAG ATGCCATGAC CTTCACCTGC 
AAAGCCCTGC TCTGTCTTGG AATGACTCTG GGCCTCTGGA TCACAGTGCT GACAGAGTTC 
CTCCCTAGGC CAATCCTCAG AGTACAGCCA GACACTGTGG TCTCTACACA GAGTAAGGTG 
ATCTTCTTCT GTGAGAGGAG TCAAGGAGCC GAACTTTATT GTCTCTATAA AAAGGGAAAT 
CCACGAAATC CACGGTGCAA AGAAATTCGA CCTAAACCTG GCAAGAAGGT TGAATTCTTC 
ATCTCAAAAA TTGAACCGTA CCATGCAGGA CATTACCACT GTTATTATCA GATCCATGGT 
CAATGGTCAG AGGACAGTGA TGCGCTGGAG CTGGTAGTGA CAGGAGTCTA TGACTACAAT 
GAACTCAGGC TGTCAGTACT GCCCAGCCCT GTGGTGACAG TGGGAAGGAA CATGACACTG 
CACTGTATCT CACATAGTCA CTATGATAAA TTCATTCTCA CCAAGGAAGA TCACAAGTTC 
ACCAGCTCAC TGGACACACA GTGTATACCT CCTAGTGGAC AGTGCCAAGC TCTGTTTGTT 
ATGGGACCCA TGACATCAAA CCACACCGGG ACATTCCGAT GTTATGGTTA CTACAAGCAT 
ACTCCACAGT TGTGGTCAAT ACCCAGTGAG CCCCTGGAAA TTCATATCTC AGGGCTGTCC 
AAGAAGCCCT CTCTGCTAAC TCACCAAGGA CACATCCTGG ACCCTGGAGT TAACCTCACA 
CTGCAGTGTT GCTCTGACAT CAACTATGAC AGATTTGCTC TGTACAAAGT TGGGGGTGTT 
GACATTATGC AGCACACTAG CCAGCAGACT GACACTGGCT TCTCCATGAC CAACTTCACA 
CTGGGCTATG TACACCACTC TACTGGAGGC CAATACAGAT GCTATGGAGC ACACAACCTC 
TCCTCTGAGT GGTCAGCATC CAGTGATCCC CTGGACATCT TGATCACAGG ACCCATTCAA 
ATGTCTACCT TGCCACCCAT AACATCCATG CCACCAGATC AGCTGGAAAG TTATGTGAAT 
GCTCTGATAG GAGTGTCTGT GGCCTTCCTG GTGTTCCTCT TCATCCTCAT CTTCATCATT 
CTCCAAAGAA GACATCAGAG AAAATTCAGA AAGGATGGTG AAGAGGCCCA GAAAGAGAAA 
GAACTACAAT ATCCTACAGG AGCTGTGGAG CCCATAAGCA GGGATAGAGA CCAGCAGAAG 
AGGTCCAATG CAGCTGCTGC CACCCAGGAG GAAAGCGTTT ATGCTTCAGT AGAGGACATG 
GAAACTGAGG ATGGTGTGGA GCTGGACACT TGGAAACCAC CTGAGGGAGA TCCACAGGGA 
GAGACATACG CCCAAGTAAA ACCCTCCAGG CTCAGGAGGG TAGAAGCTAT CATTCCTTCT 
GCCATGTCAA GGGAGCAGCT GAACACAAAA TATGAACAAG CAGAAGAGGG CCAAGAGGTG 
GACGGTCAGG CTACTGAATC CGAAGAGCCC CAGGATGTGA CCTATGCCCA GCTGTGCAGC 
AGGACACTCA GACAGGGGAC AGCTGCACCT CCTCTCTCCC AGGCAGGAGA AGCCCCAGAG 
GAGCCCAGTG TATATGCTGC TCTAGCGACT GCTTGCCCAG GAGCTGTTCC CAAGGACAAG 
GAGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113901.2
CDS	17..1765
Translation	MGTALPPGPYPLPKPFRKALYLCSQAELQPLRRDAMTFTCKALLCLGMTLGLWITVLTEFLPRPILRVQPDTVVSTQSKVIFFCERSQGAELYCLYKKGNPRNPRCKEIRPKPGKKVEFFISKIEPYHAGHYHCYYQIHGQWSEDSDALELVVTGVYDYNELRLSVLPSPVVTVGRNMTLHCISHSHYDKFILTKEDHKFTSSLDTQCIPPSGQCQALFVMGPMTSNHTGTFRCYGYYKHTPQLWSIPSEPLEIHISGLSKKPSLLTHQGHILDPGVNLTLQCCSDINYDRFALYKVGGVDIMQHTSQQTDTGFSMTNFTLGYVHHSTGGQYRCYGAHNLSSEWSASSDPLDILITGPIQMSTLPPITSMPPDQLESYVNALIGVSVAFLVFLFILIFIILQRRHQRKFRKDGEEAQKEKELQYPTGAVEPISRDRDQQKRSNAAAATQEESVYASVEDMETEDGVELDTWKPPEGDPQGETYAQVKPSRLRRVEAIIPSAMSREQLNTKYEQAEEGQEVDGQATESEEPQDVTYAQLCSRTLRQGTAAPPLSQAGEAPEEPSVYAALATACPGAVPKDKEQ

Target ORF information:

RefSeq Version	NM_031713.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus paired Ig-like receptor B (Pirb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031713.1

ORF Insert Sequence:

ATGGGGACTG CCCTGCCTCC AGGGCCATAC CCTCTTCCCA AACCCTTCAG AAAGGCTCTG 
TATCTCTGTT CTCAAGCAGA GTTGCAGCCT CTCAGAAGAG ATGCCATGAC CTTCACCTGC 
AAAGCCCTGC TCTGTCTTGG AATGACTCTG GGCCTCTGGA TCACAGTGCT GACAGAGTTC 
CTCCCTAGGC CAATCCTCAG AGTACAGCCA GACACTGTGG TCTCTACACA GAGTAAGGTG 
ATCTTCTTCT GTGAGAGGAG TCAAGGAGCC GAACTTTATT GTCTCTATAA AAAGGGAAAT 
CCACGAAATC CACGGTGCAA AGAAATTCGA CCTAAACCTG GCAAGAAGGT TGAATTCTTC 
ATCTCAAAAA TTGAACCGTA CCATGCAGGA CATTACCACT GTTATTATCA GATCCATGGT 
CAATGGTCAG AGGACAGTGA TGCGCTGGAG CTGGTAGTGA CAGGAGTCTA TGACTACAAT 
GAACTCAGGC TGTCAGTACT GCCCAGCCCT GTGGTGACAG TGGGAAGGAA CATGACACTG 
CACTGTATCT CACATAGTCA CTATGATAAA TTCATTCTCA CCAAGGAAGA TCACAAGTTC 
ACCAGCTCAC TGGACACACA GTGTATACCT CCTAGTGGAC AGTGCCAAGC TCTGTTTGTT 
ATGGGACCCA TGACATCAAA CCACACCGGG ACATTCCGAT GTTATGGTTA CTACAAGCAT 
ACTCCACAGT TGTGGTCAAT ACCCAGTGAG CCCCTGGAAA TTCATATCTC AGGGCTGTCC 
AAGAAGCCCT CTCTGCTAAC TCACCAAGGA CACATCCTGG ACCCTGGAGT TAACCTCACA 
CTGCAGTGTT GCTCTGACAT CAACTATGAC AGATTTGCTC TGTACAAAGT TGGGGGTGTT 
GACATTATGC AGCACACTAG CCAGCAGACT GACACTGGCT TCTCCATGAC CAACTTCACA 
CTGGGCTATG TACACCACTC TACTGGAGGC CAATACAGAT GCTATGGAGC ACACAACCTC 
TCCTCTGAGT GGTCAGCATC CAGTGATCCC CTGGACATCT TGATCACAGG ACCCATTCAA 
ATGTCTACCT TGCCACCCAT AACATCCATG CCACCAGATC AGCTGGAAAG TTATGTGAAT 
GCTCTGATAG GAGTGTCTGT GGCCTTCCTG GTGTTCCTCT TCATCCTCAT CTTCATCATT 
CTCCAAAGAA GACATCAGAG AAAATTCAGA AAGGATGGTG AAGAGGCCCA GAAAGAGAAA 
GAACTACAAT ATCCTACAGG AGCTGTGGAG CCCATAAGCA GGGATAGAGA CCAGCAGAAG 
AGGTCCAATG CAGCTGCTGC CACCCAGGAG GAAAGCGTTT ATGCTTCAGT AGAGGACATG 
GAAACTGAGG ATGGTGTGGA GCTGGACACT TGGAAACCAC CTGAGGGAGA TCCACAGGGA 
GAGACATACG CCCAAGTAAA ACCCTCCAGG CTCAGGAGGG TAGAAGCTAT CATTCCTTCT 
GCCATGTCAA GGGAGCAGCT GAACACAAAA TATGAACAAG CAGAAGAGGG CCAAGAGGTG 
GACGGTCAGG CTACTGAATC CGAAGAGCCC CAGGATGTGA CCTATGCCCA GCTGTGCAGC 
AGGACACTCA GACAGGGGAC AGCTGCACCT CCTCTCTCCC AGGCAGGAGA AGCCCCAGAG 
GAGCCCAGTG TATATGCTGC TCTAGCGACT GCTTGCCCAG GAGCTGTTCC CAAGGACAAG 
GAGCAGTGA