Slc30a4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc30a4
Entrez Gene ID	64469
Full Name	solute carrier family 30 member 4
General protein information	Preferred Names solute carrier family 30 member 4 Names zinc transporter 4 Dri 27/ZnT4 protein dri 27 protein solute carrier family 30 (zinc transporter), member 4 znT-4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q35
Summary	zinc transporter; involved in sequestration of zinc into endosomal/lysosomal compartments and synaptic vesicles [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_172066.1	NP_742063.1	zinc transporter 4

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC30A4	NP_037441.2
Pan troglodytes (chimpanzee)	SLC30A4	XP_510375.2
Mus musculus (house mouse)	Slc30a4	NP_035904.2
Rattus norvegicus (Norway rat)	Slc30a4	NP_742063.1
Arabidopsis thaliana (thale cress)	MTPB1	NP_180502.2
Bos taurus (cattle)	SLC30A4	XP_002690986.1
Gallus gallus (chicken)	SLC30A4	XP_003641899.1
Xenopus tropicalis (tropical clawed frog)	slc30a4	NP_001096181.1
Canis lupus familiaris (dog)	SLC30A4	XP_544664.3
Danio rerio (zebrafish)	slc30a4	NP_956937.1

Gene Ontology
Bibliography

Related articles in PubMed

Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation.
Murgia C, Grosser D, Truong-Tran AQ, Roscioli E, Michalczyk A, Ackland ML, Stoltenberg M, Danscher G, Lang C, Knight D, Perozzi G, Ruffin RE, Zalewski P
Nutrients3(11)910-28(2011 11)

The increase in zinc levels and upregulation of zinc transporters are mediated by nitric oxide in the cerebral cortex after transient ischemia in the rat.
Aguilar-Alonso P, Martinez-Fong D, Pazos-Salazar NG, Brambila E, Gonzalez-Barrios JA, Mejorada A, Flores G, Millan-Perezpe?a L, Rubio H, Leon-Chavez BA
Brain research120089-98(2008 Mar)

Differential expression of intestinal membrane transporters in cholera patients.
Flach CF, Qadri F, Bhuiyan TR, Alam NH, Jennische E, Holmgren J, L?nnroth I
FEBS letters581(17)3183-8(2007 Jul)

Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes.
Falc?n-P?rez JM, Dell'Angelica EC
Experimental cell research313(7)1473-83(2007 Apr)

Zn transporter levels and localization change throughout lactation in rat mammary gland and are regulated by Zn in mammary cells.
Kelleher SL, L?nnerdal B
The Journal of nutrition133(11)3378-85(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The loss of ZnT4 in airway inflammation contributes to airway epithelium vulnerability in diseases such as asthma.
Title: Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation.

The upregulation of ZnT1, ZnT2, and ZnT4 was to decrease the cytosolic zinc levels caused by NO after transient occlusion of the CCA.
Title: The increase in zinc levels and upregulation of zinc transporters are mediated by nitric oxide in the cerebral cortex after transient ischemia in the rat.

The following Slc30a4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc30a4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05990	NM_172066.1 Latest version!	Rattus norvegicus solute carrier family 30 member 4 (Slc30a4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc30a4 ( NM_172066.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_742063.1 Rattus norvegicus solute carrier family 30 member 4 (Slc30a4), mRNA.

Price & Availability↑

CloneID	ORa05990
Clone ID Related Accession (Same CDS sequence)	NM_172066.1
Accession Version	NM_172066.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Rattus norvegicus(Norway rat)
Product	zinc transporter 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y16774.1. On or before Jul 21, 2005 this sequence version replaced NM_001025030.1, XM_346659.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y16774.1, BC086981.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCCGGCC CCGGCGCGTG GAAGCGCCTC AAATCCCTGC TGAGGAAAGA CGACGCNCCG 
CTGTTCTTAA ATGACACCAG CGCCTTCGAC TTCTTGGACG AGGTGAGCGA CGAGGGGCTT 
TCGCGCTTTA ATAAACTTCG AGTCGTGGTG GCCGACGATG ACTCGGAAGC CCCGGAAAGG 
CCTGTGAACG GGGCGCACCC GGCCCTCCAG GCCGACGATG ACTCCTTATT GGACCAGGAA 
TTACCTTTGA CCAACAGTCA GTTGAGTTTG AAGATGGACC CCTGTGACAA CTGCAGCAAA 
CGGCGCGAGT TGCTGAAGCA GAGGAAGGTG AAGACCAGGC TGACCATCGC TGCCGTCCTC 
TACTTGCTTT TCATGATCGG AGAGCTTGTA GGTGGATACA TGGCAAATAG CTTAGCAATA 
ATGACAGATG CACTTCATAT GCTAACTGAC CTTAGTGCCA TCATACTCAC TCTTCTTGCT 
TTGTGGCTGT CTTCAAAGTC ACCAACCAGA AGATTCACCT TTGGATTTCA TCGCCTAGAG 
GTTCTGTCGG CCATGATCAG TGTCATGCTG GTGTATGTAC TTATGGGATT CCTCTTATAC 
GAGGCTATGC AGAGAACCAT CCATATGAAC TATGAAATCA ATGGCGATGT CATGCTCATC 
ACTGCAGCTG TTGGAGTTGC AGTTAATGTG ATAATGGGGT TTCTATTGAA CCAGTCCGGT 
CACCACCATT CTCACGCTCA TTCCCACTCC CTACCTTCAA ATTCTCCGAG CATGGTATCT 
AGTGGACACA GCCATGGGCA GGACAGCTTG GCCGTGAGAG CTGCATTTGT ACACGCCCTG 
GGGGATTTGG TACAAAGTGT TGGTGTGCTT ATAGCTGCAT ACATCATACG ATTCAAGCCA 
GAATACAAGA TTGCTGACCC CATCTGTACG TATATATTTT CATTACTTGT GGCATTCACA 
ACGCTCCGCA TTATATGGGA CACAGTAGTG ATAATACTGG AAGGTGTACC GAGCCATTTG 
AATGTAGACT ATATCAAAGA GTCGTTGATG AAGATAGAAG ATGTATATTC TGTGGAAGAT 
TTGAATATCT GGTCTCTCAC TTCTGGAAAA GCCACTGCCA TAGTGCACAT GCAGCTAATT 
CCCGGAAGTT CATCAAAATG GGAGGAAGTG CAGTCGAAAG CTAAGCACCT CTTGCTGAAC 
ACATTCGGCA TGTACAAGTG CACTGTTCAG CTCCAGAGCT ACAGACAGGA AGCCACCAGA 
ACTTGTGCAA ATTGTCAAAG TTCCAGTACC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_742063.1
CDS	268..1560
Translation	MAGPGAWKRLKSLLRKDDnullPLFLNDTSAFDFLDEVSDEGLSRFNKLRVVVADDDSEAPERPVNGAHPALQADDDSLLDQELPLTNSQLSLKMDPCDNCSKRRELLKQRKVKTRLTIAAVLYLLFMIGELVGGYMANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTRRFTFGFHRLEVLSAMISVMLVYVLMGFLLYEAMQRTIHMNYEINGDVMLITAAVGVAVNVIMGFLLNQSGHHHSHAHSHSLPSNSPSMVSSGHSHGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYIFSLLVAFTTLRIIWDTVVIILEGVPSHLNVDYIKESLMKIEDVYSVEDLNIWSLTSGKATAIVHMQLIPGSSSKWEEVQSKAKHLLLNTFGMYKCTVQLQSYRQEATRTCANCQSSST

Target ORF information:

RefSeq Version	NM_172066.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 30 member 4 (Slc30a4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172066.1

ORF Insert Sequence:

ATGGCCGGCC CCGGCGCGTG GAAGCGCCTC AAATCCCTGC TGAGGAAAGA CGACGCNCCG 
CTGTTCTTAA ATGACACCAG CGCCTTCGAC TTCTTGGACG AGGTGAGCGA CGAGGGGCTT 
TCGCGCTTTA ATAAACTTCG AGTCGTGGTG GCCGACGATG ACTCGGAAGC CCCGGAAAGG 
CCTGTGAACG GGGCGCACCC GGCCCTCCAG GCCGACGATG ACTCCTTATT GGACCAGGAA 
TTACCTTTGA CCAACAGTCA GTTGAGTTTG AAGATGGACC CCTGTGACAA CTGCAGCAAA 
CGGCGCGAGT TGCTGAAGCA GAGGAAGGTG AAGACCAGGC TGACCATCGC TGCCGTCCTC 
TACTTGCTTT TCATGATCGG AGAGCTTGTA GGTGGATACA TGGCAAATAG CTTAGCAATA 
ATGACAGATG CACTTCATAT GCTAACTGAC CTTAGTGCCA TCATACTCAC TCTTCTTGCT 
TTGTGGCTGT CTTCAAAGTC ACCAACCAGA AGATTCACCT TTGGATTTCA TCGCCTAGAG 
GTTCTGTCGG CCATGATCAG TGTCATGCTG GTGTATGTAC TTATGGGATT CCTCTTATAC 
GAGGCTATGC AGAGAACCAT CCATATGAAC TATGAAATCA ATGGCGATGT CATGCTCATC 
ACTGCAGCTG TTGGAGTTGC AGTTAATGTG ATAATGGGGT TTCTATTGAA CCAGTCCGGT 
CACCACCATT CTCACGCTCA TTCCCACTCC CTACCTTCAA ATTCTCCGAG CATGGTATCT 
AGTGGACACA GCCATGGGCA GGACAGCTTG GCCGTGAGAG CTGCATTTGT ACACGCCCTG 
GGGGATTTGG TACAAAGTGT TGGTGTGCTT ATAGCTGCAT ACATCATACG ATTCAAGCCA 
GAATACAAGA TTGCTGACCC CATCTGTACG TATATATTTT CATTACTTGT GGCATTCACA 
ACGCTCCGCA TTATATGGGA CACAGTAGTG ATAATACTGG AAGGTGTACC GAGCCATTTG 
AATGTAGACT ATATCAAAGA GTCGTTGATG AAGATAGAAG ATGTATATTC TGTGGAAGAT 
TTGAATATCT GGTCTCTCAC TTCTGGAAAA GCCACTGCCA TAGTGCACAT GCAGCTAATT 
CCCGGAAGTT CATCAAAATG GGAGGAAGTG CAGTCGAAAG CTAAGCACCT CTTGCTGAAC 
ACATTCGGCA TGTACAAGTG CACTGTTCAG CTCCAGAGCT ACAGACAGGA AGCCACCAGA 
ACTTGTGCAA ATTGTCAAAG TTCCAGTACC TGA